Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0096 | 0.1296 | 0.1296 |
Echinococcus granulosus | protein jagged 1 | 0.0061 | 0.063 | 0.0452 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0382 | 0.02 |
Onchocerca volvulus | Dual oxidase homolog | 0.0563 | 1 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.0061 | 0.063 | 0.063 |
Brugia malayi | Protein kinase domain containing protein | 0.0096 | 0.1296 | 0.1296 |
Mycobacterium leprae | conserved hypothetical protein | 0.0073 | 0.0855 | 0.5 |
Echinococcus multilocularis | intestinal type alkaline phosphatase 1 | 0.0516 | 0.9138 | 0.9122 |
Plasmodium vivax | hypothetical protein, conserved | 0.0073 | 0.0855 | 0.5 |
Echinococcus granulosus | intestinal type alkaline phosphatase 1 | 0.0516 | 0.9138 | 0.9122 |
Mycobacterium ulcerans | lipase LipD | 0.0073 | 0.0855 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.2623 | 0.2623 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.063 | 0.063 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.063 | 0.063 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0073 | 0.0855 | 0.0682 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.063 | 0.063 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.063 | 0.063 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.063 | 0.063 |
Loa Loa (eye worm) | beta-lactamase | 0.0073 | 0.0855 | 0.0855 |
Schistosoma mansoni | septate junction protein | 0.0061 | 0.063 | 0.0452 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0563 | 1 | 1 |
Onchocerca volvulus | 0.0049 | 0.042 | 0.0236 | |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0242 | 0.4021 | 0.4021 |
Echinococcus multilocularis | alkaline phosphatase, intestinal, gene 2 | 0.0516 | 0.9138 | 0.9122 |
Brugia malayi | Transmembrane cell adhesion receptor mua-3 precursor, putative | 0.0061 | 0.063 | 0.063 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0073 | 0.0855 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0061 | 0.063 | 0.0452 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0478 | 0.8425 | 0.8395 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0037 | 0.0188 | 0.0002 |
Onchocerca volvulus | Peroxidase homolog | 0.0563 | 1 | 1 |
Onchocerca volvulus | Slit protein homolog | 0.0061 | 0.063 | 0.045 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.063 | 0.063 |
Onchocerca volvulus | 0.0563 | 1 | 1 | |
Brugia malayi | Delta serrate ligand family protein | 0.0061 | 0.063 | 0.063 |
Echinococcus granulosus | delta-like protein 1 | 0.0061 | 0.063 | 0.0452 |
Brugia malayi | EGF-like domain containing protein | 0.0061 | 0.063 | 0.063 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0382 | 0.02 |
Brugia malayi | EGF-like domain containing protein | 0.0061 | 0.063 | 0.063 |
Echinococcus multilocularis | peroxidasin | 0.0563 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0242 | 0.4021 | 0.4021 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0478 | 0.8425 | 0.8395 |
Brugia malayi | Blistered cuticle protein 3 | 0.0563 | 1 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.0061 | 0.063 | 0.063 |
Onchocerca volvulus | 0.0073 | 0.0855 | 0.068 | |
Echinococcus granulosus | neurogenic locus protein delta | 0.0061 | 0.063 | 0.0452 |
Brugia malayi | Animal haem peroxidase family protein | 0.0563 | 1 | 1 |
Schistosoma mansoni | notch | 0.0061 | 0.063 | 0.0452 |
Schistosoma mansoni | peroxidasin | 0.0563 | 1 | 1 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.005 | 0.043 | 0.0249 |
Onchocerca volvulus | Putative cubilin | 0.0061 | 0.063 | 0.045 |
Brugia malayi | notch-like transmembrane receptor | 0.0061 | 0.063 | 0.063 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.063 | 0.063 |
Echinococcus multilocularis | protein jagged 1 | 0.0061 | 0.063 | 0.0452 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0855 | 0.0855 |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.0061 | 0.063 | 0.0452 |
Brugia malayi | follicle stimulating hormone receptor | 0.0242 | 0.4023 | 0.4023 |
Onchocerca volvulus | 0.0061 | 0.063 | 0.045 | |
Onchocerca volvulus | 0.0061 | 0.063 | 0.045 | |
Schistosoma mansoni | hypothetical protein | 0.0061 | 0.063 | 0.0452 |
Toxoplasma gondii | ABC1 family protein | 0.0073 | 0.0855 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0563 | 1 | 1 |
Onchocerca volvulus | 0.0061 | 0.063 | 0.045 | |
Onchocerca volvulus | 0.0073 | 0.0855 | 0.068 | |
Brugia malayi | EGF-like domain containing protein | 0.0061 | 0.063 | 0.063 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0382 | 0.02 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.063 | 0.063 |
Leishmania major | hypothetical protein, conserved | 0.0073 | 0.0855 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0855 | 0.0855 |
Echinococcus granulosus | alkaline phosphatase intestinal gene 2 | 0.0516 | 0.9138 | 0.9122 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0382 | 0.02 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0464 | 0.8161 | 1 |
Onchocerca volvulus | 0.0061 | 0.063 | 0.045 | |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.042 | 0.0238 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.063 | 0.063 |
Brugia malayi | Animal haem peroxidase family protein | 0.0563 | 1 | 1 |
Schistosoma mansoni | notch | 0.0061 | 0.063 | 0.0452 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0061 | 0.063 | 0.0452 |
Schistosoma mansoni | notch | 0.0061 | 0.063 | 0.0452 |
Schistosoma mansoni | hypothetical protein | 0.0061 | 0.063 | 0.0452 |
Echinococcus granulosus | fibropellin Ia | 0.0061 | 0.063 | 0.0452 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0382 | 0.02 |
Schistosoma mansoni | notch | 0.0061 | 0.063 | 0.0452 |
Loa Loa (eye worm) | hypothetical protein | 0.0563 | 1 | 1 |
Echinococcus multilocularis | protein jagged 1 | 0.0061 | 0.063 | 0.0452 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.063 | 0.063 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.063 | 0.063 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.4012 | 0.4012 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0061 | 0.063 | 0.0452 |
Mycobacterium leprae | Probable lipase LipE | 0.0073 | 0.0855 | 0.5 |
Onchocerca volvulus | Neurogenic locus notch protein homolog | 0.0061 | 0.063 | 0.045 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0382 | 0.02 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0061 | 0.063 | 0.0452 |
Brugia malayi | beta-lactamase family protein | 0.0073 | 0.0855 | 0.0855 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0073 | 0.0855 | 0.0855 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0061 | 0.063 | 0.063 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0073 | 0.0855 | 0.0682 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0855 | 0.0855 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0855 | 0.0855 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0382 | 0.02 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0073 | 0.0855 | 0.5 |
Brugia malayi | hypothetical protein | 0.0167 | 0.2623 | 0.2623 |
Loa Loa (eye worm) | hypothetical protein | 0.0563 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0061 | 0.063 | 0.0452 |
Trichomonas vaginalis | AGC family protein kinase | 0.0096 | 0.1296 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0061 | 0.063 | 0.0452 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0563 | 1 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0073 | 0.0855 | 1 |
Echinococcus multilocularis | 3 phosphoinositide dependent protein kinase 1 | 0.0096 | 0.1296 | 0.1131 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0061 | 0.063 | 0.063 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.063 | 0.063 |
Echinococcus granulosus | peroxidasin | 0.0563 | 1 | 1 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0061 | 0.063 | 0.063 |
Echinococcus multilocularis | intestinal type alkaline phosphatase | 0.0516 | 0.9138 | 0.9122 |
Onchocerca volvulus | 0.0563 | 1 | 1 | |
Brugia malayi | EGF-like domain containing protein | 0.0061 | 0.063 | 0.063 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.063 | 0.063 |
Echinococcus granulosus | single minded 2 | 0.0037 | 0.0188 | 0.0002 |
Brugia malayi | hypoxia-induced factor 1 | 0.0154 | 0.2381 | 0.2381 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0563 | 1 | 1 |
Echinococcus multilocularis | neural cadherin | 0.0061 | 0.063 | 0.0452 |
Loa Loa (eye worm) | hypothetical protein | 0.0563 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0563 | 1 | 1 |
Echinococcus multilocularis | protein jagged 2 | 0.0061 | 0.063 | 0.0452 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.063 | 0.063 |
Loa Loa (eye worm) | hypothetical protein | 0.0563 | 1 | 1 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0061 | 0.063 | 0.0452 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0563 | 1 | 1 |
Brugia malayi | Peroxidasin | 0.0563 | 1 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0073 | 0.0855 | 0.0682 |
Mycobacterium ulcerans | hypothetical protein | 0.0073 | 0.0855 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0563 | 1 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0242 | 0.4012 | 0.3899 |
Loa Loa (eye worm) | hypothetical protein | 0.0563 | 1 | 1 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0061 | 0.063 | 0.0452 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0478 | 0.8425 | 0.8395 |
Schistosoma mansoni | alkaline phosphatase | 0.0516 | 0.9138 | 0.9122 |
Onchocerca volvulus | Peroxidasin homolog | 0.0563 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0268 | 0.4508 | 0.4404 |
Echinococcus granulosus | neuropeptide s receptor | 0.0478 | 0.8425 | 0.8395 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0061 | 0.063 | 0.0452 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0096 | 0.1296 | 0.1296 |
Echinococcus multilocularis | notch | 0.0061 | 0.063 | 0.0452 |
Echinococcus multilocularis | fibropellin Ia | 0.0061 | 0.063 | 0.0452 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.063 | 0.063 |
Schistosoma mansoni | alkaline phosphatase | 0.0516 | 0.9138 | 0.9122 |
Mycobacterium ulcerans | beta-lactamase | 0.0073 | 0.0855 | 1 |
Schistosoma mansoni | slit | 0.0061 | 0.063 | 0.0452 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.0382 | 0.0382 |
Onchocerca volvulus | 0.0061 | 0.063 | 0.045 | |
Schistosoma mansoni | single-minded | 0.005 | 0.043 | 0.0249 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0563 | 1 | 1 |
Echinococcus granulosus | neurogenic locus notch protein 4 | 0.0061 | 0.063 | 0.0452 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0049 | 0.042 | 0.042 |
Schistosoma mansoni | laminin gamma-3 chain | 0.0061 | 0.063 | 0.0452 |
Echinococcus granulosus | alkaline phosphatase | 0.0516 | 0.9138 | 0.9122 |
Onchocerca volvulus | Peroxidase homolog | 0.0563 | 1 | 1 |
Echinococcus multilocularis | slit 2 protein | 0.0061 | 0.063 | 0.0452 |
Loa Loa (eye worm) | hypothetical protein | 0.0563 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.063 | 0.063 |
Brugia malayi | MH2 domain containing protein | 0.0242 | 0.4021 | 0.4021 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0096 | 0.1296 | 0.1131 |
Echinococcus granulosus | 3-phosphoinositide-dependent protein kinase 1 | 0.0096 | 0.1296 | 0.1131 |
Echinococcus multilocularis | alkaline phosphatase | 0.0516 | 0.9138 | 0.9122 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0073 | 0.0855 | 1 |
Echinococcus granulosus | notch | 0.0061 | 0.063 | 0.0452 |
Entamoeba histolytica | protein kinase, putative | 0.0096 | 0.1296 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0242 | 0.4023 | 0.4023 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.063 | 0.063 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.063 | 0.063 |
Echinococcus granulosus | slit 2 protein | 0.0061 | 0.063 | 0.0452 |
Echinococcus granulosus | intestinal type alkaline phosphatase | 0.0516 | 0.9138 | 0.9122 |
Brugia malayi | Animal haem peroxidase family protein | 0.0563 | 1 | 1 |
Onchocerca volvulus | 0.0073 | 0.0855 | 0.068 | |
Echinococcus granulosus | protein jagged 2 | 0.0061 | 0.063 | 0.0452 |
Echinococcus granulosus | neural cadherin | 0.0061 | 0.063 | 0.0452 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0855 | 0.0855 |
Brugia malayi | beta-lactamase family protein | 0.0073 | 0.0855 | 0.0855 |
Trichomonas vaginalis | AGC family protein kinase | 0.0096 | 0.1296 | 1 |
Brugia malayi | phosphoinositide-dependent protein kinase I | 0.0096 | 0.1296 | 0.1296 |
Loa Loa (eye worm) | hypothetical protein | 0.0563 | 1 | 1 |
Schistosoma mansoni | survival motor neuron protein | 0.0049 | 0.042 | 0.0238 |
Echinococcus granulosus | protein jagged 2 | 0.0061 | 0.063 | 0.0452 |
Brugia malayi | hypothetical protein | 0.0242 | 0.4012 | 0.4012 |
Echinococcus multilocularis | fat cadherin tumor suppressor | 0.0061 | 0.063 | 0.0452 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0855 | 0.0855 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0073 | 0.0855 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0096 | 0.1296 | 1 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0061 | 0.063 | 0.063 |
Giardia lamblia | High cysteine protein | 0.0061 | 0.063 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0061 | 0.063 | 0.0452 |
Loa Loa (eye worm) | hypothetical protein | 0.0563 | 1 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0073 | 0.0855 | 0.0682 |
Schistosoma mansoni | cell polarity protein | 0.0061 | 0.063 | 0.0452 |
Schistosoma mansoni | peroxidasin | 0.0563 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0563 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0563 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0563 | 1 | 1 |
Brugia malayi | bHLH-PAS transcription factor | 0.0037 | 0.0188 | 0.0188 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.063 | 0.063 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.063 | 0.063 |
Schistosoma mansoni | notch | 0.0061 | 0.063 | 0.0452 |
Brugia malayi | hypothetical protein | 0.0037 | 0.0186 | 0.0186 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0154 | 0.2381 | 0.2381 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.063 | 0.063 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.0382 | 0.0382 |
Onchocerca volvulus | Peroxidasin homolog | 0.0563 | 1 | 1 |
Loa Loa (eye worm) | Notch2 | 0.0061 | 0.063 | 0.063 |
Brugia malayi | Animal haem peroxidase family protein | 0.0563 | 1 | 1 |
Onchocerca volvulus | Neurogenic locus notch homolog | 0.0061 | 0.063 | 0.045 |
Schistosoma mansoni | notch | 0.0061 | 0.063 | 0.0452 |
Loa Loa (eye worm) | notch protein | 0.0061 | 0.063 | 0.063 |
Schistosoma mansoni | hypothetical protein | 0.0061 | 0.063 | 0.0452 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0073 | 0.0855 | 0.0855 |
Brugia malayi | beta-lactamase | 0.0073 | 0.0855 | 0.0855 |
Echinococcus multilocularis | neurogenic locus notch protein 4 | 0.0061 | 0.063 | 0.0452 |
Brugia malayi | PAS domain containing protein | 0.005 | 0.043 | 0.043 |
Loa Loa (eye worm) | hypothetical protein | 0.0563 | 1 | 1 |
Brugia malayi | Muscle positioning protein 4 | 0.0061 | 0.063 | 0.063 |
Brugia malayi | Cadherin domain containing protein | 0.0061 | 0.063 | 0.063 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0242 | 0.4012 | 0.3899 |
Brugia malayi | Cadherin domain containing protein | 0.0061 | 0.063 | 0.063 |
Brugia malayi | EGF-like domain containing protein | 0.0061 | 0.063 | 0.063 |
Loa Loa (eye worm) | hypothetical protein | 0.0563 | 1 | 1 |
Onchocerca volvulus | 0.0563 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.063 | 0.063 |
Echinococcus granulosus | protein jagged 1 | 0.0061 | 0.063 | 0.0452 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.