Detailed information for compound 1468042

Basic information

Technical information
  • TDR Targets ID: 1468042
  • Name: 4-hydroxy-9-methyl-N-[3-(2-methylpiperidin-1- yl)propyl]-2-oxopyrido[1,2-a]pyrimidine-3-car boxamide
  • MW: 358.435 | Formula: C19H26N4O3
  • H donors: 2 H acceptors: 3 LogP: 2.61 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CCCCN1CCCNC(=O)c1c(=O)nc2n(c1O)cccc2C
  • InChi: 1S/C19H26N4O3/c1-13-7-5-12-23-16(13)21-18(25)15(19(23)26)17(24)20-9-6-11-22-10-4-3-8-14(22)2/h5,7,12,14,26H,3-4,6,8-11H2,1-2H3,(H,20,24)
  • InChiKey: SYBGPAQHRGQBDT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-hydroxy-9-methyl-N-[3-(2-methyl-1-piperidyl)propyl]-2-oxo-pyrido[1,2-a]pyrimidine-3-carboxamide
  • 4-hydroxy-9-methyl-N-[3-(2-methyl-1-piperidinyl)propyl]-2-oxo-3-pyrido[1,2-a]pyrimidinecarboxamide
  • 4-hydroxy-2-keto-9-methyl-N-[3-(2-methyl-1-piperidyl)propyl]pyrido[1,2-a]pyrimidine-3-carboxamide
  • 4-hydroxy-9-methyl-N-[3-(2-methylpiperidin-1-yl)propyl]-2-oxo-pyrido[1,2-a]pyrimidine-3-carboxamide
  • C720-0562
  • NCGC00112162-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens thyroid hormone receptor, beta Starlite/ChEMBL No references
Homo sapiens EYA transcriptional coactivator and phosphatase 2 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni eyes absent homolog Get druggable targets OG5_129664 All targets in OG5_129664
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Brugia malayi hypothetical protein Get druggable targets OG5_129664 All targets in OG5_129664
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129664 All targets in OG5_129664
Schistosoma japonicum ko:K01104 protein-tyrosine phosphatase [EC3.1.3.48], putative Get druggable targets OG5_129664 All targets in OG5_129664
Echinococcus multilocularis thyroid hormone receptor alpha Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum ko:K08362 nuclear receptor, subfamily 1, group A, member 2, putative Get druggable targets OG5_134830 All targets in OG5_134830
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129664 All targets in OG5_129664
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum expressed protein Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi photoreceptor-specific nuclear receptor thyroid hormone receptor, beta 461 aa 414 aa 24.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni neuropeptide receptor 0.0017 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0036 0.1596 0.2575
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0.0289 0.0314
Schistosoma mansoni biogenic amine receptor 0.0017 0.0289 0.0289
Brugia malayi larval opioid receptor 0.0017 0.0289 0.0467
Schistosoma mansoni biogenic amine (5HT) receptor 0.0017 0.0289 0.0289
Leishmania major hypothetical protein, conserved 0.003 0.1199 0.5
Brugia malayi Serotonin receptor 0.0017 0.0289 0.0467
Onchocerca volvulus 0.0017 0.0289 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0289 0.0289
Onchocerca volvulus 0.0017 0.0289 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0289 0.0314
Schistosoma mansoni biogenic amine (5HT) receptor 0.0017 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0017 0.0289 0.0467
Loa Loa (eye worm) hypothetical protein 0.0017 0.0289 0.0467
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0017 0.0289 0.0289
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0095 0.0104
Brugia malayi hypothetical protein 0.0017 0.0289 0.0467
Entamoeba histolytica hypothetical protein 0.0043 0.2055 0.5
Onchocerca volvulus 0.0017 0.0289 1
Onchocerca volvulus 0.0017 0.0289 1
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.1199 0.5
Echinococcus multilocularis fmrfamide receptor 0.0017 0.0289 0.0289
Echinococcus granulosus neuropeptide receptor 0.0017 0.0289 0.0314
Echinococcus granulosus serotonin receptor 0.0017 0.0289 0.0314
Brugia malayi hypothetical protein 0.0017 0.0289 0.0467
Loa Loa (eye worm) neuropeptide F receptor 0.0017 0.0289 0.0467
Schistosoma mansoni histamine h1 receptor 0.0017 0.0289 0.0289
Echinococcus granulosus G protein coupled receptor 139 0.0017 0.0289 0.0314
Onchocerca volvulus 0.0017 0.0289 1
Schistosoma mansoni neuropeptide F-like receptor 0.0017 0.0289 0.0289
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0017 0.0289 0.0314
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0017 0.0289 0.0289
Schistosoma mansoni hypothetical protein 0.0043 0.2055 0.2055
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0289 0.0314
Echinococcus granulosus tachykinin peptides receptor 99D 0.0017 0.0289 0.0314
Schistosoma mansoni thyroid hormone receptor 0.0164 1 1
Onchocerca volvulus 0.0017 0.0289 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0017 0.0289 0.0314
Brugia malayi hypothetical protein 0.0017 0.0289 0.0467
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0017 0.0289 0.0289
Loa Loa (eye worm) melatonin receptor type 1A 0.0017 0.0289 0.0467
Brugia malayi Melatonin receptor type 1A 0.0017 0.0289 0.0467
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.1199 0.5
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.2214 0.2214
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0017 0.0289 0.0467
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0042 0.196 0.3164
Echinococcus multilocularis neuropeptide receptor 0.0017 0.0289 0.0289
Brugia malayi hypothetical protein 0.0017 0.0289 0.0467
Loa Loa (eye worm) hypothetical protein 0.0017 0.0289 0.0467
Brugia malayi hypothetical protein 0.0106 0.6197 1
Brugia malayi putative neuropeptide receptor NPR1 0.0017 0.0289 0.0467
Loa Loa (eye worm) hypothetical protein 0.0017 0.0289 0.0467
Loa Loa (eye worm) hypothetical protein 0.0017 0.0289 0.0467
Brugia malayi hypothetical protein 0.0017 0.0289 0.0467
Brugia malayi hypothetical protein 0.0043 0.2055 0.3316
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0289 0.0289
Echinococcus granulosus neuropeptide s receptor 0.0017 0.0289 0.0314
Echinococcus multilocularis neuropeptide Y receptor 0.0017 0.0289 0.0289
Onchocerca volvulus 0.0017 0.0289 1
Onchocerca volvulus 0.0017 0.0289 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0017 0.0289 0.0289
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0289 0.0289
Echinococcus granulosus g protein coupled receptor 0.0017 0.0289 0.0314
Loa Loa (eye worm) hypothetical protein 0.0017 0.0289 0.0467
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0289 0.0289
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.1199 0.5
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.1199 0.5
Echinococcus multilocularis serotonin receptor 0.0017 0.0289 0.0289
Onchocerca volvulus 0.0017 0.0289 1
Brugia malayi hypothetical protein 0.0017 0.0289 0.0467
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0017 0.0289 0.0314
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.1199 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0.0289 0.0289
Onchocerca volvulus 0.0017 0.0289 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0017 0.0289 0.0289
Echinococcus multilocularis somatostatin receptor 0.0017 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0017 0.0289 0.0467
Loa Loa (eye worm) hypothetical protein 0.0017 0.0289 0.0467
Schistosoma mansoni neuropeptide receptor 0.0017 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0017 0.0289 0.0467
Schistosoma mansoni biogenic amine receptor 0.0017 0.0289 0.0289
Echinococcus granulosus sex peptide receptor 0.0017 0.0289 0.0314
Schistosoma mansoni neuropeptide receptor 0.0017 0.0289 0.0289
Schistosoma mansoni hypothetical protein 0.0017 0.0289 0.0289
Schistosoma mansoni biogenic amine receptor 0.0017 0.0289 0.0289
Schistosoma mansoni amine GPCR 0.0017 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0017 0.0289 0.0467
Schistosoma mansoni opsin-like receptor 0.0017 0.0289 0.0289
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0152 0.9197 0.9197
Schistosoma mansoni amine GPCR 0.0017 0.0289 0.0289
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0017 0.0289 0.0289
Echinococcus multilocularis neuropeptide receptor A26 0.0017 0.0289 0.0289
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0289 0.0289
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0017 0.0289 0.0289
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0017 0.0289 0.0467
Loa Loa (eye worm) hypothetical protein 0.0017 0.0289 0.0467
Echinococcus granulosus neuropeptide receptor 0.0017 0.0289 0.0314
Loa Loa (eye worm) G-protein coupled receptor 0.0017 0.0289 0.0467
Brugia malayi G protein-coupled receptor 0.0017 0.0289 0.0467
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0152 0.9197 1
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0.0289 0.0314
Loa Loa (eye worm) hypothetical protein 0.0017 0.0289 0.0467
Echinococcus granulosus 7TM GPCR rhodopsin 0.0017 0.0289 0.0314
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0017 0.0289 0.0467
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.003 0.1199 0.1936
Echinococcus granulosus neuropeptides capa receptor 0.0017 0.0289 0.0314
Echinococcus multilocularis g protein coupled receptor 0.0017 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0017 0.0289 0.0467
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0017 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0017 0.0289 0.0467
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0289 0.0289
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0289 0.0289
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0017 0.0289 0.0314
Echinococcus granulosus g-protein coupled receptor 0.0017 0.0289 0.0314
Echinococcus multilocularis neuropeptide FF receptor 2 0.0017 0.0289 0.0289
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0095 0.0095
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.1199 0.5
Brugia malayi neuropeptide F receptor 0.0017 0.0289 0.0467
Loa Loa (eye worm) hypothetical protein 0.0017 0.0289 0.0467
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0017 0.0289 0.0467
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0289 0.0314
Brugia malayi putative neuropeptide receptor 0.0017 0.0289 0.0467
Echinococcus granulosus hypothetical protein 0.0017 0.0289 0.0314
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0289 0.0289
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0017 0.0289 0.0467
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0289 0.0289
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0042 0.196 0.3164
Schistosoma mansoni eyes absent homolog 0.0106 0.6197 0.6197
Schistosoma mansoni opsin-like receptor 0.0017 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0017 0.0289 0.0467
Loa Loa (eye worm) hypothetical protein 0.0017 0.0289 0.0467
Echinococcus multilocularis neuropeptide s receptor 0.0017 0.0289 0.0289
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0017 0.0289 0.0289
Echinococcus granulosus g protein coupled receptor 0.0017 0.0289 0.0314
Brugia malayi ORL1-like opioid receptor 0.0017 0.0289 0.0467
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0017 0.0289 0.0289
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.2055 0.2055
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0017 0.0289 0.0289
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0289 0.0289
Echinococcus multilocularis G-protein coupled receptor, putative 0.0017 0.0289 0.0289
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0.0289 0.0314
Onchocerca volvulus Neuropeptide F receptor homolog 0.0017 0.0289 1
Schistosoma mansoni amine GPCR 0.0017 0.0289 0.0289
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0289 0.0289
Brugia malayi G protein-coupled receptor F59B2.13 0.0017 0.0289 0.0467
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0039 0.1779 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0289 0.0289
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.0289 0.0289
Echinococcus granulosus neuropeptide FF receptor 2 0.0017 0.0289 0.0314
Onchocerca volvulus 0.0017 0.0289 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0289 0.0467
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0017 0.0289 0.0467
Loa Loa (eye worm) hypothetical protein 0.0017 0.0289 0.0467
Brugia malayi Dopamine receptor 0.0017 0.0289 0.0467
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0017 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0017 0.0289 0.0467
Echinococcus granulosus alpha 1A adrenergic receptor 0.0017 0.0289 0.0314
Schistosoma mansoni hypothetical protein 0.0017 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0017 0.0289 0.0467
Loa Loa (eye worm) hypothetical protein 0.0106 0.6197 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0289 0.0467
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0017 0.0289 0.0467
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0017 0.0289 0.0289
Echinococcus granulosus orexin receptor type 2 0.0017 0.0289 0.0314
Echinococcus granulosus neuropeptides capa receptor 0.0017 0.0289 0.0314
Loa Loa (eye worm) hypothetical protein 0.0017 0.0289 0.0467
Loa Loa (eye worm) hypothetical protein 0.0017 0.0289 0.0467
Brugia malayi follicle stimulating hormone receptor 0.0017 0.0289 0.0467
Onchocerca volvulus 0.0017 0.0289 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0017 0.0289 0.0289
Echinococcus granulosus biogenic amine 5HT receptor 0.0017 0.0289 0.0314
Brugia malayi G-protein coupled receptor 0.0017 0.0289 0.0467
Loa Loa (eye worm) hypothetical protein 0.0017 0.0289 0.0467
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0.0289 0.0289
Echinococcus multilocularis serotonin receptor 0.0017 0.0289 0.0289
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0017 0.0289 0.0314
Brugia malayi hypothetical protein 0.0017 0.0289 0.0467
Echinococcus multilocularis neuropeptides capa receptor 0.0017 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0017 0.0289 0.0467
Schistosoma mansoni neuropeptide receptor 0.0017 0.0289 0.0289
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0017 0.0289 0.0289
Onchocerca volvulus 0.0017 0.0289 1
Loa Loa (eye worm) TYRA-2 protein 0.0017 0.0289 0.0467
Echinococcus granulosus biogenic amine 5HT receptor 0.0017 0.0289 0.0314
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0017 0.0289 1
Echinococcus granulosus neuropeptide Y receptor 0.0017 0.0289 0.0314
Brugia malayi hypothetical protein 0.003 0.1199 0.1936
Onchocerca volvulus 0.0017 0.0289 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0017 0.0289 0.0289
Echinococcus granulosus peptide allatostatin:somatostatin 0.0017 0.0289 0.0314
Brugia malayi hypothetical protein 0.0017 0.0289 0.0467
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0039 0.1779 0.5
Echinococcus granulosus neuropeptide Y receptor 0.0017 0.0289 0.0314
Loa Loa (eye worm) hypothetical protein 0.0017 0.0289 0.0467
Brugia malayi Dopamine receptor protein 1 0.0017 0.0289 0.0467
Loa Loa (eye worm) hypothetical protein 0.0017 0.0289 0.0467
Echinococcus multilocularis G protein coupled receptor 139 0.0017 0.0289 0.0289
Schistosoma mansoni growth hormone secretagogue receptor 0.0017 0.0289 0.0289
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0289 0.0314
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.0289 0.0289
Echinococcus granulosus g protein coupled receptor 0.0017 0.0289 0.0314
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.1199 0.5
Schistosoma mansoni alpha-1 adrenergic receptor 0.0017 0.0289 0.0289
Schistosoma mansoni neuropeptide f receptor 76f 0.0017 0.0289 0.0289
Brugia malayi GnHR receptor homolog 0.0017 0.0289 0.0467
Schistosoma mansoni hypothetical protein 0.0152 0.9197 0.9197
Entamoeba histolytica hypothetical protein 0.0043 0.2055 0.5
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.2055 0.2234
Loa Loa (eye worm) hypothetical protein 0.0017 0.0289 0.0467
Brugia malayi RE15519p 0.0017 0.0289 0.0467
Loa Loa (eye worm) hypothetical protein 0.0017 0.0289 0.0467
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0017 0.0289 0.0467
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0017 0.0289 0.0289
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0017 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0017 0.0289 0.0467
Schistosoma mansoni adenoreceptor 0.0017 0.0289 0.0289
Schistosoma mansoni amine GPCR 0.0017 0.0289 0.0289
Entamoeba histolytica hypothetical protein 0.0043 0.2055 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0289 0.0289
Schistosoma mansoni neuropeptide F-like receptor 0.0017 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0017 0.0289 0.0467
Echinococcus multilocularis g protein coupled receptor 0.0017 0.0289 0.0289
Echinococcus granulosus fmrfamide receptor 0.0017 0.0289 0.0314
Schistosoma mansoni hypothetical protein 0.0014 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0017 0.0289 0.0467
Echinococcus multilocularis g-protein coupled receptor 0.0017 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0017 0.0289 0.0467
Echinococcus granulosus somatostatin receptor 0.0017 0.0289 0.0314
Echinococcus granulosus allatostatin A receptor 0.0017 0.0289 0.0314
Echinococcus multilocularis orexin receptor type 2 0.0017 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0017 0.0289 0.0467
Loa Loa (eye worm) hypothetical protein 0.0017 0.0289 0.0467
Loa Loa (eye worm) hypothetical protein 0.0017 0.0289 0.0467
Brugia malayi hypothetical protein 0.0017 0.0289 0.0467
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.2214 0.2214
Loa Loa (eye worm) hypothetical protein 0.0017 0.0289 0.0467
Schistosoma mansoni amine GPCR 0.0017 0.0289 0.0289
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0289 0.0289
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0017 0.0289 0.0467
Echinococcus multilocularis neuropeptide receptor 0.0017 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0106 0.6197 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0017 0.0289 0.0289
Echinococcus multilocularis g protein coupled receptor 0.0017 0.0289 0.0289
Echinococcus multilocularis dro:myosuppressin receptor 0.0017 0.0289 0.0289
Schistosoma mansoni myosin xvIII 0.0017 0.0289 0.0289
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0289 0.0314
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0017 0.0289 0.0289
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.0289 0.0289
Echinococcus multilocularis fmrfamide receptor 0.0017 0.0289 0.0289
Echinococcus multilocularis sex peptide receptor 0.0017 0.0289 0.0289
Brugia malayi Tachykinin-like peptides receptor 99D 0.0017 0.0289 0.0467
Onchocerca volvulus 0.0017 0.0289 1
Brugia malayi AKH receptor 0.0017 0.0289 0.0467
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0289 0.0289
Schistosoma mansoni opsin-like receptor 0.0017 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0017 0.0289 0.0467
Onchocerca volvulus 0.0017 0.0289 1
Echinococcus granulosus neuropeptide receptor A26 0.0017 0.0289 0.0314
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0.0289 0.0289
Echinococcus granulosus 7tm_1 domain containing protein 0.0017 0.0289 0.0314
Loa Loa (eye worm) neuropeptide F receptor 0.0017 0.0289 0.0467
Loa Loa (eye worm) G-protein coupled receptor 0.0017 0.0289 0.0467
Loa Loa (eye worm) hypothetical protein 0.0017 0.0289 0.0467
Brugia malayi Serotonin receptor 0.0017 0.0289 0.0467
Brugia malayi G-protein coupled receptor 0.0017 0.0289 0.0467
Loa Loa (eye worm) hypothetical protein 0.0017 0.0289 0.0467
Schistosoma mansoni thyroid hormone receptor 0.0164 1 1
Brugia malayi Dopamine receptor protein 2 0.0017 0.0289 0.0467
Loa Loa (eye worm) hypothetical protein 0.0017 0.0289 0.0467
Loa Loa (eye worm) hypothetical protein 0.0017 0.0289 0.0467
Loa Loa (eye worm) hypothetical protein 0.0017 0.0289 0.0467
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0017 0.0289 0.0289
Brugia malayi hypothetical protein 0.0017 0.0289 0.0467
Echinococcus multilocularis neuropeptide Y receptor 0.0017 0.0289 0.0289
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0017 0.0289 0.0467
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0289 0.0314
Entamoeba histolytica hypothetical protein 0.0043 0.2055 0.5
Echinococcus granulosus dro:myosuppressin receptor 0.0017 0.0289 0.0314
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0042 0.196 0.196
Brugia malayi sulfakinin receptor protein 0.0017 0.0289 0.0467
Schistosoma mansoni hypothetical protein 0.0017 0.0289 0.0289
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0017 0.0289 0.0314
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0289 0.0289
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0289 0.0314
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.2055 0.2055
Brugia malayi neuropeptide F receptor 0.0017 0.0289 0.0467
Echinococcus multilocularis allatostatin A receptor 0.0017 0.0289 0.0289
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0042 0.196 0.2132
Onchocerca volvulus 0.0017 0.0289 1
Schistosoma mansoni hypothetical protein 0.0017 0.0289 0.0289
Echinococcus multilocularis neuropeptides capa receptor 0.0017 0.0289 0.0289
Brugia malayi hypothetical protein 0.002 0.049 0.079
Loa Loa (eye worm) hypothetical protein 0.0017 0.0289 0.0467

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.631 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.3225 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] ChEMBL. No reference
Potency (functional) 20.7865 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 63.0957 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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