Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0063 | 0.3426 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.2391 | 0.621 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.1616 | 0.4716 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.1616 | 0.4195 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.001 | 0.0279 | 0.0277 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.5773 | 0.5772 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.001 | 0.0279 | 0.0277 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0279 | 0.0277 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0035 | 0.1796 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.001 | 0.0279 | 0.0814 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0063 | 0.3426 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0049 | 0.2595 | 0.7575 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0102 | 0.5773 | 0.5772 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.3426 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0049 | 0.2595 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.001 | 0.0279 | 0.0814 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.2391 | 0.6979 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.001 | 0.0279 | 0.0277 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0049 | 0.2595 | 0.1008 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.001 | 0.0279 | 0.072 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0005 | 0.0002 | 0.0006 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0279 | 0.0814 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.001 | 0.0279 | 0.072 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.001 | 0.0279 | 0.0814 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.1616 | 0.4716 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.1616 | 0.4716 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0279 | 0.0814 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.001 | 0.0279 | 0.0814 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0279 | 0.0814 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0279 | 0.0277 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.001 | 0.0279 | 0.0277 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0049 | 0.2595 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.001 | 0.0279 | 0.0277 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0279 | 0.0277 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0049 | 0.2595 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0063 | 0.3426 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0049 | 0.2595 | 0.1008 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0049 | 0.2595 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0102 | 0.5773 | 0.5772 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0279 | 0.0277 |
Onchocerca volvulus | 0.001 | 0.0279 | 0.5 | |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.001 | 0.0279 | 0.072 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0035 | 0.1796 | 0.5 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0035 | 0.1796 | 0.5243 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.3426 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0279 | 0.072 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.001 | 0.0279 | 0.0277 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.001 | 0.0279 | 0.072 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.2391 | 0.621 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.001 | 0.0279 | 0.0277 |
Echinococcus granulosus | FTZ F1 alpha | 0.001 | 0.0279 | 0.0814 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.3426 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0049 | 0.2595 | 1 |
Brugia malayi | nuclear hormone receptor | 0.001 | 0.0279 | 0.0277 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.001 | 0.0279 | 0.0277 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0049 | 0.2595 | 0.6741 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0279 | 0.0277 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.0279 | 0.072 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0049 | 0.2595 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0279 | 0.0277 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0049 | 0.2595 | 0.1008 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.001 | 0.0279 | 0.0277 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0279 | 0.0277 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0032 | 0.1576 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0032 | 0.1616 | 0.1614 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1616 | 0.1614 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.001 | 0.0279 | 0.072 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0279 | 0.0814 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.001 | 0.0279 | 0.0277 |
Brugia malayi | steroid hormone receptor | 0.001 | 0.0279 | 0.0277 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0049 | 0.2595 | 0.7575 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.1616 | 0.4195 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0279 | 0.0814 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0049 | 0.2595 | 0.4901 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0279 | 0.0277 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.3426 | 0.8901 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0279 | 0.072 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0049 | 0.2595 | 0.1008 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0279 | 0.0277 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0279 | 0.0814 |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0.0279 | 0.072 |
Loa Loa (eye worm) | steroid hormone receptor | 0.001 | 0.0279 | 0.0277 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.007 | 0.3849 | 0.3848 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0049 | 0.2595 | 0.7575 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0032 | 0.1616 | 0.1614 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0032 | 0.1616 | 0.1614 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0049 | 0.2595 | 0.4901 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0049 | 0.2595 | 0.2594 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.2391 | 0.2389 |
Brugia malayi | nuclear receptor NHR-88 | 0.001 | 0.0279 | 0.0277 |
Loa Loa (eye worm) | inositol-1 | 0.0035 | 0.1796 | 0.1795 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0063 | 0.3426 | 1 |
Brugia malayi | ecdysteroid receptor | 0.001 | 0.0279 | 0.0277 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.001 | 0.0279 | 0.072 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.2391 | 0.6979 |
Echinococcus granulosus | GPCR family 2 | 0.0032 | 0.1616 | 0.4716 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0279 | 0.0814 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0279 | 0.0277 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.001 | 0.0279 | 0.0277 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0063 | 0.3426 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0049 | 0.2595 | 0.7575 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.3849 | 0.3848 |
Brugia malayi | Inositol-1 | 0.0035 | 0.1796 | 0.1795 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.2391 | 0.6979 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.001 | 0.0279 | 0.0277 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0169 | 0.9718 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.1616 | 0.4195 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0279 | 0.0277 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0049 | 0.2595 | 0.4901 |
Schistosoma mansoni | coup transcription factor | 0.001 | 0.0279 | 0.072 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0049 | 0.2595 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0279 | 0.0814 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.001 | 0.0279 | 0.0277 |
Schistosoma mansoni | inositol monophosphatase | 0.0035 | 0.1796 | 0.4664 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0035 | 0.1796 | 0.5243 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0279 | 0.0814 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0279 | 0.0277 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.001 | 0.0279 | 0.072 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0005 | 0.0002 | 0.0006 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0279 | 0.0277 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.0279 | 0.0277 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.001 | 0.0279 | 0.072 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.001 | 0.0279 | 0.0277 |
Echinococcus multilocularis | GPCR, family 2 | 0.0032 | 0.1616 | 0.4716 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0.0279 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0279 | 0.0277 |
Schistosoma mansoni | inositol monophosphatase | 0.0035 | 0.1796 | 0.4664 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.001 | 0.0279 | 0.0277 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.3849 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.001 | 0.0279 | 0.0814 |
Brugia malayi | MAP kinase sur-1 | 0.0049 | 0.2595 | 0.2594 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0279 | 0.0814 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0.0279 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.2391 | 0.6979 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.1616 | 0.4195 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0.0279 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.001 | 0.0279 | 0.0814 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.001 | 0.0279 | 0.0277 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.1616 | 0.4716 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.2391 | 0.2389 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.3426 | 0.8901 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.2391 | 0.621 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0102 | 0.5773 | 0.5772 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.001 | 0.0279 | 0.0814 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.