Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | MAP kinase sur-1 | 0.0049 | 0.2595 | 0.2594 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.001 | 0.0279 | 0.0814 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.3849 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.001 | 0.0279 | 0.0277 |
Schistosoma mansoni | inositol monophosphatase | 0.0035 | 0.1796 | 0.4664 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0279 | 0.0814 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.2391 | 0.2389 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.1616 | 0.4716 |
Echinococcus multilocularis | FTZ F1 alpha | 0.001 | 0.0279 | 0.0814 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.001 | 0.0279 | 0.0277 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0.0279 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.1616 | 0.4195 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.2391 | 0.6979 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0.0279 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.001 | 0.0279 | 0.0814 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0102 | 0.5773 | 0.5772 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.2391 | 0.621 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.3426 | 0.8901 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.001 | 0.0279 | 0.0277 |
Schistosoma mansoni | coup transcription factor | 0.001 | 0.0279 | 0.072 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0279 | 0.0814 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0049 | 0.2595 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0049 | 0.2595 | 0.4901 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0279 | 0.0277 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0279 | 0.0814 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0279 | 0.0277 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0035 | 0.1796 | 0.5243 |
Schistosoma mansoni | inositol monophosphatase | 0.0035 | 0.1796 | 0.4664 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.001 | 0.0279 | 0.0277 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.001 | 0.0279 | 0.072 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.0279 | 0.0277 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0279 | 0.0277 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0005 | 0.0002 | 0.0006 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.001 | 0.0279 | 0.072 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0279 | 0.0277 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0.0279 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0032 | 0.1616 | 0.4716 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0279 | 0.0814 |
Echinococcus granulosus | GPCR family 2 | 0.0032 | 0.1616 | 0.4716 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.2391 | 0.6979 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.001 | 0.0279 | 0.072 |
Brugia malayi | ecdysteroid receptor | 0.001 | 0.0279 | 0.0277 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0063 | 0.3426 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0063 | 0.3426 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.001 | 0.0279 | 0.0277 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0279 | 0.0277 |
Brugia malayi | Inositol-1 | 0.0035 | 0.1796 | 0.1795 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.3849 | 0.3848 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0049 | 0.2595 | 0.7575 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0169 | 0.9718 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.1616 | 0.4195 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.001 | 0.0279 | 0.0277 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.2391 | 0.6979 |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0.0279 | 0.072 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0279 | 0.0814 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0279 | 0.0277 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0049 | 0.2595 | 0.1008 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0279 | 0.072 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.3426 | 0.8901 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0032 | 0.1616 | 0.1614 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0032 | 0.1616 | 0.1614 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0049 | 0.2595 | 0.7575 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.007 | 0.3849 | 0.3848 |
Loa Loa (eye worm) | steroid hormone receptor | 0.001 | 0.0279 | 0.0277 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0049 | 0.2595 | 0.2594 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0049 | 0.2595 | 0.4901 |
Loa Loa (eye worm) | inositol-1 | 0.0035 | 0.1796 | 0.1795 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.2391 | 0.2389 |
Brugia malayi | nuclear receptor NHR-88 | 0.001 | 0.0279 | 0.0277 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0279 | 0.0277 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.001 | 0.0279 | 0.0277 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.001 | 0.0279 | 0.0277 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0279 | 0.0814 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.001 | 0.0279 | 0.072 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1616 | 0.1614 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0032 | 0.1616 | 0.1614 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0032 | 0.1576 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0279 | 0.0814 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.1616 | 0.4195 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0049 | 0.2595 | 0.7575 |
Brugia malayi | steroid hormone receptor | 0.001 | 0.0279 | 0.0277 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0279 | 0.0277 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0049 | 0.2595 | 0.4901 |
Echinococcus granulosus | FTZ F1 alpha | 0.001 | 0.0279 | 0.0814 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.001 | 0.0279 | 0.0277 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.2391 | 0.621 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.001 | 0.0279 | 0.072 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.001 | 0.0279 | 0.0277 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0279 | 0.072 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.001 | 0.0279 | 0.0277 |
Brugia malayi | nuclear hormone receptor | 0.001 | 0.0279 | 0.0277 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 1 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0049 | 0.2595 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.3426 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0049 | 0.2595 | 0.1008 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0049 | 0.2595 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0279 | 0.0277 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.0279 | 0.072 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0279 | 0.0277 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0049 | 0.2595 | 0.6741 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.001 | 0.0279 | 0.0277 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0279 | 0.0277 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0279 | 0.0814 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0049 | 0.2595 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0049 | 0.2595 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0049 | 0.2595 | 0.1008 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0063 | 0.3426 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0049 | 0.2595 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0279 | 0.0277 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.001 | 0.0279 | 0.0277 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.3426 | 1 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0035 | 0.1796 | 0.5243 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0035 | 0.1796 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.001 | 0.0279 | 0.072 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0102 | 0.5773 | 0.5772 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0279 | 0.0277 |
Onchocerca volvulus | 0.001 | 0.0279 | 0.5 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.2391 | 0.621 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0063 | 0.3426 | 1 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0035 | 0.1796 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0279 | 0.0277 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.001 | 0.0279 | 0.0277 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.5773 | 0.5772 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.001 | 0.0279 | 0.0277 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.1616 | 0.4195 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.1616 | 0.4716 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.001 | 0.0279 | 0.0277 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.001 | 0.0279 | 0.0814 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.2391 | 0.6979 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0049 | 0.2595 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.3426 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0049 | 0.2595 | 0.7575 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0102 | 0.5773 | 0.5772 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0063 | 0.3426 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.001 | 0.0279 | 0.0814 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.001 | 0.0279 | 0.0814 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0279 | 0.0814 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.1616 | 0.4716 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.1616 | 0.4716 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.001 | 0.0279 | 0.0814 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0279 | 0.0814 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0005 | 0.0002 | 0.0006 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.001 | 0.0279 | 0.072 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.001 | 0.0279 | 0.072 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0049 | 0.2595 | 0.1008 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.