Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0314 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0314 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0314 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0314 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0314 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0166 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0314 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0166 | 0.1071 | 0.1071 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0314 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0314 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0314 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0314 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0314 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0314 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0314 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0314 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0314 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0314 | 1 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0166 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0314 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0314 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0314 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0314 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0314 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0314 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0314 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0314 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0314 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0314 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0166 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0314 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0314 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0314 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0314 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0314 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0314 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.1071 | 0.1071 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0166 | 0.1071 | 0.1071 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0314 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0314 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0314 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0314 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0314 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0166 | 0.1071 | 0.1071 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0314 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0314 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0314 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0314 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0314 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0314 | 1 | 1 |
Onchocerca volvulus | 0.0314 | 1 | 1 | |
Brugia malayi | nuclear receptor RXR | 0.0166 | 0.1071 | 0.1071 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0314 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0314 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0314 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0314 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0166 | 0.1071 | 0.1071 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0314 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0314 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0314 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0166 | 0.1071 | 0.1071 |
Brugia malayi | hypothetical protein | 0.0166 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0314 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0024 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.