Detailed information for compound 1468684

Basic information

Technical information
  • TDR Targets ID: 1468684
  • Name: (8R,9S,13S,14S,17S)-13-methyl-2-prop-1-ynyl-6 ,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[ a]phenanthrene-3,17-diol
  • MW: 310.43 | Formula: C21H26O2
  • H donors: 2 H acceptors: 2 LogP: 4.66 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC#Cc1cc2c(cc1O)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C
  • InChi: 1S/C21H26O2/c1-3-4-14-11-17-13(12-19(14)22)5-6-16-15(17)9-10-21(2)18(16)7-8-20(21)23/h11-12,15-16,18,20,22-23H,5-10H2,1-2H3/t15-,16+,18-,20-,21-/m0/s1
  • InChiKey: VFBWVXKSUXUBTB-OKSLILNBSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(1-Propynyl)-3,17.beta.-estradiol
  • NSC682429
  • NCI60_029477

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bos taurus Tubulin Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Giardia lamblia Alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Theileria parva tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Toxoplasma gondii alpha tubulin TUBA1 Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Cryptosporidium parvum alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit alpha Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium knowlesi alpha tubulin, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium falciparum alpha tubulin 2 Get druggable targets OG5_126605 All targets in OG5_126605
Entamoeba histolytica tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium knowlesi alpha-tubulin II, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) alpha-tubulin isotype 2 Get druggable targets OG5_126605 All targets in OG5_126605
Cryptosporidium hominis alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium vivax tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Neospora caninum tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium yoelii tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Giardia lamblia Alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Toxoplasma gondii alpha-tubulin I, putative Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium falciparum alpha tubulin 1 Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Candida albicans cytoskeletal structural protein Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha 2 Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha 2 Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania braziliensis alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis peroxisome assembly protein 26 Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium vivax tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi tubulin alpha chain - mouse Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium yoelii Tubulin/FtsZ family, putative Get druggable targets OG5_126605 All targets in OG5_126605
Babesia bovis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi Tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi Tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin subunit TubB Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha-3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania infantum alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei gambiense alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma cruzi alpha tubulin, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum ko:K07374 tubulin alpha, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Babesia bovis tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin alpha-2/alpha-4 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania infantum alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania braziliensis alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium berghei alpha tubulin 1 Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin subunit TubB Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit alpha Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium berghei alpha tubulin 2 Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha 2 Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit alpha Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin alpha-1C chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma congolense alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Theileria parva Tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum ko:K07374 tubulin alpha, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus peroxisome assembly protein 26 Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania donovani alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Entamoeba histolytica tubulin alpha-1 chain Get druggable targets OG5_126605 All targets in OG5_126605
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni tubulin subunit epsilon Tubulin   445 aa 464 aa 31.7 %
Schistosoma mansoni tubulin subunit gamma Tubulin   445 aa 436 aa 33.7 %
Loa Loa (eye worm) tubulin beta-2A chain Tubulin   445 aa 430 aa 91.4 %
Onchocerca volvulus Tubulin   445 aa 433 aa 40.0 %
Schistosoma mansoni tubulin subunit beta Tubulin   445 aa 430 aa 95.8 %
Trypanosoma brucei gambiense gamma tubulin Tubulin   445 aa 436 aa 33.5 %
Onchocerca volvulus Tubulin   445 aa 435 aa 39.5 %
Plasmodium knowlesi tubulin gamma chain, putative Tubulin   445 aa 438 aa 33.3 %
Giardia lamblia Gamma tubulin Tubulin   445 aa 460 aa 32.4 %
Dictyostelium discoideum beta tubulin Tubulin   445 aa 432 aa 75.7 %
Onchocerca volvulus Tubulin   445 aa 445 aa 36.2 %
Echinococcus multilocularis Tubulin beta 2C chain Tubulin   445 aa 428 aa 92.5 %
Leishmania mexicana epsilon tubulin, putative Tubulin   445 aa 469 aa 30.9 %
Echinococcus multilocularis tubulin gamma 1 chain Tubulin   445 aa 436 aa 34.4 %
Schistosoma japonicum Tubulin beta chain, putative Tubulin   445 aa 436 aa 96.3 %
Leishmania donovani tubulin gamma chain Tubulin   445 aa 438 aa 34.2 %
Trypanosoma congolense epsilon tubulin Tubulin   445 aa 464 aa 29.1 %
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein Tubulin   445 aa 433 aa 30.7 %
Schistosoma mansoni tubulin subunit beta Tubulin   445 aa 430 aa 92.3 %
Drosophila melanogaster gamma-Tubulin at 23C Tubulin   445 aa 439 aa 34.6 %
Loa Loa (eye worm) BEN-1 protein Tubulin   445 aa 427 aa 57.1 %
Brugia malayi Tubulin beta-1 chain Tubulin   445 aa 429 aa 87.4 %
Onchocerca volvulus Putative methyltransferase KIAA1456 Tubulin   445 aa 426 aa 49.8 %
Neospora caninum tubulin alpha chain, putative Tubulin   445 aa 433 aa 30.9 %
Trichomonas vaginalis tubulin gamma chain, putative Tubulin   445 aa 415 aa 33.3 %
Brugia malayi beta-tubulin, identical Tubulin   445 aa 430 aa 90.5 %
Babesia bovis tubulin gamma chain Tubulin   445 aa 441 aa 34.0 %
Trypanosoma brucei tubulin gamma chain Tubulin   445 aa 436 aa 33.5 %
Echinococcus multilocularis tubulin delta chain Tubulin   445 aa 461 aa 25.8 %
Leishmania major gamma-tubulin Tubulin   445 aa 438 aa 34.0 %
Giardia lamblia Epsilon tubulin Tubulin   445 aa 442 aa 27.6 %
Echinococcus granulosus tubulin alpha Tubulin   445 aa 440 aa 30.2 %
Onchocerca volvulus Tubulin   445 aa 434 aa 39.9 %
Plasmodium falciparum tubulin gamma chain Tubulin   445 aa 438 aa 32.9 %
Trypanosoma brucei epsilon tubulin Tubulin   445 aa 443 aa 29.3 %
Entamoeba histolytica tubulin family protein Tubulin   445 aa 429 aa 57.8 %
Trypanosoma brucei epsilon tubulin Tubulin   445 aa 443 aa 29.3 %
Onchocerca volvulus 60S ribosomal protein L13 homolog Tubulin   445 aa 430 aa 91.4 %
Trypanosoma cruzi tubulin gamma chain Tubulin   445 aa 436 aa 33.5 %
Onchocerca volvulus Tubulin   445 aa 433 aa 39.0 %
Trypanosoma cruzi epsilon tubulin, putative Tubulin   445 aa 456 aa 31.4 %
Brugia malayi Tubulin gamma chain Tubulin   445 aa 440 aa 31.8 %
Plasmodium knowlesi tubulin epsilon chain, putative Tubulin   445 aa 441 aa 29.0 %
Trichomonas vaginalis tubulin beta chain, putative Tubulin   445 aa 428 aa 80.6 %
Neospora caninum Beta-tubulin, related Tubulin   445 aa 446 aa 35.2 %
Trypanosoma brucei epsilon tubulin Tubulin   445 aa 443 aa 29.1 %
Plasmodium yoelii tubulin beta chain Tubulin   445 aa 445 aa 29.7 %
Leishmania infantum gamma-tubulin Tubulin   445 aa 438 aa 34.2 %
Giardia lamblia Beta tubulin Tubulin   445 aa 428 aa 88.3 %
Drosophila melanogaster beta-Tubulin at 60D Tubulin   445 aa 435 aa 90.6 %
Onchocerca volvulus Putative cytochrome c-type heme lyase Tubulin   445 aa 429 aa 87.4 %
Trypanosoma brucei gambiense epsilon tubulin Tubulin   445 aa 443 aa 29.3 %
Leishmania infantum epsilon tubulin, putative Tubulin   445 aa 475 aa 30.3 %
Plasmodium falciparum tubulin epsilon chain, putative Tubulin   445 aa 461 aa 27.8 %
Trichomonas vaginalis tubulin alpha chain, putative Tubulin   445 aa 428 aa 80.8 %
Neospora caninum hypothetical protein Tubulin   445 aa 430 aa 89.1 %
Theileria parva tubulin gamma chain, putative Tubulin   445 aa 420 aa 34.5 %
Plasmodium berghei tubulin epsilon chain, putative Tubulin   445 aa 445 aa 29.4 %
Echinococcus multilocularis tubulin alpha Tubulin   445 aa 443 aa 30.5 %
Leishmania braziliensis gamma-tubulin Tubulin   445 aa 438 aa 34.2 %
Leishmania major epsilon tubulin, putative Tubulin   445 aa 469 aa 30.9 %
Plasmodium berghei tubulin gamma chain, putative Tubulin   445 aa 438 aa 33.3 %
Onchocerca volvulus Tubulin   445 aa 427 aa 82.4 %
Echinococcus granulosus tubulin beta 4A class IVa Tubulin   445 aa 381 aa 71.1 %
Cryptosporidium hominis gamma-tubulin Tubulin   445 aa 436 aa 37.6 %
Echinococcus granulosus beta tubulin Tubulin   445 aa 427 aa 82.2 %
Giardia lamblia Beta tubulin Tubulin   445 aa 428 aa 88.3 %
Onchocerca volvulus Tyrosine kinase homolog Tubulin   445 aa 434 aa 38.2 %
Neospora caninum hypothetical protein Tubulin   445 aa 430 aa 89.8 %
Leishmania mexicana gamma-tubulin Tubulin   445 aa 438 aa 34.2 %
Loa Loa (eye worm) BEN-1 protein Tubulin   445 aa 427 aa 82.2 %
Trichomonas vaginalis tubulin epsilon chain, putative Tubulin   445 aa 428 aa 80.8 %
Babesia bovis tubulin, putative Tubulin   445 aa 459 aa 21.1 %
Onchocerca volvulus Tubulin   445 aa 427 aa 49.9 %
Plasmodium vivax tubulin epsilon chain, putative Tubulin   445 aa 444 aa 28.6 %
Dictyostelium discoideum gamma tubulin Tubulin   445 aa 429 aa 34.0 %
Toxoplasma gondii beta-1 tubulin, putative Tubulin   445 aa 430 aa 89.1 %
Neospora caninum hypothetical protein Tubulin   445 aa 430 aa 89.1 %
Leishmania braziliensis epsilon tubulin, putative Tubulin   445 aa 465 aa 30.1 %
Entamoeba histolytica tubulin gamma chain Tubulin   445 aa 428 aa 33.2 %
Echinococcus granulosus Tubulin beta 2C chain Tubulin   445 aa 428 aa 92.3 %
Trichomonas vaginalis tubulin, putative Tubulin   445 aa 428 aa 80.8 %
Echinococcus granulosus tubulin gamma 1 chain Tubulin   445 aa 436 aa 34.4 %
Echinococcus multilocularis Tubulin beta 2C chain Tubulin   445 aa 430 aa 93.7 %
Entamoeba histolytica tubulin family protein Tubulin   445 aa 428 aa 56.3 %
Toxoplasma gondii beta-tubulin, putative Tubulin   445 aa 430 aa 89.8 %
Trypanosoma congolense tubulin gamma chain Tubulin   445 aa 436 aa 33.3 %
Cryptosporidium parvum gamma tubulin Tubulin   445 aa 436 aa 37.6 %
Plasmodium vivax tubulin gamma chain, putative Tubulin   445 aa 438 aa 33.3 %
Onchocerca volvulus Regulatory-associated protein of mTOR homolog Tubulin   445 aa 440 aa 38.4 %
Loa Loa (eye worm) tubulin beta-1 chain Tubulin   445 aa 432 aa 88.0 %
Schistosoma japonicum ko:K10389 tubulin gamma, putative Tubulin   445 aa 436 aa 34.2 %
Plasmodium yoelii tubulin gamma chain Tubulin   445 aa 438 aa 33.1 %
Giardia lamblia Beta tubulin Tubulin   445 aa 428 aa 88.3 %
Onchocerca volvulus 1D304 homolog Tubulin   445 aa 433 aa 40.4 %
Onchocerca volvulus Tubulin   445 aa 441 aa 31.7 %
Toxoplasma gondii beta tubulin Tubulin   445 aa 430 aa 89.1 %
Leishmania mexicana beta tubulin Tubulin   445 aa 429 aa 85.8 %
Echinococcus multilocularis tubulin, beta 4A class IVa Tubulin   445 aa 381 aa 71.1 %
Trypanosoma cruzi epsilon tubulin, putative Tubulin   445 aa 456 aa 31.4 %
Echinococcus granulosus Tubulin beta 2C chain Tubulin   445 aa 430 aa 94.4 %
Leishmania donovani epsilon tubulin, putative Tubulin   445 aa 475 aa 30.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0082 0.027 0.1598
Echinococcus multilocularis Nuclear hormone receptor HR96 0.005 0.0141 0.0147
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0013 0.0014
Brugia malayi hypothetical protein 0.0056 0.0166 0.0172
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0082 0.027 0.0282
Schistosoma mansoni hypothetical protein 0.0038 0.009 0.009
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0082 0.027 0.0282
Echinococcus granulosus thyroid hormone receptor alpha 0.005 0.0141 0.0147
Entamoeba histolytica hypothetical protein 0.0052 0.0149 0.1562
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0218 0.0824 0.2504
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0107 0.0371 0.0386
Trypanosoma brucei alpha tubulin 0.0022 0.0023 0.001
Loa Loa (eye worm) hypothetical protein 0.0082 0.027 0.0282
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0107 0.0371 0.0386
Schistosoma mansoni carbonyl reductase 0.0082 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0022 0.0023 0.0024
Loa Loa (eye worm) latrophilin receptor protein 2 0.0038 0.009 0.0094
Schistosoma mansoni hypothetical protein 0.0082 0.027 0.027
Trichomonas vaginalis tubulin beta chain, putative 0.0022 0.0023 0.0062
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0107 0.0371 0.0386
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0082 0.027 0.0282
Schistosoma mansoni short chain dehydrogenase 0.0082 0.027 0.027
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0082 0.027 0.0282
Trypanosoma cruzi hypothetical protein, conserved 0.0082 0.027 0.0268
Onchocerca volvulus 0.0201 0.0752 0.5114
Echinococcus multilocularis roundabout 2 0.0019 0.0014 0.0014
Schistosoma mansoni steroid dehydrogenase 0.0082 0.027 0.027
Giardia lamblia Kinase, PLK 0.009 0.0304 0.0859
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0107 0.0371 0.0386
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0082 0.027 0.027
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0013 0.0014
Trypanosoma brucei oxidoreductase-like protein 0.0082 0.027 0.0268
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0082 0.027 0.0268
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0082 0.027 0.0268
Trypanosoma brucei polo-like protein kinase 0.009 0.0304 0.0303
Entamoeba histolytica short chain dehydrogenase family protein 0.0082 0.027 0.3081
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0317 0.1227 0.1267
Brugia malayi hypothetical protein 0.0082 0.027 0.0282
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0082 0.027 0.0268
Mycobacterium ulcerans ferredoxin reductase 0.0218 0.0824 0.1839
Schistosoma mansoni hypothetical protein 0.05 0.197 0.197
Brugia malayi Calcitonin receptor-like protein seb-1 0.012 0.0425 0.0443
Trichomonas vaginalis tubulin epsilon chain, putative 0.0022 0.0023 0.0062
Mycobacterium tuberculosis Probable oxidoreductase 0.0082 0.027 0.0268
Toxoplasma gondii alpha tubulin TUBA1 0.0022 0.0023 0.001
Loa Loa (eye worm) hypothetical protein 0.0082 0.027 0.0282
Mycobacterium tuberculosis Probable reductase 0.0317 0.1227 0.1267
Plasmodium falciparum thioredoxin reductase 0.0823 0.3284 0.3412
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0823 0.3284 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.005 0.0141 0.0141
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0218 0.0824 0.1622
Brugia malayi glutathione reductase 0.2374 0.9597 1
Schistosoma mansoni steroid dehydrogenase 0.0082 0.027 0.027
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0082 0.027 0.0282
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.005 0.0141 0.0147
Brugia malayi conserved hypotetical protein 0.005 0.0141 0.0147
Loa Loa (eye worm) oxidoreductase 0.0082 0.027 0.0282
Onchocerca volvulus 0.0082 0.027 0.1598
Loa Loa (eye worm) hypothetical protein 0.005 0.0141 0.0147
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0161 0.0167
Loa Loa (eye worm) hypothetical protein 0.0082 0.027 0.0282
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.006 0.0048
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0082 0.027 0.0815
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0082 0.027 0.0282
Brugia malayi tailless protein 0.005 0.0141 0.0147
Schistosoma mansoni hypothetical protein 0.0205 0.0768 0.0768
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0218 0.0824 1
Schistosoma mansoni short chain dehydrogenase 0.0082 0.027 0.027
Trypanosoma cruzi hypothetical protein, conserved 0.0218 0.0824 0.0846
Leishmania major alpha tubulin 0.0022 0.0023 0.001
Leishmania major alpha tubulin 0.0022 0.0023 0.001
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0161 0.0167
Echinococcus granulosus ecdysone induced protein 78C 0.0107 0.0371 0.0386
Brugia malayi nuclear hormone receptor 0.0107 0.0371 0.0386
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0107 0.0371 0.2331
Brugia malayi RE40412p 0.0028 0.0051 0.0054
Loa Loa (eye worm) hypothetical protein 0.005 0.0141 0.0147
Echinococcus granulosus twitchin 0.0018 0.0007 0.0007
Brugia malayi isocitrate dehydrogenase 0.0019 0.0013 0.0014
Leishmania major hypothetical protein, conserved 0.003 0.006 0.0048
Echinococcus multilocularis Tubulin alpha 1 chain 0.0022 0.0023 0.0024
Schistosoma mansoni short chain dehydrogenase 0.0082 0.027 0.027
Schistosoma mansoni carbonyl reductase 0.0082 0.027 0.027
Brugia malayi Latrophilin receptor protein 2 0.0038 0.009 0.0094
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0013 0.0014
Schistosoma mansoni steroid dehydrogenase 0.0082 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0028 0.0051 0.0054
Schistosoma mansoni thyroid hormone receptor 0.0107 0.0371 0.0371
Schistosoma mansoni alpha tubulin 0.0022 0.0023 0.0023
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0082 0.027 0.0282
Trypanosoma cruzi NADH dehydrogenase, putative 0.0218 0.0824 0.0846
Loa Loa (eye worm) hypothetical protein 0.0028 0.0051 0.0054
Trypanosoma brucei alpha tubulin 0.0022 0.0023 0.001
Echinococcus multilocularis oxidoreductase 0.0082 0.027 0.0282
Brugia malayi ecdysone receptor 0.005 0.0141 0.0147
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0082 0.027 0.0268
Trypanosoma cruzi short chain dehydrogenase, putative 0.0082 0.027 0.0268
Brugia malayi Nuclear hormone receptor-like 1 0.0056 0.0166 0.0172
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.006 0.0048
Brugia malayi serine/threonine-protein kinase plk-2 0.009 0.0304 0.0316
Brugia malayi hypothetical protein 0.0365 0.1421 0.148
Echinococcus multilocularis thyroid hormone receptor alpha 0.0107 0.0371 0.0386
Trypanosoma brucei short-chain dehydrogenase, putative 0.0082 0.027 0.0268
Giardia lamblia Thioredoxin reductase 0.0218 0.0824 0.2457
Echinococcus multilocularis glutamate synthase 0.0218 0.0824 0.0859
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0823 0.3284 0.3422
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0082 0.027 0.0815
Leishmania major dehydrogenase-like protein 0.0082 0.027 0.0268
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0082 0.027 0.0282
Loa Loa (eye worm) hypothetical protein 0.0107 0.0371 0.0386
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0218 0.0824 1
Echinococcus multilocularis peroxisome assembly protein 26 0.0022 0.0023 0.0024
Toxoplasma gondii zinc finger CDGSH-type domain-containing protein 0.0028 0.0051 0.004
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0304 0.0916
Toxoplasma gondii NADPH-glutathione reductase 0.0823 0.3284 0.3412
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0823 0.3284 1
Echinococcus multilocularis retinol dehydrogenase 11 0.0082 0.027 0.0282
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0218 0.0824 1
Schistosoma mansoni alpha tubulin 0.0022 0.0023 0.0023
Mycobacterium tuberculosis Possible oxidoreductase 0.0082 0.027 0.0268
Brugia malayi Nuclear hormone receptor-like 1 0.0056 0.0166 0.0172
Leishmania major hypothetical protein, conserved 0.0082 0.027 0.0268
Schistosoma mansoni short chain dehydrogenase 0.0082 0.027 0.027
Echinococcus multilocularis hypothetical protein 0.0022 0.0023 0.0024
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0082 0.027 0.0815
Echinococcus multilocularis carbonyl reductase 1 0.0082 0.027 0.0282
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0056 0.0166 0.0172
Brugia malayi dehydrogenases, short chain protein 2 0.0082 0.027 0.0282
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0082 0.027 0.0268
Echinococcus multilocularis nuclear receptor nhr 48 0.005 0.0141 0.0147
Loa Loa (eye worm) hypothetical protein 0.005 0.0141 0.0147
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0161 0.0167
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0082 0.027 0.027
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0082 0.027 0.0282
Onchocerca volvulus 0.0107 0.0371 0.2331
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0082 0.027 0.0282
Brugia malayi Immunoglobulin I-set domain containing protein 0.0104 0.036 0.0375
Brugia malayi hypothetical protein 0.0052 0.0149 0.0155
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0082 0.027 0.0268
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0107 0.0371 0.0386
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0218 0.0824 0.0846
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0317 0.1227 0.2802
Plasmodium vivax tubulin alpha chain, putative 0.0022 0.0023 0.001
Brugia malayi hypothetical protein 0.002 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0082 0.027 0.0282
Schistosoma mansoni short chain dehydrogenase 0.0082 0.027 0.027
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0218 0.0824 0.0846
Schistosoma mansoni steroid dehydrogenase 0.0082 0.027 0.027
Schistosoma mansoni nuclear receptor 0.005 0.0141 0.0141
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0107 0.0371 0.0386
Loa Loa (eye worm) hypothetical protein 0.0218 0.0824 0.0859
Mycobacterium tuberculosis Probable oxidoreductase 0.0082 0.027 0.0268
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0107 0.0371 0.0371
Brugia malayi Dehydrogenases, short chain protein 30 0.0082 0.027 0.0282
Echinococcus granulosus glutamate synthase 0.0218 0.0824 0.0859
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0304 0.0916
Trypanosoma cruzi hypothetical protein, conserved 0.0082 0.027 0.0268
Toxoplasma gondii oxidoreductase, putative 0.0082 0.027 0.0268
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0823 0.3284 0.3412
Plasmodium falciparum thioredoxin reductase 0.2374 0.9597 1
Onchocerca volvulus 0.0082 0.027 0.1598
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0218 0.0824 0.1839
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0823 0.3284 0.3412
Echinococcus granulosus serine:threonine protein kinase PLK1 0.009 0.0304 0.0316
Schistosoma mansoni serine/threonine protein kinase 0.009 0.0304 0.0304
Schistosoma mansoni steroid dehydrogenase 0.0082 0.027 0.027
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0082 0.027 0.0268
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0218 0.0824 0.1839
Schistosoma mansoni sulfide quinone reductase 0.0218 0.0824 0.0824
Brugia malayi Tubulin alpha-2 chain 0.0022 0.0023 0.0024
Giardia lamblia Short-chain dehydrogenase, putative 0.0082 0.027 0.0757
Loa Loa (eye worm) tubulin alpha-2 chain 0.0022 0.0023 0.0024
Schistosoma mansoni tubulin subunit alpha 0.0022 0.0023 0.0023
Echinococcus multilocularis transient receptor potential cation channel 0.0082 0.027 0.0282
Loa Loa (eye worm) hypothetical protein 0.003 0.006 0.0062
Schistosoma mansoni short chain dehydrogenase 0.0082 0.027 0.027
Leishmania major alpha tubulin 0.0022 0.0023 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0107 0.0371 0.0386
Loa Loa (eye worm) hypothetical protein 0.005 0.0141 0.0147
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0107 0.0371 0.0386
Mycobacterium ulcerans glutamate synthase subunit beta 0.0218 0.0824 0.1839
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0218 0.0824 0.0859
Schistosoma mansoni hypothetical protein 0.0038 0.009 0.009
Schistosoma mansoni coup transcription factor 0.0107 0.0371 0.0371
Echinococcus multilocularis tubulin alpha 3 chain 0.0022 0.0023 0.0024
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0218 0.0824 0.0859
Echinococcus granulosus carbonyl reductase 1 0.0082 0.027 0.0282
Brugia malayi MH2 domain containing protein 0.0075 0.0242 0.0252
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0056 0.0166 0.0166
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0823 0.3284 0.3412
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0218 0.0824 0.2504
Loa Loa (eye worm) hypothetical protein 0.0038 0.009 0.0094
Onchocerca volvulus 0.0082 0.027 0.1598
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0304 0.0916
Brugia malayi nuclear hormone receptor family member nhr-6 0.005 0.0141 0.0147
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0082 0.027 0.1598
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0082 0.027 0.0268
Echinococcus granulosus Tubulin alpha 1 chain 0.0022 0.0023 0.0024
Mycobacterium tuberculosis Probable oxidoreductase 0.0082 0.027 0.0268
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0107 0.0371 0.0386
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0218 0.0824 0.0859
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0017 0.0003 0.0003
Brugia malayi photoreceptor-specific nuclear receptor 0.0107 0.0371 0.0386
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0082 0.027 0.0268
Schistosoma mansoni hypothetical protein 0.0028 0.0051 0.0051
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.012 0.0425 0.0443
Brugia malayi hypothetical protein 0.005 0.0141 0.0147
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0082 0.027 0.0268
Schistosoma mansoni steroid dehydrogenase 0.0082 0.027 0.027
Echinococcus multilocularis Nuclear hormone receptor HR96 0.005 0.0141 0.0147
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0082 0.027 0.0815
Brugia malayi dehydrogenases, short chain protein 9 0.0082 0.027 0.0282
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0082 0.027 0.0268
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0107 0.0371 0.0386
Loa Loa (eye worm) hypothetical protein 0.0107 0.0371 0.0386
Loa Loa (eye worm) alpha-tubulin 0.0022 0.0023 0.0024
Brugia malayi Thioredoxin reductase 0.2374 0.9597 1
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0082 0.027 0.0282
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0218 0.0824 0.0846
Trypanosoma brucei trypanothione reductase 0.2374 0.9597 1
Schistosoma mansoni short chain dehydrogenase 0.0082 0.027 0.027
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0013 0.0014
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0823 0.3284 0.3422
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0082 0.027 0.0268
Leishmania major hypothetical protein, conserved 0.0218 0.0824 0.0846
Brugia malayi hypothetical protein 0.0082 0.027 0.0282
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0082 0.027 0.0282
Schistosoma mansoni hypothetical protein 0.0218 0.0824 0.0824
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0107 0.0371 0.0386
Plasmodium vivax ferrodoxin reductase, putative 0.0218 0.0824 0.0846
Echinococcus multilocularis conserved hypothetical protein 0.0028 0.0051 0.0054
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0082 0.027 0.0268
Onchocerca volvulus 0.005 0.0141 0.0653
Onchocerca volvulus 0.0082 0.027 0.1598
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0218 0.0824 0.1839
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0218 0.0824 0.0859
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0218 0.0824 0.1839
Echinococcus granulosus hypothetical protein 0.0082 0.027 0.0282
Entamoeba histolytica hypothetical protein, conserved 0.0082 0.027 0.3081
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0218 0.0824 0.2504
Echinococcus multilocularis Tubulin alpha 1 chain 0.0022 0.0023 0.0024
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0107 0.0371 0.0371
Leishmania major short chain dehydrogenase, putative 0.0082 0.027 0.0268
Trypanosoma cruzi hypothetical protein, conserved 0.0082 0.027 0.0268
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0218 0.0824 0.0846
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0082 0.027 0.0282
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.006 0.0048
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0052 0.0149 0.0155
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0161 0.0167
Schistosoma mansoni transcription factor LCR-F1 0.0052 0.0149 0.0149
Brugia malayi Dehydrogenases, short chain protein 2 0.0082 0.027 0.0282
Schistosoma mansoni carbonyl reductase 0.0082 0.027 0.027
Trichomonas vaginalis glutathione reductase, putative 0.0823 0.3284 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0107 0.0371 0.0386
Onchocerca volvulus 0.0082 0.027 0.1598
Treponema pallidum NADH oxidase 0.0823 0.3284 1
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0218 0.0824 0.0859
Schistosoma mansoni disulfide oxidoreductase 0.0218 0.0824 0.0824
Plasmodium falciparum alpha tubulin 1 0.0022 0.0023 0.001
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0082 0.027 0.0268
Trypanosoma cruzi short chain dehydrogenase, putative 0.0082 0.027 0.0268
Schistosoma mansoni retinal dehydrogenase 0.0082 0.027 0.027
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0107 0.0371 0.0386
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0107 0.0371 0.0386
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0107 0.0371 0.0386
Plasmodium falciparum steroid dehydrogenase, putative 0.0082 0.027 0.0268
Mycobacterium tuberculosis Probable dehydrogenase 0.0082 0.027 0.0268
Leishmania major alpha tubulin 0.0022 0.0023 0.001
Echinococcus granulosus neuroglian 0.0017 0.0006 0.0006
Brugia malayi orphan nuclear receptor NR2E1 0.005 0.0141 0.0147
Echinococcus multilocularis retinol dehydrogenase 13 0.0082 0.027 0.0282
Onchocerca volvulus Bile acid receptor homolog 0.0107 0.0371 0.2331
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0218 0.0824 0.2504
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.006 0.0048
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0107 0.0371 0.0386
Giardia lamblia NADH oxidase lateral transfer candidate 0.0823 0.3284 1
Trypanosoma cruzi trypanothione reductase, putative 0.0823 0.3284 0.3412
Brugia malayi hypothetical protein 0.0056 0.0166 0.0172
Leishmania major hypothetical protein, conserved 0.0082 0.027 0.0268
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0082 0.027 0.0268
Brugia malayi Nuclear hormone receptor-like 1 0.0107 0.0371 0.0386
Leishmania major alpha tubulin 0.0022 0.0023 0.001
Plasmodium falciparum CDGSH iron-sulfur domain-containing protein, putative 0.0028 0.0051 0.004
Trypanosoma cruzi alpha tubulin, putative 0.0022 0.0023 0.001
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0082 0.027 0.0268
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0082 0.027 0.0757
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0604 0.2395 0.2496
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0107 0.0371 0.0386
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0823 0.3284 0.3412
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0082 0.027 0.0268
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0304 0.0916
Leishmania major hypothetical protein, conserved 0.0082 0.027 0.0268
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0218 0.0824 0.0846
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0823 0.3284 1
Entamoeba histolytica disulphide oxidoreductase, putative 0.0218 0.0824 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.005 0.0141 0.0653
Leishmania major alpha tubulin 0.0022 0.0023 0.001
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0082 0.027 0.0282
Loa Loa (eye worm) nuclear receptor nhr-7B 0.005 0.0141 0.0147
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.2374 0.9597 1
Loa Loa (eye worm) oxidoreductase 0.0082 0.027 0.0282
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0304 0.0916
Loa Loa (eye worm) oxidoreductase 0.0082 0.027 0.0282
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0082 0.027 0.0268
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0107 0.0371 0.0386
Mycobacterium ulcerans hypothetical protein 0.0218 0.0824 0.1839
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0038 0.009 0.0094
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0082 0.027 0.0282
Loa Loa (eye worm) oxidoreductase 0.0082 0.027 0.0282
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0218 0.0824 0.0846
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0107 0.0371 0.0386
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0161 0.0161
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0082 0.027 0.0282
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0218 0.0824 0.1839
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0082 0.027 0.0282
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0082 0.027 0.0282
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0161 0.0167
Onchocerca volvulus 0.0218 0.0824 0.5645
Brugia malayi nuclear hormone receptor family member odr-7 0.005 0.0141 0.0147
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0082 0.027 0.0268
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0823 0.3284 1
Toxoplasma gondii alpha-tubulin I, putative 0.0022 0.0023 0.001
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0082 0.027 0.3081
Schistosoma mansoni nuclear hormone receptor 0.005 0.0141 0.0141
Trypanosoma cruzi trypanothione reductase, putative 0.2374 0.9597 1
Echinococcus granulosus tubulin alpha 1C chain 0.0022 0.0023 0.0024
Loa Loa (eye worm) hypothetical protein 0.0082 0.027 0.0282
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0218 0.0824 0.0846
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0823 0.3284 0.3412
Brugia malayi RE40412p 0.0028 0.0051 0.0054
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0823 0.3284 0.3412
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0014
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0082 0.027 0.0268
Trypanosoma brucei alpha tubulin 0.0022 0.0023 0.001
Leishmania major quinonoid dihydropteridine reductase 0.0082 0.027 0.0268
Mycobacterium tuberculosis Probable dehydrogenase 0.0317 0.1227 0.1267
Loa Loa (eye worm) hypothetical protein 0.0082 0.027 0.0282
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0218 0.0824 1
Loa Loa (eye worm) transcription factor SMAD2 0.0075 0.0242 0.0252
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.009 0.0304 0.0303
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0922 0.3687 0.3833
Toxoplasma gondii PfMNL-2 CISD1 family iron-sulfur protein, putative 0.0028 0.0051 0.004
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0051 0.004
Plasmodium falciparum CDGSH iron-sulfur domain-containing protein, putative 0.0028 0.0051 0.004
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0082 0.027 0.0268
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0218 0.0824 0.0846
Toxoplasma gondii thioredoxin reductase 0.2374 0.9597 1
Schistosoma mansoni hypothetical protein 0.0038 0.009 0.009
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0022 0.0023 0.0062
Onchocerca volvulus 0.0082 0.027 0.1598
Leishmania major trypanothione reductase 0.2374 0.9597 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0823 0.3284 0.3412
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0823 0.3284 0.3412
Entamoeba histolytica hypothetical protein 0.0052 0.0149 0.1562
Trichomonas vaginalis mercuric reductase, putative 0.0823 0.3284 1
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0218 0.0824 0.0859
Echinococcus granulosus Tubulin alpha 1 chain 0.0022 0.0023 0.0024
Echinococcus multilocularis FTZ F1 alpha 0.0107 0.0371 0.0386
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0218 0.0824 0.0859
Echinococcus granulosus thioredoxin glutathione reductase 0.2374 0.9597 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0038 0.009 0.0094
Loa Loa (eye worm) tubulin alpha chain 0.0022 0.0023 0.0024
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0161 0.0161
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.005 0.0141 0.0147
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0218 0.0824 0.0846
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0082 0.027 0.0268
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0013 0.0013
Schistosoma mansoni short chain dehydrogenase 0.0082 0.027 0.027
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0218 0.0824 0.0846
Onchocerca volvulus 0.0082 0.027 0.1598
Leishmania major hypothetical protein, conserved 0.0082 0.027 0.0268
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0013 0.0014
Leishmania major hypothetical protein, conserved 0.0082 0.027 0.0268
Plasmodium vivax glutathione reductase, putative 0.2374 0.9597 1
Trichomonas vaginalis glutamate synthase, putative 0.0218 0.0824 0.2504
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0056 0.0166 0.0172
Echinococcus multilocularis tubulin subunit TubB 0.0022 0.0023 0.0024
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0218 0.0824 0.0859
Loa Loa (eye worm) oxidoreductase 0.0082 0.027 0.0282
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0082 0.027 0.0282
Loa Loa (eye worm) hypothetical protein 0.005 0.0141 0.0147
Schistosoma mansoni nuclear receptor nhr-48 0.005 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.005 0.0141 0.0147
Trypanosoma cruzi hypothetical protein, conserved 0.0082 0.027 0.0268
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0107 0.0371 0.0386
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0052 0.0149 0.0155
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0218 0.0824 0.2504
Schistosoma mansoni short chain dehydrogenase 0.0082 0.027 0.027
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0107 0.0371 0.0371
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0082 0.027 0.3081
Schistosoma mansoni glutamate synthase 0.0218 0.0824 0.0824
Schistosoma mansoni zinc finger protein 0.005 0.0141 0.0141
Echinococcus multilocularis steroid dehydrogenase 0.0082 0.027 0.0282
Brugia malayi Uncharacterized hematopoietic stem/progenitor cells protein MDS029 0.0201 0.0752 0.0783
Entamoeba histolytica hypothetical protein 0.0052 0.0149 0.1562
Echinococcus multilocularis Tubulin alpha 1 chain 0.0022 0.0023 0.0024
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0218 0.0824 0.1839
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0218 0.0824 0.2504
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0082 0.027 0.0268
Loa Loa (eye worm) steroid hormone receptor 0.0107 0.0371 0.0386
Brugia malayi Steroid receptor seven-up type 2 0.0107 0.0371 0.0386
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.0141 0.0147
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0038 0.009 0.0094
Leishmania major 3-keto-dihydrosphingosine reductase 0.0082 0.027 0.0268
Echinococcus multilocularis geminin 0.0205 0.0768 0.0801
Schistosoma mansoni CDGSH-type Zn finger-containing protein-like protein 0.05 0.197 0.197
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0218 0.0824 0.0846
Plasmodium falciparum CDGSH iron-sulfur domain-containing protein, putative 0.0028 0.0051 0.004
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.006 0.0048
Trichomonas vaginalis apoptosis inducing factor, putative 0.0218 0.0824 0.2504
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0082 0.027 0.1598
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0107 0.0371 0.0386
Brugia malayi latrophilin 2 splice variant baaae 0.0082 0.027 0.0281
Brugia malayi alpha-tubulin 0.0022 0.0023 0.0024
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0082 0.027 0.0282
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0836 0.3339 0.3479
Leishmania major short chain dehydrogenase-like protein 0.0082 0.027 0.0268
Leishmania major alpha tubulin 0.0022 0.0023 0.001
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0107 0.0371 0.0386
Loa Loa (eye worm) hypothetical protein 0.0107 0.0371 0.0386
Echinococcus multilocularis neuroglian 0.0017 0.0006 0.0006
Trypanosoma brucei NADH dehydrogenase 0.0218 0.0824 0.0846
Trichomonas vaginalis tubulin epsilon chain, putative 0.0022 0.0023 0.0062
Schistosoma mansoni tubulin subunit alpha 0.0022 0.0023 0.0023
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0218 0.0824 0.1839
Trichomonas vaginalis tubulin beta chain, putative 0.0022 0.0023 0.0062
Loa Loa (eye worm) tubulin alpha chain 0.0022 0.0023 0.0024
Loa Loa (eye worm) hypothetical protein 0.005 0.0141 0.0147
Loa Loa (eye worm) hypothetical protein 0.0082 0.027 0.0282
Echinococcus granulosus tubulin alpha 3 chain 0.0022 0.0023 0.0024
Loa Loa (eye worm) hypothetical protein 0.0107 0.0371 0.0386
Echinococcus granulosus peroxisome assembly protein 26 0.0022 0.0023 0.0024
Schistosoma mansoni RAR-like nuclear receptor 0.0107 0.0371 0.0371
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.006 0.0048
Echinococcus granulosus oxidoreductase 0.0082 0.027 0.0282
Loa Loa (eye worm) oxidoreductase 0.0082 0.027 0.0282
Mycobacterium tuberculosis Probable oxidoreductase 0.0082 0.027 0.0268
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0823 0.3284 0.3412
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0082 0.027 0.0282
Echinococcus granulosus tubulin alpha chain 0.0022 0.0023 0.0024
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0082 0.027 0.0268
Brugia malayi nuclear receptor NHR-88 0.0107 0.0371 0.0386
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0107 0.0371 0.0371
Loa Loa (eye worm) hypothetical protein 0.005 0.0141 0.0147
Schistosoma mansoni nephrin 0.0017 0.0006 0.0006
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0218 0.0824 0.2504
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0082 0.027 0.0268
Trypanosoma brucei alpha tubulin 0.0022 0.0023 0.001
Schistosoma mansoni glutamate synthase 0.0218 0.0824 0.0824
Schistosoma mansoni short chain dehydrogenase 0.0082 0.027 0.027
Echinococcus multilocularis tubulin alpha chain 0.0022 0.0023 0.0024
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0317 0.1227 0.1267
Loa Loa (eye worm) hypothetical protein 0.005 0.0141 0.0147
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0218 0.0824 0.0859
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0107 0.0371 0.0386
Echinococcus granulosus tubulin alpha 3 chain 0.0022 0.0023 0.0024
Schistosoma mansoni steroid dehydrogenase 0.0082 0.027 0.027
Onchocerca volvulus 0.0082 0.027 0.1598
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0218 0.0824 1
Schistosoma mansoni hypothetical protein 0.0052 0.0149 0.0149
Brugia malayi nuclear hormone receptor 0.005 0.0141 0.0147
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0104 0.036 0.0375
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0823 0.3284 0.3412
Echinococcus multilocularis tubulin alpha chain 0.0022 0.0023 0.0024
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0082 0.027 0.0282
Leishmania major short chain dehydrogenase, putative 0.0082 0.027 0.0268
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0107 0.0371 0.0371
Echinococcus multilocularis conserved hypothetical protein 0.0082 0.027 0.0282
Giardia lamblia Hypothetical protein 0.0082 0.027 0.0757
Loa Loa (eye worm) hypothetical protein 0.0082 0.027 0.0282
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0218 0.0824 0.0859
Schistosoma mansoni glutamate synthase 0.0218 0.0824 0.0824
Loa Loa (eye worm) tubulin alpha 2 0.0017 0.0003 0.0003
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0218 0.0824 0.0846
Loa Loa (eye worm) nuclear hormone receptor 0.005 0.0141 0.0147
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0013 0.0014
Loa Loa (eye worm) oxidoreductase 0.0082 0.027 0.0282
Echinococcus multilocularis cdgsh iron sulfur domain containing protein 0.0472 0.1855 0.1933
Loa Loa (eye worm) oxidoreductase 0.0082 0.027 0.0282
Echinococcus multilocularis GPCR, family 2 0.0038 0.009 0.0094
Loa Loa (eye worm) hypothetical protein 0.0082 0.027 0.0282
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0922 0.3687 0.3833
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0038 0.009 0.0094
Schistosoma mansoni retinoic acid receptor RXR 0.0107 0.0371 0.0371
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0823 0.3284 0.3412
Onchocerca volvulus Serine\/threonine kinase homolog 0.009 0.0304 0.1842
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0082 0.027 0.0268
Echinococcus multilocularis tubulin alpha chain 0.0022 0.0023 0.0024
Echinococcus granulosus roundabout 2 0.0019 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0003
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0218 0.0824 0.2504
Trichomonas vaginalis tubulin beta chain, putative 0.0022 0.0023 0.0062
Echinococcus multilocularis carbonyl reductase 1 0.0082 0.027 0.0282
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0082 0.027 0.1598
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0218 0.0824 0.0846
Loa Loa (eye worm) programmed cell death 8 0.0218 0.0824 0.0859
Loa Loa (eye worm) glutathione reductase 0.2374 0.9597 1
Leishmania major alpha tubulin 0.0022 0.0023 0.001
Trypanosoma brucei short-chain dehydrogenase, putative 0.0082 0.027 0.0268
Plasmodium falciparum ferrodoxin reductase-like protein 0.0218 0.0824 0.0846
Schistosoma mansoni hypothetical protein 0.0205 0.0768 0.0768
Entamoeba histolytica hypothetical protein 0.0082 0.027 0.3081
Schistosoma mansoni steroid dehydrogenase 0.0082 0.027 0.027
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0082 0.027 0.027
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.0141 0.0147
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0107 0.0371 0.0386
Trypanosoma brucei short-chain dehydrogenase, putative 0.0082 0.027 0.0268
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0107 0.0371 0.0386
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0218 0.0824 0.0846
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0082 0.027 0.0268
Trichomonas vaginalis tubulin beta chain, putative 0.0022 0.0023 0.0062
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0056 0.0166 0.0172
Leishmania major short chain dehydrogenase/reductase, putative 0.0082 0.027 0.0268
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0218 0.0824 0.0846
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0082 0.027 0.0268
Echinococcus granulosus cdgsh iron sulfur domain containing protein 0.0472 0.1855 0.1933
Brugia malayi hypothetical protein 0.003 0.006 0.0062
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0107 0.0371 0.0386
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0018 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.005 0.0141 0.0147
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0082 0.027 0.0268
Loa Loa (eye worm) nuclear receptor NHR-67 0.005 0.0141 0.0147
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0038 0.009 0.0094
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0082 0.027 0.0268
Leishmania major quinonoid dihydropteridine reductase 0.0082 0.027 0.0268
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0218 0.0824 0.0859
Mycobacterium tuberculosis Possible oxidoreductase 0.0082 0.027 0.0268
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0107 0.0371 0.0386
Echinococcus multilocularis tubulin alpha chain 0.0022 0.0023 0.0024
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0107 0.0371 0.0386
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0082 0.027 0.0282
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0082 0.027 0.0815
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0823 0.3284 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0161 0.0167
Echinococcus multilocularis ecdysone induced protein 78C 0.0107 0.0371 0.0386
Loa Loa (eye worm) hypothetical protein 0.0107 0.0371 0.0386
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0082 0.027 0.0815
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0823 0.3284 0.3412
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0304 0.0916
Loa Loa (eye worm) hypothetical protein 0.0056 0.0166 0.0172
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0082 0.027 0.0282
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0082 0.027 0.0282
Plasmodium falciparum glutathione reductase 0.0823 0.3284 0.3412
Loa Loa (eye worm) hypothetical protein 0.0056 0.0166 0.0172
Echinococcus multilocularis tubulin alpha 1C chain 0.0022 0.0023 0.0024
Echinococcus granulosus GPCR family 2 0.0038 0.009 0.0094
Echinococcus granulosus alpha tubulin 0.0022 0.0023 0.0024
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0082 0.027 0.0282
Entamoeba histolytica thioredoxin reductase, putative 0.0218 0.0824 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.005 0.0141 0.0147
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0218 0.0824 0.0846
Trichomonas vaginalis tubulin beta chain, putative 0.0022 0.0023 0.0062
Leishmania major quinonoid dihydropteridine reductase 0.0082 0.027 0.0268
Loa Loa (eye worm) hypothetical protein 0.0082 0.027 0.0282
Plasmodium falciparum glutathione reductase 0.2374 0.9597 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0014
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0082 0.027 0.0268
Schistosoma mansoni short chain dehydrogenase 0.0082 0.027 0.027
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0218 0.0824 0.0846
Trichomonas vaginalis glutamate synthase, putative 0.0218 0.0824 0.2504
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0082 0.027 0.0268
Echinococcus granulosus conserved hypothetical protein 0.0028 0.0051 0.0054
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0082 0.027 0.0815
Leishmania major hypothetical protein, unknown function 0.0028 0.0051 0.004
Entamoeba histolytica hypothetical protein 0.0052 0.0149 0.1562
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0218 0.0824 0.1622
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0823 0.3284 0.3412
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0082 0.027 0.0815
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.005 0.0141 0.0147
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0082 0.027 0.0268
Mycobacterium tuberculosis Probable oxidoreductase 0.0922 0.3687 0.3833
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0823 0.3284 0.3422
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0823 0.3284 0.3412
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0218 0.0824 0.0859
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0823 0.3284 0.3412
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0013 0.0014
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0218 0.0824 0.0859
Echinococcus multilocularis tubulin alpha chain 0.0022 0.0023 0.0024
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0082 0.027 0.0268
Echinococcus granulosus tubulin alpha chain 0.0022 0.0023 0.0024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0107 0.0371 0.0386
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0218 0.0824 0.1839
Schistosoma mansoni nuclear hormone receptor 0.0107 0.0371 0.0371
Giardia lamblia Glutamate synthase 0.0218 0.0824 0.2457
Brugia malayi hypothetical protein 0.005 0.0141 0.0147
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0082 0.027 0.0268
Loa Loa (eye worm) tubulin alpha 2 0.0017 0.0003 0.0003
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0082 0.027 0.0815
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0082 0.027 0.0282
Trypanosoma brucei hypothetical protein, conserved 0.0218 0.0824 0.0846
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0218 0.0824 0.1622
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0218 0.0824 0.0846
Plasmodium vivax steroid dehydrogenase, putative 0.0082 0.027 0.0268
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0107 0.0371 0.0386
Loa Loa (eye worm) hypothetical protein 0.005 0.0141 0.0147
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0823 0.3284 0.3412
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0823 0.3284 0.3412
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0056 0.0166 0.0166
Echinococcus granulosus tubulin alpha 1C chain 0.0022 0.0023 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0107 0.0371 0.0386
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0218 0.0824 0.0859
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0082 0.027 0.0268
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0082 0.027 0.0815
Echinococcus granulosus geminin 0.0205 0.0768 0.0801
Schistosoma mansoni short chain dehydrogenase 0.0082 0.027 0.027
Echinococcus granulosus carbonyl reductase 1 0.0082 0.027 0.0282
Loa Loa (eye worm) MH2 domain-containing protein 0.0075 0.0242 0.0252
Brugia malayi Tubulin alpha-2 chain 0.0022 0.0023 0.0024
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0082 0.027 0.0815
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0823 0.3284 0.3412
Loa Loa (eye worm) hypothetical protein 0.0107 0.0371 0.0386
Echinococcus granulosus carbonyl reductase 1 0.0082 0.027 0.0282
Entamoeba histolytica serine/threonine protein kinase, putative 0.009 0.0304 0.3498
Leishmania major alpha tubulin 0.0022 0.0023 0.001
Echinococcus granulosus retinol dehydrogenase 11 0.0082 0.027 0.0282
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0218 0.0824 0.0846
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0082 0.027 0.0268
Brugia malayi nuclear receptor NHR-88 0.005 0.0141 0.0147
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0082 0.027 0.3081
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0218 0.0824 0.0846
Leishmania major alpha tubulin 0.0022 0.0023 0.001
Schistosoma mansoni thyroid hormone receptor 0.0107 0.0371 0.0371
Schistosoma mansoni alpha tubulin 0.0022 0.0023 0.0023
Schistosoma mansoni steroid dehydrogenase 0.0082 0.027 0.027
Schistosoma mansoni sulfide quinone reductase 0.0218 0.0824 0.0824
Echinococcus granulosus Nuclear hormone receptor HR96 0.005 0.0141 0.0147
Mycobacterium ulcerans dehydrogenase 0.0218 0.0824 0.1839
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0082 0.027 0.0268
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0107 0.0371 0.0371
Leishmania major hypothetical protein, conserved 0.0218 0.0824 0.0846
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0823 0.3284 0.3412
Brugia malayi nuclear receptor RXR 0.0056 0.0166 0.0172
Leishmania major alpha tubulin 0.0022 0.0023 0.001
Leishmania major hypothetical protein, conserved 0.0218 0.0824 0.0846
Loa Loa (eye worm) hypothetical protein 0.005 0.0141 0.0147
Brugia malayi steroid hormone receptor 0.0107 0.0371 0.0386
Onchocerca volvulus 0.0082 0.027 0.1598
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.009 0.0304 0.0316
Echinococcus multilocularis retinol dehydrogenase 11 0.0082 0.027 0.0282
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.005 0.0141 0.0147
Trypanosoma cruzi hypothetical protein, conserved 0.0218 0.0824 0.0846
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.009 0.0304 0.0316
Loa Loa (eye worm) thioredoxin reductase 0.2374 0.9597 1
Onchocerca volvulus 0.0082 0.027 0.1598
Leishmania major pteridine reductase 1 0.0082 0.027 0.0268
Echinococcus granulosus hypothetical protein 0.0082 0.027 0.0282
Loa Loa (eye worm) hypothetical protein 0.005 0.0141 0.0147
Schistosoma mansoni short chain dehydrogenase 0.0082 0.027 0.027
Echinococcus granulosus Tubulin alpha 1 chain 0.0022 0.0023 0.0024
Leishmania major alpha tubulin 0.0022 0.0023 0.001
Onchocerca volvulus Protein ultraspiracle homolog 0.0107 0.0371 0.2331
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0118 0.035
Echinococcus multilocularis steroid dehydrogenase 0.0082 0.027 0.0282
Toxoplasma gondii carbonyl reductase 1, putative 0.0082 0.027 0.0268
Schistosoma mansoni short chain dehydrogenase 0.0082 0.027 0.027
Trypanosoma cruzi hypothetical protein, conserved 0.0082 0.027 0.0268
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.005 0.0141 0.0141
Entamoeba histolytica short chain dehydrogenase family protein 0.0082 0.027 0.3081
Brugia malayi tubulin alpha-2 chain 0.0022 0.0023 0.0024
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0118 0.035
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0218 0.0824 0.1839
Loa Loa (eye worm) hypothetical protein 0.0056 0.0166 0.0172
Echinococcus granulosus tubulin alpha chain 0.0022 0.0023 0.0024
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0082 0.027 0.0268
Brugia malayi tubulin alpha chain - mouse 0.0022 0.0023 0.0024
Plasmodium vivax hypothetical protein, conserved 0.0082 0.027 0.0268
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0304 0.0916
Mycobacterium tuberculosis Probable oxidoreductase 0.0082 0.027 0.0268
Onchocerca volvulus Tyrosine kinase homolog 0.0088 0.0294 0.1772
Plasmodium vivax tubulin alpha chain, putative 0.0022 0.0023 0.001
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0082 0.027 0.0268
Leishmania major quinonoid dihydropteridine reductase 0.0082 0.027 0.0268
Loa Loa (eye worm) hypothetical protein 0.0056 0.0166 0.0172
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0082 0.027 0.0268
Trypanosoma cruzi NADH dehydrogenase, putative 0.0218 0.0824 0.0846
Echinococcus granulosus nuclear receptor nhr 48 0.005 0.0141 0.0147
Schistosoma mansoni cell adhesion molecule 0.0018 0.0008 0.0008
Leishmania major NADH dehydrogenase, putative 0.0218 0.0824 0.0846
Giardia lamblia Reductase, putative 0.0082 0.027 0.0757
Loa Loa (eye worm) hypothetical protein 0.0056 0.0166 0.0172
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0082 0.027 0.0282
Schistosoma mansoni steroid hormone receptor ad4bp 0.0107 0.0371 0.0371
Echinococcus multilocularis tubulin alpha 3 chain 0.0022 0.0023 0.0024
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0218 0.0824 0.2504
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0082 0.027 0.0268
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0082 0.027 0.0282
Brugia malayi nuclear receptor RXR 0.005 0.0141 0.0147
Schistosoma mansoni short chain dehydrogenase 0.0082 0.027 0.027
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0082 0.027 0.3081
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0823 0.3284 1
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0082 0.027 0.0268
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0013 0.0014
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0823 0.3284 0.3412
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0107 0.0371 0.0386
Plasmodium falciparum alpha tubulin 2 0.0022 0.0023 0.001
Onchocerca volvulus 0.0085 0.0282 0.1686
Brugia malayi ecdysteroid receptor 0.0107 0.0371 0.0386
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0218 0.0824 0.2504
Loa Loa (eye worm) dehydrogenase 0.0082 0.027 0.0282
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0218 0.0824 0.0846
Schistosoma mansoni tubulin subunit alpha 0.0022 0.0023 0.0023
Onchocerca volvulus Sepiapterin reductase homolog 0.0082 0.027 0.1598
Echinococcus multilocularis thioredoxin glutathione reductase 0.2374 0.9597 1
Echinococcus multilocularis carbonyl reductase 1 0.0082 0.027 0.0282
Mycobacterium ulcerans monoxygenase 0.0218 0.0824 0.1839
Schistosoma mansoni nuclear hormone receptor 0.005 0.0141 0.0141
Brugia malayi glutamate synthase 0.0218 0.0824 0.0859
Onchocerca volvulus 0.0365 0.1421 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.0082 0.027 0.0268
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0317 0.1227 0.1267
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0082 0.027 0.027
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0218 0.0824 0.0846
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0082 0.027 0.0268
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0823 0.3284 0.3412
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0082 0.027 0.0282
Echinococcus granulosus retinol dehydrogenase 11 0.0082 0.027 0.0282
Mycobacterium ulcerans NADH dehydrogenase 0.0218 0.0824 0.1839
Leishmania major quinonoid dihydropteridine reductase 0.0082 0.027 0.0268
Trichomonas vaginalis tubulin beta chain, putative 0.0022 0.0023 0.0062
Trypanosoma cruzi polo-like protein kinase, putative 0.009 0.0304 0.0303
Brugia malayi Tubulin alpha chain 0.0022 0.0023 0.0024
Loa Loa (eye worm) hypothetical protein 0.0107 0.0371 0.0386
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0082 0.027 0.0268
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0082 0.027 0.0268
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0218 0.0824 0.1622
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0218 0.0824 0.0846
Onchocerca volvulus 0.0082 0.027 0.1598
Loa Loa (eye worm) dehydrogenase 0.0082 0.027 0.0282
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0218 0.0824 0.0846
Echinococcus granulosus FTZ F1 alpha 0.0107 0.0371 0.0386
Loa Loa (eye worm) hypothetical protein 0.0201 0.0752 0.0783
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0008
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0604 0.2395 0.2496
Brugia malayi Nuclear hormone receptor E75 0.005 0.0141 0.0147
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0051 0.004
Loa Loa (eye worm) hypothetical protein 0.0107 0.0371 0.0386
Trichomonas vaginalis steroid dehydrogenase, putative 0.0082 0.027 0.0815
Brugia malayi nuclear receptor NHR-67 0.005 0.0141 0.0147
Echinococcus granulosus WW domain containing oxidoreductase 0.0082 0.027 0.0282
Entamoeba histolytica hypothetical protein, conserved 0.0082 0.027 0.3081
Plasmodium vivax thioredoxin reductase, putative 0.2374 0.9597 1
Leishmania major quinonoid dihydropteridine reductase 0.0082 0.027 0.0268
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0082 0.027 0.0268
Leishmania major quinonoid dihydropteridine reductase 0.0082 0.027 0.0268
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0317 0.1227 0.1267
Loa Loa (eye worm) oxidoreductase 0.0082 0.027 0.0282
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0218 0.0824 0.0846
Echinococcus multilocularis carbonyl reductase 1 0.0082 0.027 0.0282
Loa Loa (eye worm) hypothetical protein 0.0082 0.027 0.0282
Loa Loa (eye worm) alpha-tubulin 0.0022 0.0023 0.0024
Loa Loa (eye worm) hypothetical protein 0.0365 0.1421 0.148
Echinococcus granulosus tubulin subunit TubB 0.0022 0.0023 0.0024
Trypanosoma brucei short-chain dehydrogenase, putative 0.0082 0.027 0.0268
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0161 0.0161
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0823 0.3284 0.3284
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.006 0.0048
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.005 0.0141 0.0653
Mycobacterium tuberculosis Probable oxidoreductase 0.0082 0.027 0.0268
Toxoplasma gondii zinc finger cdgsh type protein 0.0028 0.0051 0.004
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0218 0.0824 0.1839
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0082 0.027 0.0268
Leishmania major oxidoreductase-like protein 0.0082 0.027 0.0268
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0922 0.3687 1
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0218 0.0824 0.0846
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0082 0.027 0.0268
Echinococcus granulosus tubulin alpha chain 0.0022 0.0023 0.0024
Loa Loa (eye worm) hypothetical protein 0.0082 0.027 0.0281
Onchocerca volvulus 0.005 0.0141 0.0653
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0082 0.027 0.3081
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0082 0.027 0.0268
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0107 0.0371 0.0386
Toxoplasma gondii selenide, water dikinase 0.0218 0.0824 0.0846
Echinococcus granulosus steroid dehydrogenase 0.0082 0.027 0.0282
Schistosoma mansoni kinase 0.0046 0.0123 0.0123
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0082 0.027 0.0282
Echinococcus multilocularis tubulin alpha 1C chain 0.0022 0.0023 0.0024
Loa Loa (eye worm) DR-78 0.005 0.0141 0.0147
Echinococcus granulosus tubulin alpha chain 0.0022 0.0023 0.0024
Leishmania major short chain dehydrogenase/reductase, putative 0.0082 0.027 0.0268
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0218 0.0824 0.2457
Schistosoma mansoni nuclear receptor 0.005 0.0141 0.0141
Echinococcus granulosus carbonyl reductase 1 0.0082 0.027 0.0282
Brugia malayi Retinol dehydrogenase 12 0.0082 0.027 0.0282
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0218 0.0824 0.0859
Schistosoma mansoni hypothetical protein 0.0038 0.009 0.009
Trypanosoma cruzi hypothetical protein, conserved 0.0082 0.027 0.0268
Toxoplasma gondii oxidoreductase, putative 0.0082 0.027 0.0268
Loa Loa (eye worm) pigment dispersing factor receptor c 0.012 0.0425 0.0443
Brugia malayi Nuclear hormone receptor E75 0.005 0.0141 0.0147
Schistosoma mansoni steroid dehydrogenase 0.0082 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.012 0.0425 0.0443
Brugia malayi oxidoreductase 0.0082 0.027 0.0282
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0823 0.3284 0.3412
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0051 0.004
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0218 0.0824 0.0859
Onchocerca volvulus 0.0082 0.027 0.1598
Trypanosoma cruzi polo-like protein kinase, putative 0.009 0.0304 0.0303

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -6.75 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.507 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.315 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.235 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.027 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.812 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.465 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.211 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.21 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.035 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.927 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) = 0.13 uM In vitro cytotoxicity value corresponding to 50% growth inhibition against MDA-MB-435(breast) cell line. ChEMBL. 9240348
GI50 (functional) = 0.13 uM Cytotoxicity against the cancer cell lines breast MDA-MB-435 ChEMBL. 12361402
GI50 (functional) = 0.34 uM In vitro cytotoxicity value corresponding to 50% growth inhibition against OVCAR-3(ovarian) cell line. ChEMBL. 9240348
GI50 (functional) = 0.34 uM Cytotoxicity against the cancer cell lines ovarian OVCAR-3 ChEMBL. 12361402
GI50 (functional) = 0.48 uM In vitro cytotoxicity value corresponding to 50% growth inhibition againstHCT-116(colon) cell line. ChEMBL. 9240348
GI50 (functional) = 0.48 uM Cytotoxicity against the cancer cell lines colon HCT-116 ChEMBL. 12361402
GI50 (functional) = 0.5 uM In vitro cytotoxicity value corresponding to 50% growth inhibition against UACC-62(melanoma) cell line. ChEMBL. 9240348
GI50 (functional) = 0.5 uM Cytotoxicity against the cancer cell lines melanoma UACC-62 ChEMBL. 12361402
GI50 (functional) = 0.95 uM The In vitro cytotoxicity corresponding to 50% growth inhibition against SF-59 (central nervous system) cell line. ChEMBL. 9240348
GI50 (functional) = 0.95 uM Cytotoxicity against the cancer cell lines CNS SF-539 ChEMBL. 12361402
GI50 (functional) = 1.7 uM In vitro cytotoxicity value corresponding to 50% growth inhibition against HOP-62(non small cell lung) cell line. ChEMBL. 9240348
GI50 (functional) = 1.7 uM Mean graph midpoint for growth inhibition of all human cancer cell lines ChEMBL. 9240348
GI50 (functional) = 1.7 uM Cytotoxicity against the cancer cell lines lung HOP-62 ChEMBL. 12361402
GI50 (functional) = 3.6 uM The In vitro cytotoxicity value corresponding to 50% growth inhibition against DU-145(prostate) cell line. ChEMBL. 9240348
GI50 (functional) = 3.6 uM Cytotoxicity against the cancer cell lines prostate DU-145 ChEMBL. 12361402
GI50 (functional) = 6.9 uM In vitro cytotoxicity value corresponding to 50% growth inhibition against SN12C (renal) cell line. ChEMBL. 9240348
GI50 (functional) = 6.9 uM Cytotoxicity against the cancer cell lines renal SN12C ChEMBL. 12361402
IC50 (functional) = 0.52 uM Inhibitory concentration required against growth of HUVEC cancer cell line ChEMBL. 15456256
IC50 (functional) = 3.99 uM Inhibitory concentration against growth of MDA-MB-231 cancer cell line ChEMBL. 15456256
IC50 (functional) = 4.8 uM Evaluated for inhibition of tubulin polymerization. ChEMBL. 9240348
IC50 (binding) = 4.9 uM Inhibition of tubulin polymerization measured at 12 uM tubulin concentration. ChEMBL. 12361402
Inhibition (binding) = 11 % Evaluated for % inhibition of colchicine binding to tubulin. ChEMBL. 9240348

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 15456256

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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