Detailed information for compound 1468751

Basic information

Technical information
  • TDR Targets ID: 1468751
  • Name: (2,4-dimethylquinolin-3-yl)-phenylmethanone
  • MW: 261.318 | Formula: C18H15NO
  • H donors: 0 H acceptors: 2 LogP: 4.3 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1nc2ccccc2c(c1C(=O)c1ccccc1)C
  • InChi: 1S/C18H15NO/c1-12-15-10-6-7-11-16(15)19-13(2)17(12)18(20)14-8-4-3-5-9-14/h3-11H,1-2H3
  • InChiKey: HQXOAMNQLQTPSF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2,4-dimethyl-3-quinolyl)-phenyl-methanone
  • (2,4-dimethyl-3-quinolyl)-phenylmethanone
  • (2,4-dimethylquinolin-3-yl)-phenyl-methanone
  • ZINC03342290

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0072 0.0255 0.0281
Trypanosoma cruzi ribonuclease H1, putative 0.0046 0.0096 0.007
Trypanosoma brucei thymidylate kinase, putative 0.0152 0.0741 0.0925
Entamoeba histolytica hypothetical protein 0.0072 0.0255 0.0281
Echinococcus multilocularis lamin dm0 0.0056 0.0157 0.0139
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.006 0.0181 0.1979
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.006 0.0181 0.1979
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0068 0.0235 0.275
Echinococcus multilocularis glycogen phosphorylase 0.0105 0.046 0.0442
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0046 0.0096 0.0761
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.006 0.0181 0.0183
Brugia malayi RNase H family protein 0.0046 0.0096 0.074
Trichomonas vaginalis thymidine kinase, putative 0.1279 0.7589 1
Giardia lamblia CDC8 0.0152 0.0741 0.0861
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0072 0.0255 0.0281
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0136 0.0123
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.006 0.0181 0.0183
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0068 0.0235 0.159
Schistosoma mansoni lipoxygenase 0.0057 0.0162 0.0152
Schistosoma mansoni thymidylate kinase 0.0152 0.0741 0.0762
Entamoeba histolytica glycogen phosphorylase, putative 0.0105 0.046 0.0553
Echinococcus multilocularis thymidylate kinase 0.0152 0.0741 0.0724
Echinococcus granulosus NADH ubiquinone oxidoreductase 42 kDa subunit 0.0072 0.0255 0.0249
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0072 0.0255 0.0281
Schistosoma mansoni hypothetical protein 0.0037 0.0043 0.0025
Giardia lamblia Glycogen phosphorylase 0.0105 0.046 0.0486
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.0451 0.3492
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0114 0.0095
Brugia malayi RNase H family protein 0.0046 0.0096 0.074
Schistosoma mansoni thyroid hormone receptor 0.015 0.0731 0.0751
Loa Loa (eye worm) inositol-1 0.0076 0.0283 0.2196
Entamoeba histolytica glycogen phosphorylase, putative 0.0105 0.046 0.0553
Entamoeba histolytica glycogen phosphorylase, putative 0.0046 0.0096 0.0071
Entamoeba histolytica hypothetical protein 0.0072 0.0255 0.0281
Loa Loa (eye worm) beta-lactamase 0.0037 0.0043 0.0331
Loa Loa (eye worm) hypothetical protein 0.0056 0.0157 0.1218
Entamoeba histolytica glycogenphosphorylase, putative 0.0046 0.0096 0.0071
Loa Loa (eye worm) hypothetical protein 0.0052 0.0136 0.1052
Plasmodium vivax thymidylate kinase, putative 0.0152 0.0741 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0043 0.0331
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0076 0.0283 0.0319
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0043 0.0025
Schistosoma mansoni NADH-ubiquinone oxidoreductase 0.0072 0.0255 0.0249
Entamoeba histolytica hypothetical protein 0.0072 0.0255 0.0281
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0283 0.0319
Schistosoma mansoni inositol monophosphatase 0.0076 0.0283 0.0279
Leishmania major ribonuclease H1, putative 0.0046 0.0096 0.007
Trichomonas vaginalis thymidine kinase, putative 0.1279 0.7589 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0236 0.125 1
Brugia malayi beta-lactamase family protein 0.0037 0.0043 0.0331
Loa Loa (eye worm) hypothetical protein 0.0055 0.0151 0.117
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0114 0.01
Brugia malayi carbohydrate phosphorylase 0.0105 0.046 0.3563
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.006 0.0181 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0255 0.0281
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0205 0.0196
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.0451 0.3492
Schistosoma mansoni ap endonuclease 0.006 0.0181 0.0171
Trypanosoma brucei unspecified product 0.0053 0.0139 0.0128
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.006 0.0181 0.0183
Schistosoma mansoni glycogen phosphorylase 0.0046 0.0096 0.0082
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0114 0.01
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0043 0.0025
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.006 0.0181 0.1144
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0114 0.0095
Toxoplasma gondii exonuclease III APE 0.006 0.0181 0.1979
Loa Loa (eye worm) glycogen phosphorylase 0.0105 0.046 0.3563
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0076 0.0283 0.0319
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0136 0.1334
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0283 0.0319
Loa Loa (eye worm) hypothetical protein 0.0242 0.129 1
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0255 0.0281
Entamoeba histolytica hypothetical protein 0.0072 0.0255 0.0281
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0076 0.0283 0.3448
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0043 0.0024
Loa Loa (eye worm) hypothetical protein 0.0071 0.0251 0.1942
Trypanosoma cruzi thymidine kinase, putative 0.1279 0.7589 1
Loa Loa (eye worm) deoxynucleoside kinase 0.0072 0.0255 0.1973
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0114 0.0882
Trypanosoma brucei RNA helicase, putative 0.0317 0.1748 0.2259
Echinococcus granulosus thymidine kinase 0.1592 0.9494 1
Loa Loa (eye worm) thymidylate kinase 0.0152 0.0741 0.5742
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0043 0.0025
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0205 0.0196
Brugia malayi beta-lactamase family protein 0.0037 0.0043 0.0331
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0057 0.0162 0.0152
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0283 0.0319
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.006 0.0181 0.0171
Chlamydia trachomatis thymidylate kinase 0.0152 0.0741 1
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0205 0.0196
Schistosoma mansoni hypothetical protein 0.0317 0.1748 0.1825
Plasmodium falciparum thymidylate kinase 0.0152 0.0741 1
Wolbachia endosymbiont of Brugia malayi thymidylate kinase 0.0152 0.0741 1
Echinococcus granulosus thymidine kinase 0.1592 0.9494 1
Giardia lamblia Hypothetical protein 0.0072 0.0255 0.0212
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0255 0.0281
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.006 0.0181 0.0114
Trypanosoma brucei ingi protein (ORF1) 0.0053 0.0139 0.0128
Schistosoma mansoni thymidine kinase 0.1592 0.9494 1
Trichomonas vaginalis thymidylate kinase, putative 0.0152 0.0741 0.0925
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0019 0.0144
Schistosoma mansoni phosphoglucomutase 0.0046 0.0096 0.0081
Loa Loa (eye worm) hypothetical protein 0.0037 0.0043 0.0331
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0072 0.0255 0.0281
Echinococcus granulosus thymidylate kinase 0.0152 0.0741 0.0762
Giardia lamblia Deoxynucleoside kinase 0.0487 0.2779 0.3581
Mycobacterium tuberculosis Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) 0.0152 0.0741 0.5783
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0114 0.01
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0205 0.2319
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.006 0.0181 0.1322
Brugia malayi Deoxynucleoside kinase family protein 0.0072 0.0255 0.1973
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0114 0.01
Mycobacterium ulcerans thymidylate kinase 0.0152 0.0741 1
Echinococcus multilocularis transfer RNA-Ile 0.1592 0.9494 0.9493
Loa Loa (eye worm) hypothetical protein 0.0037 0.0043 0.0331
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0139 0.0663 0.0645
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.006 0.0181 0.0183
Onchocerca volvulus 0.0049 0.0119 0.109
Toxoplasma gondii ribonuclease HI protein 0.0046 0.0096 0.0757
Brugia malayi RNase H family protein 0.0046 0.0096 0.074
Trichomonas vaginalis thymidylate kinase, putative 0.0152 0.0741 0.0925
Trypanosoma cruzi thymidine kinase, putative 0.1279 0.7589 1
Echinococcus granulosus geminin 0.0357 0.1986 0.2077
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0255 0.0281
Loa Loa (eye worm) intermediate filament protein 0.0056 0.0157 0.1218
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.006 0.0181 0.0183
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0043 0.0025
Onchocerca volvulus Ribonuclease H1 homolog 0.0046 0.0096 0.0757
Schistosoma mansoni hypothetical protein 0.0139 0.0663 0.068
Brugia malayi Inositol-1 0.0076 0.0283 0.2196
Trypanosoma cruzi ribonuclease H1, putative 0.0046 0.0096 0.007
Echinococcus granulosus inositol monophosphatase 1 0.0076 0.0283 0.0279
Schistosoma mansoni thymidylate kinase 0.0152 0.0741 0.0762
Trichomonas vaginalis ap endonuclease, putative 0.006 0.0181 0.0183
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0205 0.2319
Echinococcus multilocularis NADH ubiquinone oxidoreductase 42 kDa subunit 0.0072 0.0255 0.0236
Schistosoma mansoni hypothetical protein 0.0357 0.1986 0.2077
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0119 0.0921
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0139 0.0663 0.068
Brugia malayi hypothetical protein 0.0052 0.0136 0.1052
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0043 0.0331
Treponema pallidum thymidylate kinase (tmk) 0.0152 0.0741 1
Leishmania major hypothetical protein, conserved 0.006 0.0181 0.0183
Trypanosoma brucei hypothetical protein, conserved 0.0053 0.0139 0.0128
Brugia malayi hypothetical protein 0.0034 0.0023 0.0181
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0043 0.0024
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0046 0.0096 0.044
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0205 0.0186
Brugia malayi Intermediate filament tail domain containing protein 0.0056 0.0157 0.1218
Schistosoma mansoni thyroid hormone receptor 0.015 0.0731 0.0751
Loa Loa (eye worm) hypothetical protein 0.0104 0.0451 0.3492
Trypanosoma brucei thymidine kinase 0.1279 0.7589 1
Schistosoma mansoni survival motor neuron protein 0.0049 0.0119 0.0106
Echinococcus multilocularis glycogen phosphorylase 0.0105 0.046 0.0442
Echinococcus multilocularis inositol monophosphatase 1 0.0076 0.0283 0.0265
Giardia lamblia Deoxyguanosine kinase/deoxyadenosine kinase subunit, putative 0.0072 0.0255 0.0212
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0205 0.2319
Giardia lamblia Hypothetical protein 0.0072 0.0255 0.0212
Schistosoma mansoni ap endonuclease 0.006 0.0181 0.0171
Loa Loa (eye worm) hypothetical protein 0.0037 0.0043 0.0331
Schistosoma mansoni hypothetical protein 0.0071 0.0251 0.0245
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.0205 0.1341
Schistosoma mansoni phosphoglucomutase 0.0046 0.0096 0.0081
Schistosoma mansoni hypothetical protein 0.0152 0.0741 0.0762
Entamoeba histolytica hypothetical protein 0.0072 0.0255 0.0281
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.006 0.0181 0.0745
Entamoeba histolytica Thymidylate kinase, putative 0.0152 0.0741 0.0925
Echinococcus multilocularis thymidine kinase 0.1592 0.9494 0.9493
Echinococcus multilocularis Glycosyl transferase, family 35 0.0105 0.046 0.0442
Brugia malayi hypothetical protein 0.0037 0.0043 0.0329
Echinococcus multilocularis thymidine kinase 0.1592 0.9494 0.9493
Echinococcus granulosus survival motor neuron protein 1 0.0242 0.129 0.1342
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0076 0.0283 0.0319
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0043 0.0331
Schistosoma mansoni phosphoglucomutase 0.0046 0.0096 0.0081
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0136 0.0123
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0076 0.0283 0.3448
Trypanosoma brucei thymidylate kinase, putative 0.0152 0.0741 0.0925
Trichomonas vaginalis ribonuclease H1, putative 0.0046 0.0096 0.007
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0043 0.0025
Schistosoma mansoni lamin 0.0056 0.0157 0.0146
Echinococcus granulosus lamin 0.0056 0.0157 0.0146
Echinococcus granulosus ribonuclease H1 0.0046 0.0096 0.0081
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0136 0.1334
Trichomonas vaginalis thymidine kinase, putative 0.1279 0.7589 1
Echinococcus granulosus glycogen phosphorylase 0.0105 0.046 0.0466
Leishmania major thymidine kinase, putative 0.1279 0.7589 1
Onchocerca volvulus Glycogen phosphorylase homolog 0.0105 0.046 0.5973
Entamoeba histolytica hypothetical protein 0.0072 0.0255 0.0281
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0205 0.0215
Schistosoma mansoni hypothetical protein 0.0357 0.1986 0.2077
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.006 0.0181 0.1402
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0076 0.0283 0.2911
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0255 0.0281
Echinococcus multilocularis musashi 0.0056 0.0157 0.0139
Trypanosoma cruzi thymidylate kinase, putative 0.0152 0.0741 0.0925
Onchocerca volvulus Putative thymidylate kinase 0.0152 0.0741 1
Mycobacterium leprae probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) 0.0152 0.0741 1
Entamoeba histolytica thymidine kinase, putative 0.1279 0.7589 1
Toxoplasma gondii thymidylate kinase 0.0152 0.0741 1
Echinococcus granulosus Glycosyl transferase family 35 0.0105 0.046 0.0466
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0251 0.1942
Echinococcus multilocularis geminin 0.0357 0.1986 0.1971
Echinococcus multilocularis survival motor neuron protein 1 0.0242 0.129 0.1274
Brugia malayi exodeoxyribonuclease III family protein 0.006 0.0181 0.1402
Schistosoma mansoni intermediate filament proteins 0.0056 0.0157 0.0146
Trypanosoma brucei ribonuclease H1 0.0046 0.0096 0.007
Loa Loa (eye worm) hypothetical protein 0.0037 0.0043 0.0331
Trypanosoma cruzi thymidylate kinase, putative 0.0152 0.0741 0.0925
Entamoeba histolytica glycogen phosphorylase, putative 0.0046 0.0096 0.0071
Echinococcus granulosus glycogen phosphorylase 0.0105 0.046 0.0466
Brugia malayi beta-lactamase 0.0037 0.0043 0.0331
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0283 0.0319
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0019 0.0144
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0136 0.0123
Entamoeba histolytica hypothetical protein 0.0072 0.0255 0.0281
Leishmania major hypothetical protein, conserved 0.0052 0.0136 0.0123
Onchocerca volvulus 0.0056 0.0157 0.164
Giardia lamblia Thymidine kinase 0.1279 0.7589 1
Schistosoma mansoni glycogen phosphorylase 0.0105 0.046 0.0466
Brugia malayi intermediate filament protein 0.0056 0.0157 0.1218
Trichomonas vaginalis ap endonuclease, putative 0.006 0.0181 0.0183
Entamoeba histolytica exodeoxyribonuclease III, putative 0.006 0.0181 0.0183
Onchocerca volvulus 0.0056 0.0157 0.164
Echinococcus multilocularis ribonuclease H1 0.0046 0.0096 0.0077
Echinococcus granulosus Thymidine kinase 2 mitochondrial 0.1592 0.9494 1
Schistosoma mansoni lamin 0.0056 0.0157 0.0146
Trichomonas vaginalis glycogen phosphorylase, putative 0.0105 0.046 0.0553
Brugia malayi hypothetical protein 0.0242 0.129 1
Echinococcus granulosus lamin dm0 0.0056 0.0157 0.0146
Echinococcus multilocularis lamin 0.0056 0.0157 0.0139
Leishmania major thymidylate kinase-like protein 0.0152 0.0741 0.0925
Schistosoma mansoni inositol monophosphatase 0.0076 0.0283 0.0279
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.006 0.0181 0.0183
Schistosoma mansoni hypothetical protein 0.0049 0.0119 0.0106
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0114 0.0882
Trichomonas vaginalis glycogen phosphorylase, putative 0.0105 0.046 0.0553
Schistosoma mansoni glycogen phosphorylase 0.0105 0.046 0.0466
Trichomonas vaginalis inositol monophosphatase, putative 0.0076 0.0283 0.0319
Loa Loa (eye worm) hypothetical protein 0.0033 0.0019 0.0144
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0205 0.2319
Treponema pallidum exodeoxyribonuclease (exoA) 0.006 0.0181 0.1322
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0114 0.01
Trypanosoma brucei ingi protein (ORF1) 0.0053 0.0139 0.0128
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0019 0.0144
Schistosoma mansoni hypothetical protein 0.011 0.0487 0.0495
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0057 0.0162 0.0144
Entamoeba histolytica hypothetical protein 0.0072 0.0255 0.0281
Echinococcus multilocularis thyroid hormone receptor alpha 0.015 0.0731 0.0713
Echinococcus granulosus intermediate filament protein 0.0056 0.0157 0.0146
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0053 0.0139 0.0128
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0056 0.0157 0.1218
Brugia malayi thymidylate kinase 0.0152 0.0741 0.5742
Loa Loa (eye worm) hypothetical protein 0.0037 0.0043 0.0331
Entamoeba histolytica hypothetical protein 0.0072 0.0255 0.0281
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.0451 0.3492

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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