Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0025 | 0 | 0.5 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0148 | 0.3765 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0148 | 0.3765 | 0.8509 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0278 | 0.0739 |
Loa Loa (eye worm) | carboxylesterase | 0.0148 | 0.3765 | 1 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.3765 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.0761 | 0.2022 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0761 | 0.2022 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0025 | 0 | 0.5 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.0148 | 0.3765 | 0.8509 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0278 | 0.0739 |
Echinococcus multilocularis | acetylcholinesterase | 0.0148 | 0.3765 | 0.8509 |
Schistosoma mansoni | hypothetical protein | 0.017 | 0.4424 | 0.4424 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0025 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0025 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0278 | 0.0278 |
Schistosoma mansoni | hypothetical protein | 0.017 | 0.4424 | 0.4424 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0025 | 0 | 0.5 |
Echinococcus multilocularis | geminin | 0.017 | 0.4424 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.3765 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0148 | 0.3765 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.0761 | 0.2022 |
Echinococcus granulosus | geminin | 0.017 | 0.4424 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0148 | 0.3765 | 0.3765 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.0761 | 0.2022 |
Echinococcus granulosus | acetylcholinesterase | 0.0148 | 0.3765 | 0.8509 |
Echinococcus multilocularis | acetylcholinesterase | 0.0148 | 0.3765 | 0.8509 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0148 | 0.3765 | 0.8509 |
Brugia malayi | Carboxylesterase family protein | 0.0148 | 0.3765 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0025 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.