Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Pneumocystis carinii | Dihydrofolate reductase | Starlite/ChEMBL | References |
Cryptosporidium parvum | dihydrofolate reductase-thymidylate synthase | Starlite/ChEMBL | References |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Starlite/ChEMBL | References |
Rattus norvegicus | Dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0524 | 1 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0524 | 1 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0524 | 1 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.0521 | 0.9883 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0524 | 1 | 0.5 |
Brugia malayi | dihydrofolate reductase family protein | 0.0521 | 0.9883 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0521 | 0.9883 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0521 | 0.9883 | 0.5 |
Onchocerca volvulus | 0.026 | 0 | 0.5 | |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0521 | 0.9883 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0521 | 0.9883 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0521 | 0.9883 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0521 | 0.9883 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0524 | 1 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0521 | 0.9883 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0521 | 0.9883 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC20 (functional) | = 3.44 uM | Cytotoxicity data HepG2 CC20 (uM) | ChEMBL. | No reference |
IC50 (binding) | = 6.5 nM | Inhibition of Cryptosporidium hominis DHFR | ChEMBL. | 16750361 |
IC50 (binding) | = 6.5 nM | Inhibition of Cryptosporidium hominis DHFR | ChEMBL. | 16750361 |
IC50 (functional) | = 0 uM | Antimicrobial activity against Cryptosporidium parvum | ChEMBL. | 20185316 |
IC50 (binding) | = 0.03 uM | Concentration inhibiting T. gondii dihydrofolate reductase | ChEMBL. | 7629801 |
IC50 (binding) | = 0.03 uM | Inhibition of Dihydrofolate reductase of T. gondii | ChEMBL. | 7799402 |
IC50 (binding) | = 0.03 uM | Concentration inhibiting T. gondii dihydrofolate reductase | ChEMBL. | 7629801 |
IC50 (binding) | = 0.03 uM | Inhibition of Dihydrofolate reductase of T. gondii | ChEMBL. | 7799402 |
IC50 (binding) | = 0.044 uM | Concentration inhibiting rat liver dihydrofolate reductase . | ChEMBL. | 7629801 |
IC50 (binding) | = 0.044 uM | Inhibition of Dihydrofolate reductase (DHFR) of in rat liver | ChEMBL. | 7799402 |
IC50 (binding) | = 0.044 uM | Concentration inhibiting rat liver dihydrofolate reductase . | ChEMBL. | 7629801 |
IC50 (binding) | = 0.044 uM | Inhibition of Dihydrofolate reductase (DHFR) of in rat liver | ChEMBL. | 7799402 |
IC50 (binding) | = 0.051 uM | Concentration inhibiting P. carinii dihydrofolate reductase | ChEMBL. | 7629801 |
IC50 (binding) | = 0.051 uM | Inhibition of Dihydrofolate reductase of P. carinii | ChEMBL. | 7799402 |
IC50 (binding) | = 0.051 uM | Concentration inhibiting P. carinii dihydrofolate reductase | ChEMBL. | 7629801 |
IC50 (binding) | = 0.051 uM | Inhibition of Dihydrofolate reductase of P. carinii | ChEMBL. | 7799402 |
IC50 (functional) | = 0.1 uM | AntiCryptosporidium parvum activity Compounds added at t0, IC 50 (uM) | ChEMBL. | No reference |
IC50 (functional) | = 3.98 uM | AntiCryptosporidium parvum activity Compounds added 3h after t0, IC 50 (uM) | ChEMBL. | No reference |
Inhibition (binding) | Compound was evaluated for the inhibition of human FECH at 10uM | MMV_PBOX. | No reference | |
Ratio (binding) | = 0.86 | Relative affinity for dihydrofolate reductase of rat liver and P. carinii | ChEMBL. | 7799402 |
Ratio (binding) | = 1.5 | Relative affinity for dihydrofolate reductase of rat liver and T. gondii | ChEMBL. | 7799402 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Cryptosporidium parvum | ChEMBL23 | 20185316 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.