Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | FAD binding domain containing protein | 0.0091 | 0.3009 | 0.599 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0091 | 0.3009 | 0.5 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0105 | 0.4206 | 1 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0058 | 0.012 | 0.5 |
Brugia malayi | Hemopexin family protein | 0.0067 | 0.0937 | 0.1865 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0091 | 0.3009 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0081 | 0.2115 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0091 | 0.3009 | 0.5 |
Leishmania major | p450 reductase, putative | 0.0091 | 0.3009 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0091 | 0.3009 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0056 | 0 | 0.5 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0173 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0091 | 0.3009 | 0.5 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0058 | 0.012 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0091 | 0.3009 | 1 |
Brugia malayi | Matrixin family protein | 0.0115 | 0.5023 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0091 | 0.3009 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0091 | 0.3009 | 0.3009 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0058 | 0.012 | 0.0238 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.3009 | 0.599 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0091 | 0.3009 | 0.3009 |
Loa Loa (eye worm) | matrixin family protein | 0.0115 | 0.5023 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0105 | 0.4206 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0091 | 0.3009 | 0.3009 |
Loa Loa (eye worm) | matrixin family protein | 0.0105 | 0.4206 | 0.8373 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.012 | 0.0238 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0091 | 0.3009 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0091 | 0.3009 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0091 | 0.3009 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0091 | 0.3009 | 1 |
Brugia malayi | flavodoxin family protein | 0.0091 | 0.3009 | 0.599 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0091 | 0.3009 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0091 | 0.3009 | 0.3009 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0091 | 0.3009 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.0937 | 0.3113 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0091 | 0.3009 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0081 | 0.2115 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0091 | 0.3009 | 0.599 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 70 uM | Inhibition of arginine to citrulline conversion by Neuronal nitric oxide synthase from rat brain | ChEMBL. | 9651169 |
IC50 (binding) | = 70 uM | Inhibition of arginine to citrulline conversion by Neuronal nitric oxide synthase from rat brain | ChEMBL. | 9651169 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.