Detailed information for compound 1468953

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 314.405 | Formula: C16H18N4OS
  • H donors: 3 H acceptors: 2 LogP: 3.84 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc2c(c1)cn[nH]2)Nc1ccc(s1)C(C)(C)C
  • InChi: 1S/C16H18N4OS/c1-16(2,3)13-6-7-14(22-13)19-15(21)18-11-4-5-12-10(8-11)9-17-20-12/h4-9H,1-3H3,(H,17,20)(H2,18,19,21)
  • InChiKey: VCMFTYZQQOPGHM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ribosomal protein S6 kinase, 70kDa, polypeptide 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) AGC/RSK/P70 protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Giardia lamblia Kinase, AGC PKA Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum ko:K08792 serum/glucocorticoid regulated kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus sodium:potassium dependent atpase beta subunit Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica protein kinase 2, putative Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum ko:K04456 RAC serine/threonine-protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma mansoni serine/threonine-protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium vivax rac-beta serine/threonine protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium falciparum RAC-beta serine/threonine protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma cruzi Protein kinase B Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum ko:K07390 monothiol glutaredoxin, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Toxoplasma gondii AGC kinase Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma brucei rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma cruzi rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Candida albicans protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus calcium:calmodulin dependent protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum Sodium/potassium-transporting ATPase subunit beta-1, putative Get druggable targets OG5_126635 All targets in OG5_126635
Brugia malayi p70 ribosomal S6 kinase beta Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma mansoni serine/threonine-protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus serine threonine protein kinase nrc Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Neospora caninum Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1), related Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus Glutaredoxin protein 5 Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium berghei rac-beta serine/threonine protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Loa Loa (eye worm) AGC/AKT protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Candida albicans likely protein kinase similar to S. cerevisiae YPK2 (YMR104C) Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus serine/threonine protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma brucei gambiense rac serine-threonine kinase, putative,protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum RAC serine/threonine-protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma cruzi rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis rac serine:threonine kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma congolense rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium knowlesi RAC-beta serine/threonine protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium yoelii kinase Akt/PKB-related Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis Glutaredoxin protein 5 Get druggable targets OG5_126635 All targets in OG5_126635
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0045 0.0723 0.0908
Loa Loa (eye worm) hypothetical protein 0.0045 0.0723 0.0908
Loa Loa (eye worm) RasGEF domain-containing protein 0.0045 0.0723 0.0908
Schistosoma mansoni serine/threonine protein kinase 0.008 0.1592 0.1412
Echinococcus multilocularis lamin dm0 0.0031 0.0391 0.0391
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.008 0.1592 0.1592
Loa Loa (eye worm) AGC/NDR protein kinase 0.008 0.1592 0.2
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0765 0.0567
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0416 0.0942
Schistosoma mansoni vav2 0.0045 0.0723 0.0524
Echinococcus granulosus Diacylglycerol kinase theta 0.0045 0.0723 0.0723
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0046 0.0765 0.0765
Schistosoma mansoni protein kinase C mu 0.0046 0.0765 0.0567
Schistosoma mansoni serine/threonine-protein kinase 0.0035 0.0481 0.0277
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0113 0.2396 0.3008
Brugia malayi RNA binding protein 0.0065 0.1223 0.147
Trichomonas vaginalis AGC family protein kinase 0.008 0.1592 0.6326
Leishmania major importin beta-1 subunit, putative 0.0026 0.0268 1
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0035 0.0481 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0782 0.0584
Giardia lamblia Kinase, AGC PKA 0.0035 0.0481 1
Echinococcus granulosus protein kinase c iota type 0.0125 0.268 0.268
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0046 0.0765 0.0765
Schistosoma mansoni serine/threonine protein kinase 0.0426 1 1
Plasmodium vivax importin-beta 2, putative 0.0032 0.0416 0.759
Echinococcus multilocularis Diacylglycerol kinase theta 0.0045 0.0723 0.0723
Echinococcus granulosus geminin 0.0174 0.3882 0.3882
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.004 0.005
Trichomonas vaginalis AGC family protein kinase 0.0113 0.2396 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.021 0.0263
Entamoeba histolytica protein kinase 2, putative 0.0035 0.0481 0.1241
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0782 0.0782
Echinococcus granulosus serine:threonine protein kinase N2 0.008 0.1592 0.1592
Echinococcus multilocularis raf serine:threonine protein kinase 0.0045 0.0723 0.0723
Brugia malayi C1-like domain containing protein 0.0046 0.0765 0.0901
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0045 0.0723 0.0908
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0046 0.0765 0.0901
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0391 0.0491
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0046 0.0765 0.0961
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.021 0.021
Echinococcus multilocularis myotubularin protein 13 0.0045 0.0723 0.0723
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0035 0.0481 1
Trichomonas vaginalis AGC family protein kinase 0.0113 0.2396 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0723 0.0908
Toxoplasma gondii diacylglycerol kinase, putative 0.0045 0.0723 0.2349
Trichomonas vaginalis AGC family protein kinase 0.0113 0.2396 1
Echinococcus multilocularis nervana 2 0.0033 0.0439 0.0439
Schistosoma mansoni hypothetical protein 0.0174 0.3882 0.3751
Echinococcus multilocularis nervana 2 0.0033 0.0439 0.0439
Brugia malayi RhoGAP domain containing protein 0.0045 0.0723 0.0849
Schistosoma mansoni diacylglycerol kinase theta 0.0045 0.0723 0.0524
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0033 0.0439 0.0439
Trichomonas vaginalis AGC family protein kinase 0.0113 0.2396 1
Brugia malayi protein kinase C3,putative 0.0046 0.0765 0.0901
Schistosoma mansoni unc-13 (munc13) 0.0054 0.0949 0.0755
Schistosoma mansoni unc-13 (munc13) 0.0054 0.0949 0.0755
Entamoeba histolytica hypothetical protein 0.0045 0.0723 0.2349
Echinococcus multilocularis RNA directed DNA polymerase 0.0292 0.673 0.673
Schistosoma mansoni diacylglycerol kinase theta 0.0045 0.0723 0.0524
Echinococcus granulosus nervana 2 0.0033 0.0439 0.0439
Loa Loa (eye worm) hypothetical protein 0.0045 0.0723 0.0908
Echinococcus granulosus nervana 2 0.0033 0.0439 0.0439
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0268 0.0267
Brugia malayi Protein kinase c protein 2 0.0347 0.8085 1
Echinococcus multilocularis serine:threonine protein kinase N2 0.008 0.1592 0.1592
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1223 0.1035
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0416 0.0942
Schistosoma mansoni serine/threonine protein kinase 0.008 0.1592 0.1412
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0391 0.0436
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.008 0.1592 0.2
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0268 0.2153
Schistosoma mansoni serine/threonine protein kinase 0.0134 0.2906 0.2754
Brugia malayi diacylglycerol kinase 0.0045 0.0723 0.0849
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0134 0.2906 0.3649
Brugia malayi Importin beta-1 subunit 0.0032 0.0416 0.0467
Schistosoma mansoni serine/threonine protein kinase 0.008 0.1592 0.1412
Echinococcus granulosus Glutaredoxin protein 5 0.0033 0.0439 0.0439
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0782 0.0584
Brugia malayi RhoGAP domain containing protein 0.0045 0.0723 0.0849
Loa Loa (eye worm) hypothetical protein 0.0336 0.7817 0.9818
Schistosoma mansoni atypical protein kinase C 0.0125 0.268 0.2523
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.008 0.1592 0.1592
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0782 0.0584
Loa Loa (eye worm) hypothetical protein 0.0054 0.0949 0.1192
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0045 0.0723 0.0723
Loa Loa (eye worm) AGC/PKN protein kinase 0.008 0.1592 0.2
Brugia malayi Variant SH3 domain containing protein 0.0045 0.0723 0.0849
Echinococcus multilocularis rac serine:threonine kinase 0.0035 0.0481 0.0481
Schistosoma mansoni serine/threonine protein kinase 0.0426 1 1
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0035 0.0481 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0723 0.0908
Brugia malayi Protein kinase domain containing protein 0.008 0.1592 0.1929
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0033 0.0439 0.0439
Trypanosoma brucei rac serine-threonine kinase, putative 0.0113 0.2396 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0035 0.0481 0.1241
Brugia malayi Ras association domain family 1 isoform A 0.0045 0.0723 0.0849
Schistosoma mansoni serine/threonine-protein kinase 0.0035 0.0481 0.0277
Entamoeba histolytica diacylglycerol kinase, putative 0.0045 0.0723 0.2349
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0292 0.673 0.673
Entamoeba histolytica protein kinase, putative 0.008 0.1592 0.6326
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0045 0.0723 0.0723
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.1223 0.147
Loa Loa (eye worm) hypothetical protein 0.008 0.1592 0.2
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1223 0.1035
Trichomonas vaginalis AGC family protein kinase 0.0113 0.2396 1
Echinococcus multilocularis N chimaerin 0.0045 0.0723 0.0723
Onchocerca volvulus 0.0045 0.0723 0.5953
Schistosoma mansoni protein kinase C mu 0.0045 0.0723 0.0524
Loa Loa (eye worm) hypothetical protein 0.0045 0.0723 0.0908
Entamoeba histolytica protein kinase, putative 0.0113 0.2396 1
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0303 0.6998 0.8789
Schistosoma mansoni hypothetical protein 0.0045 0.0723 0.0524
Loa Loa (eye worm) raf kinase 0.0045 0.0723 0.0908
Toxoplasma gondii AGC kinase 0.0113 0.2396 1
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0416 0.0416
Schistosoma mansoni hypothetical protein 0.0174 0.3882 0.3751
Echinococcus multilocularis serine threonine protein kinase 0.0381 0.8913 0.8913
Entamoeba histolytica protein kinase, putative 0.0113 0.2396 1
Schistosoma mansoni importin beta-1 0.0032 0.0416 0.021
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0046 0.0765 0.0961
Loa Loa (eye worm) hypothetical protein 0.003 0.0377 0.0473
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1223 0.1035
Schistosoma mansoni intermediate filament proteins 0.0031 0.0391 0.0185
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0035 0.0481 0.0481
Echinococcus multilocularis Glutaredoxin protein 5 0.0033 0.0439 0.0439
Loa Loa (eye worm) hypothetical protein 0.0045 0.0723 0.0908
Schistosoma mansoni hypothetical protein 0.0342 0.7962 0.7919
Schistosoma mansoni protein kinase C 0.0054 0.0949 0.0755
Loa Loa (eye worm) AGC/AKT protein kinase 0.0113 0.2396 0.3008
Loa Loa (eye worm) hypothetical protein 0.0045 0.0723 0.0908
Brugia malayi RhoGEF domain containing protein 0.0045 0.0723 0.0849
Echinococcus granulosus protein kinase c eta type 0.0045 0.0723 0.0723
Echinococcus granulosus importin subunit beta 1 0.0032 0.0416 0.0416
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.008 0.1592 0.2
Brugia malayi RNA, U transporter 1 0.0091 0.1854 0.2254
Echinococcus granulosus protein kinase C gamma type 0.0381 0.8913 0.8913
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0342 0.7962 1
Schistosoma mansoni lamin 0.0031 0.0391 0.0185
Loa Loa (eye worm) TAR-binding protein 0.0065 0.1223 0.1536
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0079 0.155 0.6132
Brugia malayi TAR-binding protein 0.0065 0.1223 0.147
Onchocerca volvulus 0.0054 0.0949 1
Brugia malayi p70 ribosomal S6 kinase beta 0.0113 0.2396 0.2928
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0268 0.0267
Brugia malayi Hr1 repeat family protein 0.008 0.1592 0.1929
Echinococcus multilocularis unc 13 (munc13) 0.0054 0.0949 0.0949
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.008 0.1592 0.1592
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.021 0.0211
Brugia malayi Protein kinase domain containing protein 0.0113 0.2396 0.2928
Echinococcus granulosus N chimaerin 0.0045 0.0723 0.0723
Loa Loa (eye worm) RNA binding protein 0.0065 0.1223 0.1536
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0782 0.0982
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.008 0.1592 0.2
Loa Loa (eye worm) hypothetical protein 0.0032 0.0416 0.0522
Trypanosoma cruzi Protein kinase B 0.0035 0.0481 1
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.008 0.1592 0.1592
Trichomonas vaginalis AGC family protein kinase 0.0113 0.2396 1
Onchocerca volvulus 0.0045 0.0723 0.5953
Loa Loa (eye worm) hypothetical protein 0.0045 0.0723 0.0908
Echinococcus granulosus tar DNA binding protein 0.0065 0.1223 0.1223
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0054 0.0949 0.0949
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0268 0.0267
Entamoeba histolytica protein kinase, putative 0.0113 0.2396 1
Brugia malayi Protein kinase domain containing protein 0.0046 0.0765 0.0901
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0723 0.0524
Schistosoma mansoni serine/threonine kinase 0.008 0.1592 0.1412
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0035 0.0481 0.0481
Echinococcus multilocularis tar DNA binding protein 0.0065 0.1223 0.1223
Echinococcus multilocularis protein kinase c eta type 0.0045 0.0723 0.0723
Echinococcus granulosus serine threonine protein kinase nrc 0.0035 0.0481 0.0481
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0782 0.0922
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0391 0.0491
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0045 0.0723 0.0908
Brugia malayi Pleckstrin Homology Domain 0.0045 0.0723 0.0849
Loa Loa (eye worm) hypothetical protein 0.0031 0.0391 0.0491
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0782 0.0782
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.1223 0.1536
Echinococcus multilocularis geminin 0.0174 0.3882 0.3882
Entamoeba histolytica diacylglycerol kinase, putative 0.0045 0.0723 0.2349
Echinococcus granulosus intermediate filament protein 0.0031 0.0391 0.0391
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0054 0.0949 0.0949
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1223 0.1035
Echinococcus granulosus NDR protein kinase 0.008 0.1592 0.1592
Schistosoma mansoni rac gtpase activating protein 0.0045 0.0723 0.0524
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.008 0.1592 0.1592
Plasmodium falciparum importin beta, putative 0.0032 0.0416 0.759
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0045 0.0723 0.0908
Entamoeba histolytica PH domain containing protein kinase, putative 0.0035 0.0481 0.1241
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0782 0.0782
Echinococcus granulosus RNA directed DNA polymerase 0.0292 0.673 0.673
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0035 0.0481 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0723 0.0908
Echinococcus multilocularis serine:threonine protein kinase 38 0.008 0.1592 0.1592
Entamoeba histolytica hypothetical protein 0.0026 0.0268 0.0267
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0426 1 1
Echinococcus multilocularis lamin 0.0031 0.0391 0.0391
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0045 0.0723 0.0524
Echinococcus granulosus unc 13 munc13 0.0054 0.0949 0.0949
Brugia malayi intermediate filament protein 0.0031 0.0391 0.0436
Trichomonas vaginalis AGC family protein kinase 0.008 0.1592 0.6326
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0045 0.0723 0.0524
Schistosoma mansoni serine/threonine protein kinase 0.008 0.1592 0.1412
Echinococcus multilocularis snurportin 1 0.0342 0.7962 0.7962
Brugia malayi protein kinase C II. 0.0134 0.2906 0.3562
Brugia malayi Protein kinase domain containing protein 0.008 0.1592 0.1929
Trichomonas vaginalis AGC family protein kinase 0.0113 0.2396 1
Echinococcus granulosus lamin dm0 0.0031 0.0391 0.0391
Trichomonas vaginalis AGC family protein kinase 0.008 0.1592 0.6326
Echinococcus granulosus serine/threonine protein kinase 0.0035 0.0481 0.0481
Echinococcus granulosus snurportin 1 0.0342 0.7962 0.7962
Echinococcus multilocularis serine:threonine protein kinase N2 0.008 0.1592 0.1592
Echinococcus granulosus myotubularin protein 13 0.0045 0.0723 0.0723
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1223 0.1035
Echinococcus multilocularis protein kinase c epsilon type 0.0134 0.2906 0.2906
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0782 0.0782
Echinococcus multilocularis Rac GTPase activating protein 1 0.0045 0.0723 0.0723
Loa Loa (eye worm) hypothetical protein 0.0292 0.673 0.8452
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0416 0.0942
Brugia malayi diacylglycerol kinase 0.0045 0.0723 0.0849
Schistosoma mansoni lamin 0.0031 0.0391 0.0185
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.021 0.021
Trichomonas vaginalis AGC family protein kinase 0.008 0.1592 0.6326
Echinococcus granulosus Rac GTPase activating protein 1 0.0045 0.0723 0.0723
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0765 0.0567
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.008 0.1592 0.1592
Echinococcus granulosus lamin 0.0031 0.0391 0.0391
Echinococcus multilocularis musashi 0.0031 0.0391 0.0391
Echinococcus granulosus raf serine:threonine protein kinase 0.0045 0.0723 0.0723
Echinococcus multilocularis protein kinase c iota type 0.0125 0.268 0.268
Echinococcus granulosus protein kinase c epsilon type 0.0134 0.2906 0.2906

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 19 uM Inhibition of S6K1 ChEMBL. 21185721
Inhibition (binding) = 0 % Displacement of labeled dofetilide from human ERG ChEMBL. 21185721
Inhibition (ADMET) = 4 % Inhibition of CYP3A4 at 3 uM by LC/MS/MS analysis ChEMBL. 21185721
Inhibition (ADMET) = 20 % Inhibition of CYP2D6 at 3 uM by LC/MS/MS analysis ChEMBL. 21185721
Inhibition (ADMET) = 36 % Inhibition of CYP1A2 at 3 uM by LC/MS/MS analysis ChEMBL. 21185721
Inhibition (ADMET) = 52 % Inhibition of CYP2C9 at 3 uM by LC/MS/MS analysis ChEMBL. 21185721

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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