Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Nitric-oxide synthase, endothelial | Starlite/ChEMBL | References |
Mus musculus | nitric oxide synthase 2, inducible | Starlite/ChEMBL | References |
Rattus norvegicus | Nitric-oxide synthase, brain | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0091 | 0.3009 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0091 | 0.3009 | 0.3009 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.012 | 0.0238 |
Leishmania major | p450 reductase, putative | 0.0091 | 0.3009 | 1 |
Giardia lamblia | Hypothetical protein | 0.0081 | 0.2115 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0081 | 0.2115 | 0.5 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0173 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0091 | 0.3009 | 0.599 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0091 | 0.3009 | 0.5 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0058 | 0.012 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0091 | 0.3009 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0091 | 0.3009 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0091 | 0.3009 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0091 | 0.3009 | 0.5 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0058 | 0.012 | 0.0238 |
Brugia malayi | FAD binding domain containing protein | 0.0091 | 0.3009 | 0.599 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0091 | 0.3009 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0091 | 0.3009 | 0.5 |
Brugia malayi | flavodoxin family protein | 0.0091 | 0.3009 | 0.599 |
Brugia malayi | Matrixin family protein | 0.0115 | 0.5023 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0091 | 0.3009 | 0.3009 |
Brugia malayi | Hemopexin family protein | 0.0067 | 0.0937 | 0.1865 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0091 | 0.3009 | 0.3009 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.3009 | 0.599 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.0937 | 0.3113 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0091 | 0.3009 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0091 | 0.3009 | 0.3009 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0091 | 0.3009 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0091 | 0.3009 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0105 | 0.4206 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0091 | 0.3009 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0091 | 0.3009 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.0056 | 0 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0105 | 0.4206 | 0.8373 |
Loa Loa (eye worm) | matrixin family protein | 0.0115 | 0.5023 | 1 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0105 | 0.4206 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0091 | 0.3009 | 1 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0058 | 0.012 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Emax (functional) | = 41 % | Percent reversal of ACh-induced relaxation at 100 uM in rat thoracic aorta | ChEMBL. | 9651169 |
IC50 (binding) | = 2.5 uM | Inhibition of arginine to citrulline conversion by Neuronal nitric oxide synthase from rat brain | ChEMBL. | 9651169 |
IC50 (binding) | = 2.5 uM | Inhibition of arginine to citrulline conversion by Neuronal nitric oxide synthase from rat brain | ChEMBL. | 9651169 |
IC50 (binding) | = 5 uM | Inhibitory activity of conversion of radiolabeled arginine to citrulline by isomeric form of nitric oxide synthase Endothelial nitric oxide synthase from cultured bovine aortic endothelial cells | ChEMBL. | 9651169 |
IC50 (binding) | = 5 uM | Inhibitory activity of conversion of radiolabeled arginine to citrulline by isomeric form of nitric oxide synthase Endothelial nitric oxide synthase from cultured bovine aortic endothelial cells | ChEMBL. | 9651169 |
IC50 (binding) | = 11 uM | Inhibition of radiolabeled arginine conversion to citrulline by isomeric form of Inducible nitric oxide synthase from mouse RAW 264.7 cells | ChEMBL. | 9651169 |
IC50 (binding) | = 11 uM | Inhibition of radiolabeled arginine conversion to citrulline by isomeric form of Inducible nitric oxide synthase from mouse RAW 264.7 cells | ChEMBL. | 9651169 |
IC50 (functional) | = 33 uM | Inhibitory activity against N-methyl-D-aspartate (NMDA)-induced cyclic GMP accumulation in rat cerebellar slices | ChEMBL. | 9651169 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.