Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0061 | 0.0267 | 0.0898 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0116 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.0116 | 0.0364 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0132 | 0.095 |
Loa Loa (eye worm) | hypothetical protein | 0.0241 | 0.1386 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0039 | 0.0131 | 0.0636 |
Brugia malayi | Bromodomain containing protein | 0.0077 | 0.0365 | 0.2378 |
Brugia malayi | hypothetical protein | 0.0037 | 0.0116 | 0.0519 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0021 | 0.0019 | 0.0136 |
Onchocerca volvulus | 0.0049 | 0.0193 | 0.5 | |
Echinococcus multilocularis | neuropeptide s receptor | 0.0476 | 0.2853 | 0.2844 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.0116 | 0.3722 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0338 | 0.2435 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0116 | 0.5 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0049 | 0.0193 | 0.1098 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0037 | 0.0116 | 0.0366 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0159 | 0.1146 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0476 | 0.2853 | 0.2844 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0019 | 0.0242 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0037 | 0.0116 | 0.0104 |
Mycobacterium ulcerans | pantoate--beta-alanine ligase | 0.0679 | 0.4114 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.0116 | 0.0104 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0116 | 0.3722 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0147 | 0.1059 |
Toxoplasma gondii | pantoate-beta-alanine ligase | 0.0679 | 0.4114 | 0.5 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0023 | 0.0031 | 0.0019 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0476 | 0.2853 | 1 |
Mycobacterium tuberculosis | Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) | 0.0679 | 0.4114 | 0.5 |
Mycobacterium leprae | Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) | 0.0679 | 0.4114 | 0.5 |
Schistosoma mansoni | survival motor neuron protein | 0.0049 | 0.0193 | 0.6515 |
Echinococcus granulosus | neuropeptide s receptor | 0.0476 | 0.2853 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0193 | 0.6515 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0061 | 0.0267 | 0.0256 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0241 | 0.1386 | 0.4837 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0023 | 0.0031 | 0.0066 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0116 | 0.5 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0241 | 0.1386 | 0.1376 |
Schistosoma mansoni | bromodomain containing protein | 0.0065 | 0.029 | 1 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0023 | 0.0031 | 0.0679 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0116 | 0.5 |
Brugia malayi | hypothetical protein | 0.0241 | 0.1386 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.