Detailed information for compound 1469153

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 447.239 | Formula: C18H15Cl2F3N4O2
  • H donors: 2 H acceptors: 2 LogP: 4.29 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCCCn1c(C(=O)c2cc(Cl)c(c(c2)Cl)N)c2c([n+]1[O-])cc(cc2)C(F)(F)F
  • InChi: 1S/C18H15Cl2F3N4O2/c19-12-6-9(7-13(20)15(12)25)17(28)16-11-3-2-10(18(21,22)23)8-14(11)27(29)26(16)5-1-4-24/h2-3,6-8H,1,4-5,24-25H2
  • InChiKey: BSPSIIPKTHOXAR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0119 0.0419
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0968 0.6224
Loa Loa (eye worm) glutaminase 2 0.0311 0.1516 0.1516
Brugia malayi nuclear hormone receptor 0.0023 0.0033 0.0033
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0033 0.0031
Brugia malayi jmjC domain containing protein 0.0109 0.0474 0.0474
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0136 0.0613 0.0652
Plasmodium falciparum basic transcription factor 3b, putative 0.004 0.0119 0.0439
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0018
Echinococcus multilocularis GPCR, family 2 0.0035 0.0093 0.0098
Mycobacterium ulcerans hypothetical protein 0.0033 0.0083 0.0099
Onchocerca volvulus Alhambra homolog 0.0033 0.0085 0.0056
Echinococcus multilocularis microtubule associated protein 2 0.0736 0.3706 0.3966
Trichomonas vaginalis glutaminase, putative 0.0311 0.1516 0.9972
Echinococcus granulosus histone lysine methyltransferase setb 0.0055 0.0196 0.0208
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0055 0.0196 0.0206
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.0033 0.0033
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0109 0.0478 0.0509
Loa Loa (eye worm) hypothetical protein 0.0023 0.0033 0.0033
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0785 0.3959 0.4236
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.0033 0.0033
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0046 0.0152 0.0152
Schistosoma mansoni hypothetical protein 0.0033 0.0085 0.0087
Echinococcus multilocularis solute carrier family 5 0.0046 0.0153 0.0162
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.0033 0.0033
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0232 0.0244
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0046 0.0152 0.0576
Mycobacterium ulcerans hypothetical protein 0.0033 0.0082 0.0097
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0042 0.0131 0.0291
Brugia malayi maoC like domain containing protein 0.0083 0.0343 0.0343
Brugia malayi steroid hormone receptor 0.0023 0.0033 0.0033
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0075 0.0303 0.0322
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.0033 0.0033
Toxoplasma gondii NAC domain-containing protein 0.004 0.0119 0.0439
Brugia malayi Bromodomain containing protein 0.0093 0.0393 0.0393
Loa Loa (eye worm) RNA binding protein 0.0062 0.0232 0.0232
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0096 0.0099
Loa Loa (eye worm) X11 protein 0.0078 0.0317 0.0317
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0109 0.0478 0.0507
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.0033 0.0033
Mycobacterium ulcerans hypothetical protein 0.0033 0.0083 0.0099
Brugia malayi Calcitonin receptor-like protein seb-1 0.011 0.048 0.048
Loa Loa (eye worm) PHD-finger family protein 0.0033 0.0085 0.0085
Echinococcus granulosus cpg binding protein 0.0069 0.027 0.0287
Brugia malayi Pre-SET motif family protein 0.0238 0.1141 0.1141
Echinococcus multilocularis jumonji domain containing protein 0.0046 0.0152 0.0161
Trypanosoma cruzi hypothetical protein, conserved 0.0242 0.1161 1
Brugia malayi nuclear receptor NHR-88 0.0023 0.0033 0.0033
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0007 0.0006
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.0033 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0119 0.0419
Echinococcus granulosus L aminoadipate semialdehyde 0.1831 0.9344 1
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.1025 0.6612
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0109 0.0478 0.0509
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0046 0.0153 0.057
Brugia malayi jmjC domain containing protein 0.0046 0.0151 0.0151
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0046 0.0152 0.0158
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0232 0.0244
Mycobacterium ulcerans glutaminase 0.0311 0.1516 0.5815
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0968 0.6224
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0033 0.0033
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0515 0.2566 1
Schistosoma mansoni hypothetical protein 0.0023 0.0035 0.0033
Loa Loa (eye worm) oxidoreductase 0.0036 0.0099 0.0099
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.0033 0.0033
Loa Loa (eye worm) pigment dispersing factor receptor c 0.011 0.048 0.048
Mycobacterium tuberculosis Conserved protein 0.0028 0.0058 0.0199
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0033 0.0033
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0022 0.0021
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0007 0.0011
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0515 0.2566 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.0033 0.0033
Trypanosoma cruzi transcription factor btf3, putative 0.004 0.0119 0.0996
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0007 0.0025
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0093 0.0098
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0055 0.0196 0.0206
Mycobacterium ulcerans hypothetical protein 0.0033 0.0083 0.0099
Trypanosoma brucei transcription factor BTF3, putative 0.004 0.0119 0.045
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0023 0.0033 0.0033
Loa Loa (eye worm) bromodomain containing protein 0.0024 0.0038 0.0038
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0042 0.0131 0.0291
Mycobacterium ulcerans dehydratase 0.0083 0.0343 0.1135
Mycobacterium leprae conserved hypothetical protein 0.0515 0.2566 1
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0075 0.0299 0.114
Schistosoma mansoni zinc finger protein 0.003 0.0068 0.0068
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0046 0.0152 0.0152
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0515 0.2566 1
Echinococcus granulosus tar DNA binding protein 0.0062 0.0232 0.0246
Loa Loa (eye worm) acetyltransferase 0.0162 0.075 0.075
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.0033 0.0033
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1521 1
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0028 0.0058 0.021
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0028 0.0058 0.0466
Brugia malayi ecdysteroid receptor 0.0023 0.0033 0.0033
Brugia malayi acetyltransferase, GNAT family protein 0.0162 0.075 0.075
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0109 0.0478 0.0509
Toxoplasma gondii transporter, cation channel family protein 0.0023 0.0032 0.0099
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0083 0.0087
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0109 0.0478 0.0478
Echinococcus multilocularis lysine specific demethylase 5A 0.004 0.0121 0.0128
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0033 0.0033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.0033 0.0033
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0028 0.0058 0.0466
Loa Loa (eye worm) hypothetical protein 0.0023 0.0033 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0119 0.0419
Loa Loa (eye worm) histone methyltransferase 0.0021 0.0022 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0075 0.0301 0.0301
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0232 0.0232
Schistosoma mansoni jumonji/arid domain-containing protein 0.0046 0.0151 0.0157
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0232 0.0244
Brugia malayi Pre-SET motif family protein 0.0035 0.0096 0.0096
Schistosoma mansoni cpg binding protein 0.0063 0.024 0.0253
Loa Loa (eye worm) hypothetical protein 0.0023 0.0033 0.0033
Onchocerca volvulus Glucosylceramidase homolog 0.0205 0.0968 0.1005
Giardia lamblia Histone acetyltransferase GCN5 0.0043 0.0136 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.005 0.017 0.0637
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1521 1
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0046 0.0153 0.0162
Echinococcus granulosus transcription factor btf3 0.004 0.0119 0.0126
Echinococcus multilocularis thyroid hormone receptor alpha 0.0023 0.0033 0.0033
Brugia malayi sterol carrier protein 0.0033 0.0082 0.0082
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.0033 0.0031
Schistosoma mansoni hypothetical protein 0.0075 0.0301 0.0318
Brugia malayi photoreceptor-specific nuclear receptor 0.0292 0.1416 0.1416
Echinococcus multilocularis transcription factor btf3 0.004 0.0119 0.0126
Echinococcus multilocularis amyloid beta A4 protein 0.0078 0.0317 0.0337
Toxoplasma gondii hypothetical protein 0.002 0.0018 0.0043
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0033 0.0031
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0033 0.0033
Brugia malayi abnormal cell lineage protein 10 (Protein lin-10), putative 0.007 0.0274 0.0274
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1521 1
Leishmania major basic transcription factor 3a, putative 0.004 0.0119 0.045
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.0033 0.0033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.0033 0.0033
Schistosoma mansoni inositol transporter 0.0046 0.0153 0.0159
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0515 0.2566 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.0033 0.0033
Echinococcus granulosus peregrin 0.004 0.0119 0.0126
Mycobacterium tuberculosis Probable 3-hydroxyacyl-thioester dehydratase HtdY 0.0083 0.0343 0.1312
Echinococcus granulosus voltage dependent calcium channel 0.0023 0.0032 0.0033
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0028 0.0058 0.0199
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0055 0.0196 0.0196
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0041 0.0125 0.0132
Trypanosoma brucei hypothetical protein, conserved 0.0242 0.1161 0.4516
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0007 0.0025
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0109 0.0478 0.0509
Loa Loa (eye worm) hypothetical protein 0.0035 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0023 0.0033 0.0033
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0033 0.0033
Echinococcus granulosus GPCR family 2 0.0035 0.0093 0.0098
Brugia malayi F/Y-rich N-terminus family protein 0.0034 0.0087 0.0087
Brugia malayi SCP-2 sterol transfer family protein 0.0033 0.0082 0.0082
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0046 0.0152 0.016
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0046 0.0152 0.0565
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0046 0.0152 0.1276
Loa Loa (eye worm) hypothetical protein 0.0023 0.0032 0.0032
Brugia malayi GH02984p 0.042 0.2076 0.2076
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0046 0.0152 0.0565
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0515 0.2566 0.5
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.1831 0.9344 0.9344
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0515 0.2566 1
Brugia malayi glutaminase DH11.1 0.0311 0.1516 0.1516
Schistosoma mansoni jumonji/arid domain-containing protein 0.0046 0.0151 0.0157
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.005 0.017 0.0766
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0014 0.0011
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0041 0.0125 0.0132
Echinococcus granulosus citrate lyase subunit beta protein 0.0028 0.0058 0.006
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0033 0.0033
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.1025 0.6612
Loa Loa (eye worm) SCP-2 sterol transfer family protein 0.0033 0.0082 0.0082
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0232 0.0232
Loa Loa (eye worm) jmjC domain-containing protein 0.0068 0.0267 0.0267
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0312 0.1521 0.1521
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0007 0.0011
Entamoeba histolytica hypothetical protein 0.0515 0.2566 1
Echinococcus granulosus jumonji domain containing protein 0.0046 0.0152 0.0161
Mycobacterium ulcerans hypothetical protein 0.0033 0.0083 0.0099
Mycobacterium tuberculosis (3R)-hydroxyacyl-ACP dehydratase subunit HadC 0.0033 0.0083 0.0296
Mycobacterium tuberculosis Probable dehydrogenase. Possible 2-enoyl acyl-CoA hydratase. 0.0083 0.0343 0.1312
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0033 0.0031
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0238 0.1141 0.1141
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0162 0.075 0.0799
Plasmodium vivax histone acetyltransferase GCN5, putative 0.005 0.017 0.0637
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0065 0.0065
Schistosoma mansoni hypothetical protein 0.0035 0.0093 0.0096
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0093 0.0098
Loa Loa (eye worm) calcium channel 0.0109 0.0478 0.0478
Loa Loa (eye worm) glutaminase 0.0311 0.1516 0.1516
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.0033 0.0033
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0968 0.6224
Loa Loa (eye worm) hypothetical protein 0.0109 0.0478 0.0478
Loa Loa (eye worm) hypothetical protein 0.0033 0.0085 0.0085
Echinococcus multilocularis peregrin 0.004 0.0119 0.0126
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0033 0.0033
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.0033 0.0033
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0109 0.0474 0.0505
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0042 0.0131 0.0131
Echinococcus multilocularis L aminoadipate semialdehyde 0.1831 0.9344 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0007 0.0006
Schistosoma mansoni cpg binding protein 0.0069 0.027 0.0285
Schistosoma mansoni high-affinity choline transporter 0.042 0.2076 0.2219
Echinococcus granulosus FTZ F1 alpha 0.0023 0.0033 0.0033
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.0033 0.0031
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.0033 0.0033
Onchocerca volvulus 0.0271 0.131 0.1371
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0085 0.0306
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0093 0.0093
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0046 0.0153 0.0162
Toxoplasma gondii histone lysine methyltransferase SET1 0.0128 0.0573 0.221
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0022 0.0021
Brugia malayi RNA binding protein 0.0062 0.0232 0.0232
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0093 0.0093
Brugia malayi Bromodomain containing protein 0.0047 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0018
Mycobacterium tuberculosis Conserved protein 0.0033 0.0083 0.0296
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0046 0.0152 0.064
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0023 0.0033 0.0033
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0968 0.6224
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.0033 0.0033
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0232 0.0232
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0096 0.0101
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1521 1
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1521 1
Brugia malayi beta-NAC-like protein 0.004 0.0119 0.0119
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0109 0.0474 0.0505
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.0065 0.0068
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0033 0.0033
Schistosoma mansoni jumonji domain containing protein 0.0086 0.0359 0.038
Echinococcus granulosus voltage dependent calcium channel 0.0109 0.0478 0.0509
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0055 0.0196 0.0208
Brugia malayi Sodium:solute symporter family protein 0.0046 0.0153 0.0153
Schistosoma mansoni hypothetical protein 0.0035 0.0093 0.0096
Leishmania major hypothetical protein, conserved 0.0242 0.1161 0.4516
Mycobacterium tuberculosis Conserved hypothetical protein 0.0033 0.0083 0.0296
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0014 0.0013
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0515 0.2566 1
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.1831 0.9344 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0139 0.0139
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.0033 0.0031
Trichomonas vaginalis bromodomain-containing protein, putative 0.005 0.017 0.0766
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0033 0.0085 0.0087
Loa Loa (eye worm) hypothetical protein 0.0292 0.1416 0.1416
Loa Loa (eye worm) hypothetical protein 0.0057 0.0207 0.0207
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0033 0.0031
Onchocerca volvulus 0.0036 0.0099 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.0033 0.0033
Brugia malayi TAR-binding protein 0.0062 0.0232 0.0232
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0232 0.0244
Leishmania major phosphopantetheinyl transferase-like protein 0.0515 0.2566 1
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0046 0.0153 0.0162
Echinococcus multilocularis voltage dependent calcium channel 0.0109 0.0478 0.0509
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0007 0.0006
Plasmodium falciparum histone acetyltransferase GCN5 0.0043 0.0136 0.0504
Loa Loa (eye worm) jmjC domain-containing protein 0.0046 0.0151 0.0151
Echinococcus multilocularis voltage dependent calcium channel 0.0109 0.0478 0.0509
Mycobacterium ulcerans transcriptional regulator 0.0033 0.0082 0.0097
Echinococcus granulosus sodium:glucose cotransporter 2 0.0046 0.0153 0.0162
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.0033 0.0033
Mycobacterium ulcerans (3R)-hydroxyacyl-ACP dehydratase subunit HadC 0.0033 0.0083 0.0099
Schistosoma mansoni hypothetical protein 0.0436 0.2162 0.2311
Loa Loa (eye worm) hypothetical protein 0.0023 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0023 0.0033 0.0033
Trypanosoma cruzi hypothetical protein, conserved 0.0242 0.1161 1
Schistosoma mansoni transcription factor btf3 0.004 0.0119 0.0123
Entamoeba histolytica acetyltransferase, GNAT family 0.0043 0.0136 0.0068
Loa Loa (eye worm) hypothetical protein 0.0023 0.0033 0.0033
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0093 0.0098
Schistosoma mansoni glutaminase 0.0311 0.1516 0.1619
Brugia malayi hypothetical protein 0.0075 0.0301 0.0301
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.0033 0.0033
Plasmodium vivax SET domain protein, putative 0.0035 0.0096 0.035
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0109 0.0478 0.0507
Echinococcus granulosus histone acetyltransferase KAT2B 0.005 0.017 0.018
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0007 0.0006
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.0131 0.0131
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0968 0.6224
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0014 0.0013
Brugia malayi MH2 domain containing protein 0.0136 0.0614 0.0614
Schistosoma mansoni microtubule-associated protein tau 0.0736 0.3706 0.3964
Loa Loa (eye worm) hypothetical protein 0.0046 0.0153 0.0153
Plasmodium vivax basic transcription factor 3b, putative 0.004 0.0119 0.0439
Plasmodium falciparum phd finger protein, putative 0.0033 0.0085 0.0306
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.0033 0.0031
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0046 0.0152 0.0152
Echinococcus multilocularis dnaJ subfamily B 0.0436 0.2162 0.2312
Schistosoma mansoni hypothetical protein 0.0035 0.0093 0.0096
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0014 0.0011
Echinococcus multilocularis sodium channel protein 0.0046 0.0153 0.0162
Schistosoma mansoni amyloid beta A4 protein related 0.0078 0.0317 0.0335
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0312 0.1521 0.1521
Echinococcus granulosus sodium:myo inositol cotransporter 0.0046 0.0153 0.0162
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0093 0.0098
Schistosoma mansoni bromodomain containing protein 0.008 0.0324 0.0343
Onchocerca volvulus 0.0046 0.0153 0.0129
Echinococcus multilocularis citrate lyase subunit beta protein 0.0028 0.0058 0.006
Brugia malayi CXXC zinc finger family protein 0.0063 0.024 0.024
Brugia malayi isocitrate dehydrogenase 0.0018 0.0007 0.0007
Echinococcus granulosus histone acetyltransferase KAT2B 0.0155 0.0713 0.0762
Echinococcus granulosus zinc finger protein 0.003 0.0068 0.0071
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.0033 0.0031
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0968 0.6224
Loa Loa (eye worm) CXXC zinc finger family protein 0.0063 0.024 0.024
Echinococcus multilocularis high affinity choline transporter 1 0.042 0.2076 0.2221
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0075 0.0303 0.0322
Loa Loa (eye worm) hypothetical protein 0.0083 0.0343 0.0343
Schistosoma mansoni inositol transporter 0.0046 0.0153 0.0159
Trypanosoma brucei hypothetical protein, conserved 0.0515 0.2566 1
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0007 0.0007
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.0065 0.0068
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0099 0.0099
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0042 0.0131 0.0484
Brugia malayi PHD-finger family protein 0.0033 0.0085 0.0085
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.0033 0.0031
Echinococcus granulosus PHD finger protein rhinoceros 0.0033 0.0085 0.0089
Onchocerca volvulus 0.0063 0.024 0.0223
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0023 0.0033 0.0033
Mycobacterium ulcerans hypothetical protein 0.0083 0.0343 0.1135
Echinococcus granulosus solute carrier family 5 0.0046 0.0153 0.0162
Echinococcus multilocularis zinc finger protein 0.003 0.0068 0.0071
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0096 0.035
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0232 0.0246
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0007 0.0011
Loa Loa (eye worm) voltage-dependent calcium channel 0.0023 0.0032 0.0032
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0093 0.0093
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0033 0.0033
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.0301 0.0301
Schistosoma mansoni hypothetical protein 0.0035 0.0093 0.0096
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.1958 1 1
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0046 0.0152 0.0565
Onchocerca volvulus 0.0035 0.0096 0.0068
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.0033 0.0031
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0515 0.2566 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0007 0.0006
Toxoplasma gondii MaoC family domain-containing protein 0.005 0.0174 0.0654
Brugia malayi Bromodomain containing protein 0.004 0.0119 0.0119
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0515 0.2566 0.5
Echinococcus granulosus dnaJ subfamily B 0.0436 0.2162 0.2312
Echinococcus granulosus microtubule associated protein 2 0.0736 0.3706 0.3966
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.005 0.017 0.0637
Loa Loa (eye worm) transcription factor SMAD2 0.0136 0.0614 0.0614
Schistosoma mansoni sodium/solute symporter 0.0046 0.0153 0.0159
Echinococcus granulosus sodium:glucose cotransporter 0.0046 0.0153 0.0162
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0033 0.0033
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0007 0.0006
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0033 0.0033
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0515 0.2566 0.5
Trichomonas vaginalis set domain proteins, putative 0.0271 0.131 0.8559
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0046 0.0153 0.0162
Loa Loa (eye worm) hypothetical protein 0.1831 0.9344 0.9344
Loa Loa (eye worm) ICD-1 protein 0.004 0.0119 0.0119
Loa Loa (eye worm) MH2 domain-containing protein 0.0136 0.0614 0.0614
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0046 0.0152 0.1276
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0232 0.0244
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.0033 0.0033
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0109 0.0478 0.0509
Echinococcus granulosus amyloid beta A4 protein 0.0078 0.0317 0.0337
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0109 0.0478 0.0509
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0085 0.0306
Loa Loa (eye worm) hypothetical protein 0.0056 0.0203 0.0203
Loa Loa (eye worm) hypothetical protein 0.005 0.0173 0.0173
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0096 0.0099
Loa Loa (eye worm) hypothetical protein 0.008 0.0329 0.0329
Trypanosoma cruzi transcription factor btf3, putative 0.004 0.0119 0.0996
Brugia malayi PHD-finger family protein 0.0036 0.0099 0.0099
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1521 1
Echinococcus multilocularis cpg binding protein 0.0069 0.027 0.0287
Echinococcus granulosus high affinity choline transporter 1 0.042 0.2076 0.2221
Echinococcus multilocularis PHD finger protein rhinoceros 0.0033 0.0085 0.0089
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.0033 0.0033
Schistosoma mansoni coup transcription factor 0.0023 0.0033 0.0031
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.011 0.048 0.048
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0968 0.6224
Loa Loa (eye worm) hypothetical protein 0.011 0.048 0.048
Loa Loa (eye worm) hypothetical protein 0.0033 0.0082 0.0082
Schistosoma mansoni voltage-gated cation channel 0.0109 0.0478 0.0507
Schistosoma mansoni cpg binding protein 0.0069 0.027 0.0285
Mycobacterium ulcerans (3R)-hydroxyacyl-ACP dehydratase subunit HadA 0.0033 0.0083 0.0099
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0067 0.0257 0.0987
Loa Loa (eye worm) hypothetical protein 0.0075 0.0301 0.0301
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.0033 0.0033
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0028 0.0058 0.0057
Loa Loa (eye worm) hypothetical protein 0.042 0.2076 0.2076
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0046 0.0152 0.0576
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0007 0.0007
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0046 0.0153 0.0162
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0085 0.0306
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0046 0.0152 0.0152
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0046 0.0152 0.064
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0109 0.0478 0.0509
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0007 0.0003
Echinococcus multilocularis FTZ F1 alpha 0.0023 0.0033 0.0033
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0067 0.0257 0.2186
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0046 0.0152 0.016
Onchocerca volvulus 0.1831 0.9344 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0162 0.075 0.0801
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0046 0.0152 0.0132
Echinococcus granulosus lysine specific demethylase 5A 0.0046 0.0151 0.016
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.0033 0.0033

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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