Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.038 | 0.0613 | 0.1622 |
Onchocerca volvulus | 0.038 | 0.0613 | 0.8858 | |
Schistosoma mansoni | alpha-glucosidase | 0.0136 | 0.02 | 0.0529 |
Loa Loa (eye worm) | carboxylesterase | 0.038 | 0.0613 | 0.1622 |
Brugia malayi | Carboxylesterase family protein | 0.2247 | 0.3777 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.038 | 0.0613 | 0.1622 |
Onchocerca volvulus | 0.038 | 0.0613 | 0.8858 | |
Brugia malayi | Carboxylesterase family protein | 0.2247 | 0.3777 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.2247 | 0.3777 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.2247 | 0.3777 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.2247 | 0.3777 | 1 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0035 | 0.0029 | 0.0422 |
Brugia malayi | Carboxylesterase family protein | 0.038 | 0.0613 | 0.1622 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.038 | 0.0613 | 0.1622 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0029 | 0.0422 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0417 | 0.0675 | 0.5 |
Echinococcus granulosus | BC026374 protein S09 family | 0.038 | 0.0613 | 0.1622 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0035 | 0.0029 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.038 | 0.0613 | 0.1622 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0417 | 0.0675 | 0.1788 |
Echinococcus multilocularis | 0.0417 | 0.0675 | 0.1788 | |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0035 | 0.0029 | 0.0076 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0.0029 | 0.0466 |
Brugia malayi | SWIRM domain containing protein | 0.0417 | 0.0675 | 0.1788 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0417 | 0.0675 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0417 | 0.0675 | 0.1788 |
Brugia malayi | hypothetical protein | 0.038 | 0.0613 | 0.1622 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0035 | 0.0029 | 0.0076 |
Echinococcus granulosus | carboxylesterase 5A | 0.2247 | 0.3777 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0417 | 0.0675 | 0.1788 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.038 | 0.0613 | 0.0659 |
Loa Loa (eye worm) | hypothetical protein | 0.2247 | 0.3777 | 1 |
Mycobacterium ulcerans | monoamine oxidase | 0.0417 | 0.0675 | 0.0675 |
Loa Loa (eye worm) | hypothetical protein | 0.038 | 0.0613 | 0.1622 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.038 | 0.0613 | 0.1622 |
Plasmodium vivax | hypothetical protein, conserved | 0.0417 | 0.0675 | 1 |
Trypanosoma brucei | glucosidase, putative | 0.0035 | 0.0029 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.038 | 0.0613 | 0.1622 |
Echinococcus multilocularis | carboxylesterase 5A | 0.2247 | 0.3777 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0029 | 0.0422 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0035 | 0.0029 | 0.0422 |
Echinococcus multilocularis | acetylcholinesterase | 0.2247 | 0.3777 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.038 | 0.0613 | 0.0613 |
Schistosoma mansoni | amine oxidase | 0.0417 | 0.0675 | 0.1788 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0417 | 0.0675 | 0.1788 |
Loa Loa (eye worm) | hypothetical protein | 0.2247 | 0.3777 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0417 | 0.0675 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0.0029 | 0.0466 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0417 | 0.0675 | 1 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0417 | 0.0675 | 0.1788 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0417 | 0.0675 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.038 | 0.0613 | 0.1622 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.038 | 0.0613 | 0.0659 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.2247 | 0.3777 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.038 | 0.0613 | 0.1622 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0417 | 0.0675 | 0.1788 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0417 | 0.0675 | 1 |
Onchocerca volvulus | 0.038 | 0.0613 | 0.8858 | |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0035 | 0.0029 | 0.0466 |
Brugia malayi | Carboxylesterase family protein | 0.038 | 0.0613 | 0.1622 |
Schistosoma mansoni | amine oxidase | 0.0417 | 0.0675 | 0.1788 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0417 | 0.0675 | 0.1788 |
Echinococcus granulosus | neuroligin | 0.038 | 0.0613 | 0.1622 |
Loa Loa (eye worm) | carboxylesterase | 0.038 | 0.0613 | 0.1622 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.038 | 0.0613 | 0.1622 |
Brugia malayi | hypothetical protein | 0.0417 | 0.0675 | 0.1788 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0158 | 0.0237 | 0.0628 |
Echinococcus multilocularis | neuroligin | 0.038 | 0.0613 | 0.1622 |
Plasmodium vivax | hypothetical protein, conserved | 0.0417 | 0.0675 | 1 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0417 | 0.0675 | 1 |
Mycobacterium ulcerans | dehydrogenase | 0.0417 | 0.0675 | 0.0675 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0035 | 0.0029 | 0.0466 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.038 | 0.0613 | 1 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0035 | 0.0029 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.2247 | 0.3777 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0.0029 | 0.0466 |
Schistosoma mansoni | gliotactin | 0.038 | 0.0613 | 0.1622 |
Loa Loa (eye worm) | hypothetical protein | 0.0417 | 0.0675 | 0.1788 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.0165 | 0.0438 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0158 | 0.0237 | 0.0628 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0158 | 0.0237 | 0.0628 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0035 | 0.0029 | 0.0076 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.038 | 0.0613 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.038 | 0.0613 | 0.0659 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0035 | 0.0029 | 0.0466 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.0165 | 0.0438 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.592 | 1 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.038 | 0.0613 | 0.1622 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.038 | 0.0613 | 0.1622 |
Onchocerca volvulus | 0.0417 | 0.0675 | 1 | |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0417 | 0.0675 | 0.0727 |
Loa Loa (eye worm) | hypothetical protein | 0.0417 | 0.0675 | 0.1788 |
Loa Loa (eye worm) | hypothetical protein | 0.038 | 0.0613 | 0.1622 |
Loa Loa (eye worm) | hypothetical protein | 0.0417 | 0.0675 | 0.1788 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.038 | 0.0613 | 0.1622 |
Schistosoma mansoni | alpha-glucosidase | 0.0136 | 0.02 | 0.0529 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.0165 | 0.0438 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0417 | 0.0675 | 0.5 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0417 | 0.0675 | 1 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.038 | 0.0613 | 0.1622 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0417 | 0.0675 | 0.0727 |
Onchocerca volvulus | 0.038 | 0.0613 | 0.8858 | |
Loa Loa (eye worm) | hypothetical protein | 0.038 | 0.0613 | 0.1622 |
Leishmania major | UDP-galactopyranose mutase | 0.0417 | 0.0675 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | alpha glucosidase | 0.0035 | 0.0029 | 0.0076 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0158 | 0.0237 | 0.0628 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.5503 | 0.9294 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.038 | 0.0613 | 0.1622 |
Onchocerca volvulus | 0.038 | 0.0613 | 0.8858 | |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0.0029 | 0.0466 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0035 | 0.0029 | 0.0076 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0417 | 0.0675 | 0.1788 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0417 | 0.0675 | 1 |
Mycobacterium ulcerans | oxidoreductase | 0.0417 | 0.0675 | 0.0675 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0417 | 0.0675 | 0.0675 |
Echinococcus granulosus | acetylcholinesterase | 0.2247 | 0.3777 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.038 | 0.0613 | 0.1622 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0.0029 | 0.0466 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.038 | 0.0613 | 0.1622 |
Loa Loa (eye worm) | hypothetical protein | 0.0417 | 0.0675 | 0.1788 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0417 | 0.0675 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.038 | 0.0613 | 0.1622 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0158 | 0.0237 | 0.0628 |
Loa Loa (eye worm) | hypothetical protein | 0.0417 | 0.0675 | 0.1788 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0035 | 0.0029 | 0.0466 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 30 uM | The compound was evaluated for its inhibitory activity against COX- 2. | ChEMBL. | 11128651 |
IC50 (binding) | > 30 uM | The compound was evaluated for its inhibitory activity against COX- 2. | ChEMBL. | 11128651 |
IC50 (binding) | > 100 uM | The compound was evaluated for its inhibitory activity against COX- 1. | ChEMBL. | 11128651 |
IC50 (binding) | > 100 uM | The compound was evaluated for its inhibitory activity against COX- 1. | ChEMBL. | 11128651 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.