Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | mitogen-activated protein kinase 1 | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase 1 | 360 aa | 361 aa | 33.2 % |
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.1286 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0062 | 0.3669 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.3669 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0062 | 0.3669 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0062 | 0.3669 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.3669 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.3669 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0062 | 0.3669 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.1286 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0062 | 0.3669 | 1 |
Brugia malayi | MAP kinase sur-1 | 0.0062 | 0.3669 | 0.3364 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0062 | 0.3669 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0062 | 0.3669 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0062 | 0.3669 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0062 | 0.3669 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0062 | 0.3669 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0062 | 0.3669 | 0.2734 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0062 | 0.3669 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.3669 | 0.5 |
Brugia malayi | hypothetical protein | 0.003 | 0.1286 | 0.0866 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0062 | 0.3669 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.1286 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0062 | 0.3669 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0062 | 0.3669 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0062 | 0.3669 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.5481 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 89.1251 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.