Detailed information for compound 1469394

Basic information

Technical information
  • TDR Targets ID: 1469394
  • Name: 2-ethyl-4-(4-methylpiperidin-1-yl)-[1]benzoxo lo[2,3-e]pyrimidine
  • MW: 295.379 | Formula: C18H21N3O
  • H donors: 0 H acceptors: 2 LogP: 4.6 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1nc(N2CCC(CC2)C)c2c(n1)c1ccccc1o2
  • InChi: 1S/C18H21N3O/c1-3-15-19-16-13-6-4-5-7-14(13)22-17(16)18(20-15)21-10-8-12(2)9-11-21/h4-7,12H,3,8-11H2,1-2H3
  • InChiKey: ZGVZEIKMEWMJRO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-ethyl-4-(4-methyl-1-piperidyl)benzofurano[2,3-e]pyrimidine
  • 2-ethyl-4-(4-methyl-1-piperidinyl)benzofurano[2,3-e]pyrimidine
  • STOCK4S-45765
  • ZINC04302271

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0089 0.0235
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0392 0.0331
Entamoeba histolytica hypothetical protein 0.0038 0.0325 0.2226
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0015 0.0089 0.0518
Entamoeba histolytica acyl-CoA synthetase, putative 0.0052 0.0474 0.3498
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0426 0.051
Trichomonas vaginalis phosphatidylinositol-4-phosphate 5-kinase type II, putative 0.0013 0.0064 0.0229
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0231 1
Schistosoma mansoni cpg binding protein 0.003 0.0241 0.0537
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0123 0.0356
Loa Loa (eye worm) hypothetical protein 0.0039 0.0336 0.1126
Leishmania major 4-coumarate:coa ligase-like protein 0.0052 0.0474 0.8436
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0123 0.5
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0052 0.0474 0.041
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0474 0.1629
Entamoeba histolytica fatty acid elongase, putative 0.0124 0.1237 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0325 0.0387
Loa Loa (eye worm) hypothetical protein 0.0029 0.0231 0.0745
Loa Loa (eye worm) hypothetical protein 0.0149 0.1499 0.534
Echinococcus granulosus Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0013 0.0064 0.0074
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0426 0.1454
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0392 0.1408
Leishmania major 4-coumarate:coa ligase-like protein 0.0052 0.0474 0.8436
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0123 0.3535
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.055 0.0465
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0015 0.0089 0.0022
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0089 0.0527
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.055 0.0707
Entamoeba histolytica fatty acid elongase, putative 0.0124 0.1237 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0052 0.0474 0.0388
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0013 0.0064 0.013
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0426 0.1454
Onchocerca volvulus 0.0052 0.0474 0.2543
Loa Loa (eye worm) hypothetical protein 0.0052 0.0474 0.1625
Schistosoma mansoni hypothetical protein 0.0013 0.0065 0.0133
Entamoeba histolytica fatty acid elongase, putative 0.0124 0.1237 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0474 0.1625
Echinococcus multilocularis GPCR, family 2 0.0047 0.0426 0.051
Echinococcus granulosus GPCR family 2 0.0047 0.0426 0.0545
Echinococcus multilocularis Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0013 0.0064 0.0069
Echinococcus multilocularis tumor protein p63 0.0736 0.7693 0.9358
Loa Loa (eye worm) hypothetical protein 0.0108 0.1066 0.377
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0955 1 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0123 0.0056
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0123 0.0151
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0325 0.0414
Brugia malayi Calcitonin receptor-like protein seb-1 0.0149 0.1499 0.5342
Loa Loa (eye worm) hypothetical protein 0.0047 0.0426 0.145
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0786 0.8221 1
Schistosoma mansoni hypothetical protein 0.0102 0.1002 0.2281
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0015 0.0089 0.0022
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0089 0.0022
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0231 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0089 0.153
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0123 0.0442
Loa Loa (eye worm) pip kinase 2 0.0159 0.1602 0.5716
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0159 0.1602 0.1943
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0065 0.0071
Schistosoma mansoni ap endonuclease 0.0018 0.0123 0.0266
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0559 1
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type I 0.0013 0.0064 0.013
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0065 0.0075
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0089 0.023
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.0089 0.153
Loa Loa (eye worm) hypothetical protein 0.0039 0.0336 0.1126
Onchocerca volvulus 0.0108 0.1066 0.6453
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0392 0.6636
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0159 0.1602 0.3657
Entamoeba histolytica acyl-CoA synthetase, putative 0.0052 0.0474 0.3498
Entamoeba histolytica hypothetical protein 0.0038 0.0325 0.2226
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0123 0.1219
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0089 0.153
Schistosoma mansoni hypothetical protein 0.0421 0.437 1
Echinococcus granulosus cpg binding protein 0.0031 0.0259 0.0328
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0052 0.0474 0.0388
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0089 0.0235
Brugia malayi hypothetical protein 0.0148 0.1485 0.5291
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.055 0.1246
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0052 0.0474 0.0388
Echinococcus granulosus tumor protein p63 0.0736 0.7693 1
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0015 0.0089 0.0022
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.055 0.0465
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0159 0.1602 0.2076
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0955 1 1
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0015 0.0089 0.0022
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.055 0.0465
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0955 1 1
Trichomonas vaginalis phosphatidylinositol-4-phosphate 5-kinase type II, putative 0.0013 0.0064 0.0229
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0123 0.3535
Brugia malayi latrophilin 2 splice variant baaae 0.0102 0.1002 0.3542
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0015 0.0089 0.0235
Schistosoma mansoni hypothetical protein 0.0047 0.0426 0.0961
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0231 0.0169
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0015 0.0089 0.0022
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0231 0.0169
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0089 0.0235
Schistosoma mansoni cellular tumor antigen P53 0.0108 0.1066 0.2427
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0052 0.0474 0.0388
Brugia malayi hypothetical protein 0.0029 0.0231 0.0749
Onchocerca volvulus 0.003 0.0241 0.1003
Loa Loa (eye worm) glutaminase 0.0271 0.2784 1
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0089 0.0235
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0426 0.051
Mycobacterium ulcerans glutaminase 0.0271 0.2784 0.2719
Toxoplasma gondii exonuclease III APE 0.0018 0.0123 0.1198
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0089 0.153
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0474 0.1629
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0426 0.0545
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0149 0.1499 0.534
Schistosoma mansoni ap endonuclease 0.0018 0.0123 0.0266
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0314 0.0249
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0015 0.0089 0.0518
Echinococcus granulosus histone acetyltransferase KAT2B 0.0145 0.1459 0.1889
Schistosoma mansoni phosphatidylinositol-4-phosphate-5-kinaseputativ e 0.0013 0.0064 0.013
Loa Loa (eye worm) hypothetical protein 0.0039 0.0336 0.1126
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0354 0.247
Loa Loa (eye worm) hypothetical protein 0.0159 0.1602 0.5716
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0089 0.0235
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0015 0.0089 0.0219
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0314 0.0249
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0039 0.0336 0.0271
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0392 0.1408
Loa Loa (eye worm) hypothetical protein 0.0102 0.1002 0.3539
Brugia malayi Pip kinase protein 1 0.0013 0.0064 0.0142
Plasmodium vivax acetyl-CoA synthetase, putative 0.0015 0.0089 0.0026
Loa Loa (eye worm) hypothetical protein 0.0039 0.0336 0.1126
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0241 0.0781
Plasmodium vivax acyl-CoA synthetase, putative 0.0039 0.0336 0.0274
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0015 0.0089 0.153
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0955 1 1
Brugia malayi hypothetical protein 0.0038 0.0325 0.1088
Loa Loa (eye worm) hypothetical protein 0.0148 0.1485 0.5289
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0013 0.0064 0.013
Trichomonas vaginalis glutaminase, putative 0.0271 0.2784 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.0474 0.0388
Loa Loa (eye worm) FYVE finger-containing phosphoinositide kinase 0.0013 0.0064 0.0137
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0426 0.145
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0089 0.0022
Brugia malayi Pip kinase protein 2 0.0159 0.1602 0.5718
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0426 0.0545
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0026 0.0023
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0015 0.0089 0.0026
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0039 0.0336 0.0249
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0149 0.1503 0.1821
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0089 0.0022
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0026 0.0025
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0354 0.0292
Loa Loa (eye worm) hypothetical protein 0.0039 0.0336 0.1126
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0123 0.006
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0231 0.0169
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.0089 0.0321
Echinococcus multilocularis cpg binding protein 0.0031 0.0259 0.0307
Schistosoma mansoni cpg binding protein 0.0031 0.0259 0.0578
Schistosoma mansoni cpg binding protein 0.0031 0.0259 0.0578
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.055 0.0486
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.0474 0.0388
Loa Loa (eye worm) hypothetical protein 0.0015 0.0089 0.023
Loa Loa (eye worm) hypothetical protein 0.0052 0.0474 0.1625
Echinococcus granulosus phosphatidylinositol phosphate 5 kinase type III 0.0013 0.0064 0.0074
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0354 1
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0015 0.0089 0.0022
Onchocerca volvulus 0.0148 0.1485 0.9222
Brugia malayi glutaminase DH11.1 0.0271 0.2784 1
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0955 1 1
Loa Loa (eye worm) acetyltransferase 0.0149 0.1503 0.5355
Echinococcus multilocularis dnaJ subfamily B 0.0421 0.437 0.5312
Entamoeba histolytica fatty acid elongase, putative 0.0124 0.1237 1
Entamoeba histolytica hypothetical protein 0.0038 0.0325 0.2226
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0015 0.0089 0.0107
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0123 0.0141
Brugia malayi FYVE finger-containing phosphoinositide kinase, putative 0.0013 0.0064 0.0142
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0052 0.0474 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0052 0.0474 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.055 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0052 0.0474 0.3498
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.055 0.1246
Schistosoma mansoni hypothetical protein 0.0038 0.0325 0.0729
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0314 0.0249
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0231 0.3389
Entamoeba histolytica hypothetical protein 0.0038 0.0325 0.2226
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0325 0.0729
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0149 0.1503 0.3429
Entamoeba histolytica fatty acid elongase, putative 0.0124 0.1237 1
Toxoplasma gondii propionate-CoA ligase 0.0015 0.0089 0.0518
Schistosoma mansoni glutaminase 0.0271 0.2784 0.6366
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0123 0.0442
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0089 0.023
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0123 0.2045
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0089 0.0022
Schistosoma mansoni hypothetical protein 0.0047 0.0426 0.0961
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0392 0.6636
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.055 0.0662
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0474 0.1629
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0955 1 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0314 0.0249
Schistosoma mansoni acetyl-CoA synthetase 0.0015 0.0089 0.0189
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0123 0.0352
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0015 0.0089 0.01
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0474 0.041
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0123 0.3535
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0159 0.1602 0.3657
Leishmania major acetyl-CoA synthetase, putative 0.0015 0.0089 0.0527
Brugia malayi hypothetical protein 0.0018 0.0124 0.0361
Onchocerca volvulus 0.0159 0.1602 1
Loa Loa (eye worm) FYVE zinc finger family protein 0.0013 0.0064 0.0137
Brugia malayi acetyltransferase, GNAT family protein 0.0149 0.1503 0.5357
Echinococcus granulosus dnaJ subfamily B 0.0421 0.437 0.5676
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0123 0.0505
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0392 0.0501
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.0474 0.0388
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.0089 0.0321
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0015 0.0089 0.0022
Loa Loa (eye worm) glutaminase 2 0.0271 0.2784 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0231 1
Echinococcus multilocularis phosphatidylinositol phosphate 5 kinase type III 0.0013 0.0064 0.0069
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0591 0.1338
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.0089 0.153
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.055 0.9831
Loa Loa (eye worm) pip kinase 1 0.0013 0.0064 0.0137
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0955 1 1
Mycobacterium ulcerans hypothetical protein 0.0052 0.0474 0.0388
Leishmania major 4-coumarate:coa ligase-like protein 0.0052 0.0474 0.8436
Loa Loa (eye worm) hypothetical protein 0.0015 0.0089 0.023
Brugia malayi CXXC zinc finger family protein 0.003 0.0241 0.0785
Schistosoma mansoni hypothetical protein 0.0047 0.0426 0.0961
Schistosoma mansoni hypothetical protein 0.0047 0.0426 0.0961
Plasmodium falciparum acyl-CoA synthetase 0.0039 0.0336 0.0274
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0123 0.006
Leishmania major acetyl-CoA synthetase, putative 0.0015 0.0089 0.0527
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0123 0.0034
Leishmania major hypothetical protein, conserved 0.0029 0.0231 0.3447
Loa Loa (eye worm) oxidoreductase 0.0015 0.0089 0.023
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0149 0.1499 0.5342

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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