TDR Targets

Basic information

Technical information

TDR Targets ID: 1469400
Name: 2-[(2,5-diethoxy-4-morpholin-4-ylphenyl)amino ]-1-[4-(phenylmethyl)piperazin-1-yl]ethanone
MW: 482.615 | Formula: C27H38N4O4
H donors: 1 H acceptors: 1 LogP: 3.16 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1cc(N2CCOCC2)c(cc1NCC(=O)N1CCN(CC1)Cc1ccccc1)OCC
InChi: 1S/C27H38N4O4/c1-3-34-25-19-24(30-14-16-33-17-15-30)26(35-4-2)18-23(25)28-20-27(32)31-12-10-29(11-13-31)21-22-8-6-5-7-9-22/h5-9,18-19,28H,3-4,10-17,20-21H2,1-2H3
InChiKey: QIGWBJYULKXIHP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[(2,5-diethoxy-4-morpholino-phenyl)amino]-1-[4-(phenylmethyl)piperazin-1-yl]ethanone
2-[(2,5-diethoxy-4-morpholinophenyl)amino]-1-[4-(phenylmethyl)-1-piperazinyl]ethanone
1-[4-(benzyl)piperazin-1-yl]-2-[(2,5-diethoxy-4-morpholino-phenyl)amino]ethanone
2-[(2,5-diethoxy-4-morpholin-4-yl-phenyl)amino]-1-[4-(phenylmethyl)piperazin-1-yl]ethanone
Oprea1_335429

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0172	0.1543	0.2337
Echinococcus granulosus	chromobox protein 1	0.0084	0.0618	0.0871
Onchocerca volvulus		0.0036	0.0118	0.02
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0048	0.0236	0.0236
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0118	0.0047
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.3435	0.979
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0048	0.0236	0.0204
Schistosoma mansoni	chromobox protein	0.0084	0.0618	0.0872
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0062	0.0381	0.0469
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0118	0.0095
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0118	0.0047
Echinococcus multilocularis	chromobox protein 1	0.0084	0.0618	0.0598
Chlamydia trachomatis	enoyl-acyl-carrier protein reductase	0.036	0.3507	0.548
Mycobacterium ulcerans	3-oxoacyl-ACP synthase	0.0627	0.6309	1
Echinococcus granulosus	PHD finger protein rhinoceros	0.0035	0.0105	0.0122
Schistosoma mansoni	hypothetical protein	0.0035	0.0105	0.0122
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0118	0.0095
Schistosoma mansoni	hypothetical protein	0.0032	0.0066	0.0066
Mycobacterium leprae	NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE)	0.036	0.3507	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0118	1
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0118	0.0047
Entamoeba histolytica	fatty acid elongase, putative	0.0081	0.059	0.1335
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.01	0.078	0.3049
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0047	0.023	0.1857
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0043	0.0191	0.017
Entamoeba histolytica	fatty acid elongase, putative	0.0081	0.059	0.1335
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0048	0.0236	0.0204
Entamoeba histolytica	fatty acid elongase, putative	0.0081	0.059	0.1335
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0236	0.0924
Schistosoma mansoni	cellular tumor antigen P53	0.01	0.078	0.1109
Brugia malayi	glutaminase DH11.1	0.0269	0.2557	1
Entamoeba histolytica	fatty acid elongase, putative	0.0081	0.059	0.1335
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0118	0.0188
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.023	0.0422
Echinococcus multilocularis	peregrin	0.0042	0.0173	0.0152
Mycobacterium tuberculosis	Probable hydrolase	0.0036	0.0118	0.0047
Trichomonas vaginalis	esterase, putative	0.0036	0.0118	0.0095
Schistosoma mansoni	hypothetical protein	0.0032	0.0066	0.0066
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0062	0.0381	0.0438
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.3435	0.979
Plasmodium falciparum	histone acetyltransferase GCN5	0.004	0.0151	0.0239
Mycobacterium tuberculosis	Probable esterase LipL	0.0036	0.0118	0.0047
Plasmodium vivax	acyl-CoA synthetase, putative	0.0036	0.011	0.0174
Echinococcus granulosus	GPCR family 2	0.0032	0.0066	0.0066
Brugia malayi	AMP-binding enzyme family protein	0.0048	0.0236	0.0924
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0118	0.0463
Onchocerca volvulus		0.0036	0.0118	0.02
Echinococcus granulosus	microtubule associated protein 2	0.068	0.6863	0.9994
Mycobacterium ulcerans	acyl-CoA synthetase	0.0048	0.0236	0.0204
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0105	0.0166
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0172	0.1543	0.2312
Brugia malayi	AMP-binding enzyme family protein	0.0048	0.0236	0.0924
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0032	0.0066	0.0066
Echinococcus multilocularis	GPCR, family 2	0.0032	0.0066	0.0045
Loa Loa (eye worm)	jmjC domain-containing protein	0.0073	0.0498	0.1947
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0143	0.1233	0.1769
Plasmodium falciparum	beta-ketoacyl-ACP synthase III	0.0627	0.6309	1
Schistosoma mansoni	hypothetical protein	0.0068	0.0449	0.0626
Brugia malayi	beta-lactamase family protein	0.0036	0.0118	0.0463
Brugia malayi	Calcitonin receptor-like protein seb-1	0.01	0.078	0.3049
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0118	0.0095
Leishmania major	4-coumarate:coa ligase-like protein	0.0048	0.0236	0.62
Schistosoma mansoni	hypothetical protein	0.0032	0.0066	0.0066
Mycobacterium tuberculosis	3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III)	0.0627	0.6309	1
Trichomonas vaginalis	hypothetical protein	0.036	0.3507	1
Schistosoma mansoni	glutaminase	0.0269	0.2557	0.3706
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0062	0.0381	0.0361
Mycobacterium ulcerans	enoyl-(acyl carrier protein) reductase	0.036	0.3507	0.548
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0048	0.0236	0.026
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0046	0.0219	0.0388
Loa Loa (eye worm)	hypothetical protein	0.01	0.078	0.3049
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0118	0.0463
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0048	0.0236	0.0348
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0118	0.0463
Leishmania major	hypothetical protein, conserved	0.0036	0.0118	0.3106
Echinococcus multilocularis	microtubule associated protein 2	0.068	0.6863	0.6857
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0032	0.0066	0.0066
Mycobacterium ulcerans	acyl-CoA synthetase	0.0048	0.0236	0.0204
Toxoplasma gondii	aldehyde dehydrogenase	0.0062	0.0381	0.1086
Loa Loa (eye worm)	hypothetical protein	0.0036	0.011	0.0429
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0062	0.0381	0.0526
Brugia malayi	jmjC domain containing protein	0.0115	0.0944	0.3693
Echinococcus granulosus	tumor protein p63	0.068	0.6868	1
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0048	0.0236	0.0204
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0046	0.0219	0.0288
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0066	0.0258
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0048	0.0236	0.0236
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0118	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.3435	0.979
Brugia malayi	jmjC domain containing protein	0.0045	0.0207	0.0808
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0449	0.1757
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0118	0.0463
Echinococcus multilocularis	jumonji domain containing protein	0.0049	0.0249	0.0229
Schistosoma mansoni	aldehyde dehydrogenase	0.0062	0.0381	0.0526
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.01	0.078	0.3049
Schistosoma mansoni	microtubule-associated protein tau	0.068	0.6863	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0032	0.0066	0.0045
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0118	0.0463
Onchocerca volvulus		0.0036	0.0118	0.02
Loa Loa (eye worm)	hypothetical protein	0.006	0.0368	0.1441
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0046	0.0219	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0036	0.011	0.0429
Brugia malayi	PHD-finger family protein	0.0034	0.0089	0.0347
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0051	0.0268	0.2413
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0118	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0047	0.023	0.09
Plasmodium vivax	enoyl-acyl carrier protein reductase	0.036	0.3507	0.5559
Loa Loa (eye worm)	hypothetical protein	0.0036	0.011	0.0429
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0118	0.0463
Toxoplasma gondii	PHD-finger domain-containing protein	0.0035	0.0105	0.0299
Onchocerca volvulus		0.01	0.078	1
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.0118	0.0014
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0035	0.0105	0.0122
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0045	0.0207	0.0271
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.0066	0.0258
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0353	0.3435	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.3435	0.979
Wolbachia endosymbiont of Brugia malayi	3-oxoacyl-ACP synthase	0.0627	0.6309	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0048	0.0236	0.026
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0118	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0036	0.011	0.0429
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0036	0.0118	0.0047
Echinococcus granulosus	geminin	0.0205	0.1881	0.2716
Echinococcus multilocularis	lysine specific demethylase 5A	0.0043	0.0182	0.0162
Echinococcus granulosus	lysine specific demethylase 5A	0.0045	0.0207	0.0271
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0631	0.2467
Schistosoma mansoni	hypothetical protein	0.0032	0.0066	0.0066
Loa Loa (eye worm)	hypothetical protein	0.01	0.078	0.3049
Brugia malayi	beta-lactamase	0.0036	0.0118	0.0463
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0289	0.1131
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0048	0.0236	0.0204
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0043	0.0191	0.0248
Plasmodium vivax	beta-ketoacyl-acyl carrier protein synthase III precursor, putative	0.0627	0.6309	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0118	0.0095
Mycobacterium ulcerans	glutaminase	0.0269	0.2557	0.3948
Brugia malayi	beta-lactamase family protein	0.0036	0.0118	0.0463
Echinococcus granulosus	chromobox protein 1	0.0084	0.0618	0.0871
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0118	0.0463
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0172	0.1543	0.4204
Loa Loa (eye worm)	acetyltransferase	0.015	0.1306	0.5106
Mycobacterium ulcerans	3-oxoacyl-ACP synthase	0.0627	0.6309	1
Mycobacterium tuberculosis	Probable lipase LipE	0.0036	0.0118	0.0047
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0036	0.0118	0.0047
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0118	0.0142
Giardia lamblia	Histone acetyltransferase GCN5	0.004	0.0151	0.0138
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.0066	0.0258
Echinococcus granulosus	peregrin	0.0042	0.0173	0.0221
Echinococcus multilocularis	tumor protein p63	0.068	0.6868	0.6861
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0123	0.0482
Loa Loa (eye worm)	heterochromatin protein 1	0.0084	0.0618	0.2415
Echinococcus multilocularis	chromobox protein 1	0.0084	0.0618	0.0598
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0118	1
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0353	0.3435	1
Trichomonas vaginalis	chromobox protein, putative	0.0084	0.0618	0.1555
Onchocerca volvulus		0.0048	0.0236	0.1947
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.3435	0.979
Trichomonas vaginalis	glutaminase, putative	0.0269	0.2557	0.7223
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0036	0.0118	0.0047
Trichomonas vaginalis	chromobox protein, putative	0.0084	0.0618	0.1555
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0118	0.0095
Loa Loa (eye worm)	PHD-finger family protein	0.0035	0.0105	0.041
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0046	0.0219	0.0388
Brugia malayi	acetyltransferase, GNAT family protein	0.015	0.1306	0.5106
Mycobacterium ulcerans	acyl-CoA synthetase	0.0048	0.0236	0.0204
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0045	0.0207	0.0271
Plasmodium falciparum	enoyl-acyl carrier reductase	0.036	0.3507	0.5559
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0062	0.0381	1
Brugia malayi	Bromodomain containing protein	0.0042	0.0173	0.0675
Schistosoma mansoni	bromodomain containing protein	0.008	0.0575	0.0809
Schistosoma mansoni	chromobox protein	0.0084	0.0618	0.0872
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.3435	0.979
Brugia malayi	Bromodomain containing protein	0.005	0.0258	0.101
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0236	0.0924
Schistosoma mansoni	hypothetical protein	0.0205	0.1881	0.2718
Entamoeba histolytica	acyl-coA synthetase, putative	0.0048	0.0236	0.026
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.015	0.1306	0.1287
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0076	0.0529	0.0742
Plasmodium falciparum	phd finger protein, putative	0.0035	0.0105	0.0166
Brugia malayi	chromobox protein homolog 3	0.0047	0.023	0.09
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0313	0.1225
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0115	0.0944	0.0925
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0036	0.011	0.0033
Brugia malayi	Bromodomain containing protein	0.0094	0.0723	0.2827
Trichomonas vaginalis	chromobox protein, putative	0.0051	0.0268	0.0532
Giardia lamblia	Fructose-bisphosphate aldolase	0.0353	0.3435	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0118	0.0097
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.023	0.0422
Leishmania major	4-coumarate:coa ligase-like protein	0.0048	0.0236	0.62
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0062	0.0381	0.0438
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0046	0.0219	0.0623
Schistosoma mansoni	hypothetical protein	0.0205	0.1881	0.2718
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0236	0.0924
Schistosoma mansoni	aldehyde dehydrogenase	0.0062	0.0381	0.0526
Loa Loa (eye worm)	hypothetical protein	0.0036	0.011	0.0429
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0105	0.041
Toxoplasma gondii	PHD-finger domain-containing protein	0.0035	0.0105	0.0299
Mycobacterium tuberculosis	Probable lipase LipD	0.0036	0.0118	0.0047
Echinococcus multilocularis	geminin	0.0205	0.1881	0.1863
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0048	0.0236	0.0348
Loa Loa (eye worm)	glutaminase 2	0.0269	0.2557	1
Toxoplasma gondii	ABC1 family protein	0.0036	0.0118	0.0337
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.0118	0.0014
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0046	0.0219	0.0623
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0035	0.0105	0.0084
Brugia malayi	PHD-finger family protein	0.0035	0.0105	0.041
Mycobacterium ulcerans	beta-ketoacyl synthase-like protein	0.0627	0.6309	1
Onchocerca volvulus		0.0037	0.0123	0.0274
Brugia malayi	latrophilin 2 splice variant baaae	0.0068	0.0449	0.1757
Chlamydia trachomatis	oxoacyl-ACP synthase III	0.0627	0.6309	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0233	0.218	0.3361
Leishmania major	4-coumarate:coa ligase-like protein	0.0048	0.0236	0.62
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0062	0.0381	0.0438
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.015	0.1306	0.1877
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0032	0.0066	0.0045
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.3435	0.979
Treponema pallidum	fructose-bisphosphate aldolase	0.0353	0.3435	0.5
Mycobacterium ulcerans	beta-lactamase	0.0036	0.0118	0.0014
Brugia malayi	Heterochromatin protein 1	0.0084	0.0618	0.2415
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0118	0.0463
Brugia malayi	AMP-binding enzyme family protein	0.0048	0.0236	0.0924
Echinococcus granulosus	jumonji domain containing protein	0.0049	0.0249	0.0333
Schistosoma mansoni	jumonji domain containing protein	0.0092	0.0696	0.0986
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.3435	0.979
Mycobacterium ulcerans	lipase LipD	0.0036	0.0118	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0221	0.0866
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0076	0.0529	0.0509
Entamoeba histolytica	fatty acid elongase, putative	0.0081	0.059	0.1335
Plasmodium falciparum	acyl-CoA synthetase	0.0036	0.011	0.0174
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0115	0.0944	0.1349
Trichomonas vaginalis	chromobox protein, putative	0.0051	0.0268	0.0532
Mycobacterium tuberculosis	NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase)	0.036	0.3507	0.5495
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.0066	0.0258
Toxoplasma gondii	enoyl-acyl carrier reductase ENR	0.036	0.3507	1
Mycobacterium ulcerans	hypothetical protein	0.0048	0.0236	0.0204
Loa Loa (eye worm)	jmjC domain-containing protein	0.0045	0.0207	0.0808
Loa Loa (eye worm)	glutaminase	0.0269	0.2557	1
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0118	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0118	0.0463

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1626046

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1469400