Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0212 | 0.5 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0108 | 0.1118 | 0.2867 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.012 | 0.127 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0055 | 0.0302 |
Schistosoma mansoni | alpha-glucosidase | 0.014 | 0.1527 | 0.9079 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0036 | 0.0212 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0055 | 0.0302 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0055 | 0.0145 |
Echinococcus granulosus | tumor protein p63 | 0.0338 | 0.4024 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.012 | 0.127 | 0.3277 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0041 | 0.0276 | 1 |
Leishmania major | trypanothione reductase | 0.0047 | 0.0353 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0047 | 0.0353 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0055 | 0.1552 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.038 | 0.2095 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0108 | 0.1118 | 0.2867 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0055 | 0.0302 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0055 | 0.0145 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.012 | 0.127 | 0.3277 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0047 | 0.0353 | 0.0144 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0317 | 0.3763 | 1 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0317 | 0.3763 | 0.5 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.0317 | 0.3763 | 1 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.0317 | 0.3763 | 1 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0317 | 0.3763 | 1 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0036 | 0.0212 | 0.7115 |
Onchocerca volvulus | 0.0049 | 0.038 | 0.3651 | |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0024 | 0.0055 | 0.0145 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0024 | 0.0055 | 0.0145 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0024 | 0.0055 | 0.0145 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0041 | 0.0276 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0163 | 0.1814 | 0.4201 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0036 | 0.0212 | 0.5 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0036 | 0.0212 | 0.1169 |
Onchocerca volvulus | 0.0094 | 0.0946 | 1 | |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0036 | 0.0212 | 0.5 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.012 | 0.127 | 0.3277 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0212 | 0.5 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0047 | 0.0353 | 0.1944 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0024 | 0.0055 | 0.0145 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0036 | 0.0212 | 0.1169 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0041 | 0.0276 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0055 | 0.1552 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0055 | 0.0302 |
Mycobacterium tuberculosis | Probable reductase | 0.0108 | 0.1118 | 0.2867 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0055 | 0.1552 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0163 | 0.1814 | 0.1636 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0212 | 0.5 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0036 | 0.0212 | 0.5 |
Brugia malayi | glutathione reductase | 0.0047 | 0.0353 | 0.1944 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0108 | 0.1118 | 0.8749 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0055 | 0.0302 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0036 | 0.0212 | 0.6011 |
Toxoplasma gondii | thioredoxin reductase | 0.0047 | 0.0353 | 1 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0049 | 0.038 | 0.1161 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0163 | 0.1814 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0047 | 0.0353 | 0.1944 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0036 | 0.0212 | 0.7115 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0108 | 0.1118 | 0.2867 |
Brugia malayi | Cytochrome P450 family protein | 0.003 | 0.013 | 0.0719 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.0317 | 0.3763 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0024 | 0.0055 | 0.0145 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0212 | 0.6011 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0047 | 0.0353 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0047 | 0.0353 | 0.0369 |
Trypanosoma brucei | glucosidase, putative | 0.0036 | 0.0212 | 0.6011 |
Echinococcus multilocularis | tumor protein p63 | 0.0338 | 0.4024 | 0.3895 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0212 | 0.6011 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0212 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0041 | 0.0276 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.003 | 0.013 | 0.0719 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0055 | 0.0145 |
Schistosoma mansoni | alpha-glucosidase | 0.014 | 0.1527 | 0.9079 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0163 | 0.1814 | 0.1636 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0055 | 0.0302 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0163 | 0.1814 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0108 | 0.1118 | 0.2867 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.0317 | 0.3763 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0108 | 0.1118 | 0.2867 |
Chlamydia trachomatis | oxoacyl-ACP synthase III | 0.0317 | 0.3763 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.0047 | 0.0353 | 0.1944 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0212 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0041 | 0.0276 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0047 | 0.0353 | 0.0803 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.