Detailed information for compound 1469667

Basic information

Technical information
  • TDR Targets ID: 1469667
  • Name: N-(2,4-dimethoxyphenyl)-6-phenyl-1-propan-2-y lpyrazolo[5,4-b]pyridine-4-carboxamide
  • MW: 416.472 | Formula: C24H24N4O3
  • H donors: 1 H acceptors: 3 LogP: 3.98 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(OC)ccc1NC(=O)c1cc(nc2c1cnn2C(C)C)c1ccccc1
  • InChi: 1S/C24H24N4O3/c1-15(2)28-23-19(14-25-28)18(13-21(26-23)16-8-6-5-7-9-16)24(29)27-20-11-10-17(30-3)12-22(20)31-4/h5-15H,1-4H3,(H,27,29)
  • InChiKey: SCIOGANEKVLRJZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2,4-dimethoxyphenyl)-1-isopropyl-6-phenyl-pyrazolo[5,4-b]pyridine-4-carboxamide
  • N-(2,4-dimethoxyphenyl)-1-isopropyl-6-phenyl-4-pyrazolo[5,4-b]pyridinecarboxamide
  • N-(2,4-dimethoxyphenyl)-6-phenyl-1-propan-2-yl-pyrazolo[5,4-b]pyridine-4-carboxamide
  • ZINC07398245
  • T5567379

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0026 0.1752 1
Loa Loa (eye worm) hypothetical protein 0.006 1 1
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0026 0.1752 1
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0026 0.1752 0.2955
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0026 0.1752 0.5
Giardia lamblia Hypothetical protein 0.0023 0.1027 0.5
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.5929 1
Schistosoma mansoni cytochrome P450 reductase 0.0026 0.1752 0.2955
Loa Loa (eye worm) hypothetical protein 0.0041 0.5371 0.5371
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0026 0.1752 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 0.1752 0.1752
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0026 0.1752 0.5
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.5929 1
Leishmania major p450 reductase, putative 0.0026 0.1752 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.5929 1
Schistosoma mansoni hypothetical protein 0.0041 0.5371 0.906
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0026 0.1752 0.2955
Brugia malayi flavodoxin family protein 0.0026 0.1752 0.1752
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0026 0.1752 0.5
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0026 0.1752 0.2955
Brugia malayi FAD binding domain containing protein 0.0026 0.1752 0.1752
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0026 0.1752 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.5371 0.5371
Entamoeba histolytica hypothetical protein 0.0043 0.5929 0.5
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0026 0.1752 0.2955
Plasmodium falciparum nitric oxide synthase, putative 0.0026 0.1752 0.5
Entamoeba histolytica hypothetical protein 0.0043 0.5929 0.5
Entamoeba histolytica hypothetical protein 0.0043 0.5929 0.5
Giardia lamblia Nitric oxide synthase, inducible 0.0023 0.1027 0.5
Loa Loa (eye worm) FAD binding domain-containing protein 0.0026 0.1752 0.1752
Trichomonas vaginalis sulfite reductase, putative 0.0026 0.1752 1
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0026 0.1752 0.5
Brugia malayi hypothetical protein 0.0043 0.5929 0.5929
Schistosoma mansoni hypothetical protein 0.0043 0.5929 1
Entamoeba histolytica hypothetical protein 0.0043 0.5929 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 1 1
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0026 0.1752 0.5
Trypanosoma cruzi p450 reductase, putative 0.0026 0.1752 0.5
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0026 0.1752 0.5
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 1 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.3078 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5878 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 100 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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