Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Bacillus subtilis (strain 168) | ATP-dependent Clp protease proteolytic subunit | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 1 | 0.5 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.0056 | 0 | 0.5 |
Brugia malayi | RNA binding protein | 0.0076 | 0.5361 | 0.5361 |
Trichomonas vaginalis | cdc25c, putative | 0.0056 | 0 | 0.5 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0094 | 1 | 1 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0094 | 1 | 1 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 1 | 0.5 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0094 | 1 | 1 |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0056 | 0 | 0.5 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 1 | 0.5 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.0056 | 0 | 0.5 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0062 | 0.1586 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5361 | 0.5361 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5361 | 0.5361 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0094 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0094 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.5361 | 0.5361 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 1 | 1 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0094 | 1 | 0.5 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.0056 | 0 | 0.5 |
Trichomonas vaginalis | cdc25b, putative | 0.0056 | 0 | 0.5 |
Trichomonas vaginalis | m-phase inducer phosphatase, putative | 0.0056 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 1 | 0.5 |
Onchocerca volvulus | 0.0056 | 0 | 0.5 | |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.5361 | 0.5361 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.5361 | 0.5361 |
Onchocerca volvulus | 0.0056 | 0 | 0.5 | |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.5361 | 0.5361 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0062 | 0.1586 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5361 | 0.5361 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5361 | 0.5361 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 1 | 0.5 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0094 | 1 | 0.5 |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0056 | 0 | 0.5 |
Onchocerca volvulus | 0.0056 | 0 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5361 | 0.5361 |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0056 | 0 | 0.5 |
Trichomonas vaginalis | cdc25b, putative | 0.0056 | 0 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.5361 | 0.5361 |
Trichomonas vaginalis | m-phase inducer phosphatase, putative | 0.0056 | 0 | 0.5 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 1 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.5361 | 0.5361 |
Onchocerca volvulus | 0.0056 | 0 | 0.5 | |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0062 | 0.1586 | 0.1586 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0062 | 0.1586 | 0.1586 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.5361 | 0.5361 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 4.4668 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.9433 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.