Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.1362 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1362 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.1362 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.1362 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1362 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1362 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.1362 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.1362 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.1362 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.1362 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1362 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.1362 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 12 mm | Antifungal activity against Candida albicans at 100 ug/ml after 48 hrs by agar diffusion method | ChEMBL. | 20965619 |
IZ (functional) | = 15 mm | Antifungal activity against Candida albicans at 200 ug/ml after 48 hrs by agar diffusion method | ChEMBL. | 20965619 |
IZ (functional) | = 16 mm | Antibacterial activity against Escherichia coli ATCC 25922 at 100 ug/ml after 24 hrs by disc-diffusion method | ChEMBL. | 20965619 |
IZ (functional) | = 18 mm | Antibacterial activity against Escherichia coli ATCC 25922 at 200 ug/ml after 24 hrs by disc-diffusion method | ChEMBL. | 20965619 |
MBC (functional) | = 25 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 25922 after 18 to 24 hrs | ChEMBL. | 20965619 |
MFC (functional) | = 50 ug ml-1 | Antifungal activity against Candida albicans after 48 hrs | ChEMBL. | 20965619 |
MIC (functional) | = 12.5 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 25922 after 24 hrs by broth dilution technique | ChEMBL. | 20965619 |
MIC (functional) | = 25 ug ml-1 | Antifungal activity against Candida albicans after 48 hrs | ChEMBL. | 20965619 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.