Detailed information for compound 1469862

Basic information

Technical information
  • TDR Targets ID: 1469862
  • Name: [2-oxo-2-(prop-2-enylamino)ethyl] 2,3-dihydro -1H-cyclopenta[b]quinoline-9-carboxylate
  • MW: 310.347 | Formula: C18H18N2O3
  • H donors: 1 H acceptors: 3 LogP: 2.72 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCNC(=O)COC(=O)c1c2CCCc2nc2c1cccc2
  • InChi: 1S/C18H18N2O3/c1-2-10-19-16(21)11-23-18(22)17-12-6-3-4-8-14(12)20-15-9-5-7-13(15)17/h2-4,6,8H,1,5,7,9-11H2,(H,19,21)
  • InChiKey: DVHJTFTXEAFWTF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-(allylamino)-2-oxo-ethyl] 2,3-dihydro-1H-cyclopenta[b]quinoline-9-carboxylate
  • 2,3-dihydro-1H-cyclopenta[b]quinoline-9-carboxylic acid [2-(allylamino)-2-oxoethyl] ester
  • 2,3-dihydro-1H-cyclopenta[b]quinoline-9-carboxylic acid [2-(allylamino)-2-keto-ethyl] ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens phosphatidylinositol-5-phosphate 4-kinase, type II, alpha Starlite/ChEMBL No references
Homo sapiens CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium vivax NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 Get druggable targets OG5_127075 All targets in OG5_127075
Loa Loa (eye worm) pip kinase 2 Get druggable targets OG5_131617 All targets in OG5_131617
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium berghei NLI interacting factor-like phosphatase Get druggable targets OG5_127075 All targets in OG5_127075
Candida albicans Plasma membrane Sodium Response 1 Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma congolense TFIIF-stimulated CTD phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania donovani dullard-like phosphatase domain containing protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Babesia bovis Dullard-like phosphatase domain containing protein Get druggable targets OG5_127075 All targets in OG5_127075
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium yoelii NLI interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Toxoplasma gondii Dullard family phosphatase domain-containing protein Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II Get druggable targets OG5_131617 All targets in OG5_131617
Echinococcus granulosus Carboxy terminal domain RNA polymerase II Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania braziliensis hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania major hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium yoelii NLI interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium vivax NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 Get druggable targets OG5_131617 All targets in OG5_131617
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium falciparum NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus granulosus CTD small phosphatase protein like Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma mansoni hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 Get druggable targets OG5_131617 All targets in OG5_131617
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma japonicum CTD small phosphatase-like protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium knowlesi NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131617 All targets in OG5_131617
Neospora caninum hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II Get druggable targets OG5_131617 All targets in OG5_131617
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Giardia lamblia Nuclear LIM interactor-interacting factor 1 Get druggable targets OG5_127075 All targets in OG5_127075
Candida albicans Plasma membrane Sodium Response 1 Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma japonicum ko:K01090 protein phosphatase [EC3.1.3.16], putative Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Theileria parva nuclear LIM interactor-interacting factor 1, putative Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania infantum hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Neospora caninum hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis dullard protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania mexicana hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium berghei NLI interacting factor-like phosphatase Get druggable targets OG5_127075 All targets in OG5_127075
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus multilocularis Get druggable targets OG5_127075 All targets in OG5_127075
Brugia malayi Pip kinase protein 2 Get druggable targets OG5_131617 All targets in OG5_131617
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Onchocerca volvulus Get druggable targets OG5_131617 All targets in OG5_131617
Trichomonas vaginalis dullard protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium knowlesi NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Trichomonas vaginalis dullard protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma congolense hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma japonicum ko:K00889 1-phosphatidylinositol-4-phosphate 5-kinase [EC2.7.1.68], putative Get druggable targets OG5_131617 All targets in OG5_131617
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Trypanosoma brucei TFIIF-stimulated CTD phosphatase, putative CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 260 aa 263 aa 27.0 %
Trypanosoma brucei phosphatidylinositol phosphate kinase alpha phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 406 aa 341 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi FYVE finger-containing phosphoinositide kinase, putative 0.0016 0.001 0.001
Echinococcus multilocularis BC026374 protein (S09 family) 0.0138 0.1535 0.1535
Onchocerca volvulus 0.0196 0.2257 1
Echinococcus multilocularis Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0016 0.001 0.001
Loa Loa (eye worm) carboxylesterase 0.0138 0.1535 0.1535
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0138 0.1535 0.1535
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0138 0.1535 0.1535
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.001 1
Schistosoma mansoni gliotactin 0.0138 0.1535 0.1535
Mycobacterium ulcerans carboxylesterase, LipT 0.0138 0.1535 0.5
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-kinase 0.0016 0.001 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1608 0.1608
Loa Loa (eye worm) hypothetical protein 0.0196 0.2257 0.2257
Schistosoma mansoni neuroligin 3 (S09 family) 0.0138 0.1535 0.1535
Entamoeba histolytica phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.001 1
Trichomonas vaginalis phosphatidylinositol-4-phosphate 5-kinase type II, putative 0.0016 0.001 0.0063
Echinococcus granulosus para nitrobenzyl esterase 0.0138 0.1535 0.1535
Trypanosoma cruzi phosphatidylinositol (3,5) kinase, putative 0.0016 0.001 1
Loa Loa (eye worm) pip kinase 1 0.0016 0.001 0.001
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0016 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0818 1 1
Loa Loa (eye worm) hypothetical protein 0.0138 0.1535 0.1535
Giardia lamblia Hypothetical protein 0.0016 0.001 1
Schistosoma mansoni acetylcholinesterase 0.0138 0.1535 0.1535
Loa Loa (eye worm) carboxylesterase 0.0138 0.1535 0.1535
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0196 0.2257 0.2257
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0016 0.001 1
Loa Loa (eye worm) FYVE zinc finger family protein 0.0016 0.001 0.001
Brugia malayi hypothetical protein 0.0138 0.1535 0.1535
Echinococcus granulosus carboxylesterase 5A 0.0818 1 1
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0016 0.001 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0138 0.1535 0.1535
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase type II beta, putative 0.0016 0.001 1
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0138 0.1535 0.1535
Plasmodium falciparum phosphatidylinositol-4-phosphate 5-kinase 0.0016 0.001 1
Echinococcus multilocularis para nitrobenzyl esterase 0.0138 0.1535 0.1535
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.001 1
Loa Loa (eye worm) acetylcholinesterase 1 0.0818 1 1
Plasmodium vivax hypothetical protein, conserved 0.0016 0.001 1
Mycobacterium tuberculosis Carboxylesterase LipT 0.0138 0.1535 0.5
Plasmodium vivax phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.001 1
Onchocerca volvulus 0.0182 0.2085 0.762
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.001 1
Echinococcus granulosus BC026374 protein S09 family 0.0138 0.1535 0.1535
Trypanosoma brucei phosphatidylinositol phosphate kinase alpha 0.0016 0.001 1
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like protein 0.0016 0.001 1
Trichomonas vaginalis spcc417.12 protein, putative 0.0138 0.1535 1
Echinococcus multilocularis carboxylesterase 5A 0.0818 1 1
Echinococcus multilocularis phosphatidylinositol phosphate 5 kinase type III 0.0016 0.001 0.001
Leishmania major phosphatidylinositol-4-phosphate-5-kinase-likep ro tein 0.0016 0.001 1
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0138 0.1535 0.5
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0016 0.001 1
Loa Loa (eye worm) hypothetical protein 0.0818 1 1
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0196 0.2257 0.2257
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0016 0.001 1
Trypanosoma cruzi phosphatidylinositol 4-phosphate 5-kinase alpha, putative 0.0016 0.001 1
Brugia malayi hypothetical protein 0.0182 0.2085 0.2085
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1608 0.1608
Entamoeba histolytica phosphoinositide kinase, putative 0.0016 0.001 1
Brugia malayi Carboxylesterase family protein 0.0138 0.1535 0.1535
Loa Loa (eye worm) hypothetical protein 0.0182 0.2085 0.2085
Echinococcus granulosus phosphatidylinositol phosphate 5 kinase type III 0.0016 0.001 0.001
Echinococcus multilocularis acetylcholinesterase 0.0818 1 1
Loa Loa (eye worm) hypothetical protein 0.0138 0.1535 0.1535
Loa Loa (eye worm) carboxylesterase 0.0818 1 1
Trypanosoma brucei phosphatidylinositol (3,5) kinase, putative 0.0016 0.001 1
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0138 0.1535 0.5
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0138 0.1535 1
Trichomonas vaginalis phosphatidylinositol-4-phosphate 5-kinase type II, putative 0.0016 0.001 0.0063
Echinococcus multilocularis neuroligin 0.0138 0.1535 0.1535
Echinococcus granulosus neuroligin 0.0138 0.1535 0.1535
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0138 0.1535 0.1535
Brugia malayi MH2 domain containing protein 0.0144 0.1608 0.1608
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0196 0.2257 0.2257
Loa Loa (eye worm) hypothetical protein 0.0138 0.1535 0.1535
Echinococcus granulosus acetylcholinesterase 0.0818 1 1
Brugia malayi Carboxylesterase family protein 0.0138 0.1535 0.1535
Leishmania major phosphatidylinositol (3,5) kinase, putative 0.0016 0.001 1
Giardia lamblia Phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.001 1
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0196 0.2257 0.2257
Brugia malayi Carboxylesterase family protein 0.0138 0.1535 0.1535
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.001 1
Loa Loa (eye worm) FYVE finger-containing phosphoinositide kinase 0.0016 0.001 0.001
Loa Loa (eye worm) pip kinase 2 0.0196 0.2257 0.2257
Loa Loa (eye worm) hypothetical protein 0.0138 0.1535 0.1535
Loa Loa (eye worm) hypothetical protein 0.0138 0.1535 0.1535
Brugia malayi Carboxylesterase family protein 0.0138 0.1535 0.1535
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.001 1
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type I 0.0016 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0138 0.1535 0.1535
Schistosoma mansoni phosphatidylinositol-4-phosphate-5-kinaseputativ e 0.0016 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0138 0.1535 0.1535
Echinococcus multilocularis acetylcholinesterase 0.0818 1 1
Brugia malayi Pip kinase protein 2 0.0196 0.2257 0.2257
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0016 0.001 0.001
Echinococcus granulosus Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0016 0.001 0.001
Brugia malayi Carboxylesterase family protein 0.0818 1 1
Schistosoma mansoni BC026374 protein (S09 family) 0.0138 0.1535 0.1535
Brugia malayi Pip kinase protein 1 0.0016 0.001 0.001
Echinococcus granulosus acetylcholinesterase 0.0818 1 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0818 1 1
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0016 0.001 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 7.392 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493091, AID493120] ChEMBL. No reference
Potency (functional) 1 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.122 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 2.9362 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS for Inhibitors of PI5P4K: Confirmation in Primary Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 53.5818 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 67.0158 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Iota: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 67.4555 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference
Potency (functional) 2238.7211 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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