Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0959 | 0.0855 |
Trypanosoma brucei | unspecified product | 0.002 | 0.0277 | 0.0897 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0277 | 0.0165 |
Brugia malayi | MH2 domain containing protein | 0.0118 | 0.47 | 0.4639 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0277 | 0.0897 |
Echinococcus granulosus | voltage dependent L type calcium channel subunit|voltage dependent calcium channel | 0.0236 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.1687 | 0.1591 |
Schistosoma mansoni | CREB-binding protein 2 | 0.01 | 0.3898 | 0.3828 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.002 | 0.0277 | 0.0165 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 1 | 1 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu | 0.0236 | 1 | 1 |
Echinococcus multilocularis | CREB binding protein | 0.0069 | 0.248 | 0.2393 |
Echinococcus multilocularis | dna polymerase eta | 0.002 | 0.0277 | 0.0165 |
Mycobacterium ulcerans | DNA polymerase IV | 0.002 | 0.0277 | 0.5 |
Loa Loa (eye worm) | CBP-B | 0.007 | 0.2519 | 0.2433 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.002 | 0.0277 | 0.0165 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.002 | 0.0277 | 0.0165 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0277 | 0.0897 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0277 | 0.0897 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.2637 | 0.2552 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.002 | 0.0277 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0127 | 0.5095 | 0.5039 |
Echinococcus granulosus | dna polymerase kappa | 0.002 | 0.0277 | 0.0165 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.002 | 0.0277 | 0.0165 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.002 | 0.0277 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.0277 | 0.0897 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0236 | 1 | 1 |
Toxoplasma gondii | transporter, cation channel family protein | 0.0082 | 0.3083 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1497 | 0.1399 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1497 | 0.1399 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.5095 | 0.5039 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0277 | 0.0897 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.3083 | 0.3004 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1687 | 0.1591 |
Echinococcus multilocularis | CREB binding protein | 0.0016 | 0.0125 | 0.0012 |
Echinococcus granulosus | CREB binding protein | 0.01 | 0.3898 | 0.3828 |
Echinococcus granulosus | dna polymerase eta | 0.002 | 0.0277 | 0.0165 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0277 | 0.0897 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0959 | 0.0855 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0118 | 0.47 | 0.4639 |
Trypanosoma cruzi | Voltage-dependent calcium channel subunit, putative | 0.0082 | 0.3083 | 1 |
Echinococcus multilocularis | CREB binding protein | 0.0016 | 0.0125 | 0.0012 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0277 | 0.0897 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.5095 | 0.5039 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.002 | 0.0277 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0127 | 0.5095 | 0.5039 |
Schistosoma mansoni | CREB-binding protein 1 (SmCBP1) | 0.01 | 0.3898 | 0.3828 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0277 | 0.0897 |
Giardia lamblia | DINP protein human, muc B family | 0.002 | 0.0277 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.0277 | 0.0897 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.1687 | 0.1591 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.002 | 0.0277 | 0.0165 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.002 | 0.0277 | 0.5 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0236 | 1 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.002 | 0.0277 | 0.0165 |
Schistosoma mansoni | high voltage-activated calcium channel Cav1 | 0.0236 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.1497 | 0.1399 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 | 0.0236 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.1497 | 0.1399 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.1497 | 0.1399 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.1687 | 0.1591 |
Leishmania major | DNA polymerase kappa, putative | 0.002 | 0.0277 | 0.5 |
Loa Loa (eye worm) | calcium channel | 0.0236 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.002 | 0.0277 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.0277 | 0.0897 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.1497 | 0.1399 |
Brugia malayi | RNA binding protein | 0.0127 | 0.5095 | 0.5039 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0127 | 0.5095 | 0.5039 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0127 | 0.5095 | 0.5039 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0236 | 1 | 1 |
Echinococcus granulosus | CREB binding protein | 0.0016 | 0.0125 | 0.0012 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.5095 | 0.5039 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0236 | 1 | 1 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.002 | 0.0277 | 0.5 |
Echinococcus multilocularis | CREB binding protein | 0.0016 | 0.0125 | 0.0012 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.002 | 0.0277 | 0.0165 |
Mycobacterium ulcerans | DNA polymerase IV | 0.002 | 0.0277 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.1497 | 0.1399 |
Trypanosoma brucei | Voltage-dependent calcium channel subunit, putative | 0.0082 | 0.3083 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.1504 | 0.1406 |
Leishmania major | DNA polymerase eta, putative | 0.002 | 0.0277 | 0.5 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.002 | 0.0277 | 0.0165 |
Schistosoma mansoni | voltage-gated cation channel | 0.0236 | 1 | 1 |
Schistosoma mansoni | high voltage-activated calcium channel Cav2A | 0.0236 | 1 | 1 |
Echinococcus multilocularis | dna polymerase kappa | 0.002 | 0.0277 | 0.0165 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0082 | 0.3083 | 0.3004 |
Echinococcus granulosus | CREB binding protein | 0.0016 | 0.0125 | 0.0012 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.5095 | 0.5039 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0277 | 0.0897 |
Echinococcus granulosus | tar DNA binding protein | 0.0127 | 0.5095 | 0.5039 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0236 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.0959 | 0.0855 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0277 | 0.0897 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0277 | 0.0897 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.1497 | 0.1399 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1497 | 0.1399 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0118 | 0.47 | 0.4639 |
Echinococcus granulosus | CREB binding protein | 0.0062 | 0.2169 | 0.2078 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0236 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0127 | 0.5095 | 0.5039 |
Loa Loa (eye worm) | voltage-dependent calcium channel | 0.0082 | 0.3083 | 0.3004 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.2637 | 0.2552 |
Brugia malayi | TAZ zinc finger family protein | 0.01 | 0.3898 | 0.3828 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0236 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.5095 | 0.5039 |
Echinococcus multilocularis | tar DNA binding protein | 0.0127 | 0.5095 | 0.5039 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.002 | 0.0277 | 0.0897 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.