Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | ERV/ALR sulfhydryl oxidase domain-containing protein | 0.0033 | 0.0074 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0878 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 1 | 1 |
Plasmodium falciparum | FAD-linked sulfhydryl oxidase ERV1, putative | 0.0033 | 0.0074 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 1 | 1 |
Brugia malayi | Augmenter of liver regeneration | 0.0033 | 0.0074 | 0.0074 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0878 | 0.0878 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0878 | 0.081 |
Toxoplasma gondii | Erv1 / Alr family protein | 0.0033 | 0.0074 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0033 | 0.0074 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0878 | 0.081 |
Plasmodium vivax | FAD-linked sulfhydryl oxidase ERV1, putative | 0.0033 | 0.0074 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.5144 | 0.5144 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.5144 | 0.5144 |
Brugia malayi | TAR-binding protein | 0.0063 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0878 | 0.5 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0878 | 0.0878 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0878 | 0.0878 |
Loa Loa (eye worm) | hepatopoietin HPO2 | 0.0033 | 0.0074 | 0.0074 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 1 | 1 |
Trypanosoma brucei | ERV/ALR sulfhydryl oxidase domain-containing protein | 0.0033 | 0.0074 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0878 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.5144 | 0.5144 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 1 |
Toxoplasma gondii | Erv1 / Alr family protein | 0.0033 | 0.0074 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 1 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 4 | 0.0033 | 0.0074 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.5144 | 0.5144 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0878 | 0.5 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 4 | 0.0033 | 0.0074 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.