Detailed information for compound 1470569

Basic information

Technical information
  • TDR Targets ID: 1470569
  • Name: N-[4-(3-dimethylaminopropoxy)phenyl]-6,11-dih ydrobenzo[c][1]benzothiepin-11-amine
  • MW: 404.568 | Formula: C25H28N2OS
  • H donors: 1 H acceptors: 0 LogP: 5.55 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(CCCOc1ccc(cc1)NC1c2ccccc2SCc2c1cccc2)C
  • InChi: 1S/C25H28N2OS/c1-27(2)16-7-17-28-21-14-12-20(13-15-21)26-25-22-9-4-3-8-19(22)18-29-24-11-6-5-10-23(24)25/h3-6,8-15,25-26H,7,16-18H2,1-2H3
  • InChiKey: LWAPUWSQIHHHOT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 6,11-dihydrobenzo[c][1]benzothiepin-11-yl-[4-(3-dimethylaminopropoxy)phenyl]amine
  • AE-641/30152059

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0028 0.0311 0.2526
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0874 0.3558
Loa Loa (eye worm) hypothetical protein 0.0037 0.0453 0.1285
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0687 0.7663
Echinococcus granulosus neuroligin 0.0037 0.0453 0.0434
Schistosoma mansoni tar DNA-binding protein 0.0201 0.2913 0.2913
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0026 0.0277 0.1114
Toxoplasma gondii type I fatty acid synthase, putative 0.0026 0.0277 0.2539
Echinococcus granulosus cpg binding protein 0.003 0.0335 0.0315
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0263 0.2355
Loa Loa (eye worm) transcription factor SMAD2 0.0233 0.3388 1
Echinococcus multilocularis acetylcholinesterase 0.0222 0.3221 0.3207
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0171 0.2453 1
Mycobacterium ulcerans L-lysine aminotransferase 0.0024 0.0254 0.1029
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0017 0.0152 0.062
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0311 0.0863
Schistosoma mansoni hypothetical protein 0.019 0.2747 0.2747
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.1247 0.3644
Brugia malayi Carboxylesterase family protein 0.0222 0.3221 0.9507
Brugia malayi MH2 domain containing protein 0.0016 0.0128 0.0379
Mycobacterium ulcerans polyketide synthase Pks13 0.0036 0.0435 0.1767
Brugia malayi Smad1 0.0016 0.0128 0.0379
Loa Loa (eye worm) hypothetical protein 0.0009 0.0022 0.0005
Loa Loa (eye worm) hypothetical protein 0.0037 0.0453 0.1285
Echinococcus granulosus Smad4 0.0016 0.0128 0.0108
Brugia malayi hypothetical protein 0.0037 0.0453 0.1337
Schistosoma mansoni gliotactin 0.0037 0.0453 0.0453
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0874 1
Mycobacterium ulcerans acetylornithine aminotransferase 0.0024 0.0254 0.1029
Echinococcus granulosus para nitrobenzyl esterase 0.0037 0.0453 0.0434
Echinococcus multilocularis Aminotransferase class III 0.0024 0.0254 0.0235
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0024 0.0254 0.0751
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0007 0.0002 0.0009
Schistosoma mansoni acetylcholinesterase 0.0037 0.0453 0.0453
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0026 0.0277 0.1114
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0024 0.0254 0.1037
Brugia malayi MH2 domain containing protein 0.0233 0.3388 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0231 0.0625
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0171 0.2453 1
Echinococcus multilocularis ornithine aminotransferase 0.0024 0.0254 0.0235
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.0255 0.1031
Echinococcus granulosus carboxylesterase 5A 0.0222 0.3221 0.3207
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0024 0.0255 0.1039
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0024 0.0255 0.1039
Echinococcus multilocularis ornithine aminotransferase 0.0024 0.0254 0.0235
Loa Loa (eye worm) hypothetical protein 0.0222 0.3221 0.9504
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.002 0.0184 0.074
Loa Loa (eye worm) hypothetical protein 0.0222 0.3221 0.9504
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0016 0.0131 0.0527
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0037 0.0453 0.0453
Echinococcus granulosus BC026374 protein S09 family 0.0037 0.0453 0.0434
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0263 0.5
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.002 0.0188 0.0768
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0128 0.0128
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0874 1
Schistosoma mansoni smad 0.0016 0.0128 0.0128
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0874 0.0874
Brugia malayi TAR-binding protein 0.0201 0.2913 0.8597
Loa Loa (eye worm) hypothetical protein 0.0014 0.0094 0.022
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0024 0.0254 0.1029
Toxoplasma gondii type I fatty acid synthase, putative 0.0017 0.015 0.0941
Echinococcus granulosus tar DNA binding protein 0.0201 0.2913 0.2898
Echinococcus multilocularis BC026374 protein (S09 family) 0.0037 0.0453 0.0434
Brugia malayi MH1 domain containing protein 0.0009 0.0022 0.0065
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.0255 0.1031
Loa Loa (eye worm) hypothetical protein 0.0037 0.0453 0.1285
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.002 0.0184 0.0731
Schistosoma mansoni tar DNA-binding protein 0.0201 0.2913 0.2913
Echinococcus granulosus acetylcholinesterase 0.0222 0.3221 0.3207
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0024 0.0254 0.2251
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0024 0.0254 0.102
Mycobacterium tuberculosis Probable thioesterase TesA 0.002 0.0194 0.0791
Mycobacterium ulcerans thioesterase TesA 0.002 0.0194 0.0783
Echinococcus granulosus geminin 0.019 0.2747 0.2732
Onchocerca volvulus 0.0037 0.0453 0.7012
Entamoeba histolytica hypothetical protein 0.0035 0.0417 0.5
Loa Loa (eye worm) hypothetical protein 0.0037 0.0453 0.1285
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0024 0.0244 0.0993
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0008 0.0016 0.0063
Schistosoma mansoni smad1 5 8 and 0.0016 0.0128 0.0128
Schistosoma mansoni hypothetical protein 0.0035 0.0417 0.0417
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0014 0.0097 0.0397
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0036 0.0435 0.1774
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0024 0.0255 0.1031
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0277 0.1123
Schistosoma mansoni tar DNA-binding protein 0.0201 0.2913 0.2913
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0024 0.0254 0.1037
Mycobacterium ulcerans hypothetical protein 0.0171 0.2453 1
Brugia malayi RNA binding protein 0.0201 0.2913 0.8597
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.002 0.0194 0.0773
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0002 0.0007
Echinococcus multilocularis smad 0.0016 0.0128 0.0108
Echinococcus multilocularis cpg binding protein 0.003 0.0335 0.0315
Echinococcus multilocularis microtubule associated protein 2 0.0673 1 1
Entamoeba histolytica hypothetical protein 0.0035 0.0417 0.5
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0057 0.0037
Schistosoma mansoni tar DNA-binding protein 0.0201 0.2913 0.2913
Mycobacterium tuberculosis Probable aminotransferase 0.0171 0.2453 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.1247 0.3682
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0036 0.0435 0.1774
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0023 0.0231 0.0941
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0057 0.0037
Brugia malayi hypothetical protein 0.0035 0.0417 0.1231
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0026 0.0277 0.1131
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0263 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0417 0.0398
Entamoeba histolytica hypothetical protein 0.0035 0.0417 0.5
Schistosoma mansoni hypothetical protein 0.019 0.2747 0.2747
Echinococcus granulosus ornithine aminotransferase 0.0024 0.0254 0.0235
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0037 0.0453 0.1847
Brugia malayi MH2 domain containing protein 0.0016 0.0128 0.0379
Onchocerca volvulus 0.0037 0.0453 0.7012
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0037 0.0453 0.0453
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0024 0.0254 0.1029
Brugia malayi MH1 domain containing protein 0.0009 0.0022 0.0065
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0024 0.0244 0.0993
Echinococcus multilocularis tar DNA binding protein 0.0201 0.2913 0.2898
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.0277 0.1123
Mycobacterium leprae Probable polyketide synthase Pks1 0.0026 0.0277 0.1114
Giardia lamblia Methyltransferase like 2 0.0007 0 0.5
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0277 0.1131
Schistosoma mansoni Smad4 0.0016 0.0128 0.0128
Onchocerca volvulus Fatty acid synthase homolog 0.0044 0.0548 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0783 0.0783
Schistosoma mansoni BC026374 protein (S09 family) 0.0037 0.0453 0.0453
Mycobacterium leprae Polyketide synthase Pks13 0.0036 0.0435 0.1758
Loa Loa (eye worm) nuclear factor I 0.0009 0.0022 0.0005
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.002 0.0184 0.074
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0024 0.0254 0.1037
Entamoeba histolytica hypothetical protein 0.0035 0.0417 0.5
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0263 1
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0024 0.0255 0.0752
Schistosoma mansoni hypothetical protein 0.0011 0.0057 0.0057
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0874 0.0874
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0016 0.0131 0.0517
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0128 0.0321
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.1247 0.1247
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0417 0.0417
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0128 0.0108
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0024 0.0254 0.102
Schistosoma mansoni tar DNA-binding protein 0.0201 0.2913 0.2913
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.001 0.0038 0.0153
Loa Loa (eye worm) TAR-binding protein 0.0201 0.2913 0.8588
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0171 0.2453 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0874 0.3558
Brugia malayi Carboxylesterase family protein 0.0037 0.0453 0.1337
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0128 0.0321
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0024 0.0254 0.1029
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0037 0.0453 0.1847
Echinococcus multilocularis carboxylesterase 5A 0.0222 0.3221 0.3207
Loa Loa (eye worm) RNA binding protein 0.0201 0.2913 0.8588
Loa Loa (eye worm) carboxylesterase 0.0037 0.0453 0.1285
Schistosoma mansoni cpg binding protein 0.003 0.0335 0.0335
Loa Loa (eye worm) carboxylesterase 0.0037 0.0453 0.1285
Brugia malayi hypothetical protein 0.0016 0.0131 0.0386
Echinococcus granulosus acetylcholinesterase 0.0222 0.3221 0.3207
Mycobacterium ulcerans polyketide synthase 0.0026 0.0277 0.1123
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0024 0.0254 0.1029
Schistosoma mansoni microtubule-associated protein tau 0.0673 1 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0128 0.0108
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0874 0.0856
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0016 0.0127 0.0654
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.1247 0.1247
Brugia malayi MH1 domain containing protein 0.0016 0.0128 0.0379
Brugia malayi Carboxylesterase family protein 0.0037 0.0453 0.1337
Loa Loa (eye worm) fatty acid synthase 0.0024 0.025 0.0682
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0024 0.0254 0.5
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0874 0.3558
Brugia malayi RNA recognition motif domain containing protein 0.0201 0.2913 0.8597
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0222 0.3221 0.3221
Mycobacterium ulcerans fatty acid synthase Fas 0.0008 0.0005 0.001
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0024 0.0254 0.0254
Echinococcus multilocularis acetylcholinesterase 0.0222 0.3221 0.3207
Schistosoma mansoni smad1 5 8 and 0.0016 0.0128 0.0128
Brugia malayi Carboxylesterase family protein 0.0037 0.0453 0.1337
Onchocerca volvulus 0.0037 0.0453 0.7012
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.1247 0.1247
Loa Loa (eye worm) hypothetical protein 0.0041 0.0503 0.1433
Leishmania major hypothetical protein, conserved 0.0025 0.0263 0.3006
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0231 0.0681
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0263 0.5
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0128 0.0108
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0008 0.0005 0.0019
Loa Loa (eye worm) acetylcholinesterase 1 0.0222 0.3221 0.9504
Onchocerca volvulus 0.0037 0.0453 0.7012
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.0255 0.1031
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0026 0.0277 0.1131
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0024 0.0255 0.1022
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0417 0.0398
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0046 0.0581 0.1716
Trichomonas vaginalis spcc417.12 protein, putative 0.0037 0.0453 0.1847
Echinococcus granulosus Aminotransferase class III 0.0024 0.0254 0.0235
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0024 0.0254 0.1037
Schistosoma mansoni cpg binding protein 0.003 0.0335 0.0335
Loa Loa (eye worm) Smad1 0.0016 0.0128 0.0321
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0037 0.0453 0.0434
Loa Loa (eye worm) hypothetical protein 0.0025 0.0263 0.072
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0263 0.5
Mycobacterium tuberculosis Carboxylesterase LipT 0.0037 0.0453 0.1847
Brugia malayi Carboxylesterase family protein 0.0037 0.0453 0.1337
Echinococcus granulosus smad 0.0016 0.0128 0.0108
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0024 0.0254 0.102
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0037 0.0453 0.1847
Schistosoma mansoni neuroligin 3 (S09 family) 0.0037 0.0453 0.0453
Echinococcus multilocularis Smad4 0.0016 0.0128 0.0108
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0874 0.0856
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.0874 0.3564
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0024 0.0254 0.5
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0171 0.2453 1
Schistosoma mansoni cpg binding protein 0.0028 0.0311 0.0311
Brugia malayi hypothetical protein 0.0025 0.0263 0.0776
Onchocerca volvulus 0.0037 0.0453 0.7012
Echinococcus multilocularis para nitrobenzyl esterase 0.0037 0.0453 0.0434
Echinococcus multilocularis geminin 0.019 0.2747 0.2732
Brugia malayi MH1 domain containing protein 0.0016 0.0128 0.0379
Brugia malayi Carboxylesterase family protein 0.0222 0.3221 0.9507
Schistosoma mansoni smad1 5 8 and 0.0016 0.0128 0.0128
Loa Loa (eye worm) MH2 domain-containing protein 0.0233 0.3388 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.1247 0.123
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0019 0.0055
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0037 0.0453 0.0434
Mycobacterium ulcerans carboxylesterase, LipT 0.0037 0.0453 0.1839
Echinococcus multilocularis neuroligin 0.0037 0.0453 0.0434
Loa Loa (eye worm) hypothetical protein 0.0037 0.0453 0.1285
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0037 0.0453 0.0453
Mycobacterium ulcerans polyketide synthase Pks9 0.0016 0.0131 0.0527
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.1247 0.123
Loa Loa (eye worm) hypothetical protein 0.0037 0.0453 0.1285
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.1247 0.123
Loa Loa (eye worm) acyl carrier protein 0.0011 0.0058 0.0111
Onchocerca volvulus 0.0042 0.0525 0.9285
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0024 0.0255 0.1039
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0263 1
Mycobacterium ulcerans thioesterase 0.002 0.0194 0.0783
Loa Loa (eye worm) hypothetical protein 0.0037 0.0453 0.1285
Loa Loa (eye worm) carboxylesterase 0.0222 0.3221 0.9504
Mycobacterium ulcerans polyketide synthase 0.0024 0.0255 0.1031
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0024 0.0255 0.1022
Brugia malayi CXXC zinc finger family protein 0.0028 0.0311 0.0918
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0201 0.2913 0.8588
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0128 0.0108
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.1247 0.123

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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