Detailed information for compound 1471200

Basic information

Technical information
  • TDR Targets ID: 1471200
  • Name: 2-(4-chlorophenoxy)-N-(2-methoxyethyl)-N-(5-p yridin-3-yl-1,3,4-thiadiazol-2-yl)acetamide
  • MW: 404.871 | Formula: C18H17ClN4O3S
  • H donors: 0 H acceptors: 4 LogP: 2.83 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCN(c1nnc(s1)c1cccnc1)C(=O)COc1ccc(cc1)Cl
  • InChi: 1S/C18H17ClN4O3S/c1-25-10-9-23(16(24)12-26-15-6-4-14(19)5-7-15)18-22-21-17(27-18)13-3-2-8-20-11-13/h2-8,11H,9-10,12H2,1H3
  • InChiKey: VRWVKENXTDXPQA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(4-chlorophenoxy)-N-(2-methoxyethyl)-N-[5-(3-pyridyl)-1,3,4-thiadiazol-2-yl]acetamide
  • 2-(4-chlorophenoxy)-N-(2-methoxyethyl)-N-(5-pyridin-3-yl-1,3,4-thiadiazol-2-yl)ethanamide
  • ZINC04881604
  • ASN 05672126

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Flap structure-specific endonuclease 0.003 0.055 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0011 0.0099 0.0099
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0134 0.0134
Brugia malayi hypothetical protein 0.0011 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0011 0.0099 0.0099
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0134 0.0134
Trichomonas vaginalis conserved hypothetical protein 0.0228 0.5166 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0099 0.0099
Echinococcus multilocularis neuropeptide Y receptor 0.0011 0.0099 0.0099
Plasmodium falciparum lysophospholipase, putative 0.0228 0.5166 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0099 0.0099
Mycobacterium tuberculosis Possible lysophospholipase 0.0228 0.5166 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0889 0.1451
Loa Loa (eye worm) hypothetical protein 0.0011 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0011 0.0099 0.0099
Trypanosoma cruzi amidase, putative 0.0053 0.1074 0.1821
Brugia malayi Protein C20orf22 0.0013 0.0163 0.0163
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0099 0.0099
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0011 0.0099 0.0099
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0134 0.0134
Echinococcus multilocularis fmrfamide receptor 0.0011 0.0099 0.0099
Plasmodium vivax PST-A protein 0.0228 0.5166 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0099 0.0099
Echinococcus multilocularis monoacylglycerol lipase abhd12 0.0013 0.0163 0.0163
Echinococcus granulosus serotonin receptor 0.0011 0.0099 0.0099
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0134 0.0134
Echinococcus granulosus neuropeptide receptor 0.0011 0.0099 0.0099
Echinococcus granulosus 7TM GPCR rhodopsin 0.0011 0.0099 0.0099
Schistosoma mansoni neuropeptide receptor 0.0011 0.0099 0.0099
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.0053 0.1074 0.1821
Loa Loa (eye worm) hypothetical protein 0.0011 0.0099 0.0099
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0134 0.0134
Loa Loa (eye worm) flap endonuclease-1 0.003 0.055 0.055
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0099 0.0099
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0099 0.0099
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0099 0.0099
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.0099 0.0099
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0134 0.0134
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0134 0.0134
Brugia malayi ORL1-like opioid receptor 0.0011 0.0099 0.0099
Brugia malayi G protein-coupled receptor F59B2.13 0.0011 0.0099 0.0099
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0889 0.1451
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0134 0.0134
Schistosoma mansoni flap endonuclease-1 0.0027 0.0483 0.0483
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0228 0.5166 1
Echinococcus granulosus fmrfamide receptor 0.0011 0.0099 0.0099
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0099 0.0099
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0134 0.0134
Echinococcus granulosus hypothetical protein 0.0011 0.0099 0.0099
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0134 0.0134
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0134 0.0134
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.003 0.055 0.5326
Loa Loa (eye worm) hypothetical protein 0.0011 0.0099 0.0099
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0011 0.0099 0.0099
Echinococcus granulosus monoacylglycerol lipase abhd12 0.0013 0.0163 0.0163
Leishmania major flap endonuclease-1 (FEN-1), putative 0.003 0.055 0.0773
Brugia malayi G-protein coupled receptor 0.0011 0.0099 0.0099
Schistosoma mansoni hypothetical protein 0.0011 0.0099 0.0099
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0889 0.0889
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0379 0.0432
Echinococcus granulosus fatty acid amide hydrolase 1 0.0436 1 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0134 0.0134
Echinococcus multilocularis g-protein coupled receptor 0.0011 0.0099 0.0099
Echinococcus granulosus sex peptide receptor 0.0011 0.0099 0.0099
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0228 0.5166 1
Mycobacterium ulcerans peptide amidase, GatA 0.0053 0.1074 0.1821
Mycobacterium ulcerans hypothetical protein 0.0228 0.5166 1
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0053 0.1074 0.1821
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0889 0.1451
Loa Loa (eye worm) hypothetical protein 0.0013 0.0163 0.0163
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0011 0.0099 0.0099
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0134 0.0134
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0379 0.5582
Mycobacterium ulcerans lysophospholipase 0.0228 0.5166 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0099 0.0099
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1137 0.1137
Brugia malayi Amidase family protein 0.0053 0.1074 0.1074
Schistosoma mansoni biogenic amine (5HT) receptor 0.0011 0.0099 0.0099
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.0099 0.0099
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0379 0.0432
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0379 0.0379
Echinococcus granulosus neuropeptide FF receptor 2 0.0011 0.0099 0.0099
Schistosoma mansoni amine GPCR 0.0011 0.0099 0.0099
Loa Loa (eye worm) neuropeptide F receptor 0.0011 0.0099 0.0099
Brugia malayi Tachykinin-like peptides receptor 99D 0.0011 0.0099 0.0099
Brugia malayi putative neuropeptide receptor 0.0011 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0011 0.0099 0.0099
Brugia malayi putative neuropeptide receptor NPR1 0.0011 0.0099 0.0099
Schistosoma mansoni hypothetical protein 0.0011 0.0099 0.0099
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0134 0.0134
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0099 0.0099
Trypanosoma brucei monoglyceride lipase, putative 0.0228 0.5166 1
Mycobacterium tuberculosis Possible amidase (aminohydrolase) 0.0053 0.1074 0.1821
Brugia malayi hypothetical protein 0.0011 0.0099 0.0099
Brugia malayi Melatonin receptor type 1A 0.0011 0.0099 0.0099
Wolbachia endosymbiont of Brugia malayi aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0053 0.1074 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0011 0.0099 0.0099
Brugia malayi RE15519p 0.0011 0.0099 0.0099
Brugia malayi hypothetical protein 0.0011 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0012 0.0134 0.0134
Echinococcus granulosus G protein coupled receptor 139 0.0011 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0012 0.0134 0.0134
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0134 0.0134
Mycobacterium leprae PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) 0.0053 0.1074 0.067
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0134 0.0134
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0134 0.0116
Loa Loa (eye worm) hypothetical protein 0.0141 0.3143 0.3143
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0011 0.0099 0.0099
Brugia malayi Dopamine receptor protein 2 0.0011 0.0099 0.0099
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.1137 0.1137
Plasmodium falciparum lysophospholipase, putative 0.0228 0.5166 1
Brugia malayi nuclear hormone receptor 0.0012 0.0134 0.0134
Brugia malayi hypothetical protein 0.0011 0.0099 0.0099
Echinococcus granulosus g-protein coupled receptor 0.0011 0.0099 0.0099
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0099 0.0099
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0889 0.0889
Brugia malayi Dopamine receptor protein 1 0.0011 0.0099 0.0099
Schistosoma mansoni opsin-like receptor 0.0011 0.0099 0.0099
Brugia malayi Dopamine receptor 0.0011 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0011 0.0099 0.0099
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0011 0.0099 0.0099
Leishmania major monoglyceride lipase, putative 0.0228 0.5166 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0099 0.0099
Echinococcus granulosus somatostatin receptor 0.0011 0.0099 0.0099
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0379 0.0432
Plasmodium vivax glutamyl-tRNA(Gln) amidotransferase subunit A, putative 0.0053 0.1074 0.1821
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0379 0.0432
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0134 0.0134
Echinococcus granulosus biogenic amine 5HT receptor 0.0011 0.0099 0.0099
Brugia malayi Amidase family protein 0.0053 0.1074 0.1074
Loa Loa (eye worm) amidase 0.0053 0.1074 0.1074
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1137 0.1137
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0011 0.0099 0.0099
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0012 0.0134 0.0134
Schistosoma mansoni amidase 0.0436 1 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0011 0.0099 0.0099
Brugia malayi hypothetical protein 0.0011 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0011 0.0099 0.0099
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0013 0.0163 0.0163
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0134 0.0134
Echinococcus multilocularis neuropeptide Y receptor 0.0011 0.0099 0.0099
Echinococcus multilocularis allatostatin A receptor 0.0011 0.0099 0.0099
Plasmodium falciparum esterase, putative 0.0228 0.5166 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0228 0.5166 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0099 0.0099
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0099 0.0099
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0228 0.5166 1
Brugia malayi steroid hormone receptor 0.0012 0.0134 0.0134
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.003 0.055 0.0773
Schistosoma mansoni neuropeptide receptor 0.0011 0.0099 0.0099
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0134 0.0134
Echinococcus granulosus neuropeptides capa receptor 0.0011 0.0099 0.0099
Mycobacterium ulcerans amidase 0.0053 0.1074 0.1821
Schistosoma mansoni fatty-acid amide hydrolase 0.0053 0.1074 0.1074
Schistosoma mansoni amine GPCR 0.0011 0.0099 0.0099
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0099 0.0099
Echinococcus granulosus g protein coupled receptor 0.0011 0.0099 0.0099
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0134 0.0134
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0134 0.0134
Brugia malayi larval opioid receptor 0.0011 0.0099 0.0099
Trypanosoma cruzi amidase, putative 0.0053 0.1074 0.1821
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0011 0.0099 0.0099
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0889 0.734
Trypanosoma brucei monoglyceride lipase, putative 0.0228 0.5166 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0099 0.0099
Echinococcus multilocularis neuropeptides capa receptor 0.0011 0.0099 0.0099
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0011 0.0099 0.0099
Echinococcus granulosus neuropeptide receptor 0.0011 0.0099 0.0099
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0436 1 1
Echinococcus granulosus allatostatin A receptor 0.0011 0.0099 0.0099
Schistosoma mansoni hypothetical protein 0.0195 0.4405 0.4405
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0134 0.0134
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0013 0.0163 0.0163
Schistosoma mansoni myosin xvIII 0.0011 0.0099 0.0099
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0134 0.0134
Loa Loa (eye worm) inositol-1 0.0045 0.0889 0.0889
Echinococcus multilocularis serotonin receptor 0.0011 0.0099 0.0099
Leishmania major hypothetical protein, conserved 0.0053 0.1074 0.1821
Echinococcus granulosus geminin 0.0195 0.4405 0.4405
Trichomonas vaginalis conserved hypothetical protein 0.0228 0.5166 1
Mycobacterium ulcerans aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0053 0.1074 0.1821
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.0099 0.0099
Trypanosoma cruzi monoglyceride lipase, putative 0.0228 0.5166 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0099 0.0099
Echinococcus multilocularis neuropeptides capa receptor 0.0011 0.0099 0.0099
Schistosoma mansoni hypothetical protein 0.0011 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0011 0.0099 0.0099
Schistosoma mansoni neuropeptide receptor 0.0011 0.0099 0.0099
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0099 0.0099
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0011 0.0099 0.0099
Echinococcus multilocularis g protein coupled receptor 0.0011 0.0099 0.0099
Brugia malayi hypothetical protein 0.0141 0.3143 0.3143
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.0099 0.0099
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0011 0.0099 0.0099
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0011 0.0099 0.0099
Schistosoma mansoni biogenic amine (5HT) receptor 0.0011 0.0099 0.0099
Schistosoma mansoni neuropeptide F-like receptor 0.0011 0.0099 0.0099
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0889 0.1451
Plasmodium vivax flap endonuclease 1, putative 0.003 0.055 0.0773
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0134 0.0134
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0379 0.0379
Echinococcus multilocularis G-protein coupled receptor, putative 0.0011 0.0099 0.0099
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.0099 0.0099
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0228 0.5166 1
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.003 0.055 0.0773
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0011 0.0099 0.0099
Loa Loa (eye worm) TYRA-2 protein 0.0011 0.0099 0.0099
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0228 0.5166 1
Schistosoma mansoni biogenic amine receptor 0.0011 0.0099 0.0099
Loa Loa (eye worm) amidase 0.0053 0.1074 0.1074
Loa Loa (eye worm) G-protein coupled receptor 0.0011 0.0099 0.0099
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0013 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0011 0.0099 0.0099
Brugia malayi hypothetical protein 0.0011 0.0099 0.0099
Echinococcus granulosus fatty acid amide hydrolase 1 0.0436 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0099 0.0099
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0099 0.0099
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0889 0.1451
Schistosoma mansoni inositol monophosphatase 0.0045 0.0889 0.0889
Echinococcus granulosus biogenic amine 5HT receptor 0.0011 0.0099 0.0099
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0011 0.0099 0.0099
Mycobacterium tuberculosis Probable amidase AmiA2 (aminohydrolase) 0.0053 0.1074 0.1821
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0053 0.1074 0.1074
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0011 0.0099 0.0099
Echinococcus granulosus neuropeptide s receptor 0.0011 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0011 0.0099 0.0099
Plasmodium falciparum flap endonuclease 1 0.003 0.055 0.0773
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.0099 0.0099
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0013 0.0163 0.0163
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0099 0.0099
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0889 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0134 0.0134
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0134 0.0134
Schistosoma mansoni peptidase 0.0013 0.0163 0.0163
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0889 0.1451
Schistosoma mansoni inositol monophosphatase 0.0045 0.0889 0.0889
Loa Loa (eye worm) hypothetical protein 0.0011 0.0099 0.0099
Schistosoma mansoni ap endonuclease 0.0023 0.0379 0.0379
Echinococcus multilocularis neuropeptide s receptor 0.0011 0.0099 0.0099
Brugia malayi Inositol-1 0.0045 0.0889 0.0889
Loa Loa (eye worm) hypothetical protein 0.0011 0.0099 0.0099
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0011 0.0099 0.0099
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0379 0.0432
Loa Loa (eye worm) hypothetical protein 0.0011 0.0099 0.0099
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0011 0.0099 0.0099
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0011 0.0099 0.0099
Echinococcus multilocularis orexin receptor type 2 0.0011 0.0099 0.0099
Mycobacterium ulcerans amidase 0.0053 0.1074 0.1821
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0099 0.0099
Mycobacterium ulcerans amidase 0.0053 0.1074 0.1821
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0134 0.0134
Brugia malayi hypothetical protein 0.0011 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0011 0.0099 0.0099
Mycobacterium tuberculosis Probable amidase AmiC (aminohydrolase) 0.0053 0.1074 0.1821
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1137 0.1137
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0228 0.5166 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0011 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0011 0.0099 0.0099
Schistosoma mansoni hypothetical protein 0.0195 0.4405 0.4405
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0011 0.0099 0.0099
Echinococcus multilocularis G protein coupled receptor 139 0.0011 0.0099 0.0099
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0134 0.0134
Schistosoma mansoni neuropeptide receptor 0.0011 0.0099 0.0099
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.078 0.1234
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0134 0.0134
Echinococcus granulosus abhydrolase domain containing 3 0.0013 0.0163 0.0163
Mycobacterium leprae PROBABLE AMIDASE AMIC (AMINOHYDROLASE) 0.0053 0.1074 0.067
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0379 0.0432
Loa Loa (eye worm) hypothetical protein 0.0011 0.0099 0.0099
Echinococcus multilocularis geminin 0.0195 0.4405 0.4405
Echinococcus multilocularis g protein coupled receptor 0.0011 0.0099 0.0099
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0889 0.1451
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0011 0.0099 0.0099
Mycobacterium ulcerans amidase 0.0053 0.1074 0.1821
Echinococcus multilocularis neuropeptide receptor A26 0.0011 0.0099 0.0099
Echinococcus multilocularis g protein coupled receptor 0.0011 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0011 0.0099 0.0099
Brugia malayi sulfakinin receptor protein 0.0011 0.0099 0.0099
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0889 0.1451
Loa Loa (eye worm) hypothetical protein 0.0013 0.0163 0.0163
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0011 0.0099 0.0099
Echinococcus multilocularis abhydrolase domain containing 3 0.0013 0.0163 0.0163
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0099 0.0099
Schistosoma mansoni biogenic amine receptor 0.0011 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0011 0.0099 0.0099
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0011 0.0099 0.0099
Echinococcus multilocularis neuropeptide FF receptor 2 0.0011 0.0099 0.0099
Echinococcus multilocularis neuropeptide receptor 0.0011 0.0099 0.0099
Echinococcus multilocularis sex peptide receptor 0.0011 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0011 0.0099 0.0099
Brugia malayi neuropeptide F receptor 0.0011 0.0099 0.0099
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0011 0.0099 0.0099
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0379 0.0432
Echinococcus multilocularis Phospholipase carboxylesterase 0.0013 0.0163 0.0163
Echinococcus granulosus neuropeptides capa receptor 0.0011 0.0099 0.0099
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0134 0.0134
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0099 0.0099
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0134 0.0134
Entamoeba histolytica Flap nuclease, putative 0.003 0.055 0.0773
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0134 0.0134
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1137 0.1137
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0011 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0011 0.0099 0.0099
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0134 0.0134
Schistosoma mansoni biogenic amine receptor 0.0011 0.0099 0.0099
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.0053 0.1074 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0099 0.0099
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0012 0.0134 0.0134
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0099 0.0099
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.0099 0.0099
Toxoplasma gondii exonuclease III APE 0.0023 0.0379 0.2973
Loa Loa (eye worm) hypothetical protein 0.0012 0.0134 0.0134
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1137 0.1137
Loa Loa (eye worm) melatonin receptor type 1A 0.0011 0.0099 0.0099
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0134 0.0134
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0011 0.0099 0.0099
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0379 0.0379
Schistosoma mansoni adenoreceptor 0.0011 0.0099 0.0099
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0011 0.0099 0.0099
Schistosoma mansoni opsin-like receptor 0.0011 0.0099 0.0099
Brugia malayi Serotonin receptor 0.0011 0.0099 0.0099
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0134 0.0134
Echinococcus granulosus orexin receptor type 2 0.0011 0.0099 0.0099
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0379 0.0432
Brugia malayi putative amidase 0.0053 0.1074 0.1074
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0011 0.0099 0.0099
Schistosoma mansoni histamine h1 receptor 0.0011 0.0099 0.0099
Schistosoma mansoni opsin-like receptor 0.0011 0.0099 0.0099
Schistosoma mansoni coup transcription factor 0.0012 0.0134 0.0134
Schistosoma mansoni neuropeptide F-like receptor 0.0011 0.0099 0.0099
Loa Loa (eye worm) G-protein coupled receptor 0.0011 0.0099 0.0099
Mycobacterium ulcerans amidase 0.0053 0.1074 0.1821
Brugia malayi ecdysteroid receptor 0.0012 0.0134 0.0134
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0011 0.0099 0.0099
Plasmodium falciparum lysophospholipase, putative 0.0228 0.5166 1
Brugia malayi nuclear receptor NHR-88 0.0012 0.0134 0.0134
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0011 0.0099 0.0099
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0099 0.0099
Mycobacterium tuberculosis Probable amidase AmiB2 (aminohydrolase) 0.0053 0.1074 0.1821
Schistosoma mansoni ap endonuclease 0.0023 0.0379 0.0379
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0228 0.5166 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0379 0.0432
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0011 0.0099 0.0099
Mycobacterium tuberculosis Probable amidase AmiD (acylamidase) (acylase) 0.0053 0.1074 0.1821
Loa Loa (eye worm) hypothetical protein 0.0011 0.0099 0.0099
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0011 0.0099 0.0099
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0011 0.0099 0.0099
Schistosoma mansoni alpha-1 adrenergic receptor 0.0011 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0011 0.0099 0.0099
Brugia malayi follicle stimulating hormone receptor 0.0011 0.0099 0.0099
Echinococcus granulosus peptide allatostatin:somatostatin 0.0011 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0011 0.0099 0.0099
Schistosoma mansoni amine GPCR 0.0011 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0011 0.0099 0.0099
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0053 0.1074 0.1074
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0011 0.0099 0.0099
Schistosoma mansoni fatty-acid amide hydrolase 0.0436 1 1
Echinococcus granulosus fatty acid amide hydrolase 1 0.0053 0.1074 0.1074
Brugia malayi G protein-coupled receptor 0.0011 0.0099 0.0099
Onchocerca volvulus Huntingtin homolog 0.0141 0.3143 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0011 0.0099 0.0099
Brugia malayi G-protein coupled receptor 0.0011 0.0099 0.0099
Onchocerca volvulus 0.0012 0.0134 0.0116
Loa Loa (eye worm) hypothetical protein 0.0011 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0011 0.0099 0.0099
Echinococcus multilocularis serotonin receptor 0.0011 0.0099 0.0099
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0099 0.0099
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.1137 0.1137
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0134 0.0134
Brugia malayi AKH receptor 0.0011 0.0099 0.0099
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0889 0.1451
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0134 0.0134
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0011 0.0099 0.0099
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0134 0.0134
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0134 0.0134
Echinococcus multilocularis neuropeptide receptor 0.0011 0.0099 0.0099
Brugia malayi hypothetical protein 0.0011 0.0099 0.0099
Echinococcus multilocularis dro:myosuppressin receptor 0.0011 0.0099 0.0099
Echinococcus multilocularis fmrfamide receptor 0.0011 0.0099 0.0099
Schistosoma mansoni amine GPCR 0.0011 0.0099 0.0099
Echinococcus granulosus g protein coupled receptor 0.0011 0.0099 0.0099
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0134 0.0134
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0228 0.5166 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0011 0.0099 0.0099
Brugia malayi hypothetical protein 0.0011 0.0099 0.0099
Brugia malayi Flap endonuclease-1 0.003 0.055 0.055
Echinococcus multilocularis somatostatin receptor 0.0011 0.0099 0.0099
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.0099 0.0099
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0134 0.0134
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0379 0.0432
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0379 0.0432
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0379 0.0379
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0013 0.0163 0.0163
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0011 0.0099 0.0099
Echinococcus granulosus dro:myosuppressin receptor 0.0011 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0011 0.0099 0.0099
Echinococcus granulosus Phospholipase carboxylesterase 0.0013 0.0163 0.0163
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0134 0.0134
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0134 0.0134
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0011 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0012 0.0134 0.0134
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0134 0.0134
Echinococcus granulosus neuropeptide Y receptor 0.0011 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0012 0.0134 0.0134
Schistosoma mansoni hypothetical protein 0.0011 0.0099 0.0099
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0099 0.0099
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1137 0.1137
Loa Loa (eye worm) hypothetical protein 0.0011 0.0099 0.0099
Trichomonas vaginalis flap endonuclease-1, putative 0.003 0.055 0.0773
Loa Loa (eye worm) neuropeptide F receptor 0.0011 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0141 0.3143 0.3143
Loa Loa (eye worm) hypothetical protein 0.0011 0.0099 0.0099
Treponema pallidum aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0053 0.1074 1
Echinococcus granulosus abhydrolase domain containing protein 13 0.0013 0.0163 0.0163
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0011 0.0099 0.0099
Brugia malayi Serotonin receptor 0.0011 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0011 0.0099 0.0099
Brugia malayi hypothetical protein 0.0011 0.0099 0.0099
Echinococcus granulosus neuropeptide Y receptor 0.0011 0.0099 0.0099
Brugia malayi GnHR receptor homolog 0.0011 0.0099 0.0099
Schistosoma mansoni amine GPCR 0.0011 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0011 0.0099 0.0099
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0011 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0436 1 1
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0436 1 1
Echinococcus granulosus g protein coupled receptor 0.0011 0.0099 0.0099
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0134 0.0134
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0053 0.1074 0.1074
Brugia malayi neuropeptide F receptor 0.0011 0.0099 0.0099
Echinococcus multilocularis flap endonuclease 1 0.003 0.055 0.055
Echinococcus granulosus tachykinin peptides receptor 99D 0.0011 0.0099 0.0099
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0134 0.0134
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0053 0.1074 0.1074
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0134 0.0116
Brugia malayi MGC83647 protein 0.0013 0.0163 0.0163
Onchocerca volvulus Huntingtin homolog 0.0141 0.3143 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0099 0.0099
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1137 0.1137
Loa Loa (eye worm) hypothetical protein 0.0012 0.0134 0.0134
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0011 0.0099 0.0099
Brugia malayi MGC79044 protein 0.0013 0.0163 0.0163
Schistosoma mansoni growth hormone secretagogue receptor 0.0011 0.0099 0.0099
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0134 0.0134
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0134 0.0116
Echinococcus granulosus 7tm_1 domain containing protein 0.0011 0.0099 0.0099
Echinococcus granulosus neuropeptide receptor A26 0.0011 0.0099 0.0099
Echinococcus granulosus flap endonuclease 1 0.003 0.055 0.055

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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