Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | carboxylesterase | 0.0024 | 0.0336 | 0.1049 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.079 | 0.2558 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1077 | 0.3756 |
Schistosoma mansoni | gliotactin | 0.0024 | 0.0336 | 0.0321 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.023 | 0.0215 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0069 | 0.1249 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.023 | 0.0215 |
Onchocerca volvulus | 0.0024 | 0.0336 | 0.3867 | |
Schistosoma mansoni | cpg binding protein | 0.0039 | 0.064 | 0.0625 |
Trypanosoma brucei | ISWI complex protein | 0.0018 | 0.0218 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0074 | 0.1362 | 0.1349 |
Brugia malayi | Plexin repeat family protein | 0.0018 | 0.02 | 0.0361 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0024 | 0.0336 | 0.0321 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0024 | 0.0336 | 0.0321 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0021 | 0.0277 | 0.0834 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0024 | 0.0336 | 0.0321 |
Brugia malayi | Carboxylesterase family protein | 0.0024 | 0.0336 | 0.0867 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0143 | 0.2785 | 0.2774 |
Onchocerca volvulus | 0.0024 | 0.0336 | 0.3867 | |
Brugia malayi | plexin A | 0.0021 | 0.0267 | 0.0608 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0024 | 0.0336 | 0.0321 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.023 | 0.0215 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0074 | 0.1362 | 0.1349 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.023 | 0.0472 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.02 | 0.0553 |
Schistosoma mansoni | plexin | 0.001 | 0.0049 | 0.0034 |
Echinococcus granulosus | acetylcholinesterase | 0.0143 | 0.2785 | 0.2774 |
Loa Loa (eye worm) | carboxylesterase | 0.0143 | 0.2785 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.2785 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.2785 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0059 | 0.0044 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0024 | 0.0336 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0024 | 0.0336 | 0.0867 |
Onchocerca volvulus | 0.0035 | 0.0552 | 1 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0143 | 0.2785 | 0.2774 |
Echinococcus granulosus | zinc finger protein | 0.0026 | 0.0365 | 0.035 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0792 | 0.2713 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.023 | 0.0215 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0024 | 0.0336 | 0.0321 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0074 | 0.1352 | 0.1338 |
Onchocerca volvulus | 0.0024 | 0.0336 | 0.3867 | |
Echinococcus multilocularis | zinc finger protein | 0.0026 | 0.0365 | 0.035 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0024 | 0.0336 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0336 | 0.1049 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0024 | 0.0336 | 0.0321 |
Echinococcus multilocularis | neuroligin | 0.0024 | 0.0336 | 0.0321 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0939 | 0.325 |
Brugia malayi | CXXC zinc finger family protein | 0.0035 | 0.0552 | 0.1671 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0024 | 0.0336 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0018 | 0.0218 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0093 | 0.1742 | 0.611 |
Echinococcus granulosus | acetylcholinesterase | 0.0143 | 0.2785 | 0.2774 |
Trypanosoma cruzi | ISWI complex protein | 0.0018 | 0.0218 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.023 | 0.0662 |
Echinococcus granulosus | carboxylesterase 5A | 0.0143 | 0.2785 | 0.2774 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0143 | 0.2785 | 0.2774 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.085 | 0.2928 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0024 | 0.0336 | 0.0321 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0143 | 0.2785 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0024 | 0.0336 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0336 | 0.1049 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0685 | 0.067 |
Brugia malayi | Carboxylesterase family protein | 0.0143 | 0.2785 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0351 | 0.0336 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.023 | 0.0215 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0035 | 0.0552 | 0.1837 |
Echinococcus granulosus | cpg binding protein | 0.0039 | 0.064 | 0.0625 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0336 | 0.1049 |
Onchocerca volvulus | 0.0024 | 0.0336 | 0.3867 | |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0021 | 0.0262 | 0.0247 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0021 | 0.0262 | 0.0247 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0021 | 0.0278 | 0.0262 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.023 | 0.0215 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0024 | 0.0336 | 0.0321 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.023 | 0.0215 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0021 | 0.0278 | 0.0262 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0021 | 0.0262 | 0.0247 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0336 | 0.1049 |
Schistosoma mansoni | bromodomain containing protein | 0.0078 | 0.1451 | 0.1438 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0024 | 0.0336 | 0.0321 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.1595 | 0.5651 |
Schistosoma mansoni | plexin | 0.0018 | 0.02 | 0.0185 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0336 | 0.1049 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0024 | 0.0336 | 0.0321 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0494 | 1 | 1 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0029 | 0.0439 | 0.0424 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0059 | 0.0044 |
Echinococcus multilocularis | cpg binding protein | 0.0039 | 0.064 | 0.0625 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.023 | 0.0215 |
Brugia malayi | Carboxylesterase family protein | 0.0024 | 0.0336 | 0.0867 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.023 | 0.0472 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.0731 | 0.0717 |
Echinococcus granulosus | plexin a4 | 0.0021 | 0.0267 | 0.0252 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0336 | 0.0867 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0029 | 0.0439 | 0.0424 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0024 | 0.0336 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0039 | 0.064 | 0.0625 |
Echinococcus multilocularis | acetylcholinesterase | 0.0143 | 0.2785 | 0.2774 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.023 | 0.0215 |
Schistosoma mansoni | zinc finger protein | 0.0018 | 0.0218 | 0.0203 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0024 | 0.0336 | 0.5 |
Schistosoma mansoni | zinc finger protein | 0.0026 | 0.0365 | 0.035 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.0731 | 0.0717 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0685 | 0.2167 |
Trypanosoma cruzi | ISWI complex protein | 0.0018 | 0.0218 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.1077 | 0.3629 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0336 | 0.1049 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0025 | 0.0351 | 0.1103 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0685 | 0.2324 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.023 | 0.0662 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.1077 | 0.3629 |
Echinococcus multilocularis | plexin a4 | 0.0021 | 0.0267 | 0.0252 |
Brugia malayi | Carboxylesterase family protein | 0.0143 | 0.2785 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0024 | 0.0336 | 0.0867 |
Loa Loa (eye worm) | histone methyltransferase | 0.0011 | 0.0059 | 0.0036 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.023 | 0.0215 |
Onchocerca volvulus | 0.0024 | 0.0336 | 0.3867 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0024 | 0.0336 | 0.0321 |
Schistosoma mansoni | hypothetical protein | 0.001 | 0.0049 | 0.0034 |
Echinococcus granulosus | neuroligin | 0.0024 | 0.0336 | 0.0321 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.1077 | 0.3756 |
Loa Loa (eye worm) | plexin A | 0.0021 | 0.0267 | 0.0795 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.0552 | 0.0537 |
Brugia malayi | PHD-finger family protein | 0.0032 | 0.0498 | 0.147 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0278 | 0.0835 |
Schistosoma mansoni | acetylcholinesterase | 0.0024 | 0.0336 | 0.0321 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0336 | 0.1049 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0021 | 0.0278 | 0.0262 |
Schistosoma mansoni | hypothetical protein | 0.0494 | 1 | 1 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0021 | 0.0278 | 0.0262 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0021 | 0.0262 | 0.0247 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0218 | 0.0203 |
Loa Loa (eye worm) | carboxylesterase | 0.0024 | 0.0336 | 0.1049 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0029 | 0.0439 | 0.0424 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.