Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.2107 | 0.0973 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.3485 | 1 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.2107 | 0.0973 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.3485 | 1 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.3485 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3485 | 1 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.3485 | 1 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.3485 | 1 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.3485 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.1959 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.3485 | 1 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.3485 | 1 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.3485 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3485 | 1 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.3485 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 11.2 % | Inhibition of human alphaVbeta3 receptor expressed in african green monkey Vero E6 cells assessed as inhibition of SNV infection in cells at 1 uM by immunofluorescent assay | ChEMBL. | 20951038 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.