Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon receptor | 477 aa | 457 aa | 25.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.4702 | 1 | 1 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0794 | 0.1339 | 0.1339 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0794 | 0.1339 | 0.1339 |
Brugia malayi | Carboxylesterase family protein | 0.0794 | 0.1339 | 0.1339 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0794 | 0.1339 | 0.2407 |
Echinococcus granulosus | acetylcholinesterase | 0.4702 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.019 | 0 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0794 | 0.1339 | 0.5 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0794 | 0.1339 | 0.1339 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.019 | 0 | 0.5 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.019 | 0 | 0.5 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.019 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0794 | 0.1339 | 0.1339 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0794 | 0.1339 | 0.1339 |
Loa Loa (eye worm) | carboxylesterase | 0.0794 | 0.1339 | 0.1339 |
Loa Loa (eye worm) | hypothetical protein | 0.4702 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0794 | 0.1339 | 0.1339 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.019 | 0 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.4702 | 1 | 1 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.2701 | 0.5564 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0794 | 0.1339 | 0.1339 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0794 | 0.1339 | 0.1339 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0794 | 0.1339 | 0.1339 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0794 | 0.1339 | 0.1339 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.2701 | 0.5564 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0794 | 0.1339 | 0.1339 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0794 | 0.1339 | 0.1339 |
Schistosoma mansoni | gliotactin | 0.0794 | 0.1339 | 0.1339 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.019 | 0 | 0.5 |
Schistosoma mansoni | acetylcholinesterase | 0.0794 | 0.1339 | 0.1339 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0794 | 0.1339 | 0.2604 |
Loa Loa (eye worm) | hypothetical protein | 0.4702 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.019 | 0 | 0.5 |
Onchocerca volvulus | 0.0794 | 0.1339 | 1 | |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.019 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0794 | 0.1339 | 0.1339 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0794 | 0.1339 | 0.1339 |
Loa Loa (eye worm) | hypothetical protein | 0.0794 | 0.1339 | 0.1339 |
Echinococcus multilocularis | acetylcholinesterase | 0.4702 | 1 | 1 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.251 | 0.5143 | 1 |
Brugia malayi | hypothetical protein | 0.0794 | 0.1339 | 0.1339 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0794 | 0.1339 | 0.1339 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.019 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0794 | 0.1339 | 0.1339 |
Loa Loa (eye worm) | carboxylesterase | 0.4702 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.4702 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.4702 | 1 | 1 |
Onchocerca volvulus | 0.0794 | 0.1339 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0794 | 0.1339 | 0.1339 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.019 | 0 | 0.5 |
Echinococcus multilocularis | neuroligin | 0.0794 | 0.1339 | 0.1339 |
Onchocerca volvulus | 0.0794 | 0.1339 | 1 | |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.019 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.4702 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0794 | 0.1339 | 0.2604 |
Echinococcus multilocularis | acetylcholinesterase | 0.4702 | 1 | 1 |
Onchocerca volvulus | 0.0794 | 0.1339 | 1 | |
Echinococcus granulosus | neuroligin | 0.0794 | 0.1339 | 0.1339 |
Echinococcus granulosus | carboxylesterase 5A | 0.4702 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0794 | 0.1339 | 0.1339 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0794 | 0.1339 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0794 | 0.1339 | 0.2604 |
Onchocerca volvulus | 0.0794 | 0.1339 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0794 | 0.1339 | 0.1339 |
Loa Loa (eye worm) | hypothetical protein | 0.0794 | 0.1339 | 0.1339 |
Leishmania major | UDP-galactopyranose mutase | 0.019 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0794 | 0.1339 | 0.1339 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | Antagonist activity at human GCGR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation | ChEMBL. | 21147532 | |
IC50 (binding) | = 250 nM | Displacement of [125I]glucagon from human GCGR expressed in CHO cells | ChEMBL. | 21147532 |
Inhibition (functional) | = 46 % | Antagonist activity at human GIPR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation at 10 uM | ChEMBL. | 21147532 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.