Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon receptor | 477 aa | 457 aa | 25.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0236 | 0 | 0.5 |
Onchocerca volvulus | 0.0672 | 0.1164 | 1 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0672 | 0.1164 | 0.1509 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.312 | 0.7714 | 1 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0236 | 0 | 0.5 |
Schistosoma mansoni | acetylcholinesterase | 0.0672 | 0.1164 | 0.1164 |
Onchocerca volvulus | 0.0672 | 0.1164 | 1 | |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0236 | 0 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0672 | 0.1164 | 0.1509 |
Loa Loa (eye worm) | hypothetical protein | 0.0672 | 0.1164 | 0.1164 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0236 | 0 | 0.5 |
Echinococcus granulosus | neuroligin | 0.0672 | 0.1164 | 0.1164 |
Loa Loa (eye worm) | hypothetical protein | 0.0672 | 0.1164 | 0.1164 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0672 | 0.1164 | 0.1164 |
Loa Loa (eye worm) | carboxylesterase | 0.0672 | 0.1164 | 0.1164 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0672 | 0.1164 | 0.1164 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.3356 | 0.8346 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0672 | 0.1164 | 0.1164 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0672 | 0.1164 | 0.1164 |
Brugia malayi | Carboxylesterase family protein | 0.0672 | 0.1164 | 0.1164 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.3975 | 1 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0672 | 0.1164 | 0.1164 |
Brugia malayi | Carboxylesterase family protein | 0.0672 | 0.1164 | 0.1164 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0236 | 0 | 0.5 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0672 | 0.1164 | 0.1164 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0672 | 0.1164 | 0.1164 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0672 | 0.1164 | 0.1164 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0672 | 0.1164 | 0.1509 |
Plasmodium vivax | hypothetical protein, conserved | 0.0236 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3975 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0672 | 0.1164 | 0.1164 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0236 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0672 | 0.1164 | 0.1164 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0672 | 0.1164 | 0.1395 |
Echinococcus granulosus | acetylcholinesterase | 0.3975 | 1 | 1 |
Onchocerca volvulus | 0.0672 | 0.1164 | 1 | |
Loa Loa (eye worm) | carboxylesterase | 0.3975 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.3975 | 1 | 1 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.3356 | 0.8346 | 1 |
Onchocerca volvulus | 0.0672 | 0.1164 | 1 | |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0236 | 0 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0672 | 0.1164 | 0.5 |
Schistosoma mansoni | gliotactin | 0.0672 | 0.1164 | 0.1164 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0672 | 0.1164 | 0.1164 |
Loa Loa (eye worm) | hypothetical protein | 0.0672 | 0.1164 | 0.1164 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0672 | 0.1164 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.3975 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0236 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0672 | 0.1164 | 0.1164 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0236 | 0 | 0.5 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0236 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0672 | 0.1164 | 0.1164 |
Onchocerca volvulus | 0.0672 | 0.1164 | 1 | |
Echinococcus multilocularis | neuroligin | 0.0672 | 0.1164 | 0.1164 |
Loa Loa (eye worm) | hypothetical protein | 0.0672 | 0.1164 | 0.1164 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0236 | 0 | 0.5 |
Leishmania major | UDP-galactopyranose mutase | 0.0236 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.3975 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.3975 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.3975 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3975 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.3975 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0672 | 0.1164 | 0.1164 |
Brugia malayi | Carboxylesterase family protein | 0.0672 | 0.1164 | 0.1164 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0672 | 0.1164 | 0.1164 |
Echinococcus granulosus | acetylcholinesterase | 0.3975 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0672 | 0.1164 | 0.1164 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0236 | 0 | 0.5 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0672 | 0.1164 | 0.1164 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 560 nM | Antagonist activity at human GCGR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation | ChEMBL. | 21147532 |
IC50 (binding) | = 3000 nM | Displacement of [125I]glucagon from human GCGR expressed in CHO cells | ChEMBL. | 21147532 |
Inhibition (functional) | = -3 % | Antagonist activity at human GIPR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation at 10 uM | ChEMBL. | 21147532 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.