Detailed information for compound 1471638

Basic information

Technical information
  • TDR Targets ID: 1471638
  • Name: MLS000036541
  • MW: 429.471 | Formula: C24H23N5O3
  • H donors: 0 H acceptors: 3 LogP: 2.67 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCCn1c2nc3ccccc3nc2c2c1nc(C)n(c2=O)c1ccccc1OC
  • InChi: 1S/C24H23N5O3/c1-15-25-22-20(24(30)29(15)18-11-6-7-12-19(18)32-3)21-23(28(22)13-8-14-31-2)27-17-10-5-4-9-16(17)26-21/h4-7,9-12H,8,13-14H2,1-3H3
  • InChiKey: LXPWECCDVYRJCI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • SMR000042120
  • STOCK3S-58762

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens estrogen receptor 1 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.1823 0.2748
Schistosoma mansoni RAR-like nuclear receptor 0.0187 0.6394 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0187 0.6394 0.771
Onchocerca volvulus 0.0088 0.2495 0.3112
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0187 0.6394 1
Brugia malayi jmjC domain containing protein 0.0073 0.1915 0.213
Mycobacterium ulcerans lipase LipD 0.0043 0.0734 0.5
Schistosoma mansoni zinc finger protein 0.0088 0.2495 0.3903
Loa Loa (eye worm) carboxylesterase 0.0077 0.2045 0.2484
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0734 0.5
Brugia malayi tailless protein 0.0088 0.2495 0.2854
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0187 0.6394 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0088 0.2495 0.3903
Loa Loa (eye worm) hypothetical protein 0.0088 0.2495 0.3031
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0187 0.6394 0.771
Loa Loa (eye worm) hypothetical protein 0.0088 0.2495 0.3031
Loa Loa (eye worm) hypothetical protein 0.0099 0.2913 0.3538
Brugia malayi Nuclear hormone receptor-like 1 0.0099 0.2913 0.3374
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0187 0.6394 0.771
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0734 0.066
Loa Loa (eye worm) hypothetical protein 0.0043 0.0734 0.0892
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0099 0.2913 0.4477
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0187 0.6394 0.771
Echinococcus multilocularis ecdysone induced protein 78C 0.0187 0.6394 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0099 0.2913 0.3538
Loa Loa (eye worm) hypothetical protein 0.0088 0.2495 0.3031
Brugia malayi nuclear hormone receptor 0.0088 0.2495 0.2854
Onchocerca volvulus 0.0187 0.6394 1
Brugia malayi nuclear receptor NHR-88 0.0187 0.6394 0.771
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0088 0.2495 0.3815
Loa Loa (eye worm) cytochrome P450 family protein 0.0053 0.1097 0.1332
Loa Loa (eye worm) hypothetical protein 0.0043 0.0734 0.0892
Echinococcus granulosus ecdysone induced protein 78C 0.0187 0.6394 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0088 0.2495 0.3815
Brugia malayi hypothetical protein 0.0088 0.2495 0.2854
Schistosoma mansoni nuclear hormone receptor 0.0088 0.2495 0.3903
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0088 0.2495 0.2854
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0187 0.6394 1
Brugia malayi Steroid receptor seven-up type 2 0.0187 0.6394 0.771
Loa Loa (eye worm) hypothetical protein 0.0088 0.2495 0.3031
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0734 0.5
Loa Loa (eye worm) nuclear receptor NHR-67 0.0088 0.2495 0.3031
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0187 0.6394 0.771
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0091 0.0143
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0088 0.2495 0.3815
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0187 0.6394 0.7767
Echinococcus granulosus acetylcholinesterase 0.0077 0.2045 0.31
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0734 0.102
Echinococcus multilocularis carboxylesterase 5A 0.0077 0.2045 0.31
Brugia malayi photoreceptor-specific nuclear receptor 0.0187 0.6394 0.771
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0187 0.6394 1
Brugia malayi Nuclear hormone receptor E75 0.0088 0.2495 0.2854
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0734 0.1148
Echinococcus multilocularis acetylcholinesterase 0.0077 0.2045 0.31
Loa Loa (eye worm) hypothetical protein 0.0099 0.2913 0.3538
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0734 0.5
Loa Loa (eye worm) hypothetical protein 0.0088 0.2495 0.3031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0187 0.6394 0.7767
Schistosoma mansoni thyroid hormone receptor 0.0187 0.6394 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0731 0.1015
Brugia malayi beta-lactamase family protein 0.0043 0.0734 0.066
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0734 0.5
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0734 0.5
Loa Loa (eye worm) hypothetical protein 0.0052 0.1051 0.1277
Echinococcus multilocularis acetylcholinesterase 0.0077 0.2045 0.31
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0734 0.1148
Loa Loa (eye worm) hypothetical protein 0.0099 0.2913 0.3538
Brugia malayi nuclear receptor NHR-67 0.0088 0.2495 0.2854
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0187 0.6394 1
Brugia malayi nuclear receptor RXR 0.0099 0.2913 0.3374
Schistosoma mansoni nuclear receptor 0.0088 0.2495 0.3903
Echinococcus granulosus Nuclear hormone receptor HR96 0.0088 0.2495 0.3815
Schistosoma mansoni nuclear receptor 0.0088 0.2495 0.3903
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0187 0.6394 1
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0734 0.5
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.1823 0.2748
Brugia malayi Carboxylesterase family protein 0.0077 0.2045 0.2293
Brugia malayi nuclear hormone receptor family member nhr-6 0.0088 0.2495 0.2854
Loa Loa (eye worm) hypothetical protein 0.0088 0.2495 0.3031
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0187 0.6394 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.2913 0.3538
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0187 0.6394 0.771
Brugia malayi follicle stimulating hormone receptor 0.0233 0.8232 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0187 0.6394 0.7767
Brugia malayi hypothetical protein 0.0099 0.2913 0.3374
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0099 0.2913 0.4556
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0088 0.2495 0.3815
Loa Loa (eye worm) hypothetical protein 0.0088 0.2495 0.3031
Loa Loa (eye worm) acetylcholinesterase 1 0.0077 0.2045 0.2484
Loa Loa (eye worm) hypothetical protein 0.0088 0.2495 0.3031
Brugia malayi conserved hypotetical protein 0.0088 0.2495 0.2854
Echinococcus granulosus FTZ F1 alpha 0.0187 0.6394 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0088 0.2495 0.3815
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0187 0.6394 0.771
Brugia malayi Bromodomain containing protein 0.0046 0.0844 0.0796
Brugia malayi beta-lactamase family protein 0.0043 0.0734 0.066
Brugia malayi hypothetical protein 0.0088 0.2495 0.2854
Loa Loa (eye worm) beta-lactamase 0.0043 0.0734 0.0892
Loa Loa (eye worm) hypothetical protein 0.0088 0.2495 0.3031
Loa Loa (eye worm) steroid hormone receptor 0.0187 0.6394 0.7767
Schistosoma mansoni nuclear hormone receptor 0.0088 0.2495 0.3903
Onchocerca volvulus Protein ultraspiracle homolog 0.0187 0.6394 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.1866 0.2816
Trichomonas vaginalis esterase, putative 0.0043 0.0734 0.5
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0187 0.6394 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0734 0.0892
Loa Loa (eye worm) hypothetical protein 0.0046 0.0847 0.1029
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0233 0.8232 1
Onchocerca volvulus 0.0088 0.2495 0.3112
Echinococcus granulosus Nuclear hormone receptor HR96 0.0088 0.2495 0.3815
Brugia malayi beta-lactamase 0.0043 0.0734 0.066
Loa Loa (eye worm) DR-78 0.0088 0.2495 0.3031
Brugia malayi ecdysteroid receptor 0.0187 0.6394 0.771
Loa Loa (eye worm) hypothetical protein 0.0187 0.6394 0.7767
Schistosoma mansoni nuclear hormone receptor 0.0187 0.6394 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.2045 0.2484
Echinococcus granulosus nuclear receptor nhr 48 0.0088 0.2495 0.3815
Schistosoma mansoni retinoic acid receptor RXR 0.0187 0.6394 1
Leishmania major hypothetical protein, conserved 0.0043 0.0734 0.5
Onchocerca volvulus Bile acid receptor homolog 0.0187 0.6394 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0088 0.2495 0.3903
Loa Loa (eye worm) hypothetical protein 0.0085 0.2392 0.2906
Loa Loa (eye worm) hypothetical protein 0.0099 0.2913 0.3538
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0187 0.6394 0.771
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.1866 0.2816
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0088 0.2495 0.3815
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0088 0.2495 0.3031
Schistosoma mansoni thyroid hormone receptor 0.0187 0.6394 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0187 0.6394 1
Brugia malayi Nuclear hormone receptor-like 1 0.0099 0.2913 0.3374
Brugia malayi nuclear receptor NHR-88 0.0088 0.2495 0.2854
Brugia malayi orphan nuclear receptor NR2E1 0.0088 0.2495 0.2854
Brugia malayi hypothetical protein 0.0099 0.2913 0.3374
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0734 0.0892
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0099 0.2913 0.4556
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0187 0.6394 1
Loa Loa (eye worm) hypothetical protein 0.0187 0.6394 0.7767
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0077 0.2045 0.3199
Loa Loa (eye worm) hypothetical protein 0.0187 0.6394 0.7767
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0734 0.5
Mycobacterium leprae Probable lipase LipE 0.0043 0.0734 0.5
Schistosoma mansoni jumonji/arid domain-containing protein 0.0073 0.1915 0.2995
Brugia malayi Nuclear hormone receptor-like 1 0.0187 0.6394 0.771
Schistosoma mansoni bromodomain containing protein 0.0076 0.2037 0.3185
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0187 0.6394 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0073 0.1915 0.2995
Loa Loa (eye worm) hypothetical protein 0.0043 0.0734 0.0892
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0187 0.6394 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0187 0.6394 1
Schistosoma mansoni nuclear receptor nhr-48 0.0088 0.2495 0.3903
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0187 0.6394 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0187 0.6394 0.7767
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0088 0.2495 0.3112
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0187 0.6394 0.7767
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0187 0.6394 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0088 0.2495 0.3815
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0187 0.6394 0.7767
Brugia malayi nuclear hormone receptor 0.0187 0.6394 0.771
Loa Loa (eye worm) hypothetical protein 0.0088 0.2495 0.3031
Echinococcus multilocularis thyroid hormone receptor alpha 0.0187 0.6394 1
Echinococcus multilocularis FTZ F1 alpha 0.0187 0.6394 1
Brugia malayi ecdysone receptor 0.0088 0.2495 0.2854
Echinococcus multilocularis nuclear receptor nhr 48 0.0088 0.2495 0.3815
Schistosoma mansoni jumonji domain containing protein 0.0071 0.1823 0.2852
Brugia malayi nuclear receptor RXR 0.0088 0.2495 0.2854
Loa Loa (eye worm) hypothetical protein 0.0187 0.6394 0.7767
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0187 0.6394 0.771
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0734 0.102
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0734 0.5
Echinococcus granulosus acetylcholinesterase 0.0077 0.2045 0.31
Echinococcus granulosus thyroid hormone receptor alpha 0.0088 0.2495 0.3815
Loa Loa (eye worm) hypothetical protein 0.0088 0.2495 0.3031
Loa Loa (eye worm) hypothetical protein 0.0187 0.6394 0.7767
Mycobacterium ulcerans beta-lactamase 0.0043 0.0734 0.5
Loa Loa (eye worm) hypothetical protein 0.0187 0.6394 0.7767
Loa Loa (eye worm) hypothetical protein 0.0043 0.0734 0.0892
Toxoplasma gondii ABC1 family protein 0.0043 0.0734 0.5
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0099 0.2913 0.4477
Brugia malayi Nuclear hormone receptor E75 0.0088 0.2495 0.2854
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0734 0.5
Echinococcus granulosus carboxylesterase 5A 0.0077 0.2045 0.31
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0187 0.6394 1
Brugia malayi Cytochrome P450 family protein 0.0053 0.1097 0.1112
Brugia malayi nuclear hormone receptor family member odr-7 0.0088 0.2495 0.2854
Brugia malayi jmjC domain containing protein 0.0071 0.1823 0.2017
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0187 0.6394 0.771
Mycobacterium ulcerans hypothetical protein 0.0043 0.0734 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0734 0.5
Loa Loa (eye worm) hypothetical protein 0.0088 0.2495 0.3031
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0187 0.6394 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0187 0.6394 0.7767
Echinococcus granulosus lysine specific demethylase 5A 0.0073 0.1915 0.2893
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0187 0.6394 0.771
Brugia malayi steroid hormone receptor 0.0187 0.6394 0.771
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0187 0.6394 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.1823 0.2748
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0731 0.1015
Loa Loa (eye worm) nuclear hormone receptor 0.0088 0.2495 0.3031
Schistosoma mansoni coup transcription factor 0.0187 0.6394 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0187 0.6394 0.771
Loa Loa (eye worm) hypothetical protein 0.0049 0.096 0.1166
Loa Loa (eye worm) hypothetical protein 0.0187 0.6394 0.7767
Schistosoma mansoni steroid hormone receptor ad4bp 0.0187 0.6394 1
Brugia malayi Carboxylesterase family protein 0.0077 0.2045 0.2293
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0734 0.5
Loa Loa (eye worm) hypothetical protein 0.0077 0.2045 0.2484
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0187 0.6394 0.771
Loa Loa (eye worm) hypothetical protein 0.0187 0.6394 0.7767
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0187 0.6394 1
Brugia malayi Bromodomain containing protein 0.0091 0.2596 0.298
Loa Loa (eye worm) hypothetical protein 0.0043 0.0734 0.0892
Loa Loa (eye worm) hypothetical protein 0.0088 0.2495 0.3031
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.1915 0.2326
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0734 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0187 0.6394 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0088 0.2495 0.3112

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 12.67102 um PUBCHEM_BIOASSAY: Estrogen Receptor-alpha Coactivator Binding Potentiators Dose Response Confirmation. (Class of assay: confirmatory) [Related pubchem assays: 639 (Primary screen preceding this dose response confirmation assay.)] ChEMBL. No reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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