Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0212 | 1 | 0.5 | |
Echinococcus multilocularis | peroxidasin | 0.0212 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 1 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0052 | 0.179 | 0.179 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0017 | 0 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.1964 | 0.1964 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0052 | 0.179 | 0.179 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0164 | 0.7524 | 0.7524 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0068 | 0.2601 | 0.2601 |
Brugia malayi | Peroxidasin | 0.0212 | 1 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0017 | 0 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0212 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0068 | 0.2601 | 0.2601 |
Brugia malayi | Animal haem peroxidase family protein | 0.0212 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0068 | 0.2601 | 0.2601 |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 1 | 1 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0017 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1964 | 0.1964 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.487 | 0.487 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.179 | 0.179 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0017 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.179 | 0.179 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1964 | 0.1964 |
Onchocerca volvulus | Peroxidase homolog | 0.0212 | 1 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0164 | 0.7524 | 0.7524 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0017 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0212 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0112 | 0.487 | 0.487 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0212 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0212 | 1 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.2601 | 0.2601 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0052 | 0.179 | 0.179 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.1964 | 0.1964 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1964 | 0.1964 |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0164 | 0.7524 | 0.7524 |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0212 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0212 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0212 | 1 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0052 | 0.179 | 0.179 |
Onchocerca volvulus | 0.0212 | 1 | 0.5 | |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0052 | 0.179 | 0.179 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.179 | 0.179 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1964 | 0.1964 |
Loa Loa (eye worm) | RNA binding protein | 0.0068 | 0.2601 | 0.2601 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.2601 | 0.2601 |
Brugia malayi | Blistered cuticle protein 3 | 0.0212 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0112 | 0.487 | 0.487 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.7524 | 0.7524 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0017 | 0 | 0.5 |
Onchocerca volvulus | 0.0212 | 1 | 0.5 | |
Schistosoma mansoni | peroxidasin | 0.0212 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0212 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0068 | 0.2601 | 0.2601 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.179 | 0.179 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1964 | 0.1964 |
Brugia malayi | Animal haem peroxidase family protein | 0.0212 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 1 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0052 | 0.179 | 0.179 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0052 | 0.179 | 0.179 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1964 | 0.1964 |
Brugia malayi | RNA binding protein | 0.0068 | 0.2601 | 0.2601 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0212 | 1 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0212 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0212 | 1 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0052 | 0.179 | 0.179 |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0212 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.2601 | 0.2601 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0212 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.2601 | 0.2601 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.2601 | 0.2601 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0068 | 0.2601 | 0.2601 |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 1 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0017 | 0 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0017 | 0 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0052 | 0.179 | 0.179 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1964 | 0.1964 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0017 | 0 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0068 | 0.2601 | 0.2601 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0212 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0212 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.179 | 0.179 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0017 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.631 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.