Detailed information for compound 14719

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 340.38 | Formula: C17H20N6O2
  • H donors: 2 H acceptors: 2 LogP: 1.12 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CN/C(=N\C)/NCCCOCn1nc(ccc1=O)c1ccccc1
  • InChi: 1S/C17H20N6O2/c1-19-17(21-12-18)20-10-5-11-25-13-23-16(24)9-8-15(22-23)14-6-3-2-4-7-14/h2-4,6-9H,5,10-11,13H2,1H3,(H2,19,20,21)
  • InChiKey: WJWCNTXBMWQWCM-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi MIZ/SP-RING zinc finger, putative 0.0129 0.0555 0.0916
Echinococcus granulosus purine nucleoside phosphorylase 0.016 0.0738 0.1218
Trypanosoma brucei Histone-lysine N-methyltransferase, H3 lysine-76 specific 0.0116 0.0481 0.0793
Echinococcus granulosus PWWP domain containing protein 2A 0.0129 0.0555 0.0916
Schistosoma mansoni purine nucleoside phosphorylase 0.016 0.0738 0.1461
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0083 0.0292 0.0579
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.016 0.0738 1
Echinococcus multilocularis disco interacting protein 2 0.0353 0.1844 0.3044
Trypanosoma cruzi hypothetical protein, conserved 0.0129 0.0555 0.0916
Plasmodium falciparum S-adenosylmethionine decarboxylase/ornithine decarboxylase 0.0323 0.1672 0.2756
Brugia malayi Histone-lysine N-methyltransferase, H3 lysine-79 specific 0.0912 0.505 0.5553
Plasmodium vivax S-adenosylmethionine decarboxylase-ornithine decarboxylase, putative 0.0323 0.1672 0.2756
Schistosoma mansoni hypothetical protein 0.0188 0.0896 0.1775
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.016 0.0738 0.0738
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0034 0.0012 0.0024
Echinococcus multilocularis histone lysine n methyltransferase setb1 0.0038 0.0032 0.0053
Brugia malayi jmjC domain containing protein 0.0041 0.0052 0.0057
Echinococcus granulosus histone lysine N methyltransferase Ez 0.0317 0.1636 0.27
Echinococcus granulosus purine nucleoside phosphorylase 0.016 0.0738 0.1218
Plasmodium vivax histone-lysine N-methyltransferase, putative 0.0094 0.0356 0.0585
Echinococcus multilocularis histone h3 methyltransferase 0.0912 0.505 0.8335
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1616 0.9093 1
Schistosoma mansoni hypothetical protein 0.0129 0.0555 0.1099
Plasmodium vivax spermidine synthase, putative 0.1087 0.6059 1
Treponema pallidum uridine phosphorylase (udp) 0.016 0.0738 0.5
Trypanosoma brucei methylthioadenosine phosphorylase, putative 0.0867 0.4793 0.7911
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0034 0.0012 0.0024
Echinococcus granulosus polybromo 1 0.0041 0.005 0.0083
Entamoeba histolytica hypothetical protein 0.016 0.0738 0.2338
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0052 0.0103
Echinococcus multilocularis SET and MYND domain containing protein 3 0.0078 0.0267 0.044
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0033 0.0008 0.0016
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0002 0.0005
Schistosoma mansoni metastasis-associated protein 1 (mta1) 0.0041 0.005 0.01
Schistosoma mansoni hypothetical protein 0.0058 0.0148 0.0293
Onchocerca volvulus 0.0339 0.1764 0.1762
Treponema pallidum pfs protein (pfs) 0.016 0.0738 0.5
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.016 0.0738 0.2338
Echinococcus granulosus S adenosylmethionine decarboxylase proenzyme 0.0663 0.3625 0.5984
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.016 0.0738 0.0738
Toxoplasma gondii hypothetical protein 0.0776 0.4271 1
Loa Loa (eye worm) hypothetical protein 0.0912 0.505 0.5553
Echinococcus multilocularis histone lysine N methyltransferase, H3 lysine 36 0.0144 0.0644 0.1064
Echinococcus granulosus purine nucleoside phosphorylase 0.016 0.0738 0.1218
Loa Loa (eye worm) uridine phosphorylase 0.016 0.0738 0.0811
Trichomonas vaginalis set domain proteins, putative 0.1774 1 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0196 0.0939 0.155
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.0582 0.3156 0.7389
Leishmania major spermidine synthase 0.1087 0.6059 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0061 0.0067
Mycobacterium tuberculosis Probable spermidine synthase SpeE (putrescine aminopropyltransferase) (aminopropyltransferase) (SPDSY) 0.0857 0.4736 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0002 0.0004
Leishmania major histone-lysine N-methyltransferase, putative 0.0116 0.0481 0.0793
Loa Loa (eye worm) hypothetical protein 0.0066 0.0196 0.0215
Trypanosoma cruzi S-adenosylmethionine decarboxylase proenzyme, putative 0.0663 0.3625 0.5984
Schistosoma mansoni hypothetical protein 0.0188 0.0896 0.1775
Brugia malayi NNMT/PNMT/TEMT family protein 0.0998 0.5548 0.6101
Brugia malayi GATA zinc finger family protein 0.0041 0.005 0.0055
Mycobacterium leprae Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) 0.016 0.0738 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0129 0.0555 0.0916
Echinococcus multilocularis uridine phosphorylase 1 0.016 0.0738 0.1218
Trypanosoma brucei S-adenosylmethionine decarboxylase 0.0663 0.3625 0.5984
Trypanosoma brucei transcription elongation factor s-II, putative 0.0129 0.0555 0.0916
Echinococcus granulosus histone arginine methyltransferase CARMER 0.0161 0.0744 0.1227
Echinococcus granulosus jumonji domain containing protein 0.0045 0.0075 0.0124
Trypanosoma cruzi spermidine synthase, putative 0.1087 0.6059 1
Echinococcus granulosus DNA methyltransferase 2, putative 0.0582 0.3156 0.5209
Loa Loa (eye worm) S-methyl-5'-thioadenosine phosphorylase MTAP 0.0867 0.4793 0.5271
Trypanosoma cruzi Histone methylation protein DOT1, putative 0.0116 0.0481 0.0793
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.016 0.0738 0.2338
Schistosoma mansoni hypothetical protein 0.0129 0.0555 0.1099
Echinococcus multilocularis PWWP domain containing protein 2A 0.0129 0.0555 0.0916
Echinococcus granulosus lysine specific demethylase 5A 0.0041 0.0052 0.0085
Mycobacterium tuberculosis Probable 5'-methylthioadenosine phosphorylase Pnp (MTA phosphorylase) 0.0706 0.3872 0.7838
Echinococcus granulosus spermidine synthase 0.1087 0.6059 1
Loa Loa (eye worm) hypothetical protein 0.0998 0.5548 0.6101
Giardia lamblia Purine nucleoside phosphorylase lateral transfer candidate 0.016 0.0738 1
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.016 0.0738 0.2338
Trypanosoma cruzi nucleoside phosphorylase, putative 0.016 0.0738 0.1218
Toxoplasma gondii histone lysine methyltransferase SET1 0.0076 0.0251 0.0587
Echinococcus granulosus PWWP domain containing protein 2A 0.0129 0.0555 0.0916
Entamoeba histolytica MTA/SAH nucleosidase, putative 0.016 0.0738 0.2338
Loa Loa (eye worm) hypothetical protein 0.0126 0.0538 0.0592
Schistosoma mansoni microtubule-associated protein tau 0.0771 0.4242 0.8401
Plasmodium vivax SET domain protein, putative 0.0174 0.0813 0.1339
Trichomonas vaginalis purine nucleoside phosphorylase I, putative 0.016 0.0738 0.0738
Brugia malayi purine nucleoside phosphorylase I, inosine and guanosine-specific family protein 0.016 0.0738 0.0811
Echinococcus granulosus disco interacting protein 2 0.0353 0.1844 0.3044
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.016 0.0738 0.0738
Echinococcus multilocularis arginine glutamic acid dipeptide (RE) repeats 0.0041 0.005 0.0083
Echinococcus granulosus purine nucleoside phosphorylase 0.016 0.0738 0.1218
Echinococcus multilocularis purine nucleoside phosphorylase 0.016 0.0738 0.1218
Trypanosoma cruzi Histone methylation protein DOT1, putative 0.0116 0.0481 0.0793
Brugia malayi Spermidine synthase 0.1087 0.6059 0.6663
Brugia malayi jmjC domain containing protein 0.0106 0.0425 0.0467
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0034 0.0012 0.0012
Echinococcus multilocularis lysine specific demethylase 5A 0.0039 0.0041 0.0068
Schistosoma mansoni hepatoma derived growth factor 0.0129 0.0555 0.1099
Mycobacterium ulcerans spermidine synthase 0.0857 0.4736 0.986
Trichomonas vaginalis origin recognition complex subunit, putative 0.0041 0.005 0.005
Schistosoma mansoni protein arginine n-methyltransferase 0.0161 0.0744 0.1473
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.016 0.0738 0.2338
Echinococcus granulosus purine nucleoside phosphorylase 0.016 0.0738 0.1218
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0353 0.1844 0.3652
Schistosoma mansoni uridine phosphorylase 0.016 0.0738 0.1461
Echinococcus granulosus microtubule associated protein 2 0.0771 0.4242 0.7002
Schistosoma mansoni methylthioadenosine phosphorylase 0.0867 0.4793 0.9492
Brugia malayi Bromodomain containing protein 0.0032 0.0002 0.0002
Echinococcus granulosus SET and MYND domain containing protein 3 0.0078 0.0267 0.044
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.0161 0.0744 0.1227
Echinococcus granulosus geminin 0.0188 0.0896 0.1479
Echinococcus multilocularis cpg binding protein 0.0341 0.1775 0.2929
Trypanosoma cruzi transcription elongation factor s-II, putative 0.0129 0.0555 0.0916
Brugia malayi Disco-interacting protein 2 homolog 0.0353 0.1844 0.2028
Toxoplasma gondii DNA methyltransferase 2, putative 0.0582 0.3156 0.7389
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.024 0.1193 0.2362
Toxoplasma gondii hypothetical protein 0.0116 0.0481 0.1126
Leishmania major modification methylase-like protein 0.0582 0.3156 0.5209
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0174 0.0813 0.1342
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.02 0.022
Trypanosoma brucei Histone methylation protein DOT1, putative 0.0116 0.0481 0.0793
Trypanosoma cruzi nucleoside phosphorylase, putative 0.016 0.0738 0.1218
Echinococcus multilocularis protein arginine methyltransferase 0.0034 0.0012 0.002
Leishmania major S-adenosylmethionine decarboxylase 0.0663 0.3625 0.5984
Loa Loa (eye worm) hypothetical protein 0.0076 0.0255 0.0281
Entamoeba histolytica hypothetical protein 0.0129 0.0555 0.1759
Trypanosoma cruzi histone-lysine N-methyltransferase, putative 0.0116 0.0481 0.0793
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.024 0.1193 0.2362
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0034 0.0012 0.0028
Schistosoma mansoni jumonji domain containing protein 0.0084 0.03 0.0594
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.0161 0.0744 0.1741
Echinococcus multilocularis purine nucleoside phosphorylase 0.016 0.0738 0.1218
Brugia malayi SET domain containing protein 0.0317 0.1636 0.1799
Loa Loa (eye worm) SET domain-containing protein 0.0317 0.1636 0.1799
Loa Loa (eye worm) hypothetical protein 0.012 0.0503 0.0554
Trichomonas vaginalis CDC6, putative 0.0041 0.005 0.005
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0867 0.4793 0.7911
Trypanosoma cruzi spermidine synthase, putative 0.1087 0.6059 1
Schistosoma mansoni SET domain protein 0.0146 0.0655 0.1297
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0066 0.0196 0.0323
Brugia malayi PWWP domain containing protein 0.0129 0.0555 0.061
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0002 0.0002
Schistosoma mansoni cpg binding protein 0.0341 0.1775 0.3515
Echinococcus multilocularis metastasis associated protein 1 (mta1) 0.0041 0.005 0.0083
Onchocerca volvulus Purine nucleoside phosphorylase homolog 0.016 0.0738 0.0736
Echinococcus granulosus uridine phosphorylase 1 0.016 0.0738 0.1218
Brugia malayi CXXC zinc finger family protein 0.0339 0.1764 0.194
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.016 0.0738 0.0738
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.016 0.0738 0.2338
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.0052 0.0057
Echinococcus granulosus histone lysine n methyltransferase setb1 0.0038 0.0032 0.0053
Echinococcus granulosus histone lysine N methyltransferase H3 lysine 36 0.0144 0.0644 0.1064
Echinococcus multilocularis spermidine synthase 0.1087 0.6059 1
Loa Loa (eye worm) spermidine synthase 0.1087 0.6059 0.6663
Loa Loa (eye worm) hypothetical protein 0.0367 0.1921 0.2113
Loa Loa (eye worm) hypothetical protein 0.0041 0.005 0.0055
Loa Loa (eye worm) Carm1-pending protein 0.0161 0.0744 0.0818
Loa Loa (eye worm) hypothetical protein 0.0353 0.1844 0.2028
Echinococcus granulosus bromo adjacent y domain containing 1 0.0041 0.005 0.0083
Echinococcus granulosus histone lysine methyltransferase setb 0.024 0.1193 0.1969
Trypanosoma brucei uridine phosphorylase 0.016 0.0738 0.1218
Plasmodium falciparum purine nucleoside phosphorylase 0.016 0.0738 0.1215
Schistosoma mansoni histone J3 methyltransferase 0.0912 0.505 1
Echinococcus multilocularis polybromo 1 0.0041 0.005 0.0083
Echinococcus granulosus purine nucleoside phosphorylase 0.016 0.0738 0.1218
Toxoplasma gondii Purine nucleoside phosphorylase 0.016 0.0738 0.1728
Trypanosoma brucei S-adenosylmethionine decarboxylase 0.0663 0.3625 0.5984
Loa Loa (eye worm) hypothetical protein 0.0998 0.5548 0.6101
Trypanosoma cruzi S-adenosylmethionine decarboxylase proenzyme, putative 0.0663 0.3625 0.5984
Echinococcus multilocularis microtubule associated protein 2 0.0771 0.4242 0.7002
Trypanosoma brucei S-adenosylmethionine decarboxylase proenzyme, putative 0.0663 0.3625 0.5984
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.0582 0.3156 0.5209
Echinococcus multilocularis purine nucleoside phosphorylase 0.016 0.0738 0.1218
Schistosoma mansoni hypothetical protein 0.0041 0.005 0.01
Mycobacterium leprae probable uridine phosphorylase 0.016 0.0738 0.5
Brugia malayi MTAP 0.0867 0.4793 0.5271
Loa Loa (eye worm) NNMT/PNMT/TEMT family protein 0.0998 0.5548 0.6101
Toxoplasma gondii phosphorylase family protein 0.016 0.0738 0.1728
Echinococcus multilocularis hepatoma derived growth factor protein 0.0129 0.0555 0.0916
Brugia malayi hypothetical protein 0.0066 0.0196 0.0215
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0106 0.0425 0.0701
Loa Loa (eye worm) hypothetical protein 0.0367 0.1921 0.2113
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0066 0.0196 0.0323
Brugia malayi Pre-SET motif family protein 0.0211 0.1029 0.1131
Loa Loa (eye worm) S-adenosylmethionine decarboxylase proenzyme 0.0663 0.3625 0.3987
Echinococcus granulosus metastasis associated protein MTA1 0.0041 0.005 0.0083
Loa Loa (eye worm) hypothetical protein 0.0129 0.0555 0.061
Schistosoma mansoni phd finger protein 0.0129 0.0555 0.1099
Plasmodium falciparum spermidine synthase 0.1087 0.6059 1
Brugia malayi uridine phosphorylase family protein 0.016 0.0738 0.0811
Brugia malayi Carm1-pending protein 0.0161 0.0744 0.0818
Brugia malayi hypothetical protein 0.0367 0.1921 0.2113
Loa Loa (eye worm) hypothetical protein 0.0041 0.005 0.0055
Echinococcus multilocularis histone lysine n methyltransferase suv420h1 0.0152 0.0691 0.1141
Echinococcus granulosus metastasis associated protein 1 mta1 0.0041 0.005 0.0083
Giardia lamblia UPL-1 0.016 0.0738 1
Trichomonas vaginalis conserved hypothetical protein 0.016 0.0738 0.0738
Echinococcus granulosus hepatoma derived growth factor protein 0.0129 0.0555 0.0916
Schistosoma mansoni suppressor of variegation 4-20-related 0.0152 0.0691 0.1369
Trypanosoma brucei spermidine synthase 0.1087 0.6059 1
Onchocerca volvulus 0.0367 0.1921 0.1919
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0867 0.4793 0.7911
Schistosoma mansoni methylthioadenosine phosphorylase 0.016 0.0738 0.1461
Loa Loa (eye worm) SET domain-containing protein 0.0152 0.0691 0.076
Schistosoma mansoni uridine phosphorylase 0.016 0.0738 0.1461
Echinococcus multilocularis S adenosylmethionine decarboxylase proenzyme 0.0663 0.3625 0.5984
Brugia malayi PHD-finger family protein 0.0032 0.0002 0.0002
Schistosoma mansoni enhancer of zeste ezh 0.0317 0.1636 0.324
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0002 0.0004
Echinococcus granulosus protein arginine N methyltransferase 8 0.0034 0.0012 0.002
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0002 0.0004
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.016 0.0738 0.0738
Loa Loa (eye worm) hypothetical protein 0.0367 0.1921 0.2113
Loa Loa (eye worm) hypothetical protein 0.024 0.1193 0.1312
Onchocerca volvulus 0.0129 0.0555 0.0553
Brugia malayi hypothetical protein 0.0129 0.0555 0.061
Brugia malayi hypothetical protein 0.0367 0.1921 0.2113
Leishmania major nucleoside phosphorylase-like protein 0.016 0.0738 0.1218
Schistosoma mansoni metastasis-associated protein 1 (mta1) 0.0041 0.005 0.01
Trypanosoma cruzi nucleoside phosphorylase, putative 0.016 0.0738 0.1218
Schistosoma mansoni hepatoma derived growth factor 0.0129 0.0555 0.1099
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0034 0.0012 0.0016
Echinococcus multilocularis metastasis associated protein MTA1 0.0041 0.005 0.0083
Schistosoma mansoni metastasis-associated protein 1 (mta1) 0.0041 0.005 0.01
Brugia malayi SET domain containing protein 0.0135 0.0593 0.0652
Loa Loa (eye worm) hypothetical protein 0.0038 0.0032 0.0035
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0052 0.0103
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.0582 0.3156 0.6249
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.0582 0.3156 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0174 0.0813 0.1904
Brugia malayi polybromodomain protein 0.0041 0.005 0.0055
Toxoplasma gondii phosphorylase family protein 0.016 0.0738 0.1728
Echinococcus multilocularis purine nucleoside phosphorylase 0.016 0.0738 0.1218
Echinococcus granulosus histone lysine n methyltransferase suv420h1 0.0152 0.0691 0.1141
Onchocerca volvulus 0.013 0.056 0.0558
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0034 0.0012 0.0012
Mycobacterium ulcerans 5'-methylthioadenosine phosphorylase 0.0867 0.4793 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0339 0.1764 0.194
Brugia malayi SET domain containing protein 0.0058 0.015 0.0165
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0174 0.0813 0.161
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.024 0.1193 0.1969
Echinococcus multilocularis DNA methyltransferase 2, putative 0.0582 0.3156 0.5209
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0293 0.15 0.2971
Onchocerca volvulus 0.0129 0.0555 0.0553
Echinococcus multilocularis geminin 0.0188 0.0896 0.1479
Trichomonas vaginalis conserved hypothetical protein 0.016 0.0738 0.0738
Echinococcus granulosus histone h3 methyltransferase 0.0912 0.505 0.8335
Chlamydia trachomatis AMP nucleosidase 0.016 0.0738 0.5
Brugia malayi F/Y-rich N-terminus family protein 0.0035 0.0019 0.0021
Echinococcus multilocularis methylthioadenosine phosphorylase 0.0867 0.4793 0.7911
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.0582 0.3156 0.5207
Toxoplasma gondii hypothetical protein 0.0129 0.0555 0.13
Schistosoma mansoni metastasis-associated protein 1 (mta1) 0.0041 0.005 0.01
Brugia malayi S-adenosylmethionine decarboxylase proenzyme 0.0663 0.3625 0.3987
Echinococcus multilocularis purine nucleoside phosphorylase 0.016 0.0738 0.1218
Schistosoma mansoni hypothetical protein 0.0129 0.0555 0.1099
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0002 0.0005
Leishmania major hypothetical protein, conserved 0.0129 0.0555 0.0916
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0066 0.0196 0.0323
Echinococcus multilocularis jumonji domain containing protein 0.0045 0.0075 0.0124
Schistosoma mansoni bromo adjacent homology domain containing 0.0041 0.005 0.01
Echinococcus granulosus arginine glutamic acid dipeptide RE repeats 0.0041 0.005 0.0083
Loa Loa (eye worm) hypothetical protein 0.0041 0.005 0.0055
Plasmodium falciparum histone-lysine N-methyltransferase, putative 0.0094 0.0356 0.0585
Trypanosoma cruzi transcription elongation factor-like protein, putative 0.0129 0.0555 0.0916
Echinococcus multilocularis purine nucleoside phosphorylase 0.016 0.0738 0.1218
Schistosoma mansoni polybromo-1 0.0041 0.005 0.01
Schistosoma mansoni purine nucleoside phosphorylase 0.016 0.0738 0.1461
Schistosoma mansoni cpg binding protein 0.0341 0.1775 0.3515
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.0582 0.3156 0.5207
Echinococcus multilocularis PWWP domain containing protein 2A 0.0129 0.0555 0.0916
Trypanosoma cruzi spermidine synthase, putative 0.1087 0.6059 1
Schistosoma mansoni cpg binding protein 0.0339 0.1764 0.3494
Echinococcus granulosus cpg binding protein 0.0341 0.1775 0.2929
Loa Loa (eye worm) hypothetical protein 0.0032 0.0002 0.0002
Echinococcus granulosus purine nucleoside phosphorylase 0.016 0.0738 0.1218
Treponema pallidum purine nucleoside phosphorylase (deoD) 0.016 0.0738 0.5
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0034 0.0012 0.0016
Echinococcus granulosus peregrin 0.0161 0.0741 0.1223
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.016 0.0738 0.0738
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0034 0.0012 0.0012
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0034 0.0012 0.0024
Loa Loa (eye worm) hypothetical protein 0.0055 0.0135 0.0148
Leishmania major arginine N-methyltransferase-like protein 0.0034 0.0012 0.002
Brugia malayi ELM2 domain containing protein 0.0041 0.005 0.0055
Echinococcus granulosus purine nucleoside phosphorylase 0.016 0.0738 0.1218
Schistosoma mansoni hypothetical protein 0.0032 0.0002 0.0004
Echinococcus multilocularis peregrin 0.0161 0.0741 0.1223
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.016 0.0738 1
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.016 0.0738 0.0738
Trypanosoma cruzi Histone-lysine N-methyltransferase, H3 lysine-76 specific 0.0116 0.0481 0.0793
Leishmania major methylthioadenosine phosphorylase, putative 0.0867 0.4793 0.7911
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0776 0.4271 0.7048
Onchocerca volvulus 0.0353 0.1844 0.1842
Brugia malayi Pre-SET motif family protein 0.1616 0.9093 1
Entamoeba histolytica hypothetical protein 0.0066 0.0196 0.062
Echinococcus granulosus methylthioadenosine phosphorylase 0.0867 0.4793 0.7911
Trypanosoma cruzi spermidine synthase, putative 0.1087 0.6059 1
Onchocerca volvulus 0.0293 0.15 0.1498
Leishmania major hypothetical protein, conserved 0.0116 0.0481 0.0793
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0066 0.0196 0.062
Loa Loa (eye worm) PWWP domain-containing protein 0.0129 0.0555 0.061
Echinococcus granulosus protein arginine methyltransferase 0.0034 0.0012 0.002
Echinococcus multilocularis histone lysine N methyltransferase E(z) 0.0317 0.1636 0.27
Schistosoma mansoni methylthioadenosine phosphorylase 0.0867 0.4793 0.9492
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0034 0.0012 0.002
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0106 0.0425 0.0701
Plasmodium vivax purine nucleoside phosphorylase, putative 0.016 0.0738 0.1215
Leishmania major hypothetical protein, conserved 0.0116 0.0481 0.0793
Echinococcus multilocularis bromo adjacent y domain containing 1 0.0041 0.005 0.0083
Brugia malayi hypothetical protein 0.0129 0.0555 0.061
Brugia malayi SET domain containing protein 0.0152 0.0691 0.076
Trypanosoma brucei histone-lysine n-methyltransferase 0.0116 0.0481 0.0793

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) NA 0 mg kg-1 Compound was evaluated for antiulcer activity due to stress in rats after oral administration; not statistically significant ChEMBL. 6876082
ED50 (functional) < 100 mg kg-1 Effective dose for 50 percent inhibition of gastric antisecretory activity in the 4 h pylorus-ligated rat ChEMBL. 6876082
Inhibition (functional) < 49.8 % Percent inhibition of gastric antisecretory activity in the 4 h pylorus-ligated rat to that of control at a dose of 100 mg/kg ChEMBL. 6876082

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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