Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0113 | 0.0072 | 0.0072 |
Loa Loa (eye worm) | TAR-binding protein | 0.0069 | 0.0031 | 0.0031 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0072 | 0.0072 |
Loa Loa (eye worm) | hypothetical protein | 1.0794 | 1 | 1 |
Echinococcus granulosus | sodium bile acid cotransporter | 1.0794 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0069 | 0.0031 | 0.0031 |
Brugia malayi | RNA binding protein | 0.0069 | 0.0031 | 0.0031 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.0031 | 0.0031 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.013 | 0.0087 | 0.0087 |
Echinococcus multilocularis | tar DNA binding protein | 0.0069 | 0.0031 | 0.0031 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.0031 | 0.0031 |
Schistosoma mansoni | sodium-bile acid cotransporter | 0.6417 | 0.5932 | 0.5932 |
Loa Loa (eye worm) | RNA binding protein | 0.0069 | 0.0031 | 0.0031 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0039 | 0.0039 |
Onchocerca volvulus | 1.0794 | 1 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0077 | 0.0039 | 0.0039 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0113 | 0.0072 | 0.0072 |
Echinococcus granulosus | tar DNA binding protein | 0.0069 | 0.0031 | 0.0031 |
Echinococcus multilocularis | sodium bile acid cotransporter | 1.0794 | 1 | 1 |
Echinococcus multilocularis | sodium bile acid cotransporter | 1.0794 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.0031 | 0.0031 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.013 | 0.0087 | 0.0087 |
Echinococcus granulosus | sodium bile acid cotransporter | 1.0794 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0069 | 0.0031 | 0.0031 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 1.0794 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.0031 | 0.0031 |
Echinococcus multilocularis | sodium bile acid cotransporter | 1.0794 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0077 | 0.0039 | 0.0039 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.4377 | 0.4035 | 0.4035 |
Brugia malayi | MH2 domain containing protein | 0.013 | 0.0087 | 0.0087 |
Echinococcus granulosus | sodium bile acid cotransporter | 1.0794 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0113 | 0.0072 | 0.0072 |
Brugia malayi | TAR-binding protein | 0.0069 | 0.0031 | 0.0031 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.0031 | 0.0031 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antiparasitic activity against Trypanosoma cruzi T2 epimastigotes assessed as growth inhibition at 25 uM after 5 days | ChEMBL. | 20889239 | |
Inhibition (binding) | = 0 % | Inhibition of Trypanosoma cruzi triosephosphate isomerase at 400 uM after 2 hrs | ChEMBL. | 20889239 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.