Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | RNA binding protein | 0.0065 | 0.3073 | 0.4565 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0583 | 0.5 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0583 | 0.0866 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.0583 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0123 | 0.6732 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0583 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0123 | 0.6732 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0123 | 0.6732 | 1 |
Brugia malayi | TAR-binding protein | 0.0065 | 0.3073 | 0.4565 |
Echinococcus multilocularis | geminin | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0065 | 0.3073 | 0.405 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.0583 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0583 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.0583 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0583 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.0583 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0065 | 0.3073 | 0.4565 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0065 | 0.3073 | 0.405 |
Loa Loa (eye worm) | RNA binding protein | 0.0065 | 0.3073 | 0.405 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.