Detailed information for compound 1472045

Basic information

Technical information
  • TDR Targets ID: 1472045
  • Name: 1-[2-[(4-ethylphenyl)methylamino]ethylamino]p ropan-2-ol
  • MW: 236.353 | Formula: C14H24N2O
  • H donors: 3 H acceptors: 1 LogP: 1.41 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccc(cc1)CNCCNCC(O)C
  • InChi: 1S/C14H24N2O/c1-3-13-4-6-14(7-5-13)11-16-9-8-15-10-12(2)17/h4-7,12,15-17H,3,8-11H2,1-2H3
  • InChiKey: LVSVHSNVCDDROX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[2-[(4-ethylbenzyl)amino]ethylamino]propan-2-ol
  • STK283536
  • 1-({2-[(4-ethylbenzyl)amino]ethyl}amino)-2-propanol
  • AN-465/42886663

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0477 0.6747 0.6747
Schistosoma mansoni DNA polymerase eta 0.0044 0.0372 0.0552
Echinococcus granulosus dna polymerase eta 0.0044 0.0372 0.1252
Leishmania major DNA polymerase eta, putative 0.0031 0.0178 0.4775
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0221 0.2971 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0 0.5
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0698 1 1
Schistosoma mansoni hypothetical protein 0.0221 0.2971 0.4404
Loa Loa (eye worm) MH2 domain-containing protein 0.0264 0.3611 0.3611
Schistosoma mansoni tar DNA-binding protein 0.021 0.2807 0.416
Loa Loa (eye worm) latrophilin receptor protein 2 0.0221 0.2971 0.2971
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0221 0.2971 0.2971
Echinococcus granulosus tar DNA binding protein 0.021 0.2807 0.9447
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0178 0.4775
Schistosoma mansoni tar DNA-binding protein 0.021 0.2807 0.416
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0221 0.2971 1
Echinococcus granulosus GPCR family 2 0.0221 0.2971 1
Leishmania major DNA polymerase eta, putative 0.0044 0.0372 1
Trypanosoma brucei DNA polymerase eta, putative 0.0044 0.0372 1
Loa Loa (eye worm) RNA binding protein 0.021 0.2807 0.2807
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0 0.5
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.0372 0.0372
Mycobacterium ulcerans DNA polymerase IV 0.0019 0 0.5
Loa Loa (eye worm) TAR-binding protein 0.021 0.2807 0.2807
Brugia malayi RNA binding protein 0.021 0.2807 0.2807
Loa Loa (eye worm) hypothetical protein 0.0221 0.2971 0.2971
Brugia malayi RNA recognition motif domain containing protein 0.021 0.2807 0.2807
Brugia malayi latrophilin 2 splice variant baaae 0.0477 0.6747 0.6747
Schistosoma mansoni hypothetical protein 0.0221 0.2971 0.4404
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0208 0.2774 0.9337
Schistosoma mansoni tar DNA-binding protein 0.021 0.2807 0.416
Brugia malayi MH2 domain containing protein 0.0264 0.3611 0.3611
Loa Loa (eye worm) hypothetical protein 0.0698 1 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0208 0.2774 0.2774
Giardia lamblia DINP protein human, muc B family 0.0019 0 0.5
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0178 0.5
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0221 0.2971 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0221 0.2971 1
Echinococcus multilocularis GPCR, family 2 0.0221 0.2971 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0208 0.2774 0.4112
Schistosoma mansoni hypothetical protein 0.0221 0.2971 0.4404
Schistosoma mansoni hypothetical protein 0.0477 0.6747 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0208 0.2774 0.4112
Schistosoma mansoni tar DNA-binding protein 0.021 0.2807 0.416
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0208 0.2774 0.9337
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.021 0.2807 0.2807
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0208 0.2774 0.2774
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0 0.5
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0 0.5
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0372 1
Loa Loa (eye worm) transcription factor SMAD2 0.0264 0.3611 0.3611
Brugia malayi TAR-binding protein 0.021 0.2807 0.2807
Mycobacterium ulcerans DNA polymerase IV 0.0019 0 0.5
Brugia malayi Latrophilin receptor protein 2 0.0221 0.2971 0.2971
Echinococcus multilocularis tar DNA binding protein 0.021 0.2807 0.9447
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0208 0.2774 0.9337
Loa Loa (eye worm) hypothetical protein 0.0044 0.0372 0.0372
Schistosoma mansoni hypothetical protein 0.0221 0.2971 0.4404
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0208 0.2774 0.9337
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.0698 1 1
Schistosoma mansoni tar DNA-binding protein 0.021 0.2807 0.416
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0208 0.2774 0.4112
Echinococcus multilocularis dna polymerase eta 0.0044 0.0372 0.1252

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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