Detailed information for compound 147232

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 338.399 | Formula: C17H26N2O5
  • H donors: 3 H acceptors: 5 LogP: 2.76 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: C(OCc1c[nH]cn1)CCC1CCCCC1.OC(=O)/C=C\C(=O)O
  • InChi: 1S/C13H22N2O.C4H4O4/c1-2-5-12(6-3-1)7-4-8-16-10-13-9-14-11-15-13;5-3(6)1-2-4(7)8/h9,11-12H,1-8,10H2,(H,14,15);1-2H,(H,5,6)(H,7,8)/b;2-1-
  • InChiKey: WUJSZHXSRHXYKW-BTJKTKAUSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Histamine H3 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus biogenic amine 5HT receptor Histamine H3 receptor   445 aa 405 aa 25.2 %
Loa Loa (eye worm) hypothetical protein Histamine H3 receptor   445 aa 384 aa 22.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi MTAP 0.0425 0.2372 0.2608
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0079 0.0318 0.0811
Entamoeba histolytica MTA/SAH nucleosidase, putative 0.0079 0.0318 0.1238
Brugia malayi ELM2 domain containing protein 0.0031 0.0037 0.004
Echinococcus multilocularis histone lysine N methyltransferase E(z) 0.0307 0.1672 0.3926
Loa Loa (eye worm) hypothetical protein 0.0036 0.0067 0.0073
Brugia malayi hypothetical protein 0.0064 0.0229 0.0252
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0086 0.0202
Brugia malayi Carm1-pending protein 0.0156 0.0775 0.0852
Entamoeba histolytica hypothetical protein 0.0036 0.0064 0.0127
Echinococcus multilocularis Protein lozenge 0.0055 0.0176 0.0413
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0079 0.0318 0.0285
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0232 0.1229 0.2861
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.0037 0.004
Trypanosoma brucei spermidine synthase 0.0687 0.3924 1
Echinococcus multilocularis hepatoma derived growth factor protein 0.0099 0.0439 0.1031
Brugia malayi S-adenosylmethionine decarboxylase proenzyme 0.0439 0.2457 0.2701
Echinococcus granulosus hepatoma derived growth factor protein 0.0099 0.0439 0.1031
Echinococcus granulosus PWWP domain containing protein 2A 0.0099 0.0439 0.1031
Entamoeba histolytica hypothetical protein 0.0036 0.0064 0.0127
Schistosoma mansoni methylthioadenosine phosphorylase 0.0079 0.0318 0.0715
Toxoplasma gondii phosphorylase family protein 0.0079 0.0318 0.0942
Trichomonas vaginalis CDC6, putative 0.0031 0.0037 0.0002
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0127 0.0604 0.1844
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0079 0.0318 0.1238
Schistosoma mansoni SET domain protein 0.0048 0.0134 0.028
Schistosoma mansoni carbonic anhydrase-related 0.0163 0.0821 0.1899
Schistosoma mansoni carbonic anhydrase 0.0163 0.0821 0.1899
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0037 0.004
Echinococcus multilocularis protein arginine N methyltransferase 7 0.0031 0.0035 0.0081
Leishmania major modification methylase-like protein 0.0418 0.2328 0.5932
Mycobacterium leprae probable uridine phosphorylase 0.0079 0.0318 0.4327
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.0037 0.004
Echinococcus granulosus purine nucleoside phosphorylase 0.0079 0.0318 0.0748
Brugia malayi PHD-finger family protein 0.0031 0.0037 0.004
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0086 0.0095
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0234 0.0257
Loa Loa (eye worm) hypothetical protein 0.0031 0.0037 0.004
Schistosoma mansoni hepatoma derived growth factor 0.0099 0.0439 0.0999
Echinococcus multilocularis geminin 0.0716 0.4096 0.962
Loa Loa (eye worm) hypothetical protein 0.0436 0.2437 0.2679
Trypanosoma cruzi MIZ/SP-RING zinc finger, putative 0.0099 0.0439 0.1118
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0141 0.0688 0.2117
Loa Loa (eye worm) hypothetical protein 0.0962 0.5558 0.611
Plasmodium vivax spermidine synthase, putative 0.0687 0.3924 1
Echinococcus multilocularis histone h3 methyltransferase 0.0394 0.2191 0.5145
Loa Loa (eye worm) hypothetical protein 0.0074 0.0289 0.0317
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0079 0.0318 0.0285
Schistosoma mansoni suppressor of variegation 4-20-related 0.0148 0.073 0.1684
Echinococcus multilocularis DNA methyltransferase 2, putative 0.0418 0.2328 0.5467
Schistosoma mansoni hypothetical protein 0.0036 0.0064 0.0115
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0037 0.0086
Schistosoma mansoni cpg binding protein 0.0266 0.1431 0.3337
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0037 0.0086
Mycobacterium tuberculosis Probable reductase 0.0127 0.0604 0.1844
Schistosoma mansoni uridine phosphorylase 0.0079 0.0318 0.0715
Echinococcus granulosus spermidine synthase 0.0687 0.3924 0.9215
Mycobacterium ulcerans bifunctional Mta/Sah nucleosidase Mtn 0.0079 0.0318 0.0916
Brugia malayi hypothetical protein 0.0436 0.2437 0.2679
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0037 0.0108
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0037 0.0002
Entamoeba histolytica hypothetical protein 0.0036 0.0064 0.0127
Trypanosoma brucei histone-lysine n-methyltransferase 0.005 0.0149 0.0378
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0064 0.0229 0.0584
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0078 0.0312 0.0795
Plasmodium falciparum purine nucleoside phosphorylase 0.0079 0.0318 0.0811
Schistosoma mansoni cpg binding protein 0.0268 0.1441 0.3361
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0037 0.0051
Echinococcus granulosus histone lysine N methyltransferase Ez 0.0307 0.1672 0.3926
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0385 0.2133 0.4992
Trypanosoma cruzi trypanothione reductase, putative 0.0056 0.0181 0.0462
Trypanosoma cruzi Histone-lysine N-methyltransferase, H3 lysine-76 specific 0.005 0.0149 0.0378
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.0418 0.2328 0.5932
Trypanosoma cruzi hypothetical protein, conserved 0.0099 0.0439 0.1118
Trichomonas vaginalis aldo/keto reductase, putative 0.0031 0.0037 0.0002
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0037 0.0086
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0033 0.0047 0.0012
Echinococcus granulosus carbonic anhydrase 0.0163 0.0821 0.1927
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0079 0.0318 0.0285
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0163 0.0821 0.0902
Echinococcus granulosus histone arginine methyltransferase CARMER 0.0156 0.0775 0.182
Loa Loa (eye worm) hypothetical protein 0.0228 0.1205 0.1325
Brugia malayi PWWP domain containing protein 0.0099 0.0439 0.0482
Leishmania major arginine N-methyltransferase-like protein 0.0033 0.0047 0.0118
Mycobacterium tuberculosis Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase 0.0079 0.0318 0.0916
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0064 0.015
Toxoplasma gondii thioredoxin reductase 0.0056 0.0181 0.0537
Echinococcus granulosus methyl CpG binding domain protein 2 0.0028 0.0015 0.0035
Echinococcus granulosus metastasis associated protein 1 mta1 0.0031 0.0037 0.0087
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0037 0.0002
Echinococcus multilocularis purine nucleoside phosphorylase 0.0079 0.0318 0.0748
Brugia malayi glutathione reductase 0.0056 0.0181 0.0199
Brugia malayi jmjC domain containing protein 0.0102 0.0458 0.0503
Trypanosoma brucei S-adenosylmethionine decarboxylase 0.0439 0.2457 0.6261
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0141 0.0688 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0056 0.0181 0.0426
Mycobacterium tuberculosis Hypothetical protein 0.0079 0.0318 0.0916
Echinococcus multilocularis S adenosylmethionine decarboxylase proenzyme 0.0439 0.2457 0.5769
Echinococcus granulosus histone lysine n methyltransferase setb1 0.0036 0.0067 0.0156
Echinococcus granulosus arginine glutamic acid dipeptide RE repeats 0.0031 0.0037 0.0087
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0086 0.0168
Treponema pallidum purine nucleoside phosphorylase (deoD) 0.0079 0.0318 0.5
Plasmodium falciparum thioredoxin reductase 0.0056 0.0181 0.0462
Plasmodium vivax SET domain protein, putative 0.0168 0.0851 0.2168
Echinococcus granulosus polybromo 1 0.0032 0.0039 0.0093
Loa Loa (eye worm) hypothetical protein 0.0228 0.1205 0.1325
Trypanosoma brucei Histone methylation protein DOT1, putative 0.005 0.0149 0.0378
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0031 0.0037 0.0093
Brugia malayi Pre-SET motif family protein 0.0205 0.1066 0.1171
Echinococcus granulosus purine nucleoside phosphorylase 0.0079 0.0318 0.0748
Echinococcus granulosus methylthioadenosine phosphorylase 0.0425 0.2372 0.5571
Loa Loa (eye worm) oxidoreductase 0.0031 0.0037 0.004
Leishmania major hypothetical protein, conserved 0.0099 0.0439 0.1118
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0284 0.1535 0.3582
Echinococcus granulosus uridine phosphorylase 1 0.0079 0.0318 0.0748
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.0418 0.2328 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1559 0.9096 1
Brugia malayi polybromodomain protein 0.0031 0.0037 0.004
Brugia malayi Bromodomain containing protein 0.0031 0.0037 0.004
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0033 0.0047 0.0137
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0037 0.0086
Trichomonas vaginalis aldo/keto reductase, putative 0.0031 0.0037 0.0002
Brugia malayi F/Y-rich N-terminus family protein 0.0035 0.006 0.0065
Trichomonas vaginalis origin recognition complex subunit, putative 0.0031 0.0037 0.0002
Leishmania major carbonic anhydrase-like protein 0.0385 0.2133 0.5436
Brugia malayi jmjC domain containing protein 0.004 0.0086 0.0094
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0064 0.0229 0.0584
Trypanosoma cruzi spermidine synthase, putative 0.0687 0.3924 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0047 0.0052
Chlamydia trachomatis AMP nucleosidase 0.0079 0.0318 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0099 0.0439 0.1118
Schistosoma mansoni hypothetical protein 0.0031 0.0037 0.0051
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0163 0.0821 0.0902
Trypanosoma brucei transcription elongation factor s-II, putative 0.0099 0.0439 0.1118
Echinococcus granulosus histone h3 methyltransferase 0.0394 0.2191 0.5145
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0033 0.0047 0.0074
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0425 0.2372 0.6045
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0031 0.0035 0.0088
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0064 0.0229 0.0584
Plasmodium falciparum histone-lysine N-methyltransferase, putative 0.0092 0.0396 0.1008
Toxoplasma gondii histone arginine methyltransferase PRMT3 0.0031 0.0035 0.0102
Echinococcus granulosus purine nucleoside phosphorylase 0.0079 0.0318 0.0748
Leishmania major hypothetical protein, conserved 0.005 0.0149 0.0378
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0079 0.0318 1
Loa Loa (eye worm) SET domain-containing protein 0.0148 0.073 0.0802
Toxoplasma gondii phosphorylase family protein 0.0079 0.0318 0.0942
Trypanosoma cruzi protein arginine n-methyltransferase 7 0.0031 0.0035 0.0088
Loa Loa (eye worm) oxidoreductase 0.0031 0.0037 0.004
Echinococcus multilocularis spermidine synthase 0.0687 0.3924 0.9215
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0037 0.0086
Treponema pallidum uridine phosphorylase (udp) 0.0079 0.0318 0.5
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0086 0.0168
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0033 0.0049 0.0081
Brugia malayi SET domain containing protein 0.0049 0.0143 0.0157
Entamoeba histolytica hypothetical protein 0.0064 0.0229 0.0849
Toxoplasma gondii histone lysine methyltransferase SET1 0.0074 0.0291 0.086
Leishmania major arginine N-methyltransferase, type I 0.0031 0.0035 0.0088
Schistosoma mansoni lozenge 0.0055 0.0176 0.0379
Loa Loa (eye worm) hypothetical protein 0.0394 0.2191 0.2408
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0037 0.0002
Trypanosoma brucei S-adenosylmethionine decarboxylase proenzyme, putative 0.0439 0.2457 0.6261
Loa Loa (eye worm) hypothetical protein 0.0163 0.0821 0.0902
Trypanosoma brucei prostaglandin f synthase 0.0031 0.0037 0.0093
Brugia malayi hypothetical protein 0.0099 0.0439 0.0482
Echinococcus granulosus geminin 0.0716 0.4096 0.962
Echinococcus granulosus histone lysine methyltransferase setb 0.0232 0.1229 0.2886
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0168 0.0851 0.1998
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0078 0.0312 0.07
Loa Loa (eye worm) spermidine synthase 0.0687 0.3924 0.4314
Echinococcus granulosus aldo keto reductase 0.0031 0.0037 0.0086
Loa Loa (eye worm) protein arginine N-methyltransferase 0.0031 0.0035 0.0038
Schistosoma mansoni methylthioadenosine phosphorylase 0.0425 0.2372 0.5555
Echinococcus multilocularis microtubule associated protein 2 0.0743 0.4258 1
Schistosoma mansoni purine nucleoside phosphorylase 0.0079 0.0318 0.0715
Echinococcus multilocularis purine nucleoside phosphorylase 0.0079 0.0318 0.0748
Trypanosoma cruzi arginine N-methyltransferase, type III 0.0031 0.0035 0.0088
Schistosoma mansoni polybromo-1 0.0032 0.0039 0.0058
Echinococcus granulosus purine nucleoside phosphorylase 0.0079 0.0318 0.0748
Giardia lamblia UPL-1 0.0079 0.0318 1
Entamoeba histolytica hypothetical protein 0.0036 0.0064 0.0127
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0064 0.0115
Onchocerca volvulus 0.0436 0.2437 0.2409
Schistosoma mansoni histone J3 methyltransferase 0.0394 0.2191 0.5128
Trichomonas vaginalis purine nucleoside phosphorylase I, putative 0.0079 0.0318 0.0285
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0385 0.2133 0.2345
Schistosoma mansoni cpg binding protein 0.0268 0.1441 0.3361
Echinococcus multilocularis uridine phosphorylase 1 0.0079 0.0318 0.0748
Schistosoma mansoni hepatoma derived growth factor 0.0099 0.0439 0.0999
Schistosoma mansoni carbonic anhydrase-related 0.0163 0.0821 0.1899
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0078 0.0312 0.0795
Trypanosoma brucei protein arginine n-methyltransferase 7 0.0031 0.0035 0.0088
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0037 0.0086
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0102 0.0458 0.1075
Leishmania major trypanothione reductase 0.0056 0.0181 0.0462
Echinococcus granulosus aldo keto reductase 0.0031 0.0037 0.0086
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0037 0.0002
Loa Loa (eye worm) thioredoxin reductase 0.0056 0.0181 0.02
Brugia malayi Bromodomain containing protein 0.0029 0.0026 0.0028
Schistosoma mansoni hypothetical protein 0.0099 0.0439 0.0999
Leishmania major histone-lysine N-methyltransferase, putative 0.005 0.0149 0.0378
Echinococcus granulosus histone lysine n methyltransferase suv420h1 0.0148 0.073 0.1713
Brugia malayi SET domain containing protein 0.0148 0.073 0.0802
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0109 0.0257
Echinococcus granulosus microtubule associated protein 2 0.0743 0.4258 1
Onchocerca volvulus 0.0271 0.1456 0.1425
Echinococcus multilocularis histone lysine n methyltransferase setb1 0.0036 0.0067 0.0156
Schistosoma mansoni enhancer of zeste ezh 0.0307 0.1672 0.3904
Echinococcus multilocularis purine nucleoside phosphorylase 0.0079 0.0318 0.0748
Loa Loa (eye worm) oxidoreductase 0.0031 0.0037 0.004
Echinococcus multilocularis bromo adjacent y domain containing 1 0.0031 0.0037 0.0087
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0079 0.0318 0.1238
Brugia malayi hypothetical protein 0.0228 0.1205 0.1325
Brugia malayi CXXC zinc finger family protein 0.0266 0.1431 0.1573
Mycobacterium tuberculosis Conserved hypothetical protein 0.0079 0.0318 0.0916
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0056 0.0181 0.0471
Echinococcus multilocularis carbonic anhydrase 0.0163 0.0821 0.1927
Onchocerca volvulus 0.0266 0.1431 0.1399
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0033 0.0047 0.0074
Plasmodium vivax histone-lysine N-methyltransferase, putative 0.0092 0.0396 0.1008
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0168 0.0851 0.2519
Brugia malayi Protein arginine N-methyltransferase 0.0031 0.0035 0.0038
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0555 0.061
Echinococcus granulosus DNA methyltransferase 2, putative 0.0418 0.2328 0.5467
Loa Loa (eye worm) S-methyl-5'-thioadenosine phosphorylase MTAP 0.0425 0.2372 0.2608
Echinococcus granulosus metastasis associated protein MTA1 0.0031 0.0037 0.0087
Loa Loa (eye worm) hypothetical protein 0.0028 0.0015 0.0017
Schistosoma mansoni pol-related 0.0031 0.0037 0.0051
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0029 0.0026 0.006
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0385 0.2133 0.4992
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0078 0.0312 0.0795
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0163 0.0821 0.0902
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.0037 0.004
Brugia malayi hypothetical protein 0.0099 0.0439 0.0482
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0425 0.2372 0.6045
Entamoeba histolytica hypothetical protein 0.0099 0.0439 0.1763
Schistosoma mansoni hypothetical protein 0.0163 0.0821 0.1899
Leishmania major nucleoside phosphorylase-like protein 0.0079 0.0318 0.0811
Brugia malayi NNMT/PNMT/TEMT family protein 0.0962 0.5558 0.611
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0385 0.2133 0.2345
Loa Loa (eye worm) glutathione reductase 0.0056 0.0181 0.02
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0037 0.0108
Echinococcus granulosus PWWP domain containing protein 2A 0.0099 0.0439 0.1031
Schistosoma mansoni hypothetical protein 0.0716 0.4096 0.9618
Brugia malayi Thioredoxin reductase 0.0056 0.0181 0.0199
Schistosoma mansoni hypothetical protein 0.0716 0.4096 0.9618
Loa Loa (eye worm) hypothetical protein 0.0031 0.0037 0.0041
Toxoplasma gondii hypothetical protein 0.0594 0.3377 1
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0385 0.2133 0.5436
Schistosoma mansoni hypothetical protein 0.0099 0.0439 0.0999
Mycobacterium tuberculosis Probable oxidoreductase 0.0141 0.0688 0.2117
Toxoplasma gondii aldose reductase, putative 0.0031 0.0037 0.0108
Echinococcus granulosus hypothetical protein 0.0031 0.0037 0.0086
Trypanosoma brucei aldo-keto reductase, putative 0.0031 0.0037 0.0093
Mycobacterium tuberculosis Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) 0.0079 0.0318 0.0916
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0037 0.0086
Leishmania major spermidine synthase 0.0687 0.3924 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0141 0.0688 0.2117
Brugia malayi uridine phosphorylase family protein 0.0079 0.0318 0.035
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.0156 0.0775 0.182
Loa Loa (eye worm) hypothetical protein 0.0031 0.0037 0.004
Brugia malayi SET domain containing protein 0.0131 0.0631 0.0694
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0078 0.0312 0.0733
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0037 0.0086
Echinococcus granulosus protein arginine N methyltransferase 7 0.0031 0.0035 0.0081
Echinococcus multilocularis metastasis associated protein MTA1 0.0031 0.0037 0.0087
Plasmodium falciparum glutathione reductase 0.0056 0.0181 0.0462
Onchocerca volvulus 0.0228 0.1205 0.1173
Brugia malayi Disco-interacting protein 2 homolog 0.0271 0.1456 0.1601
Echinococcus multilocularis cpg binding protein 0.0268 0.1441 0.3385
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0168 0.0851 0.197
Plasmodium falciparum carbonic anhydrase 0.0163 0.0821 0.2091
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0064 0.0229 0.0849
Mycobacterium tuberculosis Probable spermidine synthase SpeE (putrescine aminopropyltransferase) (aminopropyltransferase) (SPDSY) 0.055 0.3112 1
Echinococcus granulosus transcription factor Dp 1 0.0045 0.0118 0.0278
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0385 0.2133 0.5436
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.0418 0.2328 0.5451
Echinococcus granulosus carbonic anhydrase II 0.0385 0.2133 0.5009
Mycobacterium leprae Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) 0.0079 0.0318 0.4327
Toxoplasma gondii hypothetical protein 0.0163 0.0821 0.243
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0079 0.0318 0.0811
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0109 0.0257
Schistosoma mansoni purine nucleoside phosphorylase 0.0079 0.0318 0.0715
Trypanosoma cruzi Histone methylation protein DOT1, putative 0.005 0.0149 0.0378
Trypanosoma brucei carbonic anhydrase-like protein 0.0385 0.2133 0.5436
Leishmania major aldo-keto reductase-like protein 0.0031 0.0037 0.0093
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0079 0.0318 0.0285
Echinococcus granulosus purine nucleoside phosphorylase 0.0079 0.0318 0.0748
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0232 0.1229 0.2886
Leishmania major S-adenosylmethionine decarboxylase 0.0439 0.2457 0.6261
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0163 0.0821 0.0902
Trypanosoma brucei S-adenosylmethionine decarboxylase 0.0439 0.2457 0.6261
Echinococcus granulosus carbonic anhydrase 0.0163 0.0821 0.1927
Brugia malayi Pre-SET motif family protein 0.1559 0.9096 1
Loa Loa (eye worm) hypothetical protein 0.0122 0.0577 0.0634
Schistosoma mansoni hypothetical protein 0.0031 0.0037 0.0051
Leishmania major hypothetical protein, conserved 0.005 0.0149 0.0378
Echinococcus granulosus protein arginine N methyltransferase 8 0.0033 0.0047 0.0109
Schistosoma mansoni metastasis-associated protein 1 (mta1) 0.0031 0.0037 0.0051
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0127 0.0604 0.8711
Schistosoma mansoni metastasis-associated protein 1 (mta1) 0.0031 0.0037 0.0051
Brugia malayi Histone-lysine N-methyltransferase, H3 lysine-79 specific 0.0394 0.2191 0.2408
Schistosoma mansoni SET domain protein 0.0117 0.0545 0.1249
Echinococcus granulosus disco interacting protein 2 0.0271 0.1456 0.342
Giardia lamblia PHD finger protein 15 0.0031 0.0037 0.0005
Toxoplasma gondii bicoid-interacting protein BIN3 0.0031 0.0035 0.0102
Echinococcus granulosus bromo adjacent y domain containing 1 0.0031 0.0037 0.0087
Loa Loa (eye worm) hypothetical protein 0.0115 0.0536 0.0589
Schistosoma mansoni metastasis-associated protein 1 (mta1) 0.0031 0.0037 0.0051
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0078 0.0312 0.0343
Echinococcus multilocularis histone lysine N methyltransferase, H3 lysine 36 0.0115 0.0534 0.1255
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0127 0.0604 0.1844
Schistosoma mansoni hypothetical protein 0.0099 0.0439 0.0999
Brugia malayi MH2 domain containing protein 0.0119 0.0555 0.061
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0031 0.0037 0.0002
Echinococcus granulosus S adenosylmethionine decarboxylase proenzyme 0.0439 0.2457 0.5769
Brugia malayi hypothetical protein 0.0228 0.1205 0.1325
Schistosoma mansoni phd finger protein 0.0099 0.0439 0.0999
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0037 0.0093
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0079 0.0318 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0594 0.3377 0.8605
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0037 0.0086
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0037 0.0086
Echinococcus granulosus histone lysine N methyltransferase H3 lysine 36 0.0115 0.0534 0.1255
Echinococcus granulosus aldo keto reductase 0.0031 0.0037 0.0086
Toxoplasma gondii Purine nucleoside phosphorylase 0.0079 0.0318 0.0942
Echinococcus granulosus purine nucleoside phosphorylase 0.0079 0.0318 0.0748
Plasmodium vivax glutathione reductase, putative 0.0056 0.0181 0.0462
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0037 0.0086
Loa Loa (eye worm) carbonic anhydrase 3 0.0385 0.2133 0.2345
Echinococcus multilocularis metastasis associated protein 1 (mta1) 0.0031 0.0037 0.0087
Toxoplasma gondii DNA methyltransferase 2, putative 0.0418 0.2328 0.6894
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0033 0.0047 0.0109
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0078 0.0312 0.121
Echinococcus multilocularis carbonic anhydrase 0.0163 0.0821 0.1927
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0037 0.0086
Loa Loa (eye worm) hypothetical protein 0.0064 0.0229 0.0252
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0127 0.0604 0.1844
Loa Loa (eye worm) hypothetical protein 0.0031 0.0037 0.0041
Entamoeba histolytica aldose reductase, putative 0.0031 0.0037 0.0009
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0079 0.0318 0.1238
Entamoeba histolytica aldose reductase, putative 0.0031 0.0037 0.0009
Loa Loa (eye worm) hypothetical protein 0.0228 0.1205 0.1325
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0048 0.0134 0.0314
Echinococcus multilocularis purine nucleoside phosphorylase 0.0079 0.0318 0.0748
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0081 0.0332 0.0747
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0079 0.0318 0.0285
Plasmodium falciparum spermidine synthase 0.0687 0.3924 1
Toxoplasma gondii hypothetical protein 0.0099 0.0439 0.1299
Echinococcus multilocularis SET and MYND domain containing protein 3 0.0076 0.03 0.0705
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0037 0.0086
Trichomonas vaginalis aldo/keto reductase, putative 0.0031 0.0037 0.0002
Entamoeba histolytica aldose reductase, putative 0.0031 0.0037 0.0009
Trypanosoma cruzi aldo/keto reductase, putative 0.0031 0.0037 0.0093
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0037 0.0002
Brugia malayi GATA zinc finger family protein 0.0031 0.0037 0.004
Trypanosoma cruzi S-adenosylmethionine decarboxylase proenzyme, putative 0.0439 0.2457 0.6261
Loa Loa (eye worm) hypothetical protein 0.0163 0.0821 0.0902
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0037 0.0086
Loa Loa (eye worm) hypothetical protein 0.0232 0.1229 0.1351
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0189 0.097 0.2278
Trypanosoma brucei trypanothione reductase 0.0056 0.0181 0.0462
Loa Loa (eye worm) uridine phosphorylase 0.0079 0.0318 0.035
Brugia malayi Spermidine synthase 0.0687 0.3924 0.4314
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0033 0.0047 0.0074
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.0037 0.004
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0079 0.0318 0.1238
Plasmodium falciparum S-adenosylmethionine decarboxylase/ornithine decarboxylase 0.0214 0.1121 0.2855
Onchocerca volvulus 0.0099 0.0439 0.0404
Trichomonas vaginalis set domain proteins, putative 0.1711 1 1
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0079 0.0318 0.0285
Trypanosoma cruzi Histone methylation protein DOT1, putative 0.005 0.0149 0.0378
Loa Loa (eye worm) oxidoreductase 0.0031 0.0037 0.004
Giardia lamblia Purine nucleoside phosphorylase lateral transfer candidate 0.0079 0.0318 1
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0078 0.0312 0.0733
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0163 0.0821 0.0902
Schistosoma mansoni metastasis-associated protein 1 (mta1) 0.0031 0.0037 0.0051
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0078 0.0312 0.0795
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0037 0.0002
Schistosoma mansoni carbonic anhydrase-related 0.0163 0.0821 0.1899
Loa Loa (eye worm) hypothetical protein 0.0099 0.0439 0.0483
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0232 0.1229 0.2861
Plasmodium vivax thioredoxin reductase, putative 0.0056 0.0181 0.0462
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0078 0.0312 0.0343
Echinococcus multilocularis peregrin 0.013 0.0624 0.1465
Loa Loa (eye worm) Carm1-pending protein 0.0156 0.0775 0.0852
Schistosoma mansoni methylthioadenosine phosphorylase 0.0425 0.2372 0.5555
Trypanosoma cruzi transcription elongation factor s-II, putative 0.0099 0.0439 0.1118
Trypanosoma cruzi histone-lysine N-methyltransferase, putative 0.005 0.0149 0.0378
Echinococcus multilocularis aldo keto reductase 0.0031 0.0037 0.0086
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0037 0.0086
Loa Loa (eye worm) oxidoreductase 0.0031 0.0037 0.004
Loa Loa (eye worm) NNMT/PNMT/TEMT family protein 0.0962 0.5558 0.611
Trypanosoma cruzi spermidine synthase, putative 0.0687 0.3924 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0037 0.0041
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0031 0.0037 0.0002
Schistosoma mansoni bromo adjacent homology domain containing 0.0031 0.0037 0.0051
Mycobacterium ulcerans 5'-methylthioadenosine phosphorylase 0.0425 0.2372 0.7594
Brugia malayi purine nucleoside phosphorylase I, inosine and guanosine-specific family protein 0.0079 0.0318 0.035
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0028 0.0015 0.0035
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0037 0.0002
Echinococcus granulosus purine nucleoside phosphorylase 0.0079 0.0318 0.0748
Echinococcus multilocularis disco interacting protein 2 0.0271 0.1456 0.342
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0031 0.0035 0.0088
Onchocerca volvulus 0.0099 0.0439 0.0404
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0127 0.0604 0.1844
Schistosoma mansoni aldo-keto reductase 0.0031 0.0037 0.0051
Echinococcus multilocularis carbonic anhydrase 0.0163 0.0821 0.1927
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0102 0.0458 0.1075
Echinococcus granulosus cpg binding protein 0.0268 0.1441 0.3385
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0037 0.0002
Trypanosoma cruzi spermidine synthase, putative 0.0687 0.3924 1
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0318 0.0285
Echinococcus granulosus protein arginine methyltransferase 0.0033 0.0047 0.0109
Schistosoma mansoni protein arginine n-methyltransferase 0.0156 0.0775 0.1791
Schistosoma mansoni aldo-keto reductase 0.0031 0.0037 0.0051
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0033 0.0047 0.0012
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0037 0.0002
Echinococcus multilocularis PWWP domain containing protein 2A 0.0099 0.0439 0.1031
Plasmodium vivax S-adenosylmethionine decarboxylase-ornithine decarboxylase, putative 0.0214 0.1121 0.2855
Echinococcus multilocularis methylthioadenosine phosphorylase 0.0425 0.2372 0.5571
Schistosoma mansoni uridine phosphorylase 0.0079 0.0318 0.0715
Echinococcus multilocularis transcription factor Dp 1 0.0045 0.0118 0.0278
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0064 0.015
Leishmania major methylthioadenosine phosphorylase, putative 0.0425 0.2372 0.6045
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0079 0.0318 0.0811
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0076 0.0178
Trypanosoma cruzi spermidine synthase, putative 0.0687 0.3924 1
Echinococcus granulosus purine nucleoside phosphorylase 0.0079 0.0318 0.0748
Mycobacterium tuberculosis Probable dehydrogenase 0.0127 0.0604 0.1844
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0048 0.0134 0.0314
Schistosoma mansoni microtubule-associated protein tau 0.0743 0.4258 1
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0385 0.2133 0.2345
Loa Loa (eye worm) PWWP domain-containing protein 0.0099 0.0439 0.0483
Leishmania major arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490 0.0031 0.0035 0.0088
Trypanosoma cruzi transcription elongation factor-like protein, putative 0.0099 0.0439 0.1118
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0037 0.0086
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.0418 0.2328 0.5932
Echinococcus multilocularis histone lysine n methyltransferase suv420h1 0.0148 0.073 0.1713
Echinococcus multilocularis aldo keto reductase 0.0031 0.0037 0.0086
Echinococcus multilocularis aldo keto reductase 0.0031 0.0037 0.0086
Treponema pallidum pfs protein (pfs) 0.0079 0.0318 0.5
Toxoplasma gondii hypothetical protein 0.005 0.0149 0.044
Mycobacterium tuberculosis Probable 5'-methylthioadenosine phosphorylase Pnp (MTA phosphorylase) 0.0346 0.1906 0.6077
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0033 0.0047 0.0118
Echinococcus granulosus thioredoxin glutathione reductase 0.0056 0.0181 0.0426
Onchocerca volvulus 0.0284 0.1535 0.1504
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0079 0.0318 0.0285
Loa Loa (eye worm) hypothetical protein 0.0962 0.5558 0.611
Schistosoma mansoni jumonji domain containing protein 0.0081 0.0333 0.075
Leishmania major prostaglandin f synthase, putative 0.0031 0.0037 0.0093
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0037 0.0002
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.0418 0.2328 0.6894
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0033 0.0047 0.0012
Loa Loa (eye worm) hypothetical protein 0.0436 0.2437 0.2679
Mycobacterium ulcerans purine nucleoside phosphorylase 0.0079 0.0318 0.0916
Loa Loa (eye worm) hypothetical protein 0.0271 0.1456 0.1601
Brugia malayi SET domain containing protein 0.0307 0.1672 0.1837
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0029 0.0026 0.006
Echinococcus multilocularis purine nucleoside phosphorylase 0.0079 0.0318 0.0748
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0318 0.0285
Plasmodium falciparum phd finger protein, putative 0.0031 0.0037 0.0093
Schistosoma mansoni hypothetical protein 0.0056 0.0182 0.0393
Trypanosoma brucei methylthioadenosine phosphorylase, putative 0.0425 0.2372 0.6045
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0031 0.0037 0.0002
Echinococcus multilocularis purine nucleoside phosphorylase 0.0079 0.0318 0.0748
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0037 0.0086
Mycobacterium ulcerans spermidine synthase 0.055 0.3112 1
Loa Loa (eye worm) hypothetical protein 0.0163 0.0821 0.0902
Echinococcus multilocularis arginine glutamic acid dipeptide (RE) repeats 0.0031 0.0037 0.0087
Brugia malayi hypothetical protein 0.0036 0.0064 0.007
Loa Loa (eye worm) hypothetical protein 0.0053 0.0169 0.0186
Onchocerca volvulus 0.0125 0.0592 0.0557
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0037 0.0086
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0037 0.0086
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0037 0.0002
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.0418 0.2328 0.5932
Loa Loa (eye worm) runx1 0.0055 0.0176 0.0194
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0079 0.0318 0.1238
Echinococcus granulosus peregrin 0.013 0.0624 0.1465
Echinococcus multilocularis polybromo 1 0.0032 0.0039 0.0093
Plasmodium vivax purine nucleoside phosphorylase, putative 0.0079 0.0318 0.0811
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0037 0.0002
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0037 0.0086
Echinococcus multilocularis carbonic anhydrase II 0.0385 0.2133 0.5009
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0163 0.0821 0.0902
Echinococcus multilocularis protein arginine methyltransferase 0.0033 0.0047 0.0109
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0555 0.061
Schistosoma mansoni hypothetical protein 0.0031 0.0035 0.0046
Entamoeba histolytica hypothetical protein 0.0079 0.0318 0.1238
Echinococcus multilocularis PWWP domain containing protein 2A 0.0099 0.0439 0.1031
Echinococcus multilocularis aldo keto reductase 0.0031 0.0037 0.0086
Loa Loa (eye worm) SET domain-containing protein 0.0307 0.1672 0.1838
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0037 0.0086
Loa Loa (eye worm) CXXC zinc finger family protein 0.0266 0.1431 0.1573
Trypanosoma brucei Histone-lysine N-methyltransferase, H3 lysine-76 specific 0.005 0.0149 0.0378
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0031 0.0037 0.0093
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.0156 0.0775 0.2295
Trypanosoma cruzi aldo-keto reductase 0.0031 0.0037 0.0093
Onchocerca volvulus Purine nucleoside phosphorylase homolog 0.0079 0.0318 0.0283
Trypanosoma cruzi S-adenosylmethionine decarboxylase proenzyme, putative 0.0439 0.2457 0.6261
Echinococcus granulosus methyltransferase protein 5 0.0031 0.0035 0.0081
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0037 0.0086
Echinococcus granulosus SET and MYND domain containing protein 3 0.0076 0.03 0.0705
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0271 0.1456 0.3397
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0033 0.0047 0.0118
Loa Loa (eye worm) S-adenosylmethionine decarboxylase proenzyme 0.0439 0.2457 0.2701
Trypanosoma brucei uridine phosphorylase 0.0079 0.0318 0.0811
Echinococcus granulosus carbonic anhydrase 0.0163 0.0821 0.1927

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) > 10 mg kg-1 Potency after oral administration in vivo in mice ChEMBL. 15115409
ED50 (functional) > 10 mg kg-1 Potency after oral administration in vivo in mice ChEMBL. 15115409
Kd (functional) = 4.2 Functional H2 receptor antagonistic activity in vitro assay on the isolated spontaneously beating guinea-pig right atrium ChEMBL. 15115409
Kd (functional) = 4.2 Functional Histamine H1 receptor ChEMBL. 15115409
Ki (functional) ~ 6.3 Functional Histamine H3 receptor antagonistic activity in vitro assay on synaptosomes of rat cerebral cortex ChEMBL. 15115409
Ki (binding) >= 500 nM In vitro binding affinity against rat histamine H3 receptor ChEMBL. 15115409
Ki (binding) >= 500 nM In vitro binding affinity against rat histamine H3 receptor ChEMBL. 15115409
Log Ki (functional) ~ 6.3 Functional Histamine H3 receptor antagonistic activity in vitro assay on synaptosomes of rat cerebral cortex ChEMBL. 15115409
pA2 (functional) = 4.2 Functional H2 receptor antagonistic activity in vitro assay on the isolated spontaneously beating guinea-pig right atrium ChEMBL. 15115409
pA2 (functional) = 4.2 Functional Histamine H1 receptor ChEMBL. 15115409

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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