Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | hypothetical protein | 0.005 | 0.0011 | 0.5 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0074 | 0.0191 | 0.1429 |
Brugia malayi | nuclear hormone receptor | 0.0526 | 0.3635 | 1 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0074 | 0.0191 | 0.1429 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0199 | 0.1142 | 0.1142 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0199 | 0.1142 | 0.8524 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0074 | 0.0191 | 0.1429 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0225 | 0.134 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0539 | 0.3734 | 1 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0074 | 0.0191 | 0.0527 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0312 | 0.2004 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0312 | 0.2004 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0312 | 0.2004 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0514 | 0.3547 | 0.9758 |
Mycobacterium ulcerans | hypothetical protein | 0.0164 | 0.0879 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0164 | 0.0879 | 0.5 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0199 | 0.1142 | 0.3142 |
Schistosoma mansoni | lipoxygenase | 0.0157 | 0.0825 | 0.0825 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0148 | 0.0752 | 0.3643 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0074 | 0.0191 | 0.1429 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0199 | 0.1142 | 0.3142 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0225 | 0.134 | 1 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0312 | 0.2004 | 1 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0074 | 0.0191 | 0.0527 |
Schistosoma mansoni | protein tyrosine phosphatase n11 (shp2) | 0.0074 | 0.0191 | 0.0191 |
Schistosoma mansoni | lipoxygenase | 0.0225 | 0.134 | 0.134 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0526 | 0.3635 | 1 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0199 | 0.1142 | 0.8524 |
Schistosoma mansoni | family A2 unassigned peptidase (A02 family) | 0.0247 | 0.1513 | 0.1513 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.