Detailed information for compound 1472459

Basic information

Technical information
  • TDR Targets ID: 1472459
  • Name: 4-methoxy-N-methyl-2-[4-(4-nitrophenyl)imidaz ol-1-yl]aniline
  • MW: 324.334 | Formula: C17H16N4O3
  • H donors: 1 H acceptors: 3 LogP: 3.12 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNc1ccc(cc1n1cnc(c1)c1ccc(cc1)[N+](=O)[O-])OC
  • InChi: 1S/C17H16N4O3/c1-18-15-8-7-14(24-2)9-17(15)20-10-16(19-11-20)12-3-5-13(6-4-12)21(22)23/h3-11,18H,1-2H3
  • InChiKey: XXCJLBNUVJMBQA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-methoxy-N-methyl-2-[4-(4-nitrophenyl)-1-imidazolyl]aniline
  • MLS001181319
  • Oprea1_503019
  • SMR000502572
  • STK002286
  • ZINC00355591
  • [4-methoxy-2-[4-(4-nitrophenyl)imidazol-1-yl]phenyl]-methyl-amine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Candida albicans hypothetical protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Giardia lamblia Grp94/Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium falciparum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Neospora caninum HSP90-like protein, related Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K09487 heat shock protein 90kDa beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Candida albicans hypothetical protein Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K04079 molecular chaperone HtpG, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Treponema pallidum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium berghei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Trypanosoma brucei gambiense heat shock protein 83,heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii heat shock protein HSP90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium parvum Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium ulcerans heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma japonicum IPR003367,Thrombospondin type 3 repeat;IPR002048,Calcium-binding EF-hand,domain-containing Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii putative heat shock protein 81-2 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein heat shock protein 90 alpha Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein HSP 90-alpha, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Babesia bovis hsp90 protein Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii heat shock 90 kDa protein homolog Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Plasmodium vivax heat shock protein 86, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi Endoplasmin precursor Get druggable targets OG5_126623 All targets in OG5_126623
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium hominis heat shock protein 83 Get druggable targets OG5_126623 All targets in OG5_126623
Theileria parva heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein HSP 90-beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Trypanosoma brucei gambiense lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum HSP90, related Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major heat shock protein 83-1 0.0039 0.0104 0.3673
Loa Loa (eye worm) hypothetical protein 0.0076 0.0283 0.0283
Echinococcus multilocularis Two pore potassium channel protein sup 9 0.0076 0.0283 0.0283
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0017 0.0605
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0104 0.3673
Schistosoma mansoni lipoxygenase 0.0022 0.0022 0.0022
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.0006 0.0006
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0065 0.2306
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0104 0.3673
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.0022 0.0022
Loa Loa (eye worm) doublecortin family protein 0.0022 0.0022 0.0022
Echinococcus granulosus microtubule associated protein 2 0.0782 0.3704 0.3704
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 24 0.0076 0.0283 0.3596
Echinococcus granulosus TWiK family of potassium channels protein 7 0.0076 0.0283 0.0283
Leishmania major heat shock protein 83-1 0.0039 0.0104 0.3673
Schistosoma mansoni calcium-activated potassium channel 0.0076 0.0283 0.0283
Onchocerca volvulus 0.0076 0.0283 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0019 0.0006 0.0205
Brugia malayi Cathepsin L-like precursor 0.0019 0.0006 0.0074
Schistosoma mansoni twik family of potassium channels-related 0.0076 0.0283 0.0283
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0076 0.0283 1
Trypanosoma cruzi Heat shock protein 83, putative 0.0039 0.0104 0.3673
Onchocerca volvulus 0.0076 0.0283 1
Loa Loa (eye worm) endoplasmin 0.0039 0.0104 0.0104
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 5 0.0076 0.0283 0.3596
Loa Loa (eye worm) hypothetical protein 0.2081 1 1
Leishmania major cathepsin L-like protease 0.0072 0.0264 0.9321
Leishmania major heat shock protein 83-1 0.0039 0.0104 0.3673
Leishmania major heat shock protein 83-1 0.0039 0.0104 0.3673
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog 0.0076 0.0283 0.3596
Echinococcus multilocularis potassium channel subfamily K 8 0.0076 0.0283 0.0283
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0076 0.0283 1
Echinococcus multilocularis RUN 0.0022 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0076 0.0283 0.0283
Trichomonas vaginalis heat shock protein, putative 0.0024 0.0031 0.0891
Trypanosoma brucei calcium/potassium channel (CAKC), putative 0.0076 0.0283 1
Schistosoma mansoni hypothetical protein 0.0022 0.0022 0.0022
Loa Loa (eye worm) fibroinase 0.0019 0.0006 0.0006
Schistosoma mansoni heat shock protein 0.0039 0.0104 0.0104
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0264 0.9321
Giardia lamblia Grp94/Hsp90 0.0031 0.0065 0.181
Trypanosoma brucei heat shock protein 90, putative 0.0039 0.0104 0.3673
Plasmodium falciparum endoplasmin, putative 0.0024 0.0031 0.1078
Onchocerca volvulus 0.0076 0.0283 1
Mycobacterium tuberculosis Possible transmembrane cation transporter 0.0076 0.0283 1
Schistosoma mansoni hypothetical protein 0.0076 0.0283 0.0283
Echinococcus granulosus muscleblind protein 0.018 0.0788 0.0788
Schistosoma mansoni microtubule-associated protein tau 0.0782 0.3704 0.3704
Leishmania major hypothetical protein, conserved 0.0076 0.0283 1
Brugia malayi Cytochrome P450 family protein 0.0051 0.0162 0.2059
Plasmodium vivax endoplasmin, putative 0.0039 0.0104 0.3673
Schistosoma mansoni jumonji/arid domain-containing protein 0.0067 0.0237 0.0237
Loa Loa (eye worm) hypothetical protein 0.0076 0.0283 0.0283
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0017 0.0605
Leishmania major heat shock protein 83-1 0.0039 0.0104 0.3673
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 17 0.0076 0.0283 0.3596
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0031 0.0065 0.2306
Echinococcus multilocularis cysteine protease 0.0019 0.0006 0.0006
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0017 0.0408
Leishmania major heat shock protein 83-1 0.0039 0.0104 0.3673
Loa Loa (eye worm) hypothetical protein 0.0076 0.0283 0.0283
Echinococcus multilocularis heat shock protein 90 0.0039 0.0104 0.0104
Entamoeba histolytica heat shock protein 90, putative 0.0039 0.0104 0.354
Loa Loa (eye worm) hypothetical protein 0.0019 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0076 0.0283 0.0283
Leishmania major calcium/potassium channel (CAKC), putative 0.0076 0.0283 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0076 0.0283 0.0283
Trypanosoma cruzi major cysteine proteinase, putative 0.0057 0.0189 0.6676
Schistosoma mansoni jumonji/arid domain-containing protein 0.0067 0.0237 0.0237
Giardia lamblia Heat shock protein HSP 90-alpha 0.0031 0.0065 0.181
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0031 0.0065 0.5
Echinococcus multilocularis twik family of potassium channels 0.0076 0.0283 0.0283
Echinococcus granulosus heat shock protein 90 0.0039 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0076 0.0283 0.0283
Echinococcus multilocularis endoplasmin 0.0031 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0076 0.0283 0.0283
Trypanosoma cruzi ion transport protein, putative 0.0076 0.0283 1
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 21 0.0076 0.0283 0.3596
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0066 0.0234 0.8249
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 45 0.0076 0.0283 0.3596
Echinococcus granulosus twik family of potassium channels 0.0076 0.0283 0.0283
Leishmania major heat shock protein 83-1 0.0039 0.0104 0.3673
Entamoeba histolytica heat shock protein 90, putative 0.0039 0.0104 0.354
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0031 0.0065 1
Leishmania major heat shock protein 83-1 0.0039 0.0104 0.3673
Treponema pallidum heat shock protein 90 0.0031 0.0065 1
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0031 0.0065 0.181
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0264 0.9321
Loa Loa (eye worm) hypothetical protein 0.0076 0.0283 0.0283
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0076 0.0283 0.0283
Brugia malayi Muscleblind-like protein 0.018 0.0788 1
Echinococcus multilocularis twik family of potassium channels 0.0076 0.0283 0.0283
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0022 0.0022
Schistosoma mansoni calcium-activated potassium channel 0.0076 0.0283 0.0283
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0076 0.0283 1
Leishmania major heat shock protein 83-1 0.0039 0.0104 0.3673
Loa Loa (eye worm) ctsf protein 0.0019 0.0006 0.0006
Echinococcus multilocularis muscleblind protein 1 0.018 0.0788 0.0788
Onchocerca volvulus 0.0076 0.0283 1
Plasmodium falciparum LCCL domain-containing protein 0.0022 0.0022 0.0781
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0076 0.0283 0.3596
Mycobacterium ulcerans transmembrane cation transporter 0.0076 0.0283 1
Plasmodium falciparum potassium channel 0.0076 0.0283 1
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.0076 0.0283 0.0283
Echinococcus multilocularis TWiK family of potassium channels protein 7 0.0076 0.0283 0.0283
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0017 0.0408
Brugia malayi jmjC domain containing protein 0.0067 0.0237 0.3005
Toxoplasma gondii cathepsin CPL 0.0019 0.0006 0.0205
Entamoeba histolytica calcium-gated potassium channel protein, putative 0.0076 0.0283 1
Schistosoma mansoni ap endonuclease 0.0021 0.0017 0.0017
Trypanosoma cruzi heat shock protein 90, putative 0.0023 0.0026 0.0923
Plasmodium vivax multidomain scavenger receptor, putative 0.0022 0.0022 0.0781
Loa Loa (eye worm) hypothetical protein 0.0076 0.0283 0.0283
Plasmodium vivax potassium channel, putative 0.0076 0.0283 1
Trypanosoma brucei heat shock protein 90, putative 0.0039 0.0104 0.3673
Plasmodium vivax heat shock protein 86, putative 0.0039 0.0104 0.3673
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 35 0.0076 0.0283 0.3596
Schistosoma mansoni hypothetical protein 0.2081 1 1
Loa Loa (eye worm) hypothetical protein 0.0784 0.3715 0.3715
Leishmania major cathepsin L-like protease 0.0019 0.0006 0.0205
Loa Loa (eye worm) uncoordinated protein 58 0.0076 0.0283 0.0283
Trypanosoma brucei heat shock protein, putative 0.0039 0.0104 0.3673
Plasmodium vivax vivapain-2 0.0019 0.0006 0.0205
Schistosoma mansoni endoplasmin 0.0039 0.0104 0.0104
Echinococcus granulosus heat shock protein 0.0039 0.0104 0.0104
Schistosoma mansoni lipoxygenase 0.0063 0.0217 0.0217
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0017 0.0218
Trypanosoma brucei heat shock protein, putative 0.0039 0.0104 0.3673
Loa Loa (eye worm) hypothetical protein 0.018 0.0788 0.0788
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0264 0.9321
Echinococcus multilocularis potassium channel subfamily K 8 0.0076 0.0283 0.0283
Leishmania major ion transport protein-like protein 0.0076 0.0283 1
Onchocerca volvulus 0.0076 0.0283 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0283 0.0283
Echinococcus granulosus potassium channel subfamily K 8 0.0076 0.0283 0.0283
Leishmania major heat shock protein 83-1 0.0039 0.0104 0.3673
Loa Loa (eye worm) hypothetical protein 0.0704 0.3325 0.3325
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39B 0.0076 0.0283 0.3596
Loa Loa (eye worm) S-phase kinase-associated protein 1A 0.0076 0.0283 0.0283
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0006 0.0074
Brugia malayi Cathepsin L-like precursor 0.0019 0.0006 0.0074
Loa Loa (eye worm) hypothetical protein 0.0076 0.0283 0.0283
Schistosoma mansoni endoplasmin 0.0039 0.0104 0.0104
Echinococcus granulosus calcium activated potassium channel variant 0.0076 0.0283 0.0283
Brugia malayi Cathepsin L-like precursor 0.0019 0.0006 0.0074
Loa Loa (eye worm) hypothetical protein 0.0076 0.0283 0.0283
Leishmania major heat shock protein 83-1 0.0039 0.0104 0.3673
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.0006 0.0205
Schistosoma mansoni heat shock protein 0.0039 0.0104 0.0104
Toxoplasma gondii heat shock protein 90, putative 0.0039 0.0104 0.3673
Loa Loa (eye worm) hypothetical protein 0.0076 0.0283 0.0283
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0017 0.0017
Schistosoma mansoni polycystin 1-related 0.0022 0.0022 0.0022
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0076 0.0283 0.3596
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0017 0.0408
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog 0.0076 0.0283 0.3596
Trypanosoma brucei heat shock protein, putative 0.0039 0.0104 0.3673
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0022 0.0022 0.0022
Leishmania major heat shock protein 83-1 0.0039 0.0104 0.3673
Schistosoma mansoni calcium-activated potassium channel 0.2081 1 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0283 0.0283
Giardia lamblia Hypothetical protein 0.0076 0.0283 1
Schistosoma mansoni rab6-interacting 0.0022 0.0022 0.0022
Toxoplasma gondii exonuclease III APE 0.0021 0.0017 0.0605
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0017 0.0605
Leishmania major potassium channel subunit-like protein 0.0076 0.0283 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0283 0.0283
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0065 0.2145
Schistosoma mansoni twik family of potassium channels-related 0.0076 0.0283 0.0283
Trypanosoma brucei Heat shock protein 83, putative 0.0039 0.0104 0.3673
Loa Loa (eye worm) TWK-28 protein 0.0076 0.0283 0.0283
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0063 0.0217 0.0217
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0076 0.0283 1
Echinococcus granulosus potassium channel subfamily K 0.0076 0.0283 0.0283
Leishmania major heat shock protein 83-1 0.0039 0.0104 0.3673
Echinococcus multilocularis calcium activated potassium channel variant 0.0076 0.0283 0.0283
Echinococcus multilocularis potassium channel subfamily K 0.0076 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0076 0.0283 0.0283
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0017 0.0605
Brugia malayi Cathepsin L-like precursor 0.0019 0.0006 0.0074
Echinococcus multilocularis heat shock protein 0.0039 0.0104 0.0104
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0264 0.9321
Onchocerca volvulus 0.0022 0.0022 0.0588
Leishmania major cathepsin L-like protease 0.0019 0.0006 0.0205
Loa Loa (eye worm) hypothetical protein 0.0076 0.0283 0.0283
Plasmodium vivax vivapain-2 0.0019 0.0006 0.0205
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0283 1
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0076 0.0283 0.0283
Echinococcus multilocularis microtubule associated protein 2 0.0782 0.3704 0.3704
Trypanosoma brucei heat shock protein, putative 0.0039 0.0104 0.3673
Echinococcus multilocularis small conductance calcium activated potassium 0.2081 1 1
Echinococcus granulosus cathepsin l1 0.0019 0.0006 0.0006
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.4661 0.4661
Trypanosoma brucei heat shock protein, putative 0.0039 0.0104 0.3673
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39A 0.0076 0.0283 0.3596
Schistosoma mansoni rab6-interacting 0.0022 0.0022 0.0022
Trypanosoma cruzi cruzipain precursor, putative 0.0072 0.0264 0.9321
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0076 0.0283 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0283 0.0283
Leishmania major cysteine peptidase A (CPA) 0.0019 0.0006 0.0205
Plasmodium vivax potassium channel, putative 0.0076 0.0283 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0264 0.9321
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.0022 0.0022
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0076 0.0283 1
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 7 0.0076 0.0283 0.3596
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0006 0.0006
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0022 0.0022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0264 0.9321
Loa Loa (eye worm) hypothetical protein 0.0076 0.0283 0.0283
Echinococcus granulosus RUN 0.0022 0.0022 0.0022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0264 0.9321
Plasmodium falciparum heat shock protein 90 0.0039 0.0104 0.3673
Leishmania major cathepsin L-like protease 0.0019 0.0006 0.0205
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0076 0.0283 1
Brugia malayi heat shock protein 90 0.0039 0.0104 0.1321
Leishmania major heat shock protein 83-1 0.0039 0.0104 0.3673
Brugia malayi hypothetical protein 0.0022 0.0022 0.0281
Leishmania major cathepsin L-like protease 0.0072 0.0264 0.9321
Leishmania major heat shock protein 83-1 0.0039 0.0104 0.3673
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0264 0.9321
Loa Loa (eye worm) hypothetical protein 0.0076 0.0283 0.0283
Schistosoma mansoni twik family of potassium channels-related 0.0076 0.0283 0.0283
Echinococcus multilocularis muscleblind protein 0.018 0.0788 0.0788
Leishmania major cathepsin L-like protease 0.0072 0.0264 0.9321
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0031 0.0065 0.0065
Leishmania major heat shock protein 83-1 0.0039 0.0104 0.3673
Toxoplasma gondii ion channel protein 0.0076 0.0283 1
Schistosoma mansoni ap endonuclease 0.0021 0.0017 0.0017
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0076 0.0283 0.0283
Brugia malayi hypothetical protein 0.0076 0.0283 0.3596
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0065 0.2145
Schistosoma mansoni loxhd1 0.0022 0.0022 0.0022
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0283 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0264 0.9321
Echinococcus granulosus potassium channel subfamily K 8 0.0076 0.0283 0.0283
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0264 0.9321
Giardia lamblia Heat shock protein HSP 90-alpha 0.0039 0.0104 0.3265
Loa Loa (eye worm) heat shock protein 90 0.0039 0.0104 0.0104
Echinococcus multilocularis cysteine protease 0.0019 0.0006 0.0006
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0006 0.0006
Trypanosoma brucei heat shock protein, putative 0.0039 0.0104 0.3673
Echinococcus granulosus heat shock protein 90 0.0031 0.0065 0.0065
Trypanosoma brucei calcium-activated potassium channel, putative 0.0076 0.0283 1
Onchocerca volvulus 0.0022 0.0022 0.0588
Leishmania major cathepsin L-like protease 0.0019 0.0006 0.0205
Leishmania major cathepsin L-like protease 0.0019 0.0006 0.0205
Loa Loa (eye worm) hypothetical protein 0.0076 0.0283 0.0283
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0067 0.0237 0.0237
Schistosoma mansoni twik family of potassium channels-related 0.0076 0.0283 0.0283
Echinococcus multilocularis heat shock protein 90 0.0031 0.0065 0.0065
Schistosoma mansoni jumonji domain containing protein 0.0067 0.0237 0.0237
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0006 0.0006
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0065 0.2145
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0022 0.0022
Toxoplasma gondii heat shock protein HSP90 0.0039 0.0104 0.3673
Leishmania major hypothetical protein, conserved 0.0076 0.0283 1
Trichomonas vaginalis heat shock protein, putative 0.0039 0.0104 0.354
Brugia malayi Doublecortin family protein 0.0022 0.0022 0.0281
Trypanosoma cruzi ion transport protein, putative 0.0076 0.0283 1
Brugia malayi hypothetical protein 0.0022 0.0022 0.0281
Schistosoma mansoni twik family of potassium channels-related 0.0076 0.0283 0.0283
Brugia malayi Twik (KCNK-like) family of potasium channels, alpha subunit 40 0.0076 0.0283 0.3596
Loa Loa (eye worm) hypothetical protein 0.0517 0.2418 0.2418
Schistosoma mansoni twik family of potassium channels-related 0.0076 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0076 0.0283 0.0283
Mycobacterium ulcerans ion transport protein 0.0076 0.0283 1
Loa Loa (eye worm) TWK-7 protein 0.0076 0.0283 0.0283
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 12 0.0076 0.0283 0.3596
Loa Loa (eye worm) hypothetical protein 0.0076 0.0283 0.0283
Trypanosoma brucei heat shock protein, putative 0.0039 0.0104 0.3673
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0019 0.0006 0.0205
Brugia malayi hypothetical protein 0.0076 0.0283 0.3596
Loa Loa (eye worm) hypothetical protein 0.0076 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0076 0.0283 0.0283
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 13 0.0076 0.0283 0.3596
Schistosoma mansoni twik family of potassium channels-related 0.0076 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0076 0.0283 0.0283
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0006 0.0006
Mycobacterium ulcerans heat shock protein 90 0.0031 0.0065 0.181
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0017 0.0605
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0017 0.0605
Onchocerca volvulus 0.0076 0.0283 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.0006 0.0006
Brugia malayi Endoplasmin precursor 0.0039 0.0104 0.1321
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.0006 0.0006
Trichomonas vaginalis endoplasmin, putative 0.0024 0.0031 0.0891
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0076 0.0283 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0076 0.0283 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0019 0.0006 0.0205
Loa Loa (eye worm) hypothetical protein 0.0076 0.0283 0.0283
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0264 0.9321
Echinococcus granulosus endoplasmin 0.0031 0.0065 0.0065
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0063 0.0217 0.0217
Loa Loa (eye worm) cysteine protease 0.0019 0.0006 0.0006
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0067 0.0237 0.0237
Echinococcus granulosus Two pore potassium channel protein sup 9 0.0076 0.0283 0.0283
Plasmodium falciparum potassium channel 0.0076 0.0283 1
Echinococcus granulosus twik family of potassium channels 0.0076 0.0283 0.0283
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0264 0.9321
Loa Loa (eye worm) hypothetical protein 0.0076 0.0283 0.0283
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0264 0.9321
Onchocerca volvulus 0.0076 0.0283 1
Trypanosoma cruzi heat shock protein 90, putative 0.0039 0.0104 0.3673
Brugia malayi Cathepsin L-like precursor 0.0019 0.0006 0.0074
Toxoplasma gondii ion channel protein 0.0076 0.0283 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.0237 0.0237
Echinococcus multilocularis lysine specific demethylase 5A 0.0067 0.0237 0.0237
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0264 0.9321
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0017 0.0017
Trypanosoma brucei heat shock protein, putative 0.0039 0.0104 0.3673
Echinococcus granulosus lysine specific demethylase 5A 0.0067 0.0237 0.0237
Brugia malayi jmjC domain containing protein 0.0067 0.0237 0.3005
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 28 0.0076 0.0283 0.3596
Schistosoma mansoni calcium-activated potassium channel 0.1488 0.7126 0.7126
Schistosoma mansoni twik family of potassium channels-related 0.0076 0.0283 0.0283
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.0162 0.0162
Onchocerca volvulus 0.0076 0.0283 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0022 0.0022
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0022 0.0022
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0104 0.3673
Trypanosoma cruzi heat shock protein 90, putative 0.0031 0.0065 0.2306
Brugia malayi Cathepsin L-like precursor 0.0019 0.0006 0.0074
Leishmania major heat shock protein 83-1 0.0039 0.0104 0.3673
Loa Loa (eye worm) hypothetical protein 0.0076 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.018 0.0788 0.0788
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0006 0.0006

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 18.681 uM PUBCHEM_BIOASSAY: Fluorescence Cell-Based Secondary Assay to Identify Inhibitors of Resistant C. albicans Growth in the Presence of Fluconazole. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1979, AID2007] ChEMBL. No reference
Potency (functional) 0.4147 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) 1.5849 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.9362 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 16.3535 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 23.0999 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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