Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | pyruvate kinase, muscle | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | pyruvate kinase | pyruvate kinase, muscle | 605 aa | 521 aa | 34.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | semaphorin 5B | 0.0046 | 0.2112 | 0.2112 |
Echinococcus granulosus | semaphorin 1A | 0.0046 | 0.2112 | 0.2112 |
Schistosoma mansoni | tar DNA-binding protein | 0.0141 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.136 | 0.0795 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.2112 | 0.2112 |
Schistosoma mansoni | pyruvate kinase | 0.004 | 0.1623 | 0.1623 |
Schistosoma mansoni | tar DNA-binding protein | 0.0141 | 1 | 1 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.004 | 0.1623 | 0.5 |
Loa Loa (eye worm) | plexin A | 0.0131 | 0.9114 | 0.9056 |
Echinococcus multilocularis | tar DNA binding protein | 0.0141 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.2622 | 0.2622 |
Brugia malayi | TAR-binding protein | 0.0141 | 1 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.004 | 0.1623 | 0.1623 |
Schistosoma mansoni | hypothetical protein | 0.0064 | 0.3615 | 0.3615 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.2782 | 0.231 |
Echinococcus multilocularis | hypothetical protein | 0.0046 | 0.2112 | 0.2112 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.3615 | 0.3197 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.004 | 0.1623 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.2622 | 0.2622 |
Schistosoma mansoni | plexin | 0.0111 | 0.7439 | 0.7439 |
Echinococcus granulosus | plexin a4 | 0.0131 | 0.9114 | 0.9114 |
Mycobacterium ulcerans | pyruvate kinase | 0.004 | 0.1623 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.2112 | 0.1596 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0052 | 0.2622 | 0.2139 |
Brugia malayi | hypothetical protein | 0.0046 | 0.2112 | 0.087 |
Chlamydia trachomatis | pyruvate kinase | 0.004 | 0.1623 | 0.5 |
Leishmania major | pyruvate kinase | 0.004 | 0.1623 | 0.5 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.004 | 0.1623 | 0.5 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.004 | 0.1623 | 0.5 |
Echinococcus multilocularis | semaphorin 5B | 0.0046 | 0.2112 | 0.2112 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.2782 | 0.231 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.004 | 0.1623 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.2782 | 0.1646 |
Loa Loa (eye worm) | RNA binding protein | 0.0141 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0046 | 0.2112 | 0.087 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0052 | 0.2622 | 0.146 |
Schistosoma mansoni | tar DNA-binding protein | 0.0141 | 1 | 1 |
Onchocerca volvulus | 0.0111 | 0.7439 | 1 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.2622 | 0.2622 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0141 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0141 | 1 | 1 |
Plasmodium falciparum | pyruvate kinase | 0.004 | 0.1623 | 1 |
Echinococcus granulosus | pyruvate kinase | 0.004 | 0.1623 | 0.1623 |
Echinococcus granulosus | pyruvate kinase | 0.004 | 0.1623 | 0.1623 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.2112 | 0.2112 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.004 | 0.1623 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.004 | 0.1623 | 0.1623 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.2112 | 0.1596 |
Echinococcus multilocularis | plexin a4 | 0.0131 | 0.9114 | 0.9114 |
Brugia malayi | plexin A | 0.0131 | 0.9114 | 0.8974 |
Brugia malayi | Sema domain containing protein | 0.0046 | 0.2112 | 0.087 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1623 | 0.1075 |
Schistosoma mansoni | plexin | 0.0064 | 0.3615 | 0.3615 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.2622 | 0.2622 |
Echinococcus granulosus | tar DNA binding protein | 0.0141 | 1 | 1 |
Loa Loa (eye worm) | sema domain-containing protein | 0.0046 | 0.2112 | 0.1596 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0141 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.2782 | 0.1646 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.004 | 0.1623 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.2112 | 0.1596 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0028 | 0.0614 | 1 |
Trypanosoma brucei | pyruvate kinase 1 | 0.004 | 0.1623 | 0.5 |
Loa Loa (eye worm) | pyruvate kinase | 0.004 | 0.1623 | 0.1075 |
Loa Loa (eye worm) | sema domain-containing protein | 0.0046 | 0.2112 | 0.1596 |
Loa Loa (eye worm) | pyruvate kinase | 0.004 | 0.1623 | 0.1075 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.004 | 0.1623 | 0.0304 |
Plasmodium vivax | pyruvate kinase, putative | 0.004 | 0.1623 | 1 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.004 | 0.1623 | 0.5 |
Echinococcus multilocularis | pyruvate kinase | 0.004 | 0.1623 | 0.1623 |
Schistosoma mansoni | semaphorin 5-related | 0.0046 | 0.2112 | 0.2112 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.2622 | 0.2622 |
Loa Loa (eye worm) | TAR-binding protein | 0.0141 | 1 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0032 | 0.0921 | 0.0921 |
Loa Loa (eye worm) | pyruvate kinase | 0.004 | 0.1623 | 0.1075 |
Brugia malayi | Plexin repeat family protein | 0.0111 | 0.7439 | 0.7035 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.004 | 0.1623 | 0.0304 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.2112 | 0.1596 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.2622 | 0.2622 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.2112 | 0.1596 |
Leishmania major | pyruvate kinase | 0.004 | 0.1623 | 0.5 |
Onchocerca volvulus | 0.0046 | 0.2112 | 0.084 | |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.7439 | 0.7271 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.136 | 0.136 |
Schistosoma mansoni | tar DNA-binding protein | 0.0141 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.2622 | 0.2622 |
Giardia lamblia | Pyruvate kinase | 0.004 | 0.1623 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.2112 | 0.1596 |
Brugia malayi | Sema domain containing protein | 0.0046 | 0.2112 | 0.087 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 4.1475 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 17.7828 um | PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 17.7828 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ] | ChEMBL. | No reference |
Potency (binding) | = 50.1187 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.