Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0146 | 0.057 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0.0146 | 0.0146 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.092 | 0.9467 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.092 | 0.3597 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.092 | 0.1403 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.2557 | 0.39 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.092 | 0.092 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0037 | 0.092 | 0.092 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0037 | 0.092 | 0.092 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.0146 | 0.057 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.0963 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.0146 | 0.0222 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.092 | 0.9548 |
Echinococcus granulosus | acetylcholinesterase | 0.0073 | 0.2557 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0073 | 0.2557 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0073 | 0.2557 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0073 | 0.2557 | 0.39 |
Brugia malayi | Carboxylesterase family protein | 0.0073 | 0.2557 | 0.39 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0037 | 0.092 | 0.092 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.0146 | 0.0222 |
Plasmodium vivax | hypothetical protein, conserved | 0.0037 | 0.092 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0038 | 0.0963 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.1451 | 0.5675 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.0146 | 0.5 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.0146 | 0.5 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0037 | 0.092 | 0.3597 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0146 | 0.1585 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0146 | 0.1513 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0034 | 0.0782 | 0.0782 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0146 | 0.1513 |
Trichomonas vaginalis | esterase, putative | 0.0037 | 0.092 | 0.9467 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.0963 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.1451 | 0.5675 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.092 | 0.9467 |
Toxoplasma gondii | ABC1 family protein | 0.0037 | 0.092 | 0.9548 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.6556 | 1 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0038 | 0.0963 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.092 | 0.1403 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.1451 | 0.5675 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0038 | 0.0963 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.092 | 0.1403 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.1451 | 0.5675 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.1451 | 0.5675 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.092 | 0.9467 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0037 | 0.092 | 0.092 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.1451 | 0.5675 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.0146 | 0.1513 |
Brugia malayi | Carboxylesterase family protein | 0.0073 | 0.2557 | 0.39 |
Onchocerca volvulus | 0.0161 | 0.6556 | 1 | |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0038 | 0.0963 | 0.3767 |
Leishmania major | hypothetical protein, conserved | 0.0037 | 0.092 | 0.9548 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.092 | 0.1403 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.092 | 0.9467 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.002 | 0.0146 | 0.1513 |
Loa Loa (eye worm) | inositol-1 | 0.0038 | 0.0963 | 0.1469 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0037 | 0.092 | 0.092 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0037 | 0.092 | 0.9467 |
Brugia malayi | beta-lactamase | 0.0037 | 0.092 | 0.1403 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.092 | 0.092 |
Echinococcus multilocularis | acetylcholinesterase | 0.0073 | 0.2557 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0073 | 0.2557 | 0.39 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.0963 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.2557 | 0.39 |
Mycobacterium leprae | conserved hypothetical protein | 0.0037 | 0.092 | 1 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0038 | 0.0963 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.092 | 0.1403 |
Toxoplasma gondii | exonuclease III APE | 0.002 | 0.0146 | 0.1513 |
Brugia malayi | hypothetical protein | 0.0161 | 0.6556 | 1 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0037 | 0.092 | 0.092 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0037 | 0.092 | 0.9548 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0037 | 0.092 | 0.3597 |
Echinococcus granulosus | carboxylesterase 5A | 0.0073 | 0.2557 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.092 | 0.9467 |
Mycobacterium ulcerans | hypothetical protein | 0.0037 | 0.092 | 0.9467 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0037 | 0.092 | 0.1403 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0038 | 0.0963 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0049 | 0.1451 | 0.2213 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.092 | 0.1403 |
Mycobacterium leprae | Probable lipase LipE | 0.0037 | 0.092 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0038 | 0.0963 | 0.3767 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.092 | 0.1403 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0146 | 1 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.0963 | 1 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0038 | 0.0963 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0073 | 0.2557 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.092 | 0.092 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0073 | 0.2557 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.0146 | 0.057 |
Schistosoma mansoni | inositol monophosphatase | 0.0038 | 0.0963 | 0.3767 |
Brugia malayi | Inositol-1 | 0.0038 | 0.0963 | 0.1469 |
Mycobacterium ulcerans | lipase LipD | 0.0037 | 0.092 | 0.9467 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0038 | 0.0963 | 0.3767 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0037 | 0.092 | 0.9467 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0037 | 0.092 | 0.1403 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.1451 | 0.5675 |
Loa Loa (eye worm) | beta-lactamase | 0.0037 | 0.092 | 0.1403 |
Mycobacterium ulcerans | beta-lactamase | 0.0037 | 0.092 | 0.9467 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0038 | 0.0963 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.092 | 0.1403 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0037 | 0.092 | 0.092 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.092 | 0.9548 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.092 | 0.3597 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0.1451 | 0.2213 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0146 | 0.057 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.