Detailed information for compound 1472815

Basic information

Technical information
  • TDR Targets ID: 1472815
  • Name: [4-(1-cyclohex-3-enylmethyl)piperazin-1-yl]-p henylmethanone
  • MW: 284.396 | Formula: C18H24N2O
  • H donors: 0 H acceptors: 1 LogP: 2.96 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccccc1)N1CCN(CC1)CC1CCC=CC1
  • InChi: 1S/C18H24N2O/c21-18(17-9-5-2-6-10-17)20-13-11-19(12-14-20)15-16-7-3-1-4-8-16/h1-3,5-6,9-10,16H,4,7-8,11-15H2
  • InChiKey: PRKJESMQXVZENJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [4-(1-cyclohex-3-enylmethyl)piperazin-1-yl]-phenyl-methanone
  • [4-(1-cyclohex-3-enylmethyl)-1-piperazinyl]-phenylmethanone
  • BAS 01376188
  • ST5008995

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis AGC family protein kinase 0.002 0.0151 0.3144
Trichomonas vaginalis AGC family protein kinase 0.002 0.0151 0.3144
Trichomonas vaginalis AGC family protein kinase 0.002 0.0151 0.3144
Trichomonas vaginalis AGC family protein kinase 0.002 0.0151 0.3144
Onchocerca volvulus Phospholipase A2 homolog 0.0422 1 1
Trichomonas vaginalis AGC family protein kinase 0.002 0.0151 0.3144
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0157 0.5
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0157 0.5
Trichomonas vaginalis AGC family protein kinase 0.002 0.0151 0.3144
Schistosoma mansoni ap endonuclease 0.002 0.0157 0.0631
Trichomonas vaginalis serine/threonine-protein kinase ypk, putative 0.002 0.0151 0.3144
Trichomonas vaginalis AGC family protein kinase 0.002 0.0151 0.3144
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0121 0.2627 0.2627
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0157 1
Brugia malayi Protein kinase domain containing protein 0.0033 0.0481 0.1831
Trichomonas vaginalis cAMP-dependent protein kinase catalytic subunit, putative 0.002 0.0151 0.3144
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0157 0.5
Trichomonas vaginalis AGC family protein kinase 0.002 0.0151 0.3144
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0157 0.5
Trichomonas vaginalis AGC family protein kinase 0.002 0.0151 0.3144
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0157 0.3269
Trichomonas vaginalis AGC family protein kinase 0.002 0.0151 0.3144
Trichomonas vaginalis AGC family protein kinase 0.002 0.0151 0.3144
Trichomonas vaginalis AGC family protein kinase 0.002 0.0151 0.3144
Trichomonas vaginalis AGC family protein kinase 0.002 0.0151 0.3144
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.002 0.0151 0.3144
Loa Loa (eye worm) hypothetical protein 0.0089 0.1839 0.1839
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0157 0.0157
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0157 0.5
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0157 0.0599
Trichomonas vaginalis AGC family protein kinase 0.002 0.0151 0.3144
Trichomonas vaginalis AGC family protein kinase 0.002 0.0151 0.3144
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0157 0.5
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0157 0.5
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0481 1
Trichomonas vaginalis AGC family protein kinase 0.002 0.0151 0.3144
Trichomonas vaginalis AGC family protein kinase 0.002 0.0151 0.3144
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0121 0.2627 1
Trichomonas vaginalis serine/threonine-protein kinase, putative 0.002 0.0151 0.3144
Trichomonas vaginalis AGC family protein kinase 0.002 0.0151 0.3144
Trichomonas vaginalis AGC family protein kinase 0.002 0.0151 0.3144
Trichomonas vaginalis AGC family protein kinase 0.002 0.0151 0.3144
Trichomonas vaginalis AGC family protein kinase 0.002 0.0151 0.3144
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0157 0.3269
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0157 0.5
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.002 0.0151 0.3144
Trichomonas vaginalis AGC family protein kinase 0.002 0.0151 0.3144
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0121 0.2627 1
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0033 0.0474 0.9849
Trichomonas vaginalis AGC family protein kinase 0.002 0.0151 0.3144
Trichomonas vaginalis AGC family protein kinase 0.002 0.0151 0.3144
Trichomonas vaginalis AGC family protein kinase 0.002 0.0151 0.3144
Trichomonas vaginalis AGC family protein kinase 0.002 0.0151 0.3144
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0033 0.0481 0.0481
Trichomonas vaginalis AGC family protein kinase 0.002 0.0151 0.3144
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0157 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0121 0.2627 1
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0481 1
Schistosoma mansoni ap endonuclease 0.002 0.0157 0.0631
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0116 0.2492 1
Trichomonas vaginalis AGC family protein kinase 0.002 0.0151 0.3144
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0157 0.5
Toxoplasma gondii exonuclease III APE 0.002 0.0157 1
Trichomonas vaginalis AGC family protein kinase 0.002 0.0151 0.3144
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0157 0.5
Trichomonas vaginalis AGC family protein kinase 0.002 0.0151 0.3144
Trichomonas vaginalis AGC family protein kinase 0.002 0.0151 0.3144
Brugia malayi Phospholipase A2 family protein 0.0089 0.1839 0.7002
Trichomonas vaginalis AGC family protein kinase 0.002 0.0151 0.3144
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0481 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0157 0.0599
Trichomonas vaginalis AGC family protein kinase 0.002 0.0151 0.3144
Trichomonas vaginalis AGC family protein kinase 0.002 0.0151 0.3144
Trichomonas vaginalis AGC family protein kinase 0.002 0.0151 0.3144
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0157 0.0599
Trichomonas vaginalis AGC family protein kinase 0.002 0.0151 0.3144

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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