Detailed information for compound 1473122

Basic information

Technical information
  • TDR Targets ID: 1473122
  • Name: (8R,9S,13S,14S,16R)-16-(ethoxymethyl)-3-hydro xy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6 H-cyclopenta[a]phenanthren-17-one
  • MW: 328.445 | Formula: C21H28O3
  • H donors: 1 H acceptors: 2 LogP: 3.84 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC[C@H]1C[C@@H]2[C@](C1=O)(C)CC[C@H]1[C@H]2CCc2c1ccc(c2)O
  • InChi: 1S/C21H28O3/c1-3-24-12-14-11-19-18-6-4-13-10-15(22)5-7-16(13)17(18)8-9-21(19,2)20(14)23/h5,7,10,14,17-19,22H,3-4,6,8-9,11-12H2,1-2H3/t14-,17-,18-,19+,21+/m1/s1
  • InChiKey: UOFWRCJSMZKWLE-SFWRJULSSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein hydroxysteroid (17-beta) dehydrogenase 1 328 aa 265 aa 27.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.003 0.0028 0.0431
Onchocerca volvulus 0.0328 0.0484 0.7434
Echinococcus multilocularis multidrug resistance protein 1 0.0032 0.0031 0.0156
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0282 0.0413 0.4621
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0595 0.0893 1
Mycobacterium ulcerans lipase LipD 0.0036 0.0036 0.0035
Loa Loa (eye worm) inositol-1 0.0036 0.0038 0.058
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.0423 1
Loa Loa (eye worm) hypothetical protein 0.0328 0.0484 0.7434
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0036 0.0355
Brugia malayi nuclear hormone receptor 0.0025 0.002 0.031
Schistosoma mansoni jumonji domain containing protein 0.0015 0.0006 0.0056
Entamoeba histolytica cysteine protease, putative 0.0037 0.0039 0.0908
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0014 0.0004 0.0066
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0559
Mycobacterium leprae PROBABLE GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE NADE (NAD(+) SYNTHASE [GLUTAMINE-HYDROLYSING]) 0.0081 0.0106 0.0105
Onchocerca volvulus 0.006 0.0073 0.1127
Echinococcus multilocularis cathepsin L cysteine protease 0.0073 0.0093 0.0464
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0095 0.0128 0.1251
Trichomonas vaginalis abcb9, putative 0.0046 0.0053 0.1191
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.0009 0.0147
Echinococcus multilocularis jumonji domain containing 1A 0.0015 0.0006 0.0028
Brugia malayi GMP synthase 0.0032 0.0032 0.0485
Echinococcus granulosus JmjC domain containing protein 4 0.0015 0.0006 0.0056
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0073 0.0093 0.0464
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0036 0.0804
Mycobacterium ulcerans hypothetical protein 0.0313 0.0462 0.0461
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0046 0.0053 0.0514
Loa Loa (eye worm) hypothetical protein 0.0014 0.0004 0.006
Schistosoma mansoni multidrug resistance protein 0.0046 0.0053 0.0514
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.002 0.0735
Entamoeba histolytica P-glyco protein 6, putative 0.0046 0.0053 0.1224
Plasmodium falciparum serine repeat antigen 8 0.0013 0.0003 0.0026
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0018 0.04
Mycobacterium ulcerans GMP synthase 0.0032 0.0032 0.0031
Brugia malayi Steroid receptor seven-up type 2 0.0025 0.002 0.031
Onchocerca volvulus 0.0437 0.0651 1
Entamoeba histolytica cysteinyl-tRNA synthetase, putative 0.0095 0.0128 0.3011
Echinococcus granulosus cytochrome P450 2K1 0.0019 0.0011 0.0104
Brugia malayi Cathepsin L-like precursor 0.0049 0.0056 0.0867
Echinococcus granulosus leucyl tRNA synthetase 0.0095 0.0128 0.1251
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0051
Brugia malayi sodium-independent organic anion transporter family protein 0.0328 0.0484 0.7434
Plasmodium falciparum GMP synthase [glutamine-hydrolyzing] 0.0032 0.0032 0.051
Loa Loa (eye worm) cathepsin B 0.0013 0.0003 0.0039
Schistosoma mansoni transcription factor btf3 0.0034 0.0035 0.034
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0015 0.0006 0.0099
Schistosoma mansoni glutamine-dependent NAD(+) synthetase 0.0081 0.0106 0.1035
Echinococcus multilocularis bloom syndrome protein 0.0025 0.0021 0.0103
Leishmania major cathepsin L-like protease 0.0073 0.0093 0.1034
Plasmodium falciparum cysteine--tRNA ligase 0.0095 0.0128 0.2115
Entamoeba histolytica P-glycoprotein-2 0.0046 0.0053 0.1224
Giardia lamblia Fructose-bisphosphate aldolase 0.0288 0.0423 1
Plasmodium falciparum ABC transporter B family member 7, putative 0.0014 0.0004 0.0053
Echinococcus granulosus survival motor neuron protein 1 0.0233 0.0339 0.3311
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0004 0.0036
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0046 0.0053 0.0514
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0003 0.002
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0036 0.1361
Toxoplasma gondii Alpha-galactosidase 0.0014 0.0004 0.0061
Schistosoma mansoni cathepsin F (C01 family) 0.0049 0.0056 0.0551
Plasmodium vivax multidomain scavenger receptor, putative 0.006 0.0073 0.278
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0073 0.0093 0.1432
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0036 0.0035
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0595 0.0893 1
Trypanosoma cruzi cysteine peptidase, putative 0.0024 0.0019 0.02
Loa Loa (eye worm) hypothetical protein 0.0095 0.0128 0.1969
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0009 0.03
Schistosoma mansoni polycystin 1-related 0.006 0.0073 0.0716
Leishmania major ABC-thiol transporter 0.0014 0.0004 0.0036
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0073 0.0093 0.2154
Schistosoma mansoni phosphatidylserine receptor 0.0015 0.0006 0.0056
Giardia lamblia ABC transporter, putative 0.0014 0.0004 0.0038
Schistosoma mansoni thyroid hormone receptor 0.0025 0.002 0.0197
Entamoeba histolytica cysteine proteinase, putative 0.0073 0.0093 0.2184
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0078 0.0758
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0017 0.0008 0.0148
Echinococcus granulosus multidrug resistance protein 1 0.0046 0.0053 0.0514
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0013 0.0003 0.0061
Echinococcus multilocularis pol protein 0.1323 0.2007 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0277 0.0405 0.4536
Brugia malayi cathepsin Z-like cysteine proteinase 0.0013 0.0003 0.0039
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0013 0.0003 0.0061
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0274
Entamoeba histolytica cysteine protease, putative 0.0037 0.0039 0.0908
Onchocerca volvulus 0.0073 0.0093 0.1432
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0008 0.0144
Onchocerca volvulus 0.0073 0.0093 0.1432
Loa Loa (eye worm) multidrug resistance protein 3 0.0046 0.0053 0.0809
Trypanosoma brucei metacaspase 0.0017 0.0009 0.0087
Brugia malayi hypothetical protein 0.0025 0.002 0.0308
Loa Loa (eye worm) hypothetical protein 0.0025 0.002 0.031
Echinococcus granulosus Solute carrier organic anion transporter family 0.0328 0.0484 0.4725
Brugia malayi MAP kinase sur-1 0.005 0.0059 0.0906
Brugia malayi beta-lactamase family protein 0.0036 0.0036 0.0559
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0189 0.0272 0.5615
Brugia malayi hypothetical protein 0.0437 0.0651 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0025 0.002 0.031
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0134
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0013 0.0003 0.0025
Onchocerca volvulus 0.003 0.0028 0.0431
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0073 0.0093 0.1534
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0046 0.0053 0.0514
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0019 0.0011 0.001
Echinococcus granulosus microtubule associated protein 2 0.0681 0.1024 1
Echinococcus multilocularis cysteine protease 0.0073 0.0093 0.0464
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0019 0.0011 0.001
Trypanosoma brucei Metacaspase-4 0.0017 0.0009 0.0087
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0025 0.002 0.031
Loa Loa (eye worm) hypothetical protein 0.0041 0.0044 0.0679
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0076 0.0739
Entamoeba histolytica cysteine protease, putative 0.0013 0.0003 0.0038
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0046 0.0053 0.0262
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0037 0.0039 0.043
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0282 0.0413 0.4621
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0038 0.0413
Echinococcus granulosus cpg binding protein 0.003 0.0028 0.0272
Loa Loa (eye worm) fibroinase 0.0073 0.0093 0.1432
Giardia lamblia MRP-like ABC transporter 0.0014 0.0004 0.0038
Loa Loa (eye worm) hypothetical protein 0.0328 0.0484 0.7434
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0046 0.0053 0.1191
Leishmania major cathepsin L-like protease 0.0277 0.0405 0.4536
Entamoeba histolytica P-glycoprotein-5 0.0046 0.0053 0.1224
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0025 0.002 0.031
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0013 0.0003 0.0061
Schistosoma mansoni cytochrome P450 0.0019 0.0011 0.0104
Brugia malayi TAR-binding protein 0.0062 0.0078 0.1193
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0014 0.0004 0.0063
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0095 0.0128 0.1426
Plasmodium vivax metacaspase 1, putative 0.0017 0.0009 0.0299
Echinococcus granulosus cysteinyl tRNA synthetase 0.0095 0.0128 0.1251
Schistosoma mansoni survival motor neuron protein 0.0048 0.0055 0.0535
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0038 0.0413
Leishmania major cysteinyl-tRNA synthetase, putative 0.0095 0.0128 0.1426
Toxoplasma gondii cysteine-tRNA synthetase (CysRS) 0.0095 0.0128 0.2634
Leishmania major cathepsin L-like protease 0.0073 0.0093 0.1034
Brugia malayi jmjC domain containing protein 0.0015 0.0006 0.0087
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0134
Trichomonas vaginalis taga, putative 0.0046 0.0053 0.1191
Echinococcus multilocularis microtubule associated protein 2 0.0681 0.1024 0.5102
Echinococcus multilocularis ATP binding cassette sub family B 0.0046 0.0052 0.0258
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0036 0.0035
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0018 0.04
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0003 0.002
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0036 0.0035
Plasmodium falciparum DNA-directed RNA polymerase subunit beta, putative 0.0405 0.0602 1
Brugia malayi beta-lactamase 0.0036 0.0036 0.0559
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0051
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0028 0.014
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.0372 0.8779
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0046 0.0053 0.1191
Onchocerca volvulus 0.0328 0.0484 0.7434
Loa Loa (eye worm) oxidoreductase 0.0012 0.0001 0.0014
Treponema pallidum fructose-bisphosphate aldolase 0.0288 0.0423 0.6392
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0078 0.0758
Echinococcus multilocularis FTZ F1 alpha 0.0025 0.002 0.01
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0035 0.0563
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0277 0.0405 0.4536
Toxoplasma gondii cathepsin CPL 0.0073 0.0093 0.191
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.002 0.031
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0046 0.0053 0.1191
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0025 0.002 0.031
Schistosoma mansoni hypothetical protein 0.0403 0.0599 0.5856
Schistosoma mansoni cpg binding protein 0.0028 0.0025 0.0248
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0024 0.0019 0.0288
Plasmodium falciparum enoyl-acyl carrier reductase 0.0183 0.0261 0.4331
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0102 0.0138 0.1538
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0038 0.0369
Echinococcus multilocularis cysteinyl tRNA synthetase 0.0095 0.0128 0.0638
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0013 0.0003 0.0025
Onchocerca volvulus 0.006 0.0073 0.1127
Schistosoma mansoni phd/f-box containing protein 0.0015 0.0006 0.0056
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0036 0.0804
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0019 0.0011 0.001
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0036 0.0035
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0101 0.0137 0.1335
Plasmodium vivax glutamine-dependent NAD(+) synthetase, putative 0.0081 0.0106 0.4034
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0035 0.0767
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0141 0.0198 0.0197
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0013 0.0003 0.0025
Echinococcus granulosus caspase 8 0.0017 0.0009 0.0085
Toxoplasma gondii preprocathepsin c precursor, putative 0.0013 0.0003 0.0033
Toxoplasma gondii ATP-binding cassette sub-family B member 5 0.0014 0.0004 0.0066
Echinococcus multilocularis muscleblind protein 0.0147 0.0208 0.1034
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.002 0.0215
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0018 0.0017
Echinococcus granulosus geminin 0.0167 0.0238 0.2323
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0012 0.0001 0.0014
Loa Loa (eye worm) hypothetical protein 0.0073 0.0093 0.1432
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0078 0.0758
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0013 0.0003 0.0061
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0033
Giardia lamblia Cysteinyl-tRNA synthetase 0.0095 0.0128 0.2985
Onchocerca volvulus 0.0328 0.0484 0.7434
Echinococcus multilocularis lipoxygenase domain containing protein 0.006 0.0073 0.0365
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0019 0.0011 0.001
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0035 0.038
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0025 0.002 0.031
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.0004 0.0018
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0013 0.0003 0.0026
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0073 0.0093 0.2154
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0013 0.0003 0.0018
Toxoplasma gondii protease inhibitor PI2 0.0189 0.0272 0.5615
Echinococcus granulosus netrin receptor unc 5 0.0014 0.0004 0.0036
Leishmania major cytochrome p450-like protein 0.0019 0.0011 0.0109
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0036 0.0559
Giardia lamblia Hypothetical protein 0.0014 0.0003 0.0019
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0004 0.0038
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0035 0.038
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0013 0.0003 0.0026
Trypanosoma brucei multidrug resistance protein E 0.0014 0.0004 0.0036
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0046 0.0053 0.0262
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.002 0.0197
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0046 0.0053 0.1191
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0039
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0059 0.065
Onchocerca volvulus Putative organic anion transporter 0.0328 0.0484 0.7434
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0328 0.0484 0.7434
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0277 0.0405 0.4536
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0025 0.002 0.031
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0019 0.0011 0.001
Entamoeba histolytica hypothetical protein 0.0079 0.0102 0.2398
Echinococcus multilocularis cathepsin L cysteine protease 0.0073 0.0093 0.0464
Onchocerca volvulus 0.0028 0.0025 0.039
Onchocerca volvulus 0.0328 0.0484 0.7434
Brugia malayi nuclear receptor NHR-88 0.0025 0.002 0.031
Echinococcus multilocularis cathepsin b 0.0013 0.0003 0.0013
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0101 0.0137 0.1335
Brugia malayi Cytochrome P450 family protein 0.0047 0.0054 0.0831
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0095 0.0128 0.1426
Trypanosoma brucei metacaspase 5, putative 0.0017 0.0009 0.0087
Toxoplasma gondii ABC transporter, putative 0.0014 0.0004 0.0066
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0277 0.0405 0.4536
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0252 0.592
Trypanosoma brucei NAD+ synthase, putative 0.0081 0.0106 0.1178
Brugia malayi Nuclear hormone receptor-like 1 0.0013 0.0002 0.0033
Loa Loa (eye worm) beta-lactamase 0.0036 0.0036 0.0559
Schistosoma mansoni hypothetical protein 0.0048 0.0055 0.0535
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0014 0.0004 0.0063
Leishmania major pentamidine resistance protein 1 0.0014 0.0004 0.0036
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0019 0.0011 0.001
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0046 0.0053 0.1071
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0019 0.0011 0.001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0073 0.0093 0.2154
Brugia malayi ABC transporter family protein 0.0014 0.0004 0.0063
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0017 0.0009 0.0085
Entamoeba histolytica cysteine protease, putative 0.0037 0.0039 0.0908
Entamoeba histolytica cysteine protease, putative 0.0013 0.0003 0.0038
Toxoplasma gondii bifunctional GMP synthase/glutamine amidotransferase protein 0.0032 0.0032 0.0635
Schistosoma mansoni cathepsin B (C01 family) 0.0013 0.0003 0.0025
Schistosoma mansoni rab6-interacting 0.006 0.0073 0.0716
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0003 0.0019
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0025 0.002 0.0197
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0018 0.0189
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0078 0.0758
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0025 0.002 0.031
Brugia malayi cathepsin Z-like cysteine proteinase 0.0013 0.0003 0.0039
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0046 0.0053 0.1191
Echinococcus granulosus FTZ F1 alpha 0.0025 0.002 0.0197
Schistosoma mansoni organic anion transporter 0.0328 0.0484 0.4725
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0046 0.0053 0.1191
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0039
Brugia malayi Cathepsin L-like precursor 0.0049 0.0056 0.0867
Entamoeba histolytica cysteine protease, putative 0.0037 0.0039 0.0908
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.0423 1
Trichomonas vaginalis esterase, putative 0.0036 0.0036 0.0804
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0073 0.0716
Loa Loa (eye worm) hypothetical protein 0.0024 0.0019 0.0288
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0014 0.0004 0.0003
Echinococcus granulosus bloom syndrome protein 0.0025 0.0021 0.0202
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.0372 0.8779
Entamoeba histolytica transcription factor BTF3, putative 0.0034 0.0035 0.0802
Leishmania major basic transcription factor 3a, putative 0.0034 0.0035 0.038
Schistosoma mansoni hypothetical protein 0.0019 0.0011 0.0104
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.0009 0.0147
Trypanosoma cruzi cysteine proteinase, putative 0.0037 0.0039 0.043
Schistosoma mansoni smdr1 0.0014 0.0004 0.004
Plasmodium vivax ABC transporter B family member 5, putative 0.0014 0.0004 0.0122
Schistosoma mansoni multidrug resistance protein 0.0014 0.0004 0.004
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0013 0.0123
Brugia malayi Cathepsin L-like precursor 0.0073 0.0093 0.1432
Entamoeba histolytica cysteine proteinase, putative 0.0037 0.0039 0.0908
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.002 0.0396
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0025 0.002 0.01
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0059 0.1341
Trypanosoma cruzi major cysteine proteinase, putative 0.0013 0.0003 0.0018
Brugia malayi Cathepsin L-like precursor 0.0073 0.0093 0.1432
Loa Loa (eye worm) CYP4Cod1 0.0047 0.0054 0.0831
Echinococcus granulosus cathepsin l1 0.0049 0.0056 0.0551
Plasmodium falciparum serine repeat antigen 6 0.0013 0.0003 0.0026
Toxoplasma gondii cathepsin B 0.0013 0.0003 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0093 0.2154
Echinococcus granulosus ATP binding cassette sub family B 0.0014 0.0004 0.004
Onchocerca volvulus Cathepsin F homolog 0.0073 0.0093 0.1432
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0183 0.0261 0.026
Entamoeba histolytica cysteine proteinase, putative 0.0037 0.0039 0.0908
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0018 0.0274
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0003 0.002
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0046 0.0053 0.1191
Schistosoma mansoni transcription factor LCR-F1 0.0079 0.0102 0.0998
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0019 0.0011 0.001
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0019 0.0011 0.0109
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0038 0.0613
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0038 0.0838
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0007 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0025 0.002 0.031
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0039
Schistosoma mansoni multidrug resistance protein 0.0014 0.0003 0.0033
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0036 0.0397
Loa Loa (eye worm) retinol dehydrogenase 12 0.0012 0.0001 0.0014
Echinococcus multilocularis survival motor neuron protein 1 0.0233 0.0339 0.1689
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0025 0.002 0.031
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0012 0.0001 0.0009
Toxoplasma gondii ABC transporter family protein 0.0014 0.0004 0.0066
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0073 0.0093 0.1432
Leishmania major ATP-binding cassette protein subfamily B, member 3, putative 0.0014 0.0004 0.0036
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0036 0.0035
Loa Loa (eye worm) hypothetical protein 0.0046 0.0052 0.0797
Echinococcus granulosus nuclear factor of activated T cells 5 0.0073 0.0093 0.091
Trypanosoma cruzi metacaspase 5, putative 0.0017 0.0009 0.0087
Trichomonas vaginalis ABC transporter, putative 0.0046 0.0053 0.1191
Loa Loa (eye worm) hypothetical protein 0.0437 0.0651 1
Loa Loa (eye worm) hypothetical protein 0.0189 0.0272 0.4181
Leishmania major cathepsin L-like protease 0.0277 0.0405 0.4536
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0037 0.0039 0.0384
Toxoplasma gondii glutamine-dependent NAD(+) synthetase protein, putative 0.0081 0.0106 0.2176
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0039 0.0873
Echinococcus multilocularis Protein lozenge 0.0055 0.0066 0.0328
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0018 0.04
Loa Loa (eye worm) hypothetical protein 0.0025 0.002 0.031
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0189 0.0272 0.4181
Leishmania major hypothetical protein, conserved 0.0015 0.0006 0.0053
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0078 0.1193
Plasmodium vivax vivapain-1 0.0037 0.0039 0.1472
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0025 0.002 0.0197
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0014 0.0003 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0025 0.002 0.031
Brugia malayi Doublecortin family protein 0.006 0.0073 0.1127
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0141 0.0198 0.0197
Plasmodium falciparum multidrug resistance-associated protein 1 0.0014 0.0004 0.0053
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0019 0.0011 0.001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.0423 1
Brugia malayi jmjC domain containing protein 0.006 0.0073 0.1126
Schistosoma mansoni multidrug resistance protein 0.0014 0.0004 0.004
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0238 0.5593
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0018 0.0189
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.0009 0.0147
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0093 0.2154
Brugia malayi Protein kinase domain containing protein 0.0015 0.0004 0.0068
Trypanosoma brucei protein kinase, putative 0.005 0.0059 0.065
Chlamydia trachomatis cysteine--tRNA ligase 0.0095 0.0128 0.2115
Entamoeba histolytica cysteine protease, putative 0.0013 0.0003 0.0038
Mycobacterium ulcerans hypothetical protein 0.0036 0.0036 0.0035
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0009 0.0008
Trypanosoma cruzi metacaspase, putative 0.0017 0.0009 0.0087
Entamoeba histolytica ATP-binding cassette protein, putative 0.0014 0.0004 0.0075
Mycobacterium leprae DNA-DIRECTED RNA POLYMERASE (BETA CHAIN) RPOB (TRANSCRIPTASE BETA CHAIN) (RNA POLYMERASE BETA SUBUNIT) 0.0405 0.0602 0.0601
Brugia malayi RNA binding protein 0.0062 0.0078 0.1193
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0033
Mycobacterium ulcerans beta-lactamase 0.0036 0.0036 0.0035
Onchocerca volvulus Bile acid receptor homolog 0.0025 0.002 0.031
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.0014 0.0004 0.004
Loa Loa (eye worm) cytochrome P450 family protein 0.0058 0.007 0.1079
Loa Loa (eye worm) hypothetical protein 0.0049 0.0056 0.0867
Giardia lamblia Multidrug resistance-associated protein 1 0.0014 0.0004 0.0038
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0017 0.0008 0.0007
Echinococcus granulosus lipoxygenase domain containing protein 0.006 0.0073 0.0716
Trypanosoma brucei GMP synthase [glutamine-hydrolysing] 0.0032 0.0032 0.0344
Mycobacterium leprae putative cytochrome p450 0.0019 0.0011 0.001
Brugia malayi Inositol-1 0.0036 0.0038 0.058
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0019 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0014 0.0004 0.0063
Toxoplasma gondii melibiase subfamily protein 0.0101 0.0137 0.2811
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0014 0.0004 0.0066
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0066 0.1344
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0036 0.0804
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0019 0.0011 0.001
Trichomonas vaginalis abcb9, putative 0.0046 0.0053 0.1191
Echinococcus granulosus muscleblind protein 0.0147 0.0208 0.2027
Echinococcus granulosus caspase 0.0017 0.0009 0.0085
Plasmodium falciparum multidrug resistance protein 1 0.0046 0.0053 0.086
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0253 0.0369 0.4124
Echinococcus multilocularis ATP binding cassette sub family B 0.0014 0.0004 0.002
Brugia malayi hypothetical protein 0.0233 0.0339 0.521
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0013 0.0002 0.0021
Brugia malayi Pre-SET motif family protein 0.0206 0.0297 0.4567
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0013 0.0002 0.0011
Onchocerca volvulus 0.0095 0.0128 0.1969
Entamoeba histolytica hypothetical protein 0.0079 0.0102 0.2398
Treponema pallidum cysteinyl-tRNA synthetase 0.0095 0.0128 0.0445
Onchocerca volvulus 0.0049 0.0056 0.0867
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0039
Plasmodium vivax JmjC domain containing protein 0.0015 0.0006 0.0183
Trypanosoma cruzi NAD+ synthase, putative 0.0081 0.0106 0.1178
Brugia malayi hypothetical protein 0.0328 0.0484 0.7434
Echinococcus granulosus lysine specific demethylase 6a 0.0015 0.0006 0.0056
Onchocerca volvulus 0.0328 0.0484 0.7434
Plasmodium vivax serine-repeat antigen (SERA) 0.0013 0.0003 0.0061
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0006 0.0053
Giardia lamblia NH3-dependent NAD+ synthetase 0.0081 0.0106 0.246
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0078 0.1193
Onchocerca volvulus 0.0041 0.0044 0.0679
Mycobacterium ulcerans drugs-transport transmembrane ATP-binding protein ABC transporter 0.0014 0.0004 0.0003
Onchocerca volvulus 0.0048 0.0055 0.0843
Plasmodium falciparum serine repeat antigen 2 0.0013 0.0003 0.0026
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0073 0.0093 0.0464
Trypanosoma cruzi cysteine peptidase, putative 0.0277 0.0405 0.4536
Entamoeba histolytica cysteine protease, putative 0.0037 0.0039 0.0908
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.0423 1
Entamoeba histolytica hypothetical protein 0.0013 0.0003 0.0038
Brugia malayi cathepsin F-like cysteine proteinase 0.0024 0.0019 0.0288
Brugia malayi beta-lactamase family protein 0.0036 0.0036 0.0559
Entamoeba histolytica cysteine proteinase, putative 0.0049 0.0056 0.1314
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.6545 1 1
Plasmodium falciparum multidrug resistance-associated protein 2 0.0014 0.0004 0.0053
Echinococcus multilocularis multidrug resistance protein 1 0.0046 0.0053 0.0262
Trypanosoma brucei cysteinyl-tRNA synthetase, putative 0.0095 0.0128 0.1426
Echinococcus multilocularis dnaJ subfamily B 0.0403 0.0599 0.2988
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0028 0.0274
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0229 0.0332 0.1657
Trypanosoma cruzi cruzipain precursor, putative 0.0024 0.0019 0.02
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0004 0.0018
Echinococcus granulosus multidrug resistance protein 1 0.0046 0.0053 0.0514
Schistosoma mansoni glutamine-dependent NAD(+) synthetase 0.0049 0.0056 0.0551
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0282 0.0413 0.4621
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0067 0.0085 0.0831
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0274
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0009 0.013
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0288 0.0423 1
Plasmodium vivax multidrug resistance protein 2, putative 0.0014 0.0004 0.0122
Trypanosoma brucei p-glycoprotein 0.0014 0.0004 0.0036
Schistosoma mansoni hypothetical protein 0.0014 0.0004 0.0036
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0006 0.0087
Brugia malayi Papain family cysteine protease containing protein 0.0013 0.0003 0.0039
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0013 0.0002 0.0021
Loa Loa (eye worm) hypothetical protein 0.0189 0.0272 0.4181
Mycobacterium tuberculosis Glutamine-dependent NAD(+) synthetase NadE (NAD(+) synthase [glutamine-hydrolysing]) 0.0081 0.0106 0.0105
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0046 0.0053 0.058
Echinococcus multilocularis caspase 0.0017 0.0009 0.0043
Onchocerca volvulus 0.0025 0.002 0.031
Loa Loa (eye worm) ABC transporter 0.0014 0.0004 0.0063
Brugia malayi ABC transporter transmembrane region family protein 0.0014 0.0004 0.0063
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0028 0.014
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0013 0.0003 0.0025
Loa Loa (eye worm) hypothetical protein 0.0025 0.002 0.031
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0025 0.002 0.031
Trypanosoma brucei cysteine peptidase C (CPC) 0.0013 0.0003 0.0018
Brugia malayi Cytochrome P450 family protein 0.0047 0.0054 0.0831
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0013 0.0003 0.0039
Loa Loa (eye worm) runx1 0.0055 0.0066 0.1013
Echinococcus granulosus phd:f box containing protein 0.0015 0.0006 0.0056
Brugia malayi jmjC domain containing protein 0.0015 0.0006 0.0087
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0093 0.2154
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0084 0.011 0.1224
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0109 0.0149 0.0742
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0013 0.0003 0.0018
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0014 0.0003 0.0019
Loa Loa (eye worm) glutaminase 0.027 0.0395 0.6066
Schistosoma mansoni follistatin 0.0189 0.0272 0.2657
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0038 0.0188
Plasmodium falciparum cysteine proteinase falcipain 3 0.0073 0.0093 0.1534
Plasmodium vivax vivapain-2 0.0073 0.0093 0.3541
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0025 0.002 0.031
Echinococcus multilocularis multidrug resistance associated protein 1 0.0014 0.0004 0.002
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0046 0.0053 0.0052
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0018 0.0017
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0009 0.0008
Schistosoma mansoni caspase-7 (C14 family) 0.0017 0.0009 0.0085
Schistosoma mansoni GMP synthetase 0.0032 0.0032 0.0308
Brugia malayi Cathepsin L-like precursor 0.0073 0.0093 0.1432
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0019 0.0011 0.0109
Trypanosoma cruzi metacaspase 5, putative 0.0017 0.0009 0.0087
Mycobacterium ulcerans short chain dehydrogenase 0.0017 0.0008 0.0007
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0013 0.0003 0.0038
Leishmania major cytochrome p450-like protein 0.0019 0.0011 0.0109
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0183 0.0261 0.4331
Schistosoma mansoni cathepsin F (C01 family) 0.0073 0.0093 0.091
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0046 0.0053 0.1191
Brugia malayi P-glycoprotein-like protein 0.0014 0.0004 0.0063
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0013 0.0003 0.0025
Plasmodium falciparum metacaspase 1 0.0017 0.0009 0.013
Plasmodium falciparum serine repeat antigen 5 0.0013 0.0003 0.0026
Echinococcus granulosus ATP binding cassette sub family B 0.0014 0.0003 0.0033
Echinococcus granulosus RUN 0.006 0.0073 0.0716
Loa Loa (eye worm) ABC transporter 0.0014 0.0004 0.0063
Plasmodium falciparum cysteine proteinase falcipain 1 0.0037 0.0039 0.0637
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0046 0.0053 0.0809
Entamoeba histolytica cysteine proteinase, putative 0.0037 0.0039 0.0908
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0035 0.0701
Loa Loa (eye worm) ABC transporter 0.0014 0.0004 0.0063
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0125 0.1219
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0288 0.0423 1
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0059 0.1341
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0025 0.002 0.0197
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0025 0.002 0.031
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0014 0.0004 0.0066
Trypanosoma cruzi ABC transporter, mitochondrial, putative 0.0014 0.0004 0.0036
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0277 0.0405 0.4536
Brugia malayi Papain family cysteine protease containing protein 0.0013 0.0003 0.0039
Loa Loa (eye worm) hypothetical protein 0.0147 0.0208 0.3189
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.002 0.0318
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0189 0.0272 0.4181
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0019 0.0011 0.001
Entamoeba histolytica cysteine protease, putative 0.0013 0.0003 0.0038
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0008 0.0041
Echinococcus granulosus cathepsin L cysteine proteinase 0.0073 0.0093 0.091
Onchocerca volvulus 0.0073 0.0093 0.1432
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0036 0.0397
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0125 0.1219
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0019 0.0011 0.001
Plasmodium vivax ABC transporter B family member 7, putative 0.0014 0.0004 0.0122
Loa Loa (eye worm) hypothetical protein 0.0189 0.0272 0.4181
Mycobacterium tuberculosis Iron-regulated transporter IrtA 0.0014 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0134
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0036 0.0804
Onchocerca volvulus 0.0073 0.0093 0.1432
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0012 0.0001 0.0005
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.002 0.0215
Brugia malayi cytochrome P450 0.0019 0.0011 0.0163
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0073 0.0093 0.2154
Brugia malayi hypothetical protein 0.0079 0.0102 0.157
Loa Loa (eye worm) hypothetical protein 0.0025 0.002 0.031
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0035 0.0535
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.0009 0.0147
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0046 0.0053 0.0262
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0093 0.2154
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0025 0.002 0.031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0093 0.2154
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.0021 0.0432
Entamoeba histolytica ATP-binding cassette protein, putative 0.0014 0.0004 0.0075
Brugia malayi Muscleblind-like protein 0.0147 0.0208 0.3189
Plasmodium falciparum serine repeat antigen 9 0.0013 0.0003 0.0026
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0033
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0018 0.0017
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0021 0.0432
Loa Loa (eye worm) hypothetical protein 0.0014 0.0004 0.0063
Trypanosoma cruzi ABC transporter of the mitochondrion, putative 0.0014 0.0004 0.0036
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0238 0.5593
Onchocerca volvulus 0.0023 0.0018 0.0274
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0046 0.0053 0.1191
Entamoeba histolytica cysteine protease, putative 0.0037 0.0039 0.0908
Leishmania major pteridine reductase 1 0.0017 0.0008 0.008
Leishmania major cytochrome p450-like protein 0.0047 0.0054 0.0596
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.0372 0.8779
Loa Loa (eye worm) hypothetical protein 0.0328 0.0484 0.7434
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0019 0.0011 0.001
Schistosoma mansoni netrin receptor unc5 0.0014 0.0004 0.0036
Leishmania major cathepsin L-like protease 0.0073 0.0093 0.1034
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0014 0.0004 0.0036
Echinococcus multilocularis ATP binding cassette sub family B 0.0014 0.0004 0.002
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0014 0.0004 0.0036
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0019 0.0011 0.001
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0019 0.0011 0.001
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0025 0.002 0.031
Schistosoma mansoni cpg binding protein 0.003 0.0028 0.0272
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0013 0.0003 0.0061
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0255 0.0372 0.5715
Leishmania major metacaspase, putative 0.0017 0.0009 0.0087
Mycobacterium ulcerans hypothetical protein 0.0023 0.0018 0.0017
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0036 0.0355
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.0423 1
Onchocerca volvulus Netrin receptor homolog 0.0014 0.0004 0.0057
Entamoeba histolytica cysteine protease, putative 0.0037 0.0039 0.0908
Loa Loa (eye worm) hypothetical protein 0.0328 0.0484 0.7434
Echinococcus granulosus agrin 0.0189 0.0272 0.2657
Trichomonas vaginalis ABC transporter, putative 0.0046 0.0053 0.1191
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.0009 0.0147
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0059 0.065
Entamoeba histolytica recQ family helicase, putative 0.0014 0.0003 0.0042
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0183 0.0261 0.5394
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0015 0.0006 0.0099
Brugia malayi hypothetical protein 0.0016 0.0007 0.0101
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0073 0.0716
Echinococcus multilocularis Polycystic kidney disease protein 0.006 0.0073 0.0365
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0277 0.0405 0.4536
Trypanosoma cruzi cysteine protease, putative 0.0037 0.0039 0.043
Leishmania major oxidoreductase-like protein 0.0017 0.0008 0.008
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0073 0.0093 0.2154
Brugia malayi Papain family cysteine protease containing protein 0.0037 0.0039 0.0603
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0019 0.0011 0.001
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0047 0.0054 0.0053
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0019 0.0011 0.001
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0014 0.0004 0.0003
Brugia malayi ABC transporter family protein 0.0014 0.0004 0.0063
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.0423 1
Brugia malayi Nuclear hormone receptor-like 1 0.0013 0.0002 0.0033
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0001 0.0014
Leishmania major p-glycoprotein 0.0046 0.0053 0.058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0093 0.2154
Toxoplasma gondii transporter, major facilitator family protein 0.0328 0.0484 1
Onchocerca volvulus 0.0036 0.0036 0.0559
Echinococcus granulosus GMP synthase glutamine hydrolyzing 0.0032 0.0032 0.0308
Toxoplasma gondii cathepsin CPC1 0.0013 0.0003 0.0033
Brugia malayi ecdysteroid receptor 0.0025 0.002 0.031
Schistosoma mansoni ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6) 0.0014 0.0003 0.0033
Plasmodium vivax multidrug resistance-associated protein 2, putative 0.0014 0.0004 0.0122
Brugia malayi Cathepsin L-like cysteine proteinase 0.0049 0.0056 0.0867
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0101 0.0137 0.1335
Plasmodium vivax ABC transporter B family member 3, putative 0.0014 0.0004 0.0122
Echinococcus multilocularis cathepsin L 0.0013 0.0003 0.0013
Loa Loa (eye worm) hypothetical protein 0.0025 0.002 0.031
Loa Loa (eye worm) hypothetical protein 0.0025 0.002 0.031
Echinococcus granulosus cathepsin l1 0.0073 0.0093 0.091
Leishmania major mitochondrial DNA polymerase beta 0.0595 0.0893 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.0297 0.4567
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0001 0.0014
Brugia malayi jmjC domain containing protein 0.0015 0.0006 0.0087
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0014 0.0004 0.0066
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0014 0.0004 0.0036
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0038 0.0763
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.002 0.0197
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0024 0.0019 0.0288
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0013 0.0003 0.0025
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0013 0.0003 0.0061
Schistosoma mansoni cathepsin F (C01 family) 0.0073 0.0093 0.091
Treponema pallidum DNA-directed RNA polymerase subunit beta 0.0405 0.0602 1
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0035 0.038
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0141 0.0198 0.0197
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0019 0.0011 0.001
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.0071 0.0692
Entamoeba histolytica hypothetical protein 0.0014 0.0004 0.0075
Trypanosoma cruzi major cysteine proteinase, putative 0.0217 0.0315 0.352
Mycobacterium tuberculosis Conserved protein 0.0036 0.0036 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0039 0.0873
Echinococcus multilocularis ecdysone induced protein 78C 0.0025 0.002 0.01
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0013 0.0003 0.0061
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0014 0.0004 0.0003
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0125 0.0622
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0039
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0019 0.0011 0.0109
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0032 0.0031
Loa Loa (eye worm) hypothetical protein 0.0025 0.002 0.031
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0033
Trichomonas vaginalis abcb9, putative 0.0046 0.0053 0.1191
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0007 0.0006
Entamoeba histolytica cysteine proteinase, putative 0.0073 0.0093 0.2184
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0277 0.0405 0.4536
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0025 0.002 0.031
Plasmodium vivax GMP synthetase, putative 0.0032 0.0032 0.1177
Trichomonas vaginalis ABC transporter, putative 0.0046 0.0053 0.1191
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0016 0.0251
Trypanosoma cruzi metacaspase, putative 0.0017 0.0009 0.0087
Loa Loa (eye worm) hypothetical protein 0.0127 0.0177 0.2718
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0084 0.011 0.1224
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0013 0.0003 0.0025
Brugia malayi Melibiase family protein 0.0067 0.0085 0.1308
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0046 0.0053 0.1191
Brugia malayi Cytochrome P450 family protein 0.0019 0.0011 0.0163
Brugia malayi Papain family cysteine protease containing protein 0.0073 0.0093 0.1432
Onchocerca volvulus Cathepsin L homolog 0.0073 0.0093 0.1432
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0012 0.0001 0.0009
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.0423 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.002 0.0308
Mycobacterium ulcerans DNA-directed RNA polymerase subunit beta 0.0405 0.0602 0.0601
Onchocerca volvulus 0.0073 0.0093 0.1432
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0189 0.0272 0.4181
Echinococcus multilocularis 0.0014 0.0004 0.002
Entamoeba histolytica ATP-binding cassette protein, putative 0.0014 0.0004 0.0075
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0013 0.0003 0.0025
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.0014 0.0004 0.0063
Wolbachia endosymbiont of Brugia malayi ABC-type multidrug transport system, ATPase and permease component 0.0014 0.0004 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0035 0.0767
Echinococcus multilocularis cathepsin b 0.0013 0.0003 0.0013
Brugia malayi fibroinase precursor 0.0013 0.0003 0.0039
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0037 0.0039 0.043
Onchocerca volvulus Cathepsin L homolog 0.0073 0.0093 0.1432
Schistosoma mansoni cpg binding protein 0.003 0.0028 0.0272
Loa Loa (eye worm) hypothetical protein 0.0024 0.0019 0.0288
Loa Loa (eye worm) cytochrome P450 0.0019 0.0011 0.0163
Schistosoma mansoni glutaminase 0.027 0.0395 0.3855
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0046 0.0053 0.1191
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0039
Plasmodium vivax cysteine--tRNA ligase, putative 0.0095 0.0128 0.4883
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0037 0.0039 0.0384
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0036 0.0559
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0019 0.0011 0.001
Brugia malayi Cell death protein 3 precursor 0.0058 0.0071 0.109
Brugia malayi ABC transporter family protein 0.0046 0.0053 0.0809
Schistosoma mansoni nuclear hormone receptor 0.0025 0.002 0.0197
Toxoplasma gondii ABC1 family protein 0.0036 0.0036 0.0734
Brugia malayi glutaminase DH11.1 0.027 0.0395 0.6066
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0009 0.0147
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.0028 0.0025 0.0392
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0559
Entamoeba histolytica cysteine protease, putative 0.0037 0.0039 0.0908
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0183 0.0261 0.026
Brugia malayi sodium-independent organic anion transporter family protein 0.0328 0.0484 0.7434
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0134
Schistosoma mansoni dihydropteridine reductase 0.0012 0.0001 0.0009
Chlamydia trachomatis DNA-directed RNA polymerase subunit beta 0.0405 0.0602 1
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0014 0.0004 0.0003
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0595 0.0893 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0039
Schistosoma mansoni multidrug resistance protein 0.0046 0.0053 0.0514
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0046 0.0053 0.1191
Plasmodium vivax SET domain protein, putative 0.003 0.0028 0.104
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0078 0.0387
Brugia malayi hypothetical protein 0.0041 0.0044 0.0679
Echinococcus granulosus Ankyrin 0.0014 0.0004 0.0038
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0017 0.0009 0.0134
Plasmodium falciparum serine repeat antigen 3 0.0013 0.0003 0.0026
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0046 0.0053 0.0514
Schistosoma mansoni smdr2 0.0046 0.0053 0.0514
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0101 0.0137 0.0681
Leishmania major ATP-binding cassette protein subfamily B, member 1, putative 0.0014 0.0004 0.0036
Entamoeba histolytica P-glycoprotein 5, putative 0.0046 0.0053 0.1224
Brugia malayi Uncoordinated protein 44 0.0014 0.0004 0.0057
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0087
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0238 0.5593
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.0372 0.8779
Trypanosoma brucei cytochrome P450, putative 0.0047 0.0054 0.0596
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0038 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0056 0.1281
Echinococcus multilocularis agrin 0.0189 0.0272 0.1356
Echinococcus granulosus lipoxygenase domain containing protein 0.006 0.0073 0.0716
Plasmodium vivax vivapain-3 0.0037 0.0039 0.1472
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0078 0.0758
Echinococcus multilocularis caspase 2 0.0058 0.0071 0.0353
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0028 0.0274
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0046 0.0053 0.086
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0036 0.0804
Schistosoma mansoni cathepsin S (C01 family) 0.0013 0.0003 0.0025
Onchocerca volvulus Glucosylceramidase homolog 0.0167 0.0238 0.3655
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0093 0.2154
Echinococcus granulosus cysteine protease 0.0037 0.0039 0.0384
Echinococcus granulosus multidrug resistance associated protein 1 0.0014 0.0004 0.004
Leishmania major hypothetical protein, conserved 0.0036 0.0036 0.0397
Brugia malayi sodium-independent organic anion transporter family protein 0.0328 0.0484 0.7434
Schistosoma mansoni inositol monophosphatase 0.0036 0.0038 0.0369
Schistosoma mansoni hypothetical protein 0.0079 0.0102 0.0998
Brugia malayi Cytochrome P450 family protein 0.0058 0.007 0.1079
Plasmodium falciparum ABC transporter B family member 5, putative 0.0014 0.0004 0.0053
Echinococcus multilocularis RUN 0.006 0.0073 0.0365
Echinococcus multilocularis multidrug resistance protein 1 0.0046 0.0053 0.0262
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0036 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0025 0.002 0.031
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0025 0.002 0.031
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0018 0.0017
Onchocerca volvulus 0.0017 0.0008 0.0124
Schistosoma mansoni coup transcription factor 0.0025 0.002 0.0197
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.0329 0.0328
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0037 0.0039 0.0384
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0252 0.592
Plasmodium falciparum metacaspase-like protein 0.0017 0.0009 0.013
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0025 0.002 0.0197
Onchocerca volvulus 0.0036 0.0036 0.0559
Schistosoma mansoni microtubule-associated protein tau 0.0681 0.1024 1
Brugia malayi Papain family cysteine protease containing protein 0.0013 0.0003 0.0039
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0036 0.0355
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0014 0.0003 0.0019
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0018 0.0274
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0025 0.002 0.0197
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0036 0.0035
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0025 0.002 0.0197
Plasmodium vivax hypothetical protein, conserved 0.0017 0.0009 0.0299
Brugia malayi Pre-SET motif family protein 0.003 0.0028 0.0431
Echinococcus granulosus caspase 2 0.0058 0.0071 0.0693
Loa Loa (eye worm) hypothetical protein 0.0147 0.0208 0.3189
Brugia malayi Cathepsin L-like precursor 0.0024 0.0019 0.0288
Echinococcus granulosus death domain containing protein 0.0014 0.0004 0.0036
Schistosoma mansoni protein phosphatase 2C 0.0015 0.0006 0.0056
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0046 0.0053 0.1191
Loa Loa (eye worm) hypothetical protein 0.0067 0.0085 0.1308
Schistosoma mansoni rab6-interacting 0.006 0.0073 0.0716
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0017 0.0009 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0009 0.0147
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0014 0.0004 0.0036
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0028 0.0274
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0013 0.0003 0.0026
Schistosoma mansoni hypothetical protein 0.0167 0.0238 0.2323
Plasmodium falciparum serine repeat antigen 1 0.0013 0.0003 0.0026
Brugia malayi jmjC domain containing protein 0.0058 0.0071 0.1088
Echinococcus multilocularis cysteine protease 0.0073 0.0093 0.0464
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0006 0.0053
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0018 0.0017
Plasmodium falciparum serine repeat antigen 7 0.0013 0.0003 0.0026
Schistosoma mansoni multidrug resistance protein 0.0014 0.0004 0.004
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0019 0.0011 0.001
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0017 0.0009 0.0161
Mycobacterium tuberculosis Probable drugs-transport transmembrane ATP-binding protein ABC transporter 0.0014 0.0004 0.0003
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0101 0.0137 0.1335
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0046 0.0053 0.0262
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0025 0.002 0.031
Mycobacterium tuberculosis Probable oxidoreductase 0.0017 0.0008 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0277 0.0405 0.4536
Mycobacterium leprae Conserved hypothetical protein 0.0019 0.0011 0.001
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0006 0.0087
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0013 0.0003 0.0025
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0059 0.065
Trypanosoma cruzi metacaspase, putative 0.0017 0.0009 0.0087
Schistosoma mansoni inositol monophosphatase 0.0036 0.0038 0.0369
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0189 0.0272 0.5615
Leishmania major p-glycoprotein e 0.0014 0.0004 0.0036
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0046 0.0053 0.1191
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.0071 0.0353
Echinococcus multilocularis Ankyrin 0.0014 0.0004 0.0019
Brugia malayi multidrug resistance related protein 1 0.0014 0.0004 0.0063
Loa Loa (eye worm) hypothetical protein 0.0032 0.0032 0.0485
Echinococcus granulosus Polycystic kidney disease protein 0.006 0.0073 0.0716
Entamoeba histolytica cysteine protease, putative 0.0037 0.0039 0.0908
Brugia malayi cathepsin L-like cysteine proteinase 0.0013 0.0003 0.0039
Loa Loa (eye worm) hypothetical protein 0.0014 0.0004 0.0057
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.002 0.0318
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0229 0.0332 0.3247
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0079 0.0102 0.0998
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0059 0.065
Trichomonas vaginalis hypothetical protein 0.0183 0.0261 0.6153
Loa Loa (eye worm) hypothetical protein 0.006 0.0073 0.1127
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0018 0.0017
Echinococcus granulosus dnaJ subfamily B 0.0403 0.0599 0.5856
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0038 0.0413
Brugia malayi Death domain containing protein 0.0014 0.0004 0.0057
Brugia malayi SPARC precursor 0.0189 0.0272 0.4181
Schistosoma mansoni loxhd1 0.006 0.0073 0.0716
Brugia malayi hypothetical protein 0.006 0.0073 0.1127
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0073 0.0093 0.2154
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0559
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0036 0.0181
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0013 0.0003 0.0025
Toxoplasma gondii cathepsin CPC2 0.0013 0.0003 0.0033
Schistosoma mansoni cathepsin s 0.0024 0.0019 0.0183
Echinococcus multilocularis follistatin 0.0189 0.0272 0.1356
Brugia malayi photoreceptor-specific nuclear receptor 0.0025 0.002 0.031
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0013 0.0003 0.0025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0056 0.1281
Onchocerca volvulus 0.0073 0.0093 0.1432
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0019 0.0011 0.001
Brugia malayi Cathepsin L-like precursor 0.0073 0.0093 0.1432
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0189 0.0272 0.5615
Schistosoma mansoni RAR-like nuclear receptor 0.0025 0.002 0.0197
Brugia malayi ABC transporter family protein 0.0014 0.0004 0.0063
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0328 0.0484 0.2411
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0073 0.0093 0.2154
Loa Loa (eye worm) RNA binding protein 0.0062 0.0078 0.1193
Trypanosoma cruzi NAD+ synthase, putative 0.0081 0.0106 0.1178
Onchocerca volvulus 0.0073 0.0093 0.1432
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0025 0.002 0.01
Brugia malayi prostaglandin transporter 0.0328 0.0484 0.7434
Loa Loa (eye worm) hypothetical protein 0.0437 0.0651 1
Leishmania major ATP-binding cassette protein subfamily C, member 8, putative 0.0014 0.0004 0.0036
Schistosoma mansoni steroid hormone receptor ad4bp 0.0025 0.002 0.0197
Echinococcus granulosus cathepsin L 0.0037 0.0039 0.0384
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.0372 0.8779
Schistosoma mansoni thyroid hormone receptor 0.0025 0.002 0.0197
Loa Loa (eye worm) hypothetical protein 0.0046 0.0053 0.0809
Brugia malayi hypothetical protein 0.0328 0.0484 0.7434
Mycobacterium tuberculosis Conserved hypothetical protein 0.0313 0.0462 0.0461
Plasmodium falciparum ABC transporter B family member 6, putative 0.0014 0.0004 0.0053
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.0009 0.0147
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0019 0.0011 0.001
Entamoeba histolytica cysteine proteinase 2 0.0037 0.0039 0.0908
Brugia malayi cathepsin L-like precursor 0.0049 0.0056 0.0867
Entamoeba histolytica hypothetical protein 0.0079 0.0102 0.2398
Plasmodium vivax serine-repeat antigen (SERA) 0.0013 0.0003 0.0061
Echinococcus multilocularis caspase 8 0.0017 0.0009 0.0043
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.0008 0.0278
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0019 0.0011 0.0109
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0018 0.0274
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0025 0.002 0.031
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0087
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0018 0.0017
Plasmodium vivax ABC transporter B family member 4, putative 0.0014 0.0004 0.0122
Entamoeba histolytica P-glycoprotein-2 0.0046 0.0053 0.1224
Loa Loa (eye worm) cytochrome P450 family protein 0.0047 0.0054 0.0831
Loa Loa (eye worm) cysteinyl tRNA synthetase 1 0.0095 0.0128 0.1969
Echinococcus multilocularis muscleblind protein 1 0.0147 0.0208 0.1034
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0014 0.0004 0.0036
Echinococcus multilocularis thyroid hormone receptor alpha 0.0025 0.002 0.01
Echinococcus granulosus multidrug resistance protein 1 0.0032 0.0031 0.0306
Trypanosoma cruzi metacaspase, putative 0.0017 0.0009 0.0087
Echinococcus granulosus cathepsin b 0.0013 0.0003 0.0025
Loa Loa (eye worm) hypothetical protein 0.0024 0.0019 0.0288
Plasmodium vivax multidrug resistance protein 1, putative 0.0046 0.0053 0.1985
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0036 0.0397
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0013 0.0003 0.0025
Wolbachia endosymbiont of Brugia malayi ABC-type protease secretion system, ATPase and permease component, AprD 0.0014 0.0004 0.0053
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0017 0.0009 0.0161
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0014 0.0004 0.0036
Brugia malayi cathepsin L precursor 0.0013 0.0003 0.0039
Schistosoma mansoni multidrug resistance protein 0.0046 0.0053 0.0514
Leishmania major cysteine peptidase A (CPA) 0.0073 0.0093 0.1034
Echinococcus granulosus tar DNA binding protein 0.0062 0.0078 0.0758
Echinococcus granulosus apoptotic protease activating factor 1 0.0041 0.0044 0.0432
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0559
Loa Loa (eye worm) hypothetical protein 0.006 0.0073 0.1127
Onchocerca volvulus 0.0012 0.0001 0.0014
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0125 0.1219
Loa Loa (eye worm) hypothetical protein 0.0049 0.0056 0.0867
Onchocerca volvulus 0.0013 0.0003 0.0039
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0328 0.0484 0.4725
Loa Loa (eye worm) hypothetical protein 0.0025 0.002 0.031
Schistosoma mansoni lipoxygenase 0.0122 0.0168 0.1641
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0019 0.0011 0.001
Toxoplasma gondii hypothetical protein 0.0096 0.0129 0.2651
Plasmodium falciparum ABC transporter B family member 4, putative 0.0014 0.0004 0.0053
Echinococcus multilocularis geminin 0.0167 0.0238 0.1185
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0073 0.0093 0.2154
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0014 0.0004 0.0038
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0018 0.0189
Schistosoma mansoni retinoic acid receptor RXR 0.0122 0.0169 0.1651
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0046 0.0053 0.1191
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0013 0.0003 0.0061
Brugia malayi multidrug resistance protein 3 0.0046 0.0053 0.0809
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0059 0.0576
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0004 0.0057
Brugia malayi jmjC domain containing protein 0.0015 0.0006 0.0087
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0274
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0038 0.0413
Mycobacterium tuberculosis Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC 0.6545 1 1
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0046 0.0052 0.0507
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0122 0.0169 0.1651
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.0095 0.0128 0.0127
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0013 0.0003 0.0039
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0328 0.0484 0.2411
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0019 0.0011 0.001
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0059 0.065
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0014 0.0004 0.0036
Mycobacterium ulcerans NAD synthetase 0.0081 0.0106 0.0105
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0038 0.0872
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0125 0.1219
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0046 0.0053 0.1191
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0073 0.0093 0.2154
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0013 0.0003 0.0039
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0036 0.0035
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0014 0.0004 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0009 0.0147
Entamoeba histolytica cysteine protease, putative 0.0037 0.0039 0.0908
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.0009 0.0147
Echinococcus granulosus cathepsin l cysteine peptidase 0.0073 0.0093 0.091
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0078 0.1193
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0087
Plasmodium falciparum multidrug resistance protein 2 0.0014 0.0004 0.0053
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0019 0.0011 0.001
Schistosoma mansoni agrin 0.0189 0.0272 0.2657
Echinococcus granulosus cathepsin b 0.0013 0.0003 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0035 0.0767
Echinococcus multilocularis lipoxygenase domain containing protein 0.006 0.0073 0.0365
Trypanosoma brucei ABC transporter of the mitochondrion, putative 0.0014 0.0004 0.0036
Toxoplasma gondii cytochrome p450 superfamily protein 0.0019 0.0011 0.0201
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.0125 0.1918
Echinococcus multilocularis pol protein 0.1323 0.2007 1
Trichomonas vaginalis ABC transporter, putative 0.0046 0.0053 0.1191
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0019 0.0011 0.001
Entamoeba histolytica cysteine protease, putative 0.0073 0.0093 0.2184
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0035 0.13
Entamoeba histolytica cysteine protease, putative 0.0013 0.0003 0.0038
Entamoeba histolytica P-glycoprotein 6, putative 0.0014 0.0004 0.0075
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0189 0.0272 0.4181
Plasmodium falciparum glutamine-dependent NAD(+) synthetase, putative 0.0081 0.0106 0.1747
Echinococcus multilocularis phd:f box containing protein 0.0015 0.0006 0.0028
Trichomonas vaginalis DNA helicase recq, putative 0.0014 0.0003 0.0004
Plasmodium falciparum LCCL domain-containing protein 0.006 0.0073 0.1204
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0059 0.0576
Trypanosoma cruzi multidrug resistance protein E, putative 0.0014 0.0004 0.0036
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0014 0.0004 0.0066
Brugia malayi hypothetical protein 0.006 0.0073 0.1127
Leishmania major GMP synthase, putative,glutamine amidotransferase, putative 0.0032 0.0032 0.0344
Schistosoma mansoni caspase-3 (C14 family) 0.0017 0.0009 0.0085
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0019 0.0011 0.001
Mycobacterium tuberculosis DNA-directed RNA polymerase (beta chain) RpoB (transcriptase beta chain) (RNA polymerase beta subunit) 0.0405 0.0602 0.0601
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0014 0.0004 0.0066
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0125 0.0622
Plasmodium falciparum ABC transporter B family member 3, putative 0.0014 0.0004 0.0053
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0084 0.011 0.1224
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0025 0.039
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0101 0.0137 0.0681
Mycobacterium leprae Probable lipase LipE 0.0036 0.0036 0.0035
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0238 0.5593
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0038 0.0838
Schistosoma mansoni organic anion transporter 0.0328 0.0484 0.4725
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0013 0.0002 0.0021
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0014 0.0004 0.0003
Trichomonas vaginalis set domain proteins, putative 0.0234 0.0341 0.8035
Echinococcus multilocularis GMP synthase (glutamine hydrolyzing) 0.0032 0.0032 0.0157
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0073 0.0093 0.2154
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.002 0.01
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.0009 0.0147
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0059 0.065
Trichomonas vaginalis glutaminase, putative 0.027 0.0395 0.9321
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0013 0.0003 0.0018
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0019 0.0011 0.001
Echinococcus multilocularis apoptotic protease activating factor 1 0.0041 0.0044 0.022
Entamoeba histolytica cysteine protease, putative 0.0037 0.0039 0.0908
Echinococcus granulosus follistatin 0.0189 0.0272 0.2657
Loa Loa (eye worm) ctsf protein 0.0073 0.0093 0.1432
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0014 0.0004 0.0038
Plasmodium vivax ABC transporter B family member 6, putative 0.0014 0.0004 0.0122
Loa Loa (eye worm) hypothetical protein 0.0049 0.0056 0.0867
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0025 0.002 0.0197
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0015 0.0006 0.0056
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0125 0.1219
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0013 0.0002 0.0033
Brugia malayi nuclear receptor RXR 0.0013 0.0002 0.0033
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.002 0.0215
Loa Loa (eye worm) steroid hormone receptor 0.0025 0.002 0.031
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.0009 0.0147
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0019 0.0011 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0093 0.2154
Trypanosoma brucei oxidoreductase-like protein 0.0017 0.0008 0.008
Loa Loa (eye worm) hypothetical protein 0.0058 0.0071 0.109
Trichomonas vaginalis cysteinyl-tRNA synthetase, putative 0.0095 0.0128 0.2985
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0009 0.0147
Schistosoma mansoni lipoxygenase 0.0229 0.0332 0.3247
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0101 0.0137 0.1335
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0559
Onchocerca volvulus 0.0189 0.0272 0.4181
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0059 0.1201
Trypanosoma brucei ABC transporter, mitochondrial, putative 0.0014 0.0004 0.0036
Plasmodium vivax unspecified product 0.0024 0.0019 0.0684
Echinococcus granulosus lysine specific demethylase 5A 0.006 0.0073 0.0716
Trypanosoma cruzi cysteine peptidase, putative 0.0037 0.0039 0.043
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0007 0.0006
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0238 0.5593
Entamoeba histolytica P-glycoprotein-1 0.0046 0.0053 0.1224
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0073 0.0093 0.0464
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0277 0.0405 0.4536
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0008 0.008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0093 0.2154
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0046 0.0053 0.1191
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0059 0.0576
Mycobacterium tuberculosis Conserved protein 0.0036 0.0036 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0093 0.2154
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0067 0.0085 0.0831
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0036 0.0035
Loa Loa (eye worm) hypothetical protein 0.0233 0.0339 0.521
Echinococcus multilocularis 0.0019 0.0011 0.0053
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0079 0.0102 0.0509
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.0021 0.0318
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0059 0.0294
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0004 0.0036
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0018 0.0017
Plasmodium vivax unspecified product 0.0037 0.0039 0.1472
Echinococcus granulosus multidrug resistance protein 1 0.0032 0.0031 0.0306
Trypanosoma cruzi cruzipain precursor, putative 0.0277 0.0405 0.4536
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0134
Leishmania major cathepsin L-like protease 0.0277 0.0405 0.4536
Plasmodium falciparum JmjC domain-containing protein, putative 0.0015 0.0006 0.0079
Echinococcus multilocularis lysine specific demethylase 6a 0.0015 0.0006 0.0028
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0277 0.0405 0.4536
Brugia malayi steroid hormone receptor 0.0025 0.002 0.031
Brugia malayi Cathepsin L-like precursor 0.0073 0.0093 0.1432
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0073 0.1126
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0183 0.0261 0.4331
Onchocerca volvulus 0.0234 0.0341 0.5237
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0093 0.2154
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0013 0.0003 0.0061
Mycobacterium ulcerans component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD 0.0014 0.0004 0.0003
Brugia malayi beta-NAC-like protein 0.0034 0.0035 0.0535
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0046 0.0053 0.1191
Trypanosoma cruzi cytochrome P450, putative 0.0047 0.0054 0.0596
Brugia malayi Cathepsin L-like precursor 0.0073 0.0093 0.1432
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0073 0.0093 0.1534
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0028 0.0561
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0067 0.0085 0.1963
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0019 0.0011 0.001
Schistosoma mansoni hypothetical protein 0.006 0.0073 0.0716
Echinococcus granulosus ATP binding cassette sub family B 0.0014 0.0004 0.004
Onchocerca volvulus Putative organic anion transporter 0.0328 0.0484 0.7434
Loa Loa (eye worm) hypothetical protein 0.0328 0.0484 0.7434
Brugia malayi ABC transporter 0.0014 0.0003 0.0051
Loa Loa (eye worm) RecQ helicase 0.0025 0.0021 0.0318
Plasmodium vivax multidrug resistance-associated protein 1, putative 0.0014 0.0004 0.0122
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0046 0.0053 0.1191
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0019 0.0011 0.001
Trypanosoma cruzi MFS transporter, putative 0.0328 0.0484 0.5414
Leishmania major NAD synthase, putative 0.0081 0.0106 0.1178
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0093 0.2154
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0019 0.0011 0.0109
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0009 0.013
Entamoeba histolytica P-glycoprotein-2, putative 0.0014 0.0003 0.0057
Giardia lamblia Multidrug resistance-associated protein 1 0.0014 0.0003 0.0019
Echinococcus multilocularis ATP binding cassette sub family B 0.0014 0.0004 0.002
Trypanosoma brucei metacaspase MCA3 0.0017 0.0009 0.0087
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0095 0.0128 0.1251
Echinococcus granulosus cathepsin L cysteine protease 0.0037 0.0039 0.0384
Entamoeba histolytica ABC transporter, putative 0.0014 0.0004 0.0075
Giardia lamblia Multidrug resistance-associated protein 1 0.0014 0.0004 0.0038
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0046 0.0053 0.0262
Entamoeba histolytica cysteine protease, putative 0.0037 0.0039 0.0908
Plasmodium falciparum serine repeat antigen 4 0.0013 0.0003 0.0026
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0017 0.0008 0.0007
Giardia lamblia Multidrug resistance-associated protein Mrp2 0.0014 0.0003 0.0019
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0017 0.0008 0.008
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0013 0.0003 0.0061
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0006 0.0087
Brugia malayi CXXC zinc finger family protein 0.0028 0.0025 0.039
Trypanosoma cruzi cysteine proteinase, putative 0.0037 0.0039 0.043
Entamoeba histolytica hypothetical protein 0.0034 0.0035 0.0802
Echinococcus multilocularis transcription factor btf3 0.0034 0.0035 0.0173
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0017 0.0009 0.0161
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0013 0.0003 0.0039
Brugia malayi hypothetical protein 0.0013 0.0002 0.0033
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.0372 0.8779
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0025 0.002 0.01
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0032 0.0031 0.0684
Loa Loa (eye worm) hypothetical protein 0.0328 0.0484 0.7434
Loa Loa (eye worm) cytochrome P450 family protein 0.0047 0.0054 0.0831
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0019 0.0011 0.001
Brugia malayi Papain family cysteine protease containing protein 0.0037 0.0039 0.0603
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0059 0.1341
Loa Loa (eye worm) hypothetical protein 0.0328 0.0484 0.7434
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0189 0.0272 0.5615
Entamoeba histolytica cysteine proteinase, putative 0.0037 0.0039 0.0908
Schistosoma mansoni multidrug resistance protein 0.0014 0.0004 0.004
Trypanosoma brucei metacaspase MCA2 0.0017 0.0009 0.0087
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0093 0.2154
Loa Loa (eye worm) hypothetical protein 0.0046 0.0053 0.0809
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0059 0.0294
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0017 0.0008 0.0007
Brugia malayi cathepsin F-like cysteine proteinase 0.0013 0.0003 0.0039
Entamoeba histolytica cysteine proteinase 1, putative 0.0037 0.0039 0.0908
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0046 0.0053 0.1191
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0019 0.0011 0.001
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0032 0.0031
Wolbachia endosymbiont of Brugia malayi DNA-directed RNA polymerase subunit beta/beta' 0.0405 0.0602 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.0423 1
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0059 0.1341
Plasmodium falciparum cysteine--tRNA ligase 0.0095 0.0128 0.2115
Brugia malayi ABC transporter transmembrane region family protein 0.0014 0.0003 0.0051
Mycobacterium tuberculosis Conserved protein 0.0036 0.0036 0.0035
Brugia malayi cysteinyl tRNA synthetase protein 1 0.0095 0.0128 0.1969
Leishmania major hypothetical protein, conserved 0.0025 0.002 0.0215
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0019 0.0011 0.001
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0059 0.065
Trypanosoma cruzi cysteine peptidase, putative 0.0277 0.0405 0.4536
Mycobacterium ulcerans glutaminase 0.027 0.0395 0.0394
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0019 0.0011 0.001
Trypanosoma cruzi cysteine peptidase, putative 0.0277 0.0405 0.4536
Brugia malayi hypothetical protein 0.0014 0.0004 0.0063
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0046 0.0053 0.1191
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0046 0.0053 0.1191
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0018 0.0017
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0025 0.002 0.0197
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0025 0.0248
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0059 0.0906
Schistosoma mansoni hypothetical protein 0.0041 0.0044 0.0432
Trypanosoma cruzi cysteine peptidase, putative 0.0073 0.0093 0.1034
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0059 0.1341
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0189 0.0272 0.4181
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0073 0.0093 0.2154
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0019 0.0011 0.001
Onchocerca volvulus 0.0036 0.0036 0.0559
Loa Loa (eye worm) glutaminase 2 0.027 0.0395 0.6066
Trichomonas vaginalis nh(3)-dependent NAD(+) synthetase, putative 0.0081 0.0106 0.246
Entamoeba histolytica multidrug resistance protein, putative 0.0014 0.0004 0.0075
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0055 0.0843
Echinococcus multilocularis expressed protein 0.0189 0.0272 0.1356
Echinococcus granulosus multidrug resistance protein 1 0.0046 0.0053 0.0514
Onchocerca volvulus Cell death protein 3 homolog 0.0058 0.0071 0.109
Loa Loa (eye worm) agrin synaptic family protein 0.0189 0.0272 0.4181
Entamoeba histolytica P-glycoprotein 6, putative 0.0014 0.0004 0.0075
Brugia malayi hypothetical protein 0.0013 0.0002 0.0033
Onchocerca volvulus Cathepsin L homolog 0.0013 0.0003 0.0039
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0025 0.002 0.0197
Echinococcus granulosus jumonji domain containing 1A 0.0015 0.0006 0.0056
Plasmodium vivax vivapain-2 0.0073 0.0093 0.3541
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0038 0.0838
Echinococcus multilocularis cathepsin L 0.0037 0.0039 0.0196
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0009 0.0147
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.002 0.01
Loa Loa (eye worm) hypothetical protein 0.0189 0.0272 0.4181
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0036 0.0035
Brugia malayi ABC transporter 0.0014 0.0004 0.0063
Schistosoma mansoni cathepsin C 0.0013 0.0003 0.0025
Echinococcus granulosus multidrug resistance associated protein 7 0.0014 0.0004 0.004
Wolbachia endosymbiont of Brugia malayi cysteinyl-tRNA synthetase 0.0095 0.0128 0.2115
Echinococcus multilocularis multidrug resistance associated protein 7 0.0014 0.0004 0.002
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0028 0.0274
Echinococcus granulosus ecdysone induced protein 78C 0.0025 0.002 0.0197
Brugia malayi ABC transporter transmembrane region family protein 0.0014 0.0004 0.0063
Leishmania major cathepsin L-like protease 0.0073 0.0093 0.1034
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0025 0.002 0.0197
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0013 0.0003 0.0038
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0013 0.0003 0.0025
Entamoeba histolytica P-glycoprotein-2, putative 0.0046 0.0053 0.1224
Brugia malayi cathepsin B-like cysteine proteinase 0.0013 0.0003 0.0039
Leishmania major cathepsin L-like protease 0.0073 0.0093 0.1034
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0183 0.0261 0.026
Echinococcus multilocularis ATP binding cassette sub family B 0.0014 0.0004 0.002
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0046 0.0053 0.1071
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.0125 0.1918
Echinococcus multilocularis cpg binding protein 0.003 0.0028 0.0139
Echinococcus multilocularis pol protein 0.1323 0.2007 1
Loa Loa (eye worm) doublecortin family protein 0.006 0.0073 0.1127
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0084 0.011 0.1224
Onchocerca volvulus Putative organic anion transporter 0.0328 0.0484 0.7434
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0238 0.5593
Echinococcus multilocularis pol protein 0.1323 0.2007 1
Echinococcus granulosus transcription factor btf3 0.0034 0.0035 0.034
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0025 0.002 0.01
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0559
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.0071 0.0353
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0037 0.0039 0.043
Entamoeba histolytica cysteine protease, putative 0.0037 0.0039 0.0908
Trypanosoma cruzi cytochrome P450, putative 0.0047 0.0054 0.0596
Schistosoma mansoni jumonji domain containing protein 0.0058 0.0071 0.0692
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0009 0.0147
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0004 0.0057
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0019 0.0011 0.001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0028 0.0274
Schistosoma mansoni caspase-7 (C14 family) 0.0058 0.0071 0.0693
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0025 0.002 0.031
Loa Loa (eye worm) cysteine protease 0.0073 0.0093 0.1432
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0277 0.0405 0.4536
Plasmodium vivax unspecified product 0.0013 0.0003 0.0061
Entamoeba histolytica hypothetical protein 0.0079 0.0102 0.2398
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0015 0.0006 0.0053
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0255 0.0372 0.5715
Echinococcus granulosus cathepsin L 0.0013 0.0003 0.0025
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0134
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0013 0.0003 0.0025
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0238 0.5593
Entamoeba histolytica P-glycoprotein 5, putative 0.0014 0.0003 0.0057
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0018 0.0017
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0019 0.0011 0.001
Entamoeba histolytica NAD synthetase, putative 0.0081 0.0106 0.2488
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0093 0.2154
Echinococcus multilocularis JmjC domain containing protein 4 0.0015 0.0006 0.0028
Schistosoma mansoni lozenge 0.0055 0.0066 0.0644
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0017 0.0009 0.0085
Onchocerca volvulus 0.0046 0.0053 0.0809
Entamoeba histolytica cysteine protease, putative 0.0013 0.0003 0.0038
Entamoeba histolytica ATP-binding cassette protein, putative 0.0014 0.0004 0.0075
Schistosoma mansoni multidrug resistance protein 0.0014 0.0004 0.004
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0019 0.0011 0.001
Schistosoma mansoni hypothetical protein 0.0167 0.0238 0.2323
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0183 0.0261 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0025 0.002 0.031
Brugia malayi secreted modular calcium-binding protein 1 0.0189 0.0272 0.4181

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.32 uM Inhibition of 17beta HSD1 in T47D cells ChEMBL. 16480268
Inhibition (functional) = 19 % Inhibition of 17beta HSD2 in MDA-MB231cells at 10 uM ChEMBL. 16480268
Inhibition (functional) = 92 % Inhibition of 17beta HSD1 in T47D cells at 10 uM ChEMBL. 16480268

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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