Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | huntingtin | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | animal heme peroxidase | 0.0165 | 1 | 1 |
Brugia malayi | Peroxidasin | 0.0165 | 1 | 1 |
Echinococcus granulosus | peroxidasin | 0.0165 | 1 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0165 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 1 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0165 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0165 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0165 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0165 | 1 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0165 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0165 | 1 | 1 |
Onchocerca volvulus | 0.0165 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0165 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0165 | 1 | 0.5 |
Onchocerca volvulus | 0.0165 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0165 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0165 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0165 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0165 | 1 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0165 | 1 | 0.5 |
Onchocerca volvulus | 0.0165 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0165 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0165 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0165 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0165 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0165 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 5.6234 um | PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.