Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 1 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.4732 | 0.4732 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.1218 | 0.1218 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 1 | 1 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0016 | 0.0816 | 0.0816 |
Schistosoma mansoni | lamin | 0.0033 | 0.4732 | 0.4732 |
Echinococcus multilocularis | musashi | 0.0033 | 0.4732 | 0.4732 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0017 | 0.1218 | 0.1218 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0678 | 0.0678 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0016 | 0.0816 | 0.0816 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 1 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.4732 | 0.4732 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0816 | 0.0816 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.4593 | 0.4593 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.4732 | 0.4732 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.4732 | 0.4732 |
Echinococcus multilocularis | lamin | 0.0033 | 0.4732 | 0.4732 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.4732 | 0.4732 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.4732 | 0.4732 |
Onchocerca volvulus | 0.0033 | 0.4732 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.4732 | 0.4732 |
Onchocerca volvulus | 0.0033 | 0.4732 | 1 | |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.4732 | 0.4732 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.4732 | 0.4732 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 1 | 1 |
Echinococcus granulosus | lamin | 0.0033 | 0.4732 | 0.4732 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0033 | 0.4732 | 0.4732 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0678 | 0.0678 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.2387 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 6.3096 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 16.5113 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 17.7828 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.