Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | 0.0083 | 0.0042 | 0.0042 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0179 | 0.0213 |
Schistosoma mansoni | proliferation-associated protein 2G4 38kDa (M24 family) | 0.0102 | 0.0179 | 0.0179 |
Loa Loa (eye worm) | hypothetical protein | 0.0362 | 0.1996 | 0.2377 |
Loa Loa (eye worm) | thymidylate synthase | 0.0314 | 0.166 | 0.1977 |
Entamoeba histolytica | aminopeptidase, putative | 0.0102 | 0.0179 | 0.5 |
Plasmodium falciparum | HP12 protein homolog, putative | 0.0467 | 0.2735 | 0.3111 |
Echinococcus granulosus | methionyl aminopeptidase 2 | 0.0102 | 0.0179 | 0.0179 |
Brugia malayi | metallopeptidase family M24 containing protein | 0.0102 | 0.0179 | 0.0213 |
Schistosoma mansoni | chromatin-specific transcription elongation factor 140 kDa subunit (M24 family) | 0.0102 | 0.0179 | 0.0179 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.1505 | 1 | 1 |
Brugia malayi | cyclin-dependent kinase 7 homolog | 0.0099 | 0.0155 | 0.0185 |
Toxoplasma gondii | hypothetical protein | 0.0467 | 0.2735 | 0.3111 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0314 | 0.166 | 0.2995 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0314 | 0.166 | 0.1802 |
Echinococcus multilocularis | methionyl aminopeptidase 1 (M24 family) | 0.0809 | 0.5124 | 0.5124 |
Plasmodium falciparum | methionine aminopeptidase 1a, putative | 0.0809 | 0.5124 | 0.6018 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0362 | 0.1996 | 0.2212 |
Schistosoma mansoni | aminopeptidase P homologue (M24 family) | 0.0102 | 0.0179 | 0.0179 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0083 | 0.0042 | 0.0042 |
Giardia lamblia | Xaa-Pro dipeptidase | 0.0102 | 0.0179 | 0.5 |
Brugia malayi | metallopeptidase family M24 containing protein | 0.0102 | 0.0179 | 0.0213 |
Mycobacterium ulcerans | methionine aminopeptidase MapB | 0.0809 | 0.5124 | 1 |
Schistosoma mansoni | aminopeptidase P1 (M24 family) | 0.0102 | 0.0179 | 0.0179 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0102 | 0.0179 | 0.5 |
Brugia malayi | initiation factor 2-associated protein. | 0.0102 | 0.0179 | 0.0213 |
Echinococcus granulosus | geminin | 0.0179 | 0.0717 | 0.0717 |
Mycobacterium tuberculosis | Methionine aminopeptidase MapB (map) (peptidase M) | 0.0809 | 0.5124 | 1 |
Echinococcus granulosus | methionine aminopeptidase type I | 0.0102 | 0.0179 | 0.0179 |
Toxoplasma gondii | methionine aminopeptidase | 0.1276 | 0.8395 | 1 |
Giardia lamblia | Methionine aminopeptidase | 0.0102 | 0.0179 | 0.5 |
Entamoeba histolytica | Xaa-Pro dipeptidase, putative | 0.0102 | 0.0179 | 0.5 |
Onchocerca volvulus | 0.0314 | 0.166 | 1 | |
Toxoplasma gondii | cell-cycle-associated protein kinase, putative | 0.023 | 0.107 | 0.1085 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0144 | 0.0472 | 0.0563 |
Echinococcus multilocularis | geminin | 0.0179 | 0.0717 | 0.0717 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0144 | 0.0472 | 0.0563 |
Echinococcus granulosus | thymidylate synthase | 0.0314 | 0.166 | 0.166 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0149 | 0.0509 | 1 |
Echinococcus multilocularis | Proliferation associated protein 2G4 | 0.0102 | 0.0179 | 0.0179 |
Echinococcus granulosus | FACT complex subunit SPT16 | 0.0102 | 0.0179 | 0.0179 |
Brugia malayi | metallopeptidase family M24 containing protein | 0.0102 | 0.0179 | 0.0213 |
Echinococcus multilocularis | Xaa Pro aminopeptidase 3 | 0.0102 | 0.0179 | 0.0179 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0362 | 0.1996 | 0.2377 |
Mycobacterium tuberculosis | Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) | 0.0809 | 0.5124 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0179 | 0.0717 | 0.0717 |
Echinococcus granulosus | xaa Pro dipeptidase | 0.0102 | 0.0179 | 0.0179 |
Echinococcus granulosus | Proliferation associated protein 2G4 | 0.0102 | 0.0179 | 0.0179 |
Entamoeba histolytica | methionine aminopeptidase, putative | 0.0102 | 0.0179 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0467 | 0.2735 | 0.3111 |
Loa Loa (eye worm) | DNA-binding protein | 0.0102 | 0.0179 | 0.0213 |
Echinococcus granulosus | methionyl aminopeptidase 1 M24 family | 0.1276 | 0.8395 | 0.8395 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0314 | 0.166 | 0.166 |
Brugia malayi | Methionine aminopeptidase protein type I | 0.1276 | 0.8395 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0362 | 0.1996 | 0.2212 |
Schistosoma mansoni | methionyl aminopeptidase 2 (M24 family) | 0.0102 | 0.0179 | 0.0179 |
Mycobacterium ulcerans | methionine aminopeptidase | 0.0809 | 0.5124 | 1 |
Echinococcus multilocularis | methionyl aminopeptidase 2 | 0.0102 | 0.0179 | 0.0179 |
Loa Loa (eye worm) | CMGC/CDK/CDK7 protein kinase | 0.0083 | 0.0042 | 0.005 |
Toxoplasma gondii | methionine aminopeptidase | 0.0809 | 0.5124 | 0.6018 |
Trypanosoma brucei | methionine aminopeptidase, type I, putative | 0.1276 | 0.8395 | 1 |
Echinococcus granulosus | Xaa Pro aminopeptidase 3 | 0.0102 | 0.0179 | 0.0179 |
Schistosoma mansoni | proliferation-associated protein 2G4 38kDa (M24 family) | 0.0102 | 0.0179 | 0.0179 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0149 | 0.0509 | 0.0667 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0314 | 0.166 | 0.1802 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0467 | 0.2735 | 0.3111 |
Plasmodium falciparum | MO15-related protein kinase | 0.0246 | 0.1183 | 0.1223 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0149 | 0.0509 | 0.0401 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0179 | 0.0213 |
Trypanosoma brucei | methionine aminopeptidase, putative | 0.1276 | 0.8395 | 1 |
Leishmania major | methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 | 0.1276 | 0.8395 | 1 |
Brugia malayi | hypothetical protein | 0.0149 | 0.0509 | 0.0606 |
Giardia lamblia | Xaa-Pro dipeptidase | 0.0102 | 0.0179 | 0.5 |
Trypanosoma cruzi | metallo- peptidase, Clan MG, Family M24 | 0.1276 | 0.8395 | 1 |
Schistosoma mansoni | methionyl aminopeptidase 1 (M24 family) | 0.0809 | 0.5124 | 0.5124 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0467 | 0.2735 | 0.3111 |
Plasmodium vivax | hypothetical protein, conserved | 0.0467 | 0.2735 | 0.3111 |
Plasmodium falciparum | methionine aminopeptidase 1b, putative | 0.1276 | 0.8395 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0362 | 0.1996 | 0.2212 |
Mycobacterium leprae | PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) | 0.0809 | 0.5124 | 1 |
Schistosoma mansoni | methionyl aminopeptidase 1 (M24 family) | 0.0809 | 0.5124 | 0.5124 |
Echinococcus multilocularis | xaa Pro dipeptidase | 0.0102 | 0.0179 | 0.0179 |
Brugia malayi | DNA-binding protein, 42 kDa containing protein | 0.0102 | 0.0179 | 0.0213 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.0758 | 0.0903 |
Echinococcus multilocularis | methionine aminopeptidase, type I | 0.0102 | 0.0179 | 0.0179 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0314 | 0.166 | 0.1802 |
Plasmodium vivax | cyclin dependent kinase 7 (cdk7), putative | 0.0246 | 0.1183 | 0.1223 |
Echinococcus granulosus | cyclin dependent kinase 7 | 0.0083 | 0.0042 | 0.0042 |
Wolbachia endosymbiont of Brugia malayi | methionine aminopeptidase | 0.0809 | 0.5124 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0314 | 0.166 | 0.1802 |
Echinococcus multilocularis | cyclin dependent kinase 7 | 0.0083 | 0.0042 | 0.0042 |
Echinococcus granulosus | xaa Pro dipeptidase | 0.0102 | 0.0179 | 0.0179 |
Mycobacterium ulcerans | thymidylate synthase | 0.0314 | 0.166 | 0.2995 |
Schistosoma mansoni | hypothetical protein | 0.0179 | 0.0717 | 0.0717 |
Entamoeba histolytica | peptidase, putative | 0.0102 | 0.0179 | 0.5 |
Schistosoma mansoni | Xaa-Pro dipeptidase (M24 family) | 0.0102 | 0.0179 | 0.0179 |
Trypanosoma brucei | metallo- peptidase, Clan MG, Family M24 | 0.1276 | 0.8395 | 1 |
Echinococcus granulosus | xaa pro aminopeptidase | 0.0102 | 0.0179 | 0.0179 |
Plasmodium vivax | methionine aminopeptidase 1a, putative | 0.0809 | 0.5124 | 0.6018 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0467 | 0.2735 | 0.3111 |
Echinococcus multilocularis | xaa pro aminopeptidase | 0.0102 | 0.0179 | 0.0179 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0179 | 0.0213 |
Treponema pallidum | methionine aminopeptidase (map) | 0.0809 | 0.5124 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0314 | 0.166 | 0.1802 |
Mycobacterium leprae | PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) | 0.0809 | 0.5124 | 1 |
Chlamydia trachomatis | methionine aminopeptidase | 0.0809 | 0.5124 | 1 |
Plasmodium vivax | methionine aminopeptidase 1b, putative | 0.1276 | 0.8395 | 1 |
Toxoplasma gondii | methionine aminopeptidase, type i, putative | 0.0809 | 0.5124 | 0.6018 |
Schistosoma mansoni | peptidase | 0.0102 | 0.0179 | 0.0179 |
Loa Loa (eye worm) | metallopeptidase family M24 containing protein | 0.0102 | 0.0179 | 0.0213 |
Loa Loa (eye worm) | methionine aminopeptidase type I | 0.1276 | 0.8395 | 1 |
Echinococcus multilocularis | methionyl aminopeptidase 1 (M24 family) | 0.1276 | 0.8395 | 0.8395 |
Schistosoma mansoni | microtubule-associated protein tau | 0.1505 | 1 | 1 |
Brugia malayi | thymidylate synthase | 0.0314 | 0.166 | 0.1977 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0314 | 0.166 | 0.2995 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0314 | 0.166 | 0.1802 |
Trypanosoma cruzi | metallo- peptidase, Clan MG, Family M24 | 0.1276 | 0.8395 | 1 |
Loa Loa (eye worm) | initiation factor 2-associated protein | 0.0102 | 0.0179 | 0.0213 |
Echinococcus multilocularis | thymidylate synthase | 0.0314 | 0.166 | 0.166 |
Echinococcus multilocularis | xaa Pro dipeptidase | 0.0102 | 0.0179 | 0.0179 |
Echinococcus multilocularis | FACT complex subunit SPT16 | 0.0102 | 0.0179 | 0.0179 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.