TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 222.287 | Formula: C11H18N4O
H donors: 0 H acceptors: 2 LogP: 1.24 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: CN(c1noc(n1)C1CN2CCC1CC2)C
InChi: 1S/C11H18N4O/c1-14(2)11-12-10(16-13-11)9-7-15-5-3-8(9)4-6-15/h8-9H,3-7H2,1-2H3
InChiKey: VCFKLODMDFHOCW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0087	0.1271	0.1271
Mycobacterium ulcerans	penicillin-binding membrane protein PbpB	0.0074	0.0959	0.2605
Brugia malayi	EGF-like domain containing protein	0.0087	0.1271	0.1271
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0087	0.1271	0.1271
Loa Loa (eye worm)	hypothetical protein	0.0435	0.9432	0.9432
Mycobacterium ulcerans	bifunctional penicillin-binding protein 1A/1B PonA1	0.0074	0.0959	0.2605
Trypanosoma cruzi	Adenine phosphoribosyltransferase, putative	0.0044	0.0266	0.0723
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1271	0.1271
Mycobacterium tuberculosis	Conserved protein	0.0044	0.0266	0.1009
Echinococcus multilocularis	adenine phosphoribosyltransferase	0.0044	0.0266	0.0282
Giardia lamblia	Adenine phosphoribosyltransferase	0.0044	0.0266	0.0723
Onchocerca volvulus	Dual oxidase homolog	0.0435	0.9432	0.9432
Loa Loa (eye worm)	orotate phosphoribosyltransferase	0.0044	0.0266	0.0266
Echinococcus granulosus	slit 2 protein	0.0087	0.1271	0.1347
Plasmodium falciparum	basic transcription factor 3b, putative	0.0036	0.0073	0.0198
Schistosoma mansoni	cell polarity protein	0.0087	0.1271	0.1347
Onchocerca volvulus		0.019	0.3681	0.3681
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1271	0.1271
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1271	0.1271
Mycobacterium ulcerans	bifunctional pyrimidine regulatory protein PyrR/uracil phosphoribosyltransferase	0.0044	0.0266	0.0723
Brugia malayi	hypothetical protein	0.0037	0.0097	0.0097
Mycobacterium tuberculosis	Possible penicillin-binding lipoprotein	0.0074	0.0959	0.3637
Toxoplasma gondii	EGF family domain-containing protein	0.0087	0.1271	0.3451
Plasmodium vivax	orotate phosphoribosyltransferase, putative	0.0044	0.0266	0.0723
Loa Loa (eye worm)	runx1	0.0058	0.0574	0.0574
Echinococcus granulosus	peroxidasin	0.0435	0.9432	1
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1271	0.1271
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0087	0.1271	0.1347
Treponema pallidum	adenine phosphoribosyltransferase	0.0044	0.0266	0.2774
Echinococcus granulosus	voltage dependent calcium channel	0.0075	0.0991	0.105
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1271	0.1271
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.0075	0.0991	0.105
Loa Loa (eye worm)	animal heme peroxidase	0.0435	0.9432	0.9432
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0073	0.0198
Mycobacterium ulcerans	hypoxanthine-guanine phosphoribosyltransferase Hpt	0.019	0.3681	1
Onchocerca volvulus	Putative cubilin	0.0087	0.1271	0.1271
Mycobacterium tuberculosis	Amidophosphoribosyltransferase PurF (glutamine phosphoribosylpyrophosphate amidotransferase) (ATASE) (gpatase)	0.0044	0.0266	0.1009
Mycobacterium tuberculosis	Probable pyrimidine operon regulatory protein PyrR	0.0044	0.0266	0.1009
Schistosoma mansoni	hypothetical protein	0.0087	0.1271	0.1347
Leishmania major	hypoxanthine-guanine phosphoribosyltransferase	0.019	0.3681	1
Onchocerca volvulus		0.0087	0.1271	0.1271
Entamoeba histolytica	hypothetical protein	0.0037	0.0097	1
Brugia malayi	Animal haem peroxidase family protein	0.0435	0.9432	0.9432
Schistosoma mansoni	peroxidasin	0.0435	0.9432	1
Echinococcus multilocularis	protein jagged 2	0.0087	0.1271	0.1347
Trypanosoma brucei	hypoxanthine-guanine phosphoribosyltransferase, putative	0.019	0.3681	1
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0075	0.0991	0.105
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0087	0.1271	0.1347
Loa Loa (eye worm)	hypothetical protein	0.0459	1	1
Echinococcus multilocularis	neurogenic locus notch protein	0.0087	0.1271	0.1347
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0959	0.2605
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1271	0.1271
Brugia malayi	EGF-like domain containing protein	0.0087	0.1271	0.1271
Echinococcus multilocularis	voltage dependent calcium channel	0.0075	0.0991	0.105
Brugia malayi	hypothetical protein	0.0435	0.9432	0.9432
Plasmodium vivax	basic transcription factor 3b, putative	0.0036	0.0073	0.0198
Onchocerca volvulus	Slit protein homolog	0.0087	0.1271	0.1271
Echinococcus multilocularis	slit 2 protein	0.0087	0.1271	0.1347
Onchocerca volvulus		0.0459	1	1
Echinococcus multilocularis	neurogenic locus notch protein	0.0087	0.1271	0.1347
Brugia malayi	notch-like transmembrane receptor	0.0087	0.1271	0.1271
Trypanosoma cruzi	Adenine phosphoribosyltransferase, putative	0.0044	0.0266	0.0723
Treponema pallidum	hypothetical protein	0.0044	0.0266	0.2774
Trypanosoma brucei	Adenine phosphoribosyltransferase, putative	0.0044	0.0266	0.0723
Brugia malayi	EGF-like domain containing protein	0.0087	0.1271	0.1271
Trypanosoma cruzi	Voltage-dependent calcium channel subunit, putative	0.0046	0.0298	0.0809
Brugia malayi	Adenine phosphoribosyltransferase	0.0044	0.0266	0.0266
Schistosoma mansoni	orotidine 5'-phosphate decarboxylase	0.0044	0.0266	0.0282
Schistosoma mansoni	septate junction protein	0.0087	0.1271	0.1347
Loa Loa (eye worm)	hypothetical protein	0.0435	0.9432	0.9432
Loa Loa (eye worm)	hypothetical protein	0.0435	0.9432	0.9432
Schistosoma mansoni	lozenge	0.0058	0.0574	0.0609
Trypanosoma cruzi	hypoxanthine-guanine phosphoribosyltransferase, putative	0.019	0.3681	1
Brugia malayi	Cadherin domain containing protein	0.0087	0.1271	0.1271
Onchocerca volvulus		0.0435	0.9432	0.9432
Schistosoma mansoni	notch	0.0087	0.1271	0.1347
Mycobacterium leprae	PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE	0.0074	0.0959	0.3637
Loa Loa (eye worm)	hypothetical protein	0.0435	0.9432	0.9432
Brugia malayi	Calcium binding EGF domain containing protein	0.0087	0.1271	0.1271
Trypanosoma cruzi	transcription factor btf3, putative	0.0036	0.0073	0.0198
Mycobacterium leprae	Probable hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (IMP pho	0.0145	0.2637	1
Schistosoma mansoni	hypothetical protein	0.0087	0.1271	0.1347
Treponema pallidum	penicillin-binding protein (pbp-1)	0.0074	0.0959	1
Trichomonas vaginalis	hypoxanthine-guanine phosphoribosyltransferase, putative	0.019	0.3681	1
Echinococcus granulosus	protein jagged 1	0.0087	0.1271	0.1347
Mycobacterium ulcerans	bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2	0.0074	0.0959	0.2605
Trypanosoma cruzi	Adenine phosphoribosyltransferase, putative	0.0044	0.0266	0.0723
Mycobacterium ulcerans	penicillin-binding protein PbpA	0.0074	0.0959	0.2605
Schistosoma mansoni	hypothetical protein	0.0087	0.1271	0.1347
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1271	0.1271
Loa Loa (eye worm)	hypothetical protein	0.0435	0.9432	0.9432
Echinococcus multilocularis	protein jagged 1	0.0087	0.1271	0.1347
Loa Loa (eye worm)	hypothetical protein	0.0435	0.9432	0.9432
Brugia malayi	EGF-like domain containing protein	0.0087	0.1271	0.1271
Treponema pallidum	penicillin-binding protein (pbp-3)	0.0074	0.0959	1
Echinococcus multilocularis	transcription factor btf3	0.0036	0.0073	0.0077
Trypanosoma brucei	transcription factor BTF3, putative	0.0036	0.0073	0.0198
Mycobacterium ulcerans	hypothetical protein	0.0044	0.0266	0.0723
Entamoeba histolytica	hypothetical protein	0.0037	0.0097	1
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1271	0.1271
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1271	0.1271
Giardia lamblia	Guanine phosphoribosyltransferase	0.019	0.3681	1
Onchocerca volvulus	Peroxidase homolog	0.0435	0.9432	0.9432
Echinococcus granulosus	fibropellin Ia	0.0087	0.1271	0.1347
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1271	0.1271
Echinococcus multilocularis	hypoxanthine guanine phosphoribosyltransferase	0.019	0.3681	0.3903
Brugia malayi	Peroxidasin	0.0435	0.9432	0.9432
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1271	0.1271
Brugia malayi	Delta serrate ligand family protein	0.0087	0.1271	0.1271
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1271	0.1271
Mycobacterium tuberculosis	Adenine phosphoribosyltransferase Apt (APRT) (AMP diphosphorylase) (AMP pyrophosphorylase) (transphosphoribosidase)	0.0044	0.0266	0.1009
Trypanosoma cruzi	orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative	0.0044	0.0266	0.0723
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1271	0.1271
Schistosoma mansoni	hypoxanthine-guanine phosphoribosyltransferase	0.019	0.3681	0.3903
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0991	0.0991
Schistosoma mansoni	Adenine phosphoribosyltransferase	0.0044	0.0266	0.0282
Mycobacterium leprae	PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN	0.0074	0.0959	0.3637
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0044	0.0266	0.1009
Echinococcus granulosus	uridine 5' monophosphate synthase	0.0044	0.0266	0.0282
Echinococcus granulosus	neural cadherin	0.0087	0.1271	0.1347
Loa Loa (eye worm)	blistered cuticle protein 3	0.0435	0.9432	0.9432
Schistosoma mansoni	slit	0.0087	0.1271	0.1347
Plasmodium vivax	hypoxanthine-guanine phosphoribosyltransferase, putative	0.019	0.3681	1
Onchocerca volvulus		0.0435	0.9432	0.9432
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1271	0.1271
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1271	0.1271
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.0075	0.0991	0.0991
Loa Loa (eye worm)	hypothetical protein	0.0435	0.9432	0.9432
Mycobacterium leprae	PROBABLE OROTATE PHOSPHORIBOSYLTRANSFERASE PYRE (OPRT) (OPRTASE)	0.0044	0.0266	0.1009
Mycobacterium leprae	AMIDOPHOSPHORIBOSYLTRANSFERASE PURF (GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE) (ATASE) (GPATASE)	0.0044	0.0266	0.1009
Echinococcus granulosus	delta-like protein 1	0.0087	0.1271	0.1347
Schistosoma mansoni	notch	0.0087	0.1271	0.1347
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1271	0.1271
Brugia malayi	Blistered cuticle protein 3	0.0435	0.9432	0.9432
Brugia malayi	EGF-like domain containing protein	0.0087	0.1271	0.1271
Schistosoma mansoni	hypothetical protein	0.0037	0.0097	0.0103
Schistosoma mansoni	hypothetical protein	0.0087	0.1271	0.1347
Loa Loa (eye worm)	Notch2	0.0087	0.1271	0.1271
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsI	0.0074	0.0959	1
Toxoplasma gondii	hypoxanthine-xanthine-guanine phosphoribosyl transferase HXGPRT	0.019	0.3681	1
Mycobacterium tuberculosis	Hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (imp pyrophosphor	0.0145	0.2637	1
Onchocerca volvulus		0.0087	0.1271	0.1271
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1271	0.1271
Schistosoma mansoni	peroxidasin	0.0435	0.9432	1
Loa Loa (eye worm)	adenine phosphoribosyltransferase	0.0044	0.0266	0.0266
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0073	0.0198
Chlamydia trachomatis	transglycolase/transpeptidase	0.0074	0.0959	1
Brugia malayi	GCC2 and GCC3 family protein	0.0087	0.1271	0.1271
Brugia malayi	Animal haem peroxidase family protein	0.0435	0.9432	0.9432
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.0075	0.0991	0.105
Echinococcus granulosus	neurogenic locus notch protein	0.0087	0.1271	0.1347
Echinococcus granulosus	neurogenic locus protein delta	0.0087	0.1271	0.1347
Echinococcus granulosus	transcription factor btf3	0.0036	0.0073	0.0077
Echinococcus granulosus	notch	0.0087	0.1271	0.1347
Echinococcus granulosus	neurogenic locus notch protein	0.0087	0.1271	0.1347
Loa Loa (eye worm)	calcium channel	0.0075	0.0991	0.0991
Brugia malayi	EGF-like domain containing protein	0.0087	0.1271	0.1271
Trypanosoma brucei	hypoxanthine-guanine phosphoribosyltransferase	0.019	0.3681	1
Loa Loa (eye worm)	animal heme peroxidase	0.0435	0.9432	0.9432
Mycobacterium tuberculosis	Probable orotate phosphoribosyltransferase PyrE (OPRT) (oprtase)	0.0044	0.0266	0.1009
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.0075	0.0991	0.105
Brugia malayi	orotate phosphoribosyltransferase family protein	0.0044	0.0266	0.0266
Trypanosoma cruzi	orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative	0.0044	0.0266	0.0723
Mycobacterium ulcerans	orotate phosphoribosyltransferase	0.0044	0.0266	0.0723
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1271	0.1271
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1271	0.1271
Onchocerca volvulus	Adenine phosphoribosyltransferase homolog	0.0044	0.0266	0.0266
Echinococcus granulosus	hypoxanthine guanine phosphoribosyltransferase	0.019	0.3681	0.3903
Loa Loa (eye worm)	hypothetical protein	0.0435	0.9432	0.9432
Mycobacterium ulcerans	penicillin-binding lipoprotein	0.0074	0.0959	0.2605
Leishmania major	orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative,OMPDCase-OPRTase, putative	0.0044	0.0266	0.0723
Echinococcus granulosus	protein jagged 2	0.0087	0.1271	0.1347
Schistosoma mansoni	notch	0.0087	0.1271	0.1347
Loa Loa (eye worm)	hypothetical protein	0.0435	0.9432	0.9432
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0073	0.0198
Loa Loa (eye worm)	hypothetical protein	0.0435	0.9432	0.9432
Trypanosoma brucei	Voltage-dependent calcium channel subunit, putative	0.0046	0.0298	0.0809
Brugia malayi	EGF-like domain containing protein	0.0087	0.1271	0.1271
Chlamydia trachomatis	transglycolase/transpeptidase	0.0074	0.0959	1
Trichomonas vaginalis	Ribose-phosphate pyrophosphokinase, putative	0.0044	0.0266	0.0723
Brugia malayi	Cadherin domain containing protein	0.0087	0.1271	0.1271
Loa Loa (eye worm)	hypothetical protein	0.0459	1	1
Schistosoma mansoni	transcription factor btf3	0.0036	0.0073	0.0077
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0097	0.0103
Echinococcus granulosus	adenine phosphoribosyltransferase	0.0044	0.0266	0.0282
Echinococcus multilocularis	neurogenic locus protein delta	0.0087	0.1271	0.1347
Trypanosoma cruzi	hypoxanthine-guanine phosphoribosyltransferase, putative	0.019	0.3681	1
Leishmania major	adenine phosphoribosyltransferase	0.0044	0.0266	0.0723
Schistosoma mansoni	hypothetical protein	0.0087	0.1271	0.1347
Entamoeba histolytica	hypothetical protein	0.0036	0.0073	0.7467
Schistosoma mansoni	notch	0.0087	0.1271	0.1347
Onchocerca volvulus		0.0087	0.1271	0.1271
Treponema pallidum	penicillin-binding protein (pbp-2)	0.0074	0.0959	1
Trypanosoma brucei	hypoxanthine-guanine phosphoribosyltransferase	0.019	0.3681	1
Schistosoma mansoni	hypoxanthine-guanine phosphoribosyltransferase	0.0044	0.0266	0.0282
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0075	0.0991	0.105
Schistosoma mansoni	hypoxanthine-guanine phosphoribosyltransferase	0.0044	0.0266	0.0282
Schistosoma mansoni	hypothetical protein	0.0087	0.1271	0.1347
Brugia malayi	Animal haem peroxidase family protein	0.0435	0.9432	0.9432
Echinococcus multilocularis	neural cadherin	0.0087	0.1271	0.1347
Trypanosoma cruzi	Adenine phosphoribosyltransferase, putative	0.0044	0.0266	0.0723
Echinococcus multilocularis	hypoxanthine guanine phosphoribosyltransferase	0.019	0.3681	0.3903
Mycobacterium tuberculosis	Conserved protein	0.0044	0.0266	0.1009
Echinococcus multilocularis	voltage dependent calcium channel	0.0075	0.0991	0.105
Onchocerca volvulus		0.0435	0.9432	0.9432
Mycobacterium tuberculosis	Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen	0.0074	0.0959	0.3637
Onchocerca volvulus	Peroxidasin homolog	0.0435	0.9432	0.9432
Echinococcus granulosus	protein jagged 2	0.0087	0.1271	0.1347
Echinococcus multilocularis	notch	0.0087	0.1271	0.1347
Echinococcus multilocularis	Protein lozenge	0.0058	0.0574	0.0609
Trypanosoma cruzi	hypoxanthine-guanine phosphoribosyltransferase, putative	0.019	0.3681	1
Trypanosoma brucei	orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative	0.0044	0.0266	0.0723
Schistosoma mansoni	voltage-gated cation channel	0.0075	0.0991	0.105
Echinococcus multilocularis	fibropellin Ia	0.0087	0.1271	0.1347
Schistosoma mansoni	Adenine phosphoribosyltransferase	0.0044	0.0266	0.0282
Leishmania major	basic transcription factor 3a, putative	0.0036	0.0073	0.0198
Brugia malayi	Phosphoribosyl transferase domain containing protein	0.019	0.3681	0.3681
Schistosoma mansoni	notch	0.0087	0.1271	0.1347
Loa Loa (eye worm)	hypothetical protein	0.0435	0.9432	0.9432
Mycobacterium leprae	Probable penicillin-binding protein PbpA	0.0074	0.0959	0.3637
Onchocerca volvulus		0.0087	0.1271	0.1271
Loa Loa (eye worm)	hypothetical protein	0.0435	0.9432	0.9432
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.0075	0.0991	0.105
Onchocerca volvulus	Peroxidasin homolog	0.0435	0.9432	0.9432
Onchocerca volvulus	Neurogenic locus notch homolog	0.0087	0.1271	0.1271
Mycobacterium leprae	POSSIBLE PENICILLIN-BINDING LIPOPROTEIN	0.0074	0.0959	0.3637
Onchocerca volvulus		0.0087	0.1271	0.1271
Plasmodium falciparum	orotate phosphoribosyltransferase	0.0044	0.0266	0.0723
Toxoplasma gondii	NAC domain-containing protein	0.0036	0.0073	0.0198
Brugia malayi	Muscle positioning protein 4	0.0087	0.1271	0.1271
Echinococcus granulosus	hypoxanthine guanine phosphoribosyltransferase	0.019	0.3681	0.3903
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1271	0.1271
Entamoeba histolytica	hypothetical protein	0.0037	0.0097	1
Brugia malayi	Animal haem peroxidase family protein	0.0435	0.9432	0.9432
Echinococcus granulosus	protein jagged 1	0.0087	0.1271	0.1347
Plasmodium falciparum	hypoxanthine-guanine phosphoribosyltransferase	0.019	0.3681	1
Entamoeba histolytica	hypothetical protein	0.0037	0.0097	1
Schistosoma mansoni	hypothetical protein	0.0087	0.1271	0.1347
Loa Loa (eye worm)	hypothetical protein	0.0435	0.9432	0.9432
Giardia lamblia	High cysteine protein	0.0087	0.1271	0.3451
Brugia malayi	Calcium binding EGF domain containing protein	0.0087	0.1271	0.1271
Trypanosoma brucei	Adenine phosphoribosyltransferase, putative	0.0044	0.0266	0.0723
Schistosoma mansoni	hypoxanthine-guanine phosphoribosyltransferase	0.019	0.3681	0.3903
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0087	0.1271	0.1347
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0075	0.0991	0.105
Loa Loa (eye worm)	ICD-1 protein	0.0036	0.0073	0.0073
Mycobacterium tuberculosis	Probable penicillin-binding protein PbpA	0.0074	0.0959	0.3637
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1271	0.1271
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0097	0.0103
Onchocerca volvulus	Chorion peroxidase homolog	0.0435	0.9432	0.9432
Brugia malayi	Calcium binding EGF domain containing protein	0.0087	0.1271	0.1271
Echinococcus multilocularis	neurogenic locus protein delta	0.0087	0.1271	0.1347
Treponema pallidum	phosphoribosylpyrophosphate synthetase	0.0044	0.0266	0.2774
Loa Loa (eye worm)	notch protein	0.0087	0.1271	0.1271
Loa Loa (eye worm)	hypothetical protein	0.0435	0.9432	0.9432
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0097	0.0103
Schistosoma mansoni	uracil phosphoribosyltransferase	0.0044	0.0266	0.0282
Schistosoma mansoni	laminin gamma-3 chain	0.0087	0.1271	0.1347
Echinococcus multilocularis	uridine 5' monophosphate synthase	0.0044	0.0266	0.0282
Echinococcus multilocularis	peroxidasin	0.0435	0.9432	1
Schistosoma mansoni	notch	0.0087	0.1271	0.1347
Mycobacterium ulcerans	amidophosphoribosyltransferase	0.0044	0.0266	0.0723
Trypanosoma cruzi	transcription factor btf3, putative	0.0036	0.0073	0.0198
Wolbachia endosymbiont of Brugia malayi	amidophosphoribosyltransferase	0.0044	0.0266	0.2774
Mycobacterium ulcerans	adenine phosphoribosyltransferase	0.0044	0.0266	0.0723
Loa Loa (eye worm)	animal heme peroxidase	0.0435	0.9432	0.9432
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1271	0.1271
Wolbachia endosymbiont of Brugia malayi	orotate phosphoribosyltransferase	0.0044	0.0266	0.2774
Onchocerca volvulus	Peroxidase homolog	0.0435	0.9432	0.9432
Echinococcus multilocularis	protein jagged 1	0.0087	0.1271	0.1347
Leishmania major	xanthine phosphoribosyltransferase	0.019	0.3681	1
Toxoplasma gondii	orotate phosphoribosyltransferase	0.0044	0.0266	0.0723
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0075	0.0991	0.105
Trypanosoma cruzi	hypoxanthine-guanine phosphoribosyltransferase, putative	0.019	0.3681	1
Brugia malayi	beta-NAC-like protein	0.0036	0.0073	0.0073
Echinococcus granulosus	neurogenic locus notch protein 4	0.0087	0.1271	0.1347
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.0075	0.0991	0.105
Entamoeba histolytica	transcription factor BTF3, putative	0.0036	0.0073	0.7467
Trichomonas vaginalis	ribose-phosphate pyrophosphokinase, putative	0.0044	0.0266	0.0723
Loa Loa (eye worm)	animal heme peroxidase	0.0435	0.9432	0.9432
Brugia malayi	Animal haem peroxidase family protein	0.0435	0.9432	0.9432

Activities

Activity type	Activity value	Assay description	Source	Reference
K app (binding)	= 0.021 uM	In vitro displacement of [3H]-OXO-M from muscarinic acetylcholine receptor in rat cortical homogenates	ChEMBL.	2319559
K app (binding)	= 0.021 uM	In vitro displacement of [3H]-OXO-M from muscarinic acetylcholine receptor in rat cortical homogenates	ChEMBL.	2319559
K app (binding)	= 0.2 uM	In vitro for its ability to displace [3H]-NMS from muscarinic acetylcholine receptor in rat cortical homogenates	ChEMBL.	2319559
K app (binding)	= 0.2 uM	In vitro for its ability to displace [3H]-NMS from muscarinic acetylcholine receptor in rat cortical homogenates	ChEMBL.	2319559
Ratio (binding)	= 9.5	The ratio of Kapp([3H]-NMS) / Kapp([3H]-OXO-M) was determined	ChEMBL.	2319559

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 14736