Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.4092 | 0.6206 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.5976 | 1 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.4092 | 0.6206 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.101 | 0 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.101 | 0 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.4092 | 0.6206 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.5976 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.5976 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.101 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.5976 | 1 | 1 |
Onchocerca volvulus | 0.101 | 0 | 0.5 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.5976 | 1 | 1 |
Onchocerca volvulus | 0.101 | 0 | 0.5 | |
Onchocerca volvulus | 0.101 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.2091 | 0.2178 | 0.2178 |
Onchocerca volvulus | 0.101 | 0 | 0.5 | |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.101 | 0 | 0.5 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.4092 | 0.6206 | 0.6206 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.101 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.5976 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.5976 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.5976 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.5976 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.4092 | 0.6206 | 0.6206 |
Loa Loa (eye worm) | hypothetical protein | 0.5976 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.5976 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.5976 | 1 | 1 |
Onchocerca volvulus | 0.101 | 0 | 0.5 | |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.101 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0058 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | = 0.631 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.