Detailed information for compound 1473647

Basic information

Technical information
  • TDR Targets ID: 1473647
  • Name: ethyl 5-methyl-4-phenyl-2-[[2-(1,3,4-thiadiaz ol-2-ylsulfanyl)acetyl]amino]thiophene-3-carb oxylate
  • MW: 419.541 | Formula: C18H17N3O3S3
  • H donors: 1 H acceptors: 4 LogP: 4.93 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1c(NC(=O)CSc2nncs2)sc(c1c1ccccc1)C
  • InChi: 1S/C18H17N3O3S3/c1-3-24-17(23)15-14(12-7-5-4-6-8-12)11(2)27-16(15)20-13(22)9-25-18-21-19-10-26-18/h4-8,10H,3,9H2,1-2H3,(H,20,22)
  • InChiKey: XPFDLXZMUBXFPK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-methyl-2-[[1-oxo-2-(1,3,4-thiadiazol-2-ylthio)ethyl]amino]-4-phenyl-3-thiophenecarboxylic acid ethyl ester
  • 5-methyl-4-phenyl-2-[[2-(1,3,4-thiadiazol-2-ylthio)acetyl]amino]thiophene-3-carboxylic acid ethyl ester
  • ethyl 5-methyl-4-phenyl-2-[2-(1,3,4-thiadiazol-2-ylsulfanyl)ethanoylamino]thiophene-3-carboxylate
  • MLS000388718
  • SMR000254891
  • T5531905

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans hydrolase 0.0021 0.0119 0.0551
Brugia malayi nuclear receptor NHR-67 0.002 0.0114 0.009
Loa Loa (eye worm) hypothetical protein 0.0037 0.0457 0.0457
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0114 0.0102
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0114 0.0102
Loa Loa (eye worm) hypothetical protein 0.0032 0.036 0.036
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0037 0.0457 0.0445
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.122 0.176
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0052 0.0781 0.0769
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.002 0.0114 0.0133
Trichomonas vaginalis NADH-ubiquinone oxidoreductase flavoprotein, putative 0.0078 0.1343 1
Echinococcus granulosus survival motor neuron protein 1 0.0483 1 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.062 0.062
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0167 0.0143
Trypanosoma cruzi Aph-1 protein, putative 0.0093 0.1666 1
Brugia malayi diacylglycerol kinase 0.0037 0.0457 0.0434
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.1245 1
Brugia malayi Hr1 repeat family protein 0.0052 0.0781 0.0759
Brugia malayi Matrixin family protein 0.0017 0.004 0.0016
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.1048 0.1026
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0781 0.5739
Loa Loa (eye worm) matrixin family protein 0.0041 0.0555 0.0555
Schistosoma mansoni hypothetical protein 0.0037 0.0457 0.0638
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.122 0.122
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0043 0.0605 0.0582
Echinococcus granulosus Diacylglycerol kinase theta 0.0037 0.0457 0.0445
Echinococcus multilocularis gamma secretase subunit aph 1 0.0239 0.4783 0.4777
Brugia malayi Pleckstrin Homology Domain 0.0037 0.0457 0.0434
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0043 0.0605 0.0582
Schistosoma mansoni hypothetical protein 0.0205 0.4054 0.5931
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0373 0.0373
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0013
Echinococcus granulosus transcription factor Dp 1 0.0037 0.047 0.0458
Loa Loa (eye worm) hypothetical protein 0.0033 0.0373 0.0373
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0718 0.4224
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.004 0.054 0.0759
Loa Loa (eye worm) hypothetical protein 0.0043 0.0605 0.0605
Brugia malayi ecdysteroid receptor 0.0043 0.0605 0.0582
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0023 0.0167 0.021
Leishmania major cathepsin L-like protease 0.0062 0.1001 0.7412
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0037 0.0457 0.0457
Echinococcus multilocularis unc 13 (munc13) 0.0044 0.062 0.0608
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0274 0.1894
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0247 0.4957 0.4957
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0781 0.1114
Brugia malayi nuclear receptor RXR 0.0023 0.0167 0.0143
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.1048 0.6231
Echinococcus granulosus nuclear receptor nhr 48 0.002 0.0114 0.0102
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0238 0.4771 0.4764
Schistosoma mansoni nuclear receptor 0.002 0.0114 0.0133
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0043 0.0605 0.0582
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.122 0.7283
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.122 0.9071
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0043 0.0605 0.0593
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0023 0.0167 0.0154
Onchocerca volvulus NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial homolog 0.0042 0.057 0.3102
Loa Loa (eye worm) hypothetical protein 0.002 0.0114 0.0114
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0098 0.1782 0.1762
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.1245 0.926
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0481 0.0673
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0043 0.0605 0.0582
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0622 0.088
Onchocerca volvulus 0.0033 0.0373 0.1985
Leishmania major hypothetical protein, conserved 0.0072 0.122 0.9071
Loa Loa (eye worm) hypothetical protein 0.0072 0.122 0.122
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1245 0.9247
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0622 0.088
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.1724 0.2502
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0037 0.0457 0.0457
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0457 0.0638
Echinococcus multilocularis serine threonine protein kinase 0.0297 0.6038 0.6033
Trypanosoma cruzi Aph-1 protein, putative 0.0093 0.1666 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0167 0.021
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0043 0.0605 0.0593
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0043 0.0605 0.0855
Loa Loa (eye worm) AGC/NDR protein kinase 0.0052 0.0781 0.0781
Loa Loa (eye worm) ctsf protein 0.0016 0.0024 0.0024
Onchocerca volvulus Matrix metalloproteinase homolog 0.0038 0.0483 0.2608
Loa Loa (eye worm) hypothetical protein 0.002 0.0114 0.0114
Loa Loa (eye worm) nuclear hormone receptor 0.002 0.0114 0.0114
Mycobacterium leprae conserved hypothetical protein 0.0072 0.122 1
Echinococcus granulosus Protein kinase C brain isozyme 0.0334 0.6819 0.6815
Brugia malayi Variant SH3 domain containing protein 0.0037 0.0457 0.0434
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1001 0.249
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1001 0.249
Echinococcus granulosus myotubularin protein 13 0.0037 0.0457 0.0445
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.1048 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0043 0.0605 0.0605
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0781 0.5739
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.052 0.3763
Loa Loa (eye worm) hypothetical protein 0.0052 0.0781 0.0781
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0167
Brugia malayi nuclear hormone receptor family member odr-7 0.002 0.0114 0.009
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0043 0.0605 0.0593
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.1048 0.301
Brugia malayi C1-like domain containing protein 0.0038 0.0481 0.0458
Loa Loa (eye worm) hypothetical protein 0.0072 0.122 0.122
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0622 0.088
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.122 0.1235
Echinococcus granulosus unc 13 munc13 0.0044 0.062 0.0608
Onchocerca volvulus 0.0037 0.0457 0.2464
Trichomonas vaginalis esterase, putative 0.0072 0.122 0.9071
Onchocerca volvulus 0.002 0.0114 0.0513
Echinococcus granulosus ecdysone induced protein 78C 0.0043 0.0605 0.0593
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.122 0.1209
Schistosoma mansoni diacylglycerol kinase theta 0.0037 0.0457 0.0638
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.122 0.1235
Loa Loa (eye worm) hypothetical protein 0.0043 0.0605 0.0605
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0114 0.0102
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.1182 0.1182
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0021 0.0119 0.0075
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0043 0.0605 0.0855
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.122 0.176
Loa Loa (eye worm) cysteine protease 0.0016 0.0024 0.0024
Brugia malayi Nuclear hormone receptor E75 0.002 0.0114 0.009
Wolbachia endosymbiont of Brugia malayi NADH dehydrogenase I subunit F 0.0078 0.1343 0.5
Trichomonas vaginalis NADH-ubiquinone oxidoreductase flavoprotein, putative 0.0078 0.1343 1
Echinococcus multilocularis serine:threonine protein kinase N2 0.0052 0.0781 0.0769
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.002 0.0114 0.0102
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0024 0.0024
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.002 0.0114 0.0102
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.122 0.9071
Brugia malayi nuclear receptor NHR-88 0.0043 0.0605 0.0582
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0038 0.0481 0.0469
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0037 0.0457 0.0638
Schistosoma mansoni hypothetical protein 0.0205 0.4054 0.5931
Brugia malayi Protein kinase domain containing protein 0.0052 0.0781 0.0759
Onchocerca volvulus 0.002 0.0114 0.0513
Schistosoma mansoni hypothetical protein 0.0024 0.0192 0.0247
Schistosoma mansoni vav2 0.0037 0.0457 0.0638
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.122 0.9054
Onchocerca volvulus Bile acid receptor homolog 0.0043 0.0605 0.3303
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0044 0.062 0.0608
Echinococcus multilocularis NADH dehydrogenase (ubiquinone) flavoprotein 1 0.0078 0.1343 0.1332
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1001 0.249
Brugia malayi RhoGAP domain containing protein 0.0037 0.0457 0.0434
Brugia malayi Matrixin family protein 0.0041 0.0555 0.0532
Echinococcus granulosus serine:threonine protein kinase N2 0.0052 0.0781 0.0769
Loa Loa (eye worm) hypothetical protein 0.002 0.0114 0.0114
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0043 0.0605 0.3303
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0043 0.0605 0.0593
Loa Loa (eye worm) hypothetical protein 0.0043 0.0605 0.0605
Loa Loa (eye worm) hypothetical protein 0.0037 0.0457 0.0457
Brugia malayi MH2 domain containing protein 0.0144 0.2761 0.2743
Echinococcus multilocularis N chimaerin 0.0037 0.0457 0.0445
Toxoplasma gondii AGC kinase 0.0052 0.0781 0.6198
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0781 0.5739
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0584 0.4249
Echinococcus multilocularis raf serine:threonine protein kinase 0.0037 0.0457 0.0445
Onchocerca volvulus 0.0033 0.0373 0.1985
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0622 0.061
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.0114 0.0513
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0334 0.6819 0.6815
Echinococcus granulosus gamma secretase subunit aph 1 0.0239 0.4783 0.4777
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1001 0.249
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0781 0.5739
Echinococcus multilocularis protein kinase c epsilon type 0.0096 0.1724 0.1714
Loa Loa (eye worm) hypothetical protein 0.0275 0.5552 0.5552
Loa Loa (eye worm) hypothetical protein 0.0016 0.0024 0.0024
Loa Loa (eye worm) AGC/PKN protein kinase 0.0052 0.0781 0.0781
Brugia malayi Matrixin family protein 0.0017 0.004 0.0016
Brugia malayi nuclear receptor RXR 0.002 0.0114 0.009
Trichomonas vaginalis chromobox protein, putative 0.007 0.1182 0.878
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1001 0.249
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0043 0.0605 0.0582
Leishmania major NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.0078 0.1343 1
Schistosoma mansoni coup transcription factor 0.0043 0.0605 0.0855
Schistosoma mansoni gamma-secretase subunit aph-1 0.0239 0.4783 0.7004
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0043 0.0605 0.0855
Brugia malayi Protein kinase domain containing protein 0.0052 0.0781 0.0759
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0274 0.1894
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0096 0.1724 0.1724
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0062 0.0998 0.0987
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0043 0.0605 0.0593
Schistosoma mansoni steroid hormone receptor ad4bp 0.0043 0.0605 0.0855
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.1245 0.1234
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0024 0.0012
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.122 0.9071
Schistosoma mansoni NADH-ubiquinone oxidoreductase 0.0078 0.1343 0.1941
Schistosoma mansoni protein kinase C mu 0.0037 0.0457 0.0638
Loa Loa (eye worm) hypothetical protein 0.0021 0.0119 0.0119
Mycobacterium tuberculosis Conserved protein 0.0072 0.122 0.1235
Echinococcus multilocularis cysteine protease 0.0016 0.0024 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0043 0.0605 0.0582
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0043 0.0605 0.0605
Loa Loa (eye worm) hypothetical protein 0.0037 0.0457 0.0457
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1245 0.9247
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.052 0.2822
Plasmodium vivax hypothetical protein, conserved 0.0072 0.122 1
Schistosoma mansoni nuclear hormone receptor 0.0043 0.0605 0.0855
Loa Loa (eye worm) RasGEF domain-containing protein 0.0037 0.0457 0.0457
Echinococcus multilocularis myotubularin protein 13 0.0037 0.0457 0.0445
Loa Loa (eye worm) hypothetical protein 0.002 0.0114 0.0114
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0781 0.5739
Mycobacterium tuberculosis Conserved protein 0.0072 0.122 0.1235
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1001 0.249
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0024 0.0012
Brugia malayi Protein kinase domain containing protein 0.0038 0.0481 0.0458
Schistosoma mansoni rac gtpase activating protein 0.0037 0.0457 0.0638
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0043 0.0605 0.0582
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0037 0.0457 0.0638
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0781 0.5739
Echinococcus granulosus NADH dehydrogenase ubiquinone flavoprotein 1 0.0078 0.1343 0.1332
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.1048 0.1048
Echinococcus multilocularis FTZ F1 alpha 0.0043 0.0605 0.0593
Brugia malayi Heterochromatin protein 1 0.007 0.1182 0.116
Brugia malayi Ras association domain family 1 isoform A 0.0037 0.0457 0.0434
Brugia malayi hypothetical protein 0.002 0.0114 0.009
Loa Loa (eye worm) hypothetical protein 0.002 0.0114 0.0114
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0622 0.061
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0038 0.0481 0.0481
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1001 0.249
Schistosoma mansoni hypothetical protein 0.0098 0.1782 0.2587
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0781 0.1114
Brugia malayi Matrixin family protein 0.0017 0.004 0.0016
Schistosoma mansoni nuclear receptor nhr-48 0.002 0.0114 0.0133
Schistosoma mansoni RAR-like nuclear receptor 0.0043 0.0605 0.0855
Loa Loa (eye worm) matrixin family protein 0.0038 0.0483 0.0483
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0167
Echinococcus granulosus protein kinase c eta type 0.0037 0.0457 0.0445
Schistosoma mansoni lamin 0.0033 0.0373 0.0514
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.122 0.1235
Echinococcus multilocularis protein kinase c iota type 0.0088 0.1562 0.1551
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0622 0.061
Mycobacterium tuberculosis Conserved protein 0.0072 0.122 0.1235
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0043 0.0605 0.0582
Echinococcus multilocularis protein kinase c eta type 0.0037 0.0457 0.0445
Schistosoma mansoni diacylglycerol kinase theta 0.0037 0.0457 0.0638
Echinococcus granulosus cathepsin l1 0.0016 0.0024 0.0012
Schistosoma mansoni survival motor neuron protein 0.0098 0.1782 0.2587
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.122 0.1209
Brugia malayi chromobox protein homolog 3 0.0039 0.052 0.0497
Echinococcus multilocularis RNA directed DNA polymerase 0.0238 0.4771 0.4764
Brugia malayi nuclear receptor NHR-88 0.002 0.0114 0.009
Loa Loa (eye worm) DR-78 0.002 0.0114 0.0114
Schistosoma mansoni serine/threonine protein kinase 0.0334 0.6819 1
Brugia malayi intermediate filament protein 0.0033 0.0373 0.035
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0043 0.0605 0.0855
Trypanosoma cruzi NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.0078 0.1343 0.8029
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.005 0.005
Schistosoma mansoni nuclear hormone receptor 0.002 0.0114 0.0133
Loa Loa (eye worm) fibroinase 0.0016 0.0024 0.0024
Echinococcus granulosus protein kinase c iota type 0.0088 0.1562 0.1551
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.1001 0.5951
Leishmania major cathepsin L-like protease 0.0062 0.1001 0.7412
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0043 0.0605 0.0855
Loa Loa (eye worm) hypothetical protein 0.0037 0.0457 0.0457
Loa Loa (eye worm) AGC/AKT protein kinase 0.0052 0.0781 0.0781
Loa Loa (eye worm) hypothetical protein 0.002 0.0114 0.0114
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0239 0.4783 0.4783
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.122 0.1235
Brugia malayi p70 ribosomal S6 kinase beta 0.0052 0.0781 0.0759
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.1048 0.6231
Loa Loa (eye worm) hypothetical protein 0.0037 0.0457 0.0457
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1001 0.249
Onchocerca volvulus Matrilysin homolog 0.0017 0.004 0.0089
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0043 0.0605 0.0582
Loa Loa (eye worm) hypothetical protein 0.0037 0.0457 0.0457
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.122 0.9054
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0167
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0024 0.0012
Schistosoma mansoni retinoic acid receptor RXR 0.0043 0.0605 0.0855
Brugia malayi nuclear hormone receptor 0.002 0.0114 0.009
Echinococcus granulosus lamin dm0 0.0033 0.0373 0.0361
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0052 0.0781 0.0781
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0781 0.1114
Echinococcus multilocularis geminin 0.0205 0.4054 0.4047
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0043 0.0605 0.0593
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.047 0.0458
Echinococcus granulosus Rac GTPase activating protein 1 0.0037 0.0457 0.0445
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0052 0.0781 0.0781
Loa Loa (eye worm) raf kinase 0.0037 0.0457 0.0457
Onchocerca volvulus 0.0043 0.0605 0.3303
Trypanosoma brucei Aph-1 protein, putative 0.0093 0.1666 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.122 0.1235
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0052 0.0781 0.0769
Loa Loa (eye worm) hypothetical protein 0.002 0.0114 0.0114
Trypanosoma brucei NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial 0.0078 0.1343 0.6345
Schistosoma mansoni unc-13 (munc13) 0.0044 0.062 0.0876
Brugia malayi diacylglycerol kinase 0.0037 0.0457 0.0434
Onchocerca volvulus 0.0031 0.0338 0.1785
Loa Loa (eye worm) matrix metalloproteinase 0.0017 0.004 0.004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1001 0.249
Mycobacterium ulcerans lipase LipD 0.0072 0.122 0.9054
Echinococcus granulosus raf serine:threonine protein kinase 0.0037 0.0457 0.0445
Loa Loa (eye worm) steroid hormone receptor 0.0043 0.0605 0.0605
Brugia malayi Protein kinase domain containing protein 0.0052 0.0781 0.0759
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.1245 0.1261
Echinococcus granulosus protein kinase C gamma type 0.0297 0.6038 0.6033
Brugia malayi NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial precursor 0.0078 0.1343 0.1322
Echinococcus granulosus intermediate filament protein 0.0033 0.0373 0.0361
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0051 0.0757 0.5559
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0167 0.0143
Mycobacterium ulcerans hypothetical protein 0.0072 0.122 0.9054
Onchocerca volvulus Protein ultraspiracle homolog 0.0043 0.0605 0.3303
Entamoeba histolytica diacylglycerol kinase, putative 0.0037 0.0457 0.4233
Brugia malayi protein kinase C II. 0.0096 0.1724 0.1704
Mycobacterium ulcerans NADH dehydrogenase I subunit F 0.0078 0.1343 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0043 0.0605 0.0582
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0072 0.122 0.122
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0622 0.061
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0461 0.9539 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0043 0.0605 0.0605
Toxoplasma gondii ABC1 family protein 0.0072 0.122 0.9796
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.052 0.3763
Entamoeba histolytica hypothetical protein 0.0037 0.0457 0.4233
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0023 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0167
Brugia malayi Hemopexin family protein 0.0024 0.0192 0.0168
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.0605 0.0593
Loa Loa (eye worm) hypothetical protein 0.002 0.0114 0.0114
Schistosoma mansoni atypical protein kinase C 0.0088 0.1562 0.2263
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0038 0.0481 0.0458
Loa Loa (eye worm) hypothetical protein 0.0037 0.0457 0.0457
Echinococcus multilocularis Diacylglycerol kinase theta 0.0037 0.0457 0.0445
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0373 0.035
Trichomonas vaginalis chromobox protein, putative 0.007 0.1182 0.878
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.2761 0.2761
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0024 0.0012
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.002 0.0114 0.009
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0043 0.0605 0.0582
Entamoeba histolytica diacylglycerol kinase, putative 0.0037 0.0457 0.4233
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1001 0.249
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.122 0.1235
Echinococcus multilocularis cysteine protease 0.0016 0.0024 0.0012
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0052 0.0781 0.0781
Schistosoma mansoni protein kinase C mu 0.0038 0.0481 0.0673
Trypanosoma brucei NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial, putative 0.0078 0.1343 0.6345
Loa Loa (eye worm) hypothetical protein 0.002 0.0114 0.0114
Echinococcus granulosus thyroid hormone receptor alpha 0.002 0.0114 0.0102
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0024 0.5
Entamoeba histolytica protein kinase, putative 0.0052 0.0781 0.7395
Echinococcus multilocularis nuclear receptor nhr 48 0.002 0.0114 0.0102
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.1001 0.5951
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0043 0.0605 0.0593
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0373 0.0373
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0043 0.0605 0.0605
Loa Loa (eye worm) hypothetical protein 0.0017 0.004 0.004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.0605 0.0593
Brugia malayi beta-lactamase family protein 0.0072 0.122 0.1199
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.013 0.2447 0.2437
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0024 0.0012
Brugia malayi hypothetical protein 0.0023 0.0167 0.0143
Schistosoma mansoni unc-13 (munc13) 0.0044 0.062 0.0876
Echinococcus granulosus protein kinase c epsilon type 0.0096 0.1724 0.1714
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.1048 0.1036
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0043 0.0605 0.0605
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0037 0.0457 0.0457
Echinococcus multilocularis serine:threonine protein kinase N2 0.0052 0.0781 0.0769
Brugia malayi ecdysone receptor 0.002 0.0114 0.009
Loa Loa (eye worm) hypothetical protein 0.0043 0.0605 0.0605
Treponema pallidum nitrogen fixation protein (rnfC) 0.0017 0.0048 0.5
Brugia malayi hypothetical protein 0.0023 0.0167 0.0143
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.1001 0.5951
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0037 0.0457 0.0445
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.122 0.7283
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0024 0.0012
Loa Loa (eye worm) hypothetical protein 0.0072 0.122 0.122
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0062 0.0998 0.0987
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0781 0.5739
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1245 0.1797
Schistosoma mansoni thyroid hormone receptor 0.0173 0.3375 0.4932
Loa Loa (eye worm) hypothetical protein 0.002 0.0114 0.0114
Brugia malayi Protein kinase c protein 2 0.0283 0.5738 0.5728
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0044 0.062 0.0608
Loa Loa (eye worm) hypothetical protein 0.0017 0.004 0.004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1001 0.249
Echinococcus granulosus geminin 0.0205 0.4054 0.4047
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0021 0.0119 0.0095
Echinococcus multilocularis lamin 0.0033 0.0373 0.0361
Schistosoma mansoni nuclear hormone receptor 0.002 0.0114 0.0133
Schistosoma mansoni protein kinase C 0.0044 0.062 0.0876
Schistosoma mansoni serine/threonine protein kinase 0.0334 0.6819 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.1245 0.1234
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.1048 0.1506
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0052 0.0781 0.0769
Loa Loa (eye worm) NADH-ubiquinone oxidoreductase 51 kDa subunit 0.0078 0.1343 0.1343
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0052 0.0781 0.0781
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0038 0.0481 0.0469
Brugia malayi gamma-secretase subunit aph-1 0.0239 0.4783 0.4771
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0781 0.5739
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0038 0.0481 0.0481
Echinococcus granulosus lamin 0.0033 0.0373 0.0361
Brugia malayi orphan nuclear receptor NR2E1 0.002 0.0114 0.009
Schistosoma mansoni zinc finger protein 0.002 0.0114 0.0133
Echinococcus granulosus FTZ F1 alpha 0.0043 0.0605 0.0593
Brugia malayi conserved hypotetical protein 0.002 0.0114 0.009
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.122 0.9071
Onchocerca volvulus 0.0072 0.122 0.6803
Mycobacterium leprae Probable lipase LipE 0.0072 0.122 1
Brugia malayi protein kinase C3,putative 0.0038 0.0481 0.0458
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.1001 0.5951
Leishmania major cathepsin L-like protease 0.0062 0.1001 0.7412
Brugia malayi hypothetical protein 0.002 0.0114 0.009
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.0605 0.0593
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.122 0.1199
Brugia malayi RhoGAP domain containing protein 0.0037 0.0457 0.0434
Loa Loa (eye worm) hypothetical protein 0.0043 0.0605 0.0605
Echinococcus multilocularis Rac GTPase activating protein 1 0.0037 0.0457 0.0445
Onchocerca volvulus 0.0098 0.1782 1
Echinococcus multilocularis chromobox protein 1 0.007 0.1182 0.1171
Schistosoma mansoni hypothetical protein 0.013 0.2447 0.3566
Onchocerca volvulus 0.0044 0.062 0.3387
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.122 0.9071
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0167
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.0605 0.0593
Toxoplasma gondii diacylglycerol kinase, putative 0.0037 0.0457 0.3548
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0584 0.4249
Echinococcus multilocularis thyroid hormone receptor alpha 0.0173 0.3375 0.3367
Schistosoma mansoni chromobox protein 0.007 0.1182 0.1704
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.122 0.4961
Echinococcus granulosus chromobox protein 1 0.007 0.1182 0.1171
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0043 0.0605 0.0855
Trypanosoma cruzi NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.0078 0.1343 0.8029
Loa Loa (eye worm) hypothetical protein 0.0072 0.122 0.122
Loa Loa (eye worm) hypothetical protein 0.0043 0.0605 0.0605
Mycobacterium ulcerans beta-lactamase 0.0072 0.122 0.9054
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0781 0.5739
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0887 0.5251
Loa Loa (eye worm) hypothetical protein 0.0043 0.0605 0.0605
Echinococcus granulosus NDR protein kinase 0.0052 0.0781 0.0769
Schistosoma mansoni lamin 0.0033 0.0373 0.0514
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0781 0.5739
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1245 0.9247
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0052 0.0781 0.0769
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.005 0.0026
Loa Loa (eye worm) hypothetical protein 0.0037 0.0457 0.0457
Brugia malayi Matrixin family protein 0.0017 0.004 0.0016
Entamoeba histolytica protein kinase, putative 0.0052 0.0781 0.7395
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0017 0.004 0.0023
Loa Loa (eye worm) hypothetical protein 0.0037 0.0457 0.0457
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0052 0.0781 0.0769
Schistosoma mansoni chromobox protein 0.007 0.1182 0.1704
Echinococcus multilocularis survival motor neuron protein 1 0.0483 1 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.002 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0031 0.0338 0.0338
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.0114 0.0513
Loa Loa (eye worm) beta-lactamase 0.0072 0.122 0.122
Loa Loa (eye worm) hypothetical protein 0.002 0.0114 0.0114
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0052 0.0781 0.0769
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0114 0.0102
Loa Loa (eye worm) hypothetical protein 0.002 0.0114 0.0114
Schistosoma mansoni thyroid hormone receptor 0.0173 0.3375 0.4932
Echinococcus multilocularis musashi 0.0033 0.0373 0.0361
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0781 0.5739
Brugia malayi photoreceptor-specific nuclear receptor 0.0043 0.0605 0.0582
Loa Loa (eye worm) hypothetical protein 0.0039 0.052 0.052
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0024 0.5
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0622 0.0599
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0043 0.0605 0.0605
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.013 0.2447 0.2437
Loa Loa (eye worm) hypothetical protein 0.002 0.0114 0.0114
Entamoeba histolytica protein kinase, putative 0.0052 0.0781 0.7395
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.122 0.1235
Brugia malayi tailless protein 0.002 0.0114 0.009
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0114 0.0102
Entamoeba histolytica protein kinase, putative 0.0052 0.0781 0.7395
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0584 0.3187
Brugia malayi beta-lactamase 0.0072 0.122 0.1199
Loa Loa (eye worm) hypothetical protein 0.0043 0.0605 0.0605
Brugia malayi nuclear hormone receptor family member nhr-6 0.002 0.0114 0.009
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0043 0.0605 0.0582
Mycobacterium tuberculosis Probable NADH dehydrogenase I (chain F) NuoF (NADH-ubiquinone oxidoreductase chain F) 0.0078 0.1343 0.1364
Onchocerca volvulus 0.0037 0.0457 0.2464
Echinococcus multilocularis lamin dm0 0.0033 0.0373 0.0361
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1245 0.1797
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0024 0.5
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.1048 0.7761
Loa Loa (eye worm) nuclear receptor NHR-67 0.002 0.0114 0.0114
Schistosoma mansoni intermediate filament proteins 0.0033 0.0373 0.0514
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.002 0.0114 0.0133
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0023 0.0167 0.0154
Brugia malayi Nuclear hormone receptor-like 1 0.0043 0.0605 0.0582
Loa Loa (eye worm) hypothetical protein 0.0238 0.4771 0.4771
Schistosoma mansoni serine/threonine kinase 0.0052 0.0781 0.1114
Loa Loa (eye worm) hypothetical protein 0.0072 0.122 0.122
Brugia malayi beta-lactamase family protein 0.0072 0.122 0.1199
Onchocerca volvulus 0.0017 0.004 0.0089
Echinococcus granulosus chromobox protein 1 0.007 0.1182 0.1171
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.2761 0.2761
Brugia malayi Nuclear hormone receptor E75 0.002 0.0114 0.009
Schistosoma mansoni nuclear receptor 0.002 0.0114 0.0133
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0043 0.0605 0.0593
Loa Loa (eye worm) hypothetical protein 0.0037 0.0457 0.0457
Brugia malayi steroid hormone receptor 0.0043 0.0605 0.0582
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0622 0.0622
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.1048 0.1036
Loa Loa (eye worm) hypothetical protein 0.0017 0.004 0.004
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0043 0.0605 0.0582
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0114 0.0102
Brugia malayi nuclear hormone receptor 0.0043 0.0605 0.0582
Onchocerca volvulus 0.0072 0.122 0.6803
Onchocerca volvulus Matrilysin homolog 0.0038 0.0483 0.2608
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0781 0.1114
Echinococcus multilocularis ecdysone induced protein 78C 0.0043 0.0605 0.0593
Echinococcus multilocularis chromobox protein 1 0.007 0.1182 0.1171
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.002 0.0114 0.0102
Echinococcus granulosus RNA directed DNA polymerase 0.0238 0.4771 0.4764
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0481 0.0673
Brugia malayi Steroid receptor seven-up type 2 0.0043 0.0605 0.0582
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0043 0.0605 0.0593
Echinococcus granulosus N chimaerin 0.0037 0.0457 0.0445
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0043 0.0605 0.0605
Loa Loa (eye worm) hypothetical protein 0.0483 1 1
Echinococcus multilocularis serine:threonine protein kinase 38 0.0052 0.0781 0.0769
Onchocerca volvulus 0.0072 0.122 0.6803
Onchocerca volvulus 0.0024 0.0192 0.0954
Brugia malayi RhoGEF domain containing protein 0.0037 0.0457 0.0434

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.4467 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.3078 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (binding) = 28.1838 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 84.9214 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Saccharomyces cerevisiae ChEMBL23
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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