Detailed information for compound 1473678

Basic information

Technical information
  • TDR Targets ID: 1473678
  • Name: 1-chloro-1,1-difluoro-4-[2-(1H-indol-3-yl)eth ylamino]butan-2-ol
  • MW: 302.747 | Formula: C14H17ClF2N2O
  • H donors: 3 H acceptors: 1 LogP: 2.98 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(C(Cl)(F)F)CCNCCc1c[nH]c2c1cccc2
  • InChi: 1S/C14H17ClF2N2O/c15-14(16,17)13(20)6-8-18-7-5-10-9-19-12-4-2-1-3-11(10)12/h1-4,9,13,18-20H,5-8H2
  • InChiKey: RJNMQSSCHXQTDF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • SMR000336167
  • 9R-1065
  • 1-chloro-1,1-difluoro-4-{[2-(1H-indol-3-yl)ethyl]amino}-2-butanol
  • MLS000764021

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens galactosidase, alpha Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma japonicum Alpha-N-acetylgalactosaminidase precursor, putative Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma japonicum Alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma japonicum Alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Echinococcus granulosus Alpha N acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Neospora caninum hypothetical protein Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma japonicum Alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
Echinococcus multilocularis Alpha N acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma japonicum expressed protein Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Brugia malayi Melibiase family protein Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Toxoplasma gondii melibiase subfamily protein Get druggable targets OG5_127620 All targets in OG5_127620
Echinococcus multilocularis Glycoside hydrolase, family 27 Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma japonicum ko:K01204 alpha-N-acetylgalactosaminidase [EC3.2.1.49], putative Get druggable targets OG5_127620 All targets in OG5_127620
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.0075 0.0146
Brugia malayi tailless protein 0.0017 0.0002 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0109 0.0202
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0036 0.0077 0.0118
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0036 0.0075 0.0075
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0036 0.0075 0.0094
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0004 0.0004
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0045 0.0109 0.0109
Brugia malayi RNA binding protein 0.0062 0.0176 0.034
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0093 0.0172
Echinococcus granulosus tumor protein p63 0.1015 0.3851 0.4833
Echinococcus granulosus intermediate filament protein 0.0056 0.0152 0.0191
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0074 0.0142
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.0075 0.0075
Brugia malayi nuclear receptor RXR 0.0019 0.001 0.0019
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0212 0.041
Loa Loa (eye worm) hypothetical protein 0.0056 0.0153 0.0319
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0017 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0091 0.0288 0.0605
Echinococcus multilocularis microtubule associated protein 2 0.2083 0.7969 0.7969
Schistosoma mansoni intermediate filament proteins 0.0056 0.0152 0.0191
Onchocerca volvulus Protein ultraspiracle homolog 0.0036 0.0075 0.0136
Trichomonas vaginalis replication factor C large subunit, putative 0.0021 0.0016 0.003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0248 0.0891 0.1119
Echinococcus multilocularis phd:f box containing protein 0.0047 0.0117 0.0117
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0071 0.0212 0.038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0065 0.012
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0135 0.023
Schistosoma mansoni chromobox protein 0.0034 0.0068 0.0085
Toxoplasma gondii melibiase subfamily protein 0.0124 0.0414 0.0801
Giardia lamblia Fructose-bisphosphate aldolase 0.0288 0.1049 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1049 0.1948
Trypanosoma cruzi FHA domain containing protein, putative 0.0021 0.0016 0.0032
Brugia malayi hypothetical protein 0.0021 0.0016 0.0031
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0068 0.0125
Echinococcus granulosus jumonji domain containing 1A 0.0047 0.0117 0.0147
Entamoeba histolytica acyl-CoA synthetase, putative 0.0243 0.0874 0.4333
Onchocerca volvulus 0.0076 0.0228 0.042
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0071 0.0212 0.041
Mycobacterium tuberculosis Conserved protein 0.0142 0.0484 0.0937
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0038 0.0071
Trypanosoma cruzi hypothetical protein, conserved 0.0142 0.0484 0.0937
Toxoplasma gondii histone lysine methyltransferase SET1 0.0126 0.0421 0.0815
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0176 0.0614 0.1137
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0036 0.0075 0.0155
Loa Loa (eye worm) hypothetical protein 0.0243 0.0874 0.1846
Loa Loa (eye worm) hypothetical protein 0.0142 0.0484 0.1021
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.0353 0.0683
Brugia malayi Bromodomain containing protein 0.0159 0.0548 0.1061
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0036 0.0075 0.0155
Schistosoma mansoni hypothetical protein 0.0091 0.0287 0.036
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0243 0.0874 0.1691
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0534 0.1995 0.2504
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0056 0.0153 0.0296
Onchocerca volvulus Netrin receptor homolog 0.0035 0.0071 0.0128
Onchocerca volvulus 0.0071 0.0212 0.039
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0036 0.0077 0.0149
Trichomonas vaginalis D-aminoacylase, putative 0.0142 0.0484 0.0899
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0034 0.0068 0.0131
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0045 0.0109 0.0467
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0247 0.0888 0.0888
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0056 0.0154 0.0299
Loa Loa (eye worm) hypothetical protein 0.0071 0.0212 0.0444
Loa Loa (eye worm) hypothetical protein 0.0024 0.003 0.006
Schistosoma mansoni bromodomain containing protein 0.0261 0.0944 0.1184
Echinococcus granulosus methyl CpG binding domain protein 2 0.0068 0.0201 0.0252
Echinococcus multilocularis PHD finger protein rhinoceros 0.0145 0.0496 0.0496
Loa Loa (eye worm) hypothetical protein 0.0021 0.0016 0.003
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0034 0.0068 0.0259
Brugia malayi orphan nuclear receptor NR2E1 0.0017 0.0002 0.0004
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.1356 0.5165 1
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0071 0.0212 0.041
Schistosoma mansoni netrin receptor unc5 0.0035 0.0071 0.0089
Loa Loa (eye worm) hypothetical protein 0.0182 0.0637 0.1344
Echinococcus granulosus jumonji domain containing protein 0.0202 0.0716 0.0898
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0111 0.0111
Plasmodium falciparum acyl-CoA synthetase 0.0182 0.0637 0.1233
Echinococcus multilocularis nibrin 0.0021 0.0016 0.0016
Brugia malayi Melibiase family protein 0.0082 0.0255 0.0493
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1049 0.1948
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0309 0.1127 0.2383
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0034 0.0068 0.0131
Loa Loa (eye worm) hypothetical protein 0.0026 0.0037 0.0073
Echinococcus granulosus inositol monophosphatase 1 0.0041 0.0094 0.0118
Brugia malayi hypothetical protein 0.0757 0.2855 0.5527
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0016 0.003
Loa Loa (eye worm) PHD-finger family protein 0.0145 0.0496 0.1047
Onchocerca volvulus 0.0142 0.0484 0.0895
Echinococcus multilocularis neuropeptide receptor A26 0.0509 0.1901 0.1901
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0073 0.0136
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0142 0.0484 0.0937
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0016 0.0031
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0047 0.0117 0.0227
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0071 0.0212 0.0266
Onchocerca volvulus 0.0243 0.0874 0.1619
Echinococcus multilocularis JmjC domain containing protein 4 0.0047 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0035 0.0072 0.0147
Schistosoma mansoni methyl-cpg binding protein mbd 0.0068 0.0201 0.0252
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0071 0.0212 0.041
Loa Loa (eye worm) hypothetical protein 0.0248 0.0891 0.1883
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0065 0.012
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.004 0.0093 0.0179
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0021 0.0016 0.0031
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0212 0.041
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0153 0.0284
Loa Loa (eye worm) hypothetical protein 0.0036 0.0075 0.0155
Trypanosoma cruzi hypothetical protein, conserved 0.0142 0.0484 0.0937
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0071 0.0212 0.0444
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.0353 0.0683
Echinococcus granulosus histone lysine methyltransferase setb 0.0248 0.0891 0.1119
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0153 0.0284
Plasmodium falciparum phd finger protein, putative 0.0145 0.0496 0.0961
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1049 0.1948
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0041 0.0051
Toxoplasma gondii Alpha-galactosidase 0.0018 0.0004 0.0008
Plasmodium vivax hypothetical protein, conserved 0.0051 0.0133 0.0257
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0041 0.0079
Brugia malayi Phospholipase A2 family protein 0.0374 0.1377 0.2666
Plasmodium vivax SET domain containing protein 0.0021 0.0018 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0029 0.0055
Echinococcus multilocularis beta LACTamase domain containing family member 0.0142 0.0484 0.0484
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0153 0.0284
Brugia malayi jmjC domain containing protein 0.0047 0.0117 0.0227
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0078 0.0239 0.0432
Toxoplasma gondii GAF domain-containing protein 0.004 0.0093 0.0179
Schistosoma mansoni hypothetical protein 0.0091 0.0287 0.036
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0002 0.0004
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1049 0.1948
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0004 0.0008
Entamoeba histolytica protein kinase, putative 0.0037 0.0081 0.0327
Echinococcus granulosus FTZ F1 alpha 0.0036 0.0075 0.0094
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.1356 0.5165 1
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0021 0.0016 0.0031
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0031 0.006
Brugia malayi Thioredoxin reductase 0.0047 0.0119 0.0231
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0341 0.125 0.125
Loa Loa (eye worm) hypothetical protein 0.0142 0.0484 0.1021
Loa Loa (eye worm) hypothetical protein 0.0024 0.0031 0.0061
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.0109 0.021
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0031 0.006
Loa Loa (eye worm) hypothetical protein 0.0047 0.0117 0.0244
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0004 0.0008
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0019 0.001 0.001
Entamoeba histolytica hypothetical protein 0.008 0.0246 0.1163
Onchocerca volvulus 0.0056 0.0152 0.0279
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.1356 0.5165 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0111 0.023
Onchocerca volvulus 0.0021 0.0016 0.0026
Loa Loa (eye worm) hypothetical protein 0.0243 0.0874 0.1846
Echinococcus multilocularis expressed conserved protein 0.0206 0.0732 0.0732
Schistosoma mansoni cellular tumor antigen P53 0.0149 0.051 0.064
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0153 0.0284
Echinococcus multilocularis dnaJ subfamily B 0.0398 0.1471 0.1471
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0031 0.006
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0176 0.0176
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0036 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0142 0.0484 0.1021
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0071 0.0212 0.041
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0153 0.0284
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1049 0.1948
Brugia malayi nuclear hormone receptor family member nhr-6 0.0017 0.0002 0.0004
Schistosoma mansoni hypothetical protein 0.0061 0.0174 0.0218
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0036 0.0075 0.0146
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0239 0.0462
Schistosoma mansoni SET domain protein 0.0019 0.0009 0.0011
Leishmania major acetyl-CoA synthetase, putative 0.0071 0.0212 0.041
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.0075 0.0146
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0529 0.1978 0.383
Entamoeba histolytica hypothetical protein 0.008 0.0246 0.1163
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0078 0.0239 0.0299
Loa Loa (eye worm) latrophilin receptor protein 2 0.0098 0.0313 0.0659
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0052 0.0106
Brugia malayi acetyltransferase, GNAT family protein 0.0169 0.0589 0.114
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0041 0.0079
Echinococcus granulosus JmjC domain containing protein 4 0.0047 0.0117 0.0147
Echinococcus multilocularis lysine specific demethylase 6a 0.0047 0.0117 0.0117
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0153 0.0284
Echinococcus granulosus fetal alzheimer antigen falz 0.0094 0.0298 0.0374
Brugia malayi Protein kinase domain containing protein 0.0035 0.0072 0.014
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0094 0.0181
Schistosoma mansoni hypothetical protein 0.0034 0.0068 0.0085
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0498 0.1856 0.3593
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0071 0.0212 0.041
Onchocerca volvulus Phospholipase A2 homolog 0.0374 0.1377 0.2554
Entamoeba histolytica hypothetical protein 0.008 0.0246 0.1163
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0094 0.0181
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.1356 0.5165 1
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0034 0.0068 0.0259
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0071 0.0212 0.041
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0071 0.0212 0.038
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0056 0.0152 0.0318
Loa Loa (eye worm) hypothetical protein 0.0078 0.0239 0.0501
Loa Loa (eye worm) RNA binding protein 0.0062 0.0176 0.0367
Echinococcus granulosus PHD finger protein rhinoceros 0.0145 0.0496 0.0623
Loa Loa (eye worm) hypothetical protein 0.0284 0.1031 0.218
Brugia malayi intermediate filament protein 0.0056 0.0152 0.0294
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.003 0.0055
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0004 0.0004
Echinococcus granulosus death domain containing protein 0.0035 0.0071 0.0089
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0093 0.0172
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1241 0.4724 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.0075 0.0094
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0212 0.041
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0047 0.0117 0.0227
Echinococcus multilocularis Chromo domain 0.0034 0.0068 0.0068
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0068 0.0125
Plasmodium falciparum heterochromatin protein 1 0.0034 0.0068 0.0131
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0034 0.0068 0.0085
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0047 0.0116 0.0216
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0036 0.0075 0.0146
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0153 0.0284
Mycobacterium leprae conserved hypothetical protein 0.004 0.0093 0.0148
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0073 0.0136
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0071 0.0212 0.0989
Brugia malayi M-phase phosphoprotein, mpp8 0.0034 0.0068 0.0131
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0176 0.022
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0036 0.0075 0.0094
Trichomonas vaginalis chromobox protein, putative 0.0034 0.0068 0.0125
Leishmania major hypothetical protein, conserved 0.0024 0.0031 0.006
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.0075 0.0146
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0198 0.0249
Leishmania major acetyl-CoA synthetase, putative 0.0071 0.0212 0.041
Onchocerca volvulus Phospholipase A2 homolog 0.0374 0.1377 0.2554
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0239 0.3746
Chlamydia trachomatis DNA ligase 0.0021 0.0016 0.0255
Brugia malayi hypothetical protein 0.0019 0.001 0.0019
Brugia malayi Immunoglobulin I-set domain containing protein 0.0035 0.0071 0.0138
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0018 0.0035
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0056 0.0153 0.0284
Brugia malayi SET domain containing protein 0.0042 0.0097 0.0189
Echinococcus multilocularis geminin 0.0496 0.1851 0.1851
Brugia malayi hypothetical protein 0.0019 0.001 0.0019
Echinococcus granulosus nuclear receptor nhr 48 0.0017 0.0002 0.0003
Mycobacterium ulcerans acyl-CoA synthetase 0.0243 0.0874 0.1691
Plasmodium vivax hypothetical protein, conserved 0.004 0.0093 0.0179
Brugia malayi ecdysteroid receptor 0.0036 0.0075 0.0146
Loa Loa (eye worm) hypothetical protein 0.0243 0.0874 0.1846
Trichomonas vaginalis conserved hypothetical protein 0.0116 0.0385 0.0714
Loa Loa (eye worm) hypothetical protein 0.0036 0.0075 0.0155
Echinococcus multilocularis sterol regulatory element binding protein 0.0094 0.03 0.03
Loa Loa (eye worm) hypothetical protein 0.0249 0.0896 0.1893
Entamoeba histolytica acyl-CoA synthetase, putative 0.0243 0.0874 0.4333
Loa Loa (eye worm) hypothetical protein 0.0026 0.0037 0.0073
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0027 0.0041 0.0048
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0035 0.0072 0.009
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0017 0.0002 0.0003
Echinococcus multilocularis jumonji domain containing protein 0.0202 0.0716 0.0716
Loa Loa (eye worm) hypothetical protein 0.0757 0.2855 0.6041
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.0109 0.021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.003 0.0055
Toxoplasma gondii PHD-finger domain-containing protein 0.0145 0.0496 0.0961
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0068 0.0131
Echinococcus granulosus chromobox protein 1 0.0207 0.0736 0.0923
Schistosoma mansoni patched 1 0.0094 0.03 0.0377
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0065 0.0125
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0172 0.0599 0.1159
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0182 0.0637 0.1233
Echinococcus multilocularis peregrin 0.0159 0.0548 0.0548
Schistosoma mansoni steroid hormone receptor ad4bp 0.0036 0.0075 0.0094
Brugia malayi topoisomerase 0.0021 0.0016 0.0031
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0037 0.0081 0.0081
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0021 0.0016 0.003
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.008 0.0246 0.0309
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0288 0.1049 0.522
Loa Loa (eye worm) PHD-finger family protein 0.0083 0.0256 0.0538
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0534 0.1995 0.1995
Mycobacterium ulcerans hypothetical protein 0.0243 0.0874 0.1691
Schistosoma mansoni hypothetical protein 0.0098 0.0313 0.0393
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0178 0.0624 0.1317
Echinococcus multilocularis cpg binding protein 0.0067 0.0194 0.0194
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0035 0.0071 0.0089
Mycobacterium ulcerans hypothetical protein 0.0142 0.0484 0.0937
Loa Loa (eye worm) hypothetical protein 0.0021 0.0016 0.003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0036 0.0075 0.0155
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0017
Toxoplasma gondii hypothetical protein 0.004 0.0093 0.0179
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0108 0.0353 0.0654
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0153 0.0284
Loa Loa (eye worm) intermediate filament protein 0.0056 0.0152 0.0318
Loa Loa (eye worm) hypothetical protein 0.0167 0.0582 0.1229
Brugia malayi nuclear receptor NHR-67 0.0017 0.0002 0.0004
Brugia malayi nuclear hormone receptor family member odr-7 0.0017 0.0002 0.0004
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0036 0.0077 0.015
Plasmodium vivax heterochromatin protein 1, putative 0.0034 0.0068 0.0131
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0176 0.0367
Onchocerca volvulus 0.0213 0.0758 0.1405
Brugia malayi AMP-binding enzyme family protein 0.0243 0.0874 0.1691
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0111 0.0139
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0019 0.001 0.0012
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0037 0.0081 0.0102
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0071 0.0212 0.041
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0142 0.0484 0.0937
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0119 0.0231
Echinococcus multilocularis ecdysone induced protein 78C 0.0036 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0154 0.0531 0.1119
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0176 0.034
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0047 0.0116 0.0216
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0058 0.0159 0.0159
Loa Loa (eye worm) oxidoreductase 0.0071 0.0212 0.0444
Onchocerca volvulus 0.0056 0.0152 0.0278
Echinococcus granulosus lamin dm0 0.0056 0.0152 0.0191
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0017 0.0002 0.0004
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0036 0.0075 0.0094
Mycobacterium tuberculosis Probable lipase LipE 0.0142 0.0484 0.0937
Echinococcus granulosus prolyl tRNA synthetase mitochondrial 0.0031 0.0055 0.007
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0002 0.0003
Loa Loa (eye worm) jmjC domain-containing protein 0.0047 0.0117 0.0244
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0169 0.0589 0.0739
Loa Loa (eye worm) steroid hormone receptor 0.0036 0.0075 0.0155
Trichomonas vaginalis esterase, putative 0.0142 0.0484 0.0899
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0034 0.0068 0.0131
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0071 0.0212 0.041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0039 0.0073
Echinococcus multilocularis lamin dm0 0.0056 0.0152 0.0152
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0031 0.006
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0212 0.041
Brugia malayi Pax transcription activation domain interacting protein 0.0021 0.0016 0.0031
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0021 0.0016 0.003
Echinococcus multilocularis chromobox protein 2 0.0034 0.0068 0.0068
Leishmania major trypanothione reductase 0.0047 0.0119 0.0231
Brugia malayi jmjC domain containing protein 0.0475 0.177 0.3426
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0153 0.0284
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0016 0.0031
Echinococcus granulosus lamin 0.0056 0.0152 0.0191
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0071 0.0212 0.041
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0036 0.0075 0.0146
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0041 0.0388
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0016 0.003
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.0414 0.0519
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.0153 0.0284
Brugia malayi Pre-SET motif family protein 0.0179 0.0627 0.1215
Schistosoma mansoni transcription factor LCR-F1 0.008 0.0246 0.0309
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0047 0.0116 0.0216
Brugia malayi conserved hypotetical protein 0.0017 0.0002 0.0004
Schistosoma mansoni hypothetical protein 0.0496 0.1851 0.2323
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0036 0.0075 0.0094
Brugia malayi Met-10+ like-protein 0.0027 0.0041 0.0079
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0153 0.0284
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0004 0.0008
Echinococcus multilocularis mixed lineage leukemia protein mll 0.002 0.0015 0.0015
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0041 0.0094 0.0181
Brugia malayi SET domain containing protein 0.0019 0.0009 0.0017
Brugia malayi hypothetical protein 0.0017 0.0002 0.0004
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.0153 0.0284
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0071 0.0212 0.041
Trichomonas vaginalis set domain proteins, putative 0.1413 0.5385 1
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0036 0.0077 0.015
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0142 0.0484 0.1021
Trichomonas vaginalis chromobox protein, putative 0.0207 0.0736 0.1366
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0529 0.1978 0.3674
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0071 0.0212 0.041
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0068 0.0125
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0153 0.0284
Loa Loa (eye worm) inositol-1 0.0041 0.0094 0.0194
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.003 0.0055
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0071 0.0212 0.041
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0153 0.0284
Echinococcus multilocularis chromobox protein 1 0.0207 0.0736 0.0736
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0172 0.0599 0.1159
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0176 0.022
Plasmodium falciparum GAF domain-related protein, putative 0.004 0.0093 0.0179
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0071 0.0212 0.041
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0094 0.0174
Schistosoma mansoni nuclear receptor 0.0017 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0082 0.0255 0.0535
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0034 0.0068 0.0131
Schistosoma mansoni hypothetical protein 0.0035 0.0071 0.0089
Schistosoma mansoni chromobox protein 0.0034 0.0068 0.0085
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0078 0.0239 0.0462
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.0135 0.0261
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0907 0.3434 0.6648
Loa Loa (eye worm) hypothetical protein 0.0149 0.051 0.1075
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0071 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0034 0.0068 0.0139
Echinococcus multilocularis musashi 0.0056 0.0152 0.0152
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0038 0.0071
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0142 0.0484 0.0937
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0093 0.0172
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0094 0.0181
Brugia malayi jmjC domain containing protein 0.0186 0.0656 0.127
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0124 0.0414 0.0414
Brugia malayi nuclear receptor RXR 0.0017 0.0002 0.0004
Loa Loa (eye worm) jmjC domain-containing protein 0.0047 0.0117 0.0244
Echinococcus multilocularis lamin 0.0056 0.0152 0.0152
Mycobacterium ulcerans putative regulatory protein 0.004 0.0093 0.0179
Brugia malayi jmjC domain containing protein 0.0047 0.0117 0.0227
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0111 0.0111
Schistosoma mansoni peptidase Clp (S14 family) 0.0078 0.0239 0.0299
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0475 0.177 0.2221
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0071 0.0212 0.041
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0068 0.0125
Mycobacterium tuberculosis Conserved protein 0.0142 0.0484 0.0937
Schistosoma mansoni hypothetical protein 0.0098 0.0313 0.0393
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0004 0.0004
Plasmodium falciparum thioredoxin reductase 0.0047 0.0119 0.0231
Onchocerca volvulus 0.1413 0.5386 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0111 0.0215
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0529 0.1978 0.3674
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0073 0.0136
Echinococcus granulosus histone acetyltransferase KAT2B 0.0056 0.0154 0.0194
Echinococcus granulosus phd:f box containing protein 0.0047 0.0117 0.0147
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.0075 0.0146
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0141 0.048 0.093
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0019 0.001 0.0012
Trichomonas vaginalis hypothetical protein 0.0034 0.0068 0.0125
Brugia malayi Uncoordinated protein 44 0.0035 0.0071 0.0138
Schistosoma mansoni phosphatidylserine receptor 0.0047 0.0117 0.0147
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0021 0.0016 0.0031
Brugia malayi isocitrate dehydrogenase 0.0017 0.0004 0.0008
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0002 0.0003
Onchocerca volvulus 0.0071 0.0212 0.039
Brugia malayi latrophilin 2 splice variant baaae 0.0211 0.0751 0.1453
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.0353 0.0683
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0109 0.0225
Loa Loa (eye worm) hypothetical protein 0.0034 0.0068 0.0139
Echinococcus granulosus beta LACTamase domain containing family member 0.0142 0.0484 0.0608
Onchocerca volvulus 0.0034 0.0068 0.0122
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0071 0.0212 0.0444
Loa Loa (eye worm) hypothetical protein 0.0047 0.0117 0.0244
Toxoplasma gondii ABC1 family protein 0.0142 0.0484 0.0937
Onchocerca volvulus 0.0036 0.0075 0.0136
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0036 0.0075 0.0075
Plasmodium vivax hypothetical protein, conserved 0.0142 0.0484 0.0937
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0036 0.0075 0.0094
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0002 0.0003
Trichomonas vaginalis chromobox protein, putative 0.0125 0.0419 0.0777
Echinococcus granulosus Chromobox protein 3 0.0034 0.0068 0.0085
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.0008 0.0016
Treponema pallidum DNA ligase (lig) 0.0021 0.0016 0.0155
Echinococcus granulosus peregrin 0.0159 0.0548 0.0688
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0145 0.0496 0.0623
Schistosoma mansoni cpg binding protein 0.0056 0.0152 0.019
Schistosoma mansoni topbp1 0.0021 0.0016 0.002
Trichomonas vaginalis antibiotic synthetase, putative 0.0071 0.0212 0.0393
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0098 0.0313 0.0393
Loa Loa (eye worm) hypothetical protein 0.0034 0.0068 0.0139
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0036 0.0075 0.0155
Trichomonas vaginalis penicillin-binding protein, putative 0.0142 0.0484 0.0899
Echinococcus granulosus nibrin 0.0021 0.0016 0.002
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0239 0.0462
Schistosoma mansoni zinc finger protein 0.0061 0.0174 0.0218
Brugia malayi Protein cec-1. 0.0034 0.0068 0.0131
Plasmodium vivax glutathione reductase, putative 0.0047 0.0119 0.0231
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0039 0.0073
Trichomonas vaginalis Heterochromatin protein, putative 0.0034 0.0068 0.0125
Loa Loa (eye worm) hypothetical protein 0.0442 0.164 0.3468
Leishmania major hypothetical protein, conserved 0.0142 0.0484 0.0937
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0017
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0004 0.0008
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0071 0.0212 0.041
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0211 0.0751 0.1585
Brugia malayi AMP-binding enzyme family protein 0.0243 0.0874 0.1691
Brugia malayi CXXC zinc finger family protein 0.0056 0.0152 0.0294
Brugia malayi jmjC domain containing protein 0.0047 0.0117 0.0227
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0119 0.0248
Echinococcus granulosus lysine specific demethylase 6a 0.0047 0.0117 0.0147
Loa Loa (eye worm) hypothetical protein 0.0036 0.0077 0.016
Schistosoma mansoni hypothetical protein 0.0098 0.0313 0.0393
Trypanosoma cruzi ISWI complex protein 0.0061 0.0174 0.0336
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0093 0.0172
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0142 0.0484 0.0608
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0254 0.0471
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0068 0.0125
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0073 0.0136
Echinococcus granulosus zinc finger protein 0.0086 0.0267 0.0335
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0094 0.0298 0.0374
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0058 0.0159 0.02
Loa Loa (eye worm) jmjC domain-containing protein 0.0186 0.0656 0.1385
Giardia lamblia Histone acetyltransferase GCN5 0.0043 0.0103 0.0979
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0056 0.0153 0.0153
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.1356 0.5165 1
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0021 0.0016 0.003
Loa Loa (eye worm) hypothetical protein 0.0098 0.0313 0.0659
Loa Loa (eye worm) acetyltransferase 0.0169 0.0589 0.1243
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0212 0.041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0065 0.012
Mycobacterium tuberculosis Probable prolyl-tRNA synthetase ProS (proline--tRNA ligase) (PRORS) (global RNA synthesis factor) (proline translase) 0.0027 0.0041 0.0079
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0034 0.0068 0.0131
Echinococcus granulosus neuropeptide receptor A26 0.0509 0.1901 0.2385
Brugia malayi beta-lactamase family protein 0.0142 0.0484 0.0937
Brugia malayi Bromodomain containing protein 0.0308 0.1125 0.2178
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0002 0.0004
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0034 0.0068 0.0125
Echinococcus multilocularis neuropeptide s receptor 0.0509 0.1901 0.1901
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.0414 0.0519
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0068 0.0125
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0004 0.0008
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0004 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0016 0.003
Loa Loa (eye worm) histone methyltransferase 0.0024 0.0029 0.0056
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0153 0.0284
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0002 0.0003
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0243 0.0874 0.1691
Schistosoma mansoni chromobox protein 0.0207 0.0736 0.0923
Brugia malayi DKFZp564C0469 protein 0.0021 0.0016 0.0031
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0004 0.0005
Plasmodium falciparum proline--tRNA ligase, putative 0.0031 0.0055 0.0107
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0065 0.012
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0212 0.041
Brugia malayi ecdysone receptor 0.0017 0.0002 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0016 0.003
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0212 0.041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0029 0.0055
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0248 0.0891 0.0891
Loa Loa (eye worm) hypothetical protein 0.0182 0.0637 0.1344
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0034 0.0068 0.0085
Plasmodium falciparum replication factor C subunit 1, putative 0.0021 0.0016 0.0031
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.1356 0.5165 1
Brugia malayi TAR-binding protein 0.0062 0.0176 0.034
Echinococcus multilocularis netrin receptor unc 5 0.0035 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0182 0.0637 0.1344
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0036 0.0075 0.0094
Loa Loa (eye worm) hypothetical protein 0.0309 0.1127 0.2383
Brugia malayi Intermediate filament tail domain containing protein 0.0056 0.0152 0.0294
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0182 0.0637 1
Schistosoma mansoni hypothetical protein 0.0496 0.1851 0.2323
Brugia malayi Calcitonin receptor-like protein seb-1 0.0309 0.1127 0.2183
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0073 0.0136
Plasmodium falciparum dihydroorotate dehydrogenase 0.1356 0.5165 1
Schistosoma mansoni survival motor neuron protein 0.0154 0.0532 0.0668
Brugia malayi Bromodomain containing protein 0.0158 0.0545 0.1055
Schistosoma mansoni RAR-like nuclear receptor 0.0036 0.0075 0.0094
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.1356 0.5165 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0017 0.0002 0.0002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0172 0.0599 0.1159
Loa Loa (eye worm) hypothetical protein 0.0115 0.0382 0.0805
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0021 0.0016 0.0000017434
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0056 0.0153 0.0192
Loa Loa (eye worm) hypothetical protein 0.0176 0.0614 0.1296
Schistosoma mansoni lamin 0.0056 0.0152 0.0191
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0179 0.0627 0.0627
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0047 0.0116 0.0216
Trypanosoma brucei hypothetical protein, conserved 0.0142 0.0484 0.0937
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0071 0.0212 0.041
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0068 0.0125
Schistosoma mansoni jumonji domain containing protein 0.0378 0.1393 0.1748
Echinococcus granulosus Niemann Pick C1 protein 0.022 0.0784 0.0984
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0037 0.0081 0.0081
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0004 0.0008
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.001 0.0012
Schistosoma mansoni cpg binding protein 0.0067 0.0194 0.0243
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0071 0.0212 0.041
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0309 0.1127 0.2183
Schistosoma mansoni hypothetical protein 0.0211 0.0751 0.0942
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0094 0.0181
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0056 0.0154 0.0299
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0056 0.0153 0.0296
Echinococcus granulosus survival motor neuron protein 1 0.0757 0.2855 0.3582
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0171 0.0598 0.075
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0534 0.1995 0.3705
Brugia malayi PHD-finger family protein 0.0058 0.0162 0.0313
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0004 0.0008
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0051 0.0133 0.0257
Schistosoma mansoni inositol monophosphatase 0.0041 0.0094 0.0118
Mycobacterium tuberculosis Probable reductase 0.0108 0.0353 0.0683
Brugia malayi steroid hormone receptor 0.0036 0.0075 0.0146
Echinococcus granulosus chromobox protein 1 0.0207 0.0736 0.0923
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0036 0.0075 0.0146
Brugia malayi CHE-14 protein 0.0094 0.03 0.0581
Brugia malayi nuclear hormone receptor 0.0017 0.0002 0.0004
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0094 0.03 0.0632
Loa Loa (eye worm) hypothetical protein 0.0142 0.0484 0.1021
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0016 0.003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0036 0.0075 0.0155
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0119 0.0231
Schistosoma mansoni acetyl-CoA synthetase 0.0071 0.0212 0.0266
Loa Loa (eye worm) beta-lactamase 0.0142 0.0484 0.1021
Plasmodium falciparum JmjC domain-containing protein, putative 0.0047 0.0117 0.0227
Toxoplasma gondii PHD-finger domain-containing protein 0.0145 0.0496 0.0961
Schistosoma mansoni microtubule-associated protein tau 0.2083 0.7969 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0109 0.0202
Echinococcus multilocularis protein dispatched 1 0.0108 0.0352 0.0352
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0243 0.0874 0.1691
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0243 0.0874 0.1665
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.0109 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0254 0.0471
Trichomonas vaginalis chromobox protein, putative 0.0034 0.0068 0.0125
Giardia lamblia Replication factor C, subunit 1 0.0021 0.0016 0.0155
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0052 0.0101
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0109 0.0202
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0111 0.0139
Schistosoma mansoni chromobox protein 0.0207 0.0736 0.0923
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0017 0.0002 0.0002
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0061 0.0174 0.0336
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.1356 0.5165 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0071 0.0212 0.041
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0015 0.0015
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.0414 0.0519
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0111 0.0139
Schistosoma mansoni zinc finger protein 0.0017 0.0002 0.0003
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.0109 0.0136
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0125 0.0419 0.0774
Loa Loa (eye worm) hypothetical protein 0.0116 0.0385 0.081
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0498 0.1856 0.1856
Giardia lamblia PHD finger protein 15 0.0145 0.0496 0.4731
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0047 0.0117 0.0227
Plasmodium vivax proline--tRNA ligase, putative 0.0031 0.0055 0.0107
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0068 0.0125
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0111 0.0139
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0056 0.0153 0.0284
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0135 0.0169
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0169 0.0589 0.0589
Onchocerca volvulus Alhambra homolog 0.0145 0.0496 0.0918
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0034 0.0068 0.0131
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0071 0.0212 0.041
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0047 0.0116 0.0216
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0081 0.0102
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0083 0.0155
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0082 0.0255 0.0473
Leishmania major hypothetical protein, conserved 0.0061 0.0174 0.0336
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0002 0.0002
Schistosoma mansoni topbp1 0.0021 0.0016 0.002
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0243 0.0874 0.1691
Loa Loa (eye worm) hypothetical protein 0.0021 0.0016 0.003
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.001 0.0019
Loa Loa (eye worm) hypothetical protein 0.0094 0.03 0.0632
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0109 0.021
Echinococcus granulosus thyroid hormone receptor alpha 0.0017 0.0002 0.0003
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0239 0.3746
Schistosoma mansoni hypothetical protein 0.0091 0.0287 0.036
Schistosoma mansoni protein phosphatase 2C 0.0047 0.0117 0.0147
Mycobacterium tuberculosis Probable esterase LipL 0.0142 0.0484 0.0937
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0056 0.0154 0.0287
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0035 0.0071 0.0146
Echinococcus granulosus neuropeptide s receptor 0.0509 0.1901 0.2385
Loa Loa (eye worm) hypothetical protein 0.0374 0.1377 0.2912
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0141 0.048 0.0901
Schistosoma mansoni bromodomain containing protein 0.0024 0.003 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0068 0.0125
Onchocerca volvulus 0.0142 0.0484 0.0895
Loa Loa (eye worm) hypothetical protein 0.0036 0.0075 0.0155
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1049 0.1948
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.0109 0.021
Trichomonas vaginalis penicillin-binding protein, putative 0.0142 0.0484 0.0899
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0098 0.0313 0.0313
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1049 0.1948
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0036 0.0075 0.0136
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0142 0.0484 0.0937
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0212 0.041
Schistosoma mansoni prolyl-tRNA synthetase 0.0031 0.0055 0.007
Brugia malayi CHD4 protein 0.0045 0.0109 0.0212
Echinococcus multilocularis replication factor c subunit 1 0.0021 0.0016 0.0016
Schistosoma mansoni jumonji/arid domain-containing protein 0.0186 0.0656 0.0823
Loa Loa (eye worm) jmjC domain-containing protein 0.03 0.1092 0.2309
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0071 0.0212 0.041
Echinococcus multilocularis inositol monophosphatase 1 0.0041 0.0094 0.0094
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0153 0.0284
Echinococcus multilocularis protein patched 0.0094 0.03 0.03
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.012 0.0399 0.0773
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0141 0.048 0.093
Trypanosoma brucei trypanothione reductase 0.0047 0.0119 0.0231
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.0075 0.0146
Brugia malayi Associated with TFs and helicases family protein 0.0034 0.0068 0.0131
Trichomonas vaginalis D-aminoacylase, putative 0.0142 0.0484 0.0899
Loa Loa (eye worm) hypothetical protein 0.0034 0.0068 0.0139
Plasmodium falciparum histone acetyltransferase GCN5 0.0043 0.0103 0.0199
Mycobacterium ulcerans esterase/lipase LipP 0.0142 0.0484 0.0937
Plasmodium vivax acetyl-CoA synthetase, putative 0.0071 0.0212 0.041
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0034 0.0068 0.0125
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0045 0.0109 0.0467
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0098 0.0313 0.0393
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0036 0.0075 0.0094
Entamoeba histolytica hypothetical protein 0.008 0.0246 0.1163
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0179 0.0627 0.0787
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0004 0.0008
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0036 0.0075 0.0094
Loa Loa (eye worm) CHromoDomain protein family member 0.0045 0.0109 0.0227
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0529 0.1978 0.3674
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0071 0.0212 0.041
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0182 0.0637 0.1233
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0017 0.0002 0.0002
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0004 0.0004
Leishmania major 4-coumarate:coa ligase-like protein 0.0243 0.0874 0.1691
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0039 0.0073
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0071 0.0212 0.041
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.0153 0.0284
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0068 0.0131
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0041 0.0094 0.0391
Loa Loa (eye worm) hypothetical protein 0.0034 0.0068 0.014
Onchocerca volvulus 0.0071 0.0212 0.039
Schistosoma mansoni hypothetical protein 0.0145 0.0496 0.0623
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.1356 0.5165 1
Echinococcus multilocularis chromobox protein 1 0.0207 0.0736 0.0736
Echinococcus granulosus cpg binding protein 0.0067 0.0194 0.0243
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0021 0.0016 0.0031
Schistosoma mansoni thyroid hormone receptor 0.0036 0.0075 0.0094
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0017
Chlamydia trachomatis proline--tRNA ligase 0.0036 0.0077 0.1216
Loa Loa (eye worm) hypothetical protein 0.0055 0.0148 0.0309
Schistosoma mansoni chromosome transmission fidelity factor 0.0021 0.0016 0.002
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0047 0.012 0.0232
Loa Loa (eye worm) hypothetical protein 0.0145 0.0496 0.1047
Entamoeba histolytica hypothetical protein 0.0034 0.0068 0.0259
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0094 0.0174
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0153 0.0284
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0004 0.0004
Echinococcus multilocularis Niemann Pick C1 protein 0.0314 0.1147 0.1147
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0082 0.0255 0.032
Toxoplasma gondii ATPase, AAA family protein 0.0021 0.0016 0.0031
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0098 0.0313 0.0607
Echinococcus multilocularis thyroid hormone receptor alpha 0.0036 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0021 0.0016 0.003
Echinococcus multilocularis zinc finger protein 0.0086 0.0267 0.0267
Mycobacterium ulcerans acyl-CoA synthetase 0.0243 0.0874 0.1691
Onchocerca volvulus 0.0034 0.0068 0.0122
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0047 0.012 0.0232
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0153 0.0284
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0529 0.1978 0.3674
Brugia malayi beta-lactamase family protein 0.0142 0.0484 0.0937
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0056 0.0153 0.0296
Onchocerca volvulus Bile acid receptor homolog 0.0036 0.0075 0.0136
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0047 0.0117 0.0227
Echinococcus granulosus chromobox protein 2 0.0034 0.0068 0.0085
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0288 0.1049 0.522
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0239 0.0462
Plasmodium vivax replication factor C subunit 1, putative 0.0021 0.0016 0.0031
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0212 0.041
Schistosoma mansoni nuclear hormone receptor 0.0036 0.0075 0.0094
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0047 0.012 0.0232
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0153 0.0284
Echinococcus granulosus microtubule associated protein 2 0.2083 0.7969 1
Brugia malayi PHD-finger family protein 0.0145 0.0496 0.0961
Echinococcus multilocularis Ankyrin 0.0035 0.0072 0.0072
Echinococcus granulosus mixed lineage leukemia protein mll 0.002 0.0015 0.0019
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0056 0.0153 0.0284
Mycobacterium ulcerans acyl-CoA synthetase 0.0243 0.0874 0.1691
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.004 0.0093 0.0179
Loa Loa (eye worm) hypothetical protein 0.0071 0.0212 0.0444
Brugia malayi Latrophilin receptor protein 2 0.0098 0.0313 0.0607
Echinococcus granulosus Niemann Pick C1 protein 0.0314 0.1147 0.144
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0021 0.0016 0.0031
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0019 0.001 0.0017
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0153 0.0284
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0036 0.0075 0.0094
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.008 0.0246 0.0246
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.0135 0.0261
Loa Loa (eye worm) hypothetical protein 0.0036 0.0075 0.0155
Echinococcus granulosus GPCR family 2 0.0098 0.0313 0.0393
Toxoplasma gondii propionate-CoA ligase 0.0071 0.0212 0.041
Mycobacterium leprae conserved hypothetical protein 0.0142 0.0484 0.0909
Plasmodium vivax hypothetical protein, conserved 0.0145 0.0496 0.0961
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.0109 0.0109
Echinococcus granulosus histone acetyltransferase KAT2B 0.0155 0.0535 0.0672
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.012 0.0399 0.0773
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.0353 0.0683
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0041 0.0094 0.0174
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0031 0.006
Echinococcus granulosus netrin receptor unc 5 0.0035 0.0071 0.0089
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0036 0.0075 0.0075
Brugia malayi jmjC domain containing protein 0.0047 0.0117 0.0227
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0034 0.0068 0.0085
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.1356 0.5165 1
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0135 0.0135
Echinococcus multilocularis FTZ F1 alpha 0.0036 0.0075 0.0075
Trichomonas vaginalis antibiotic synthetase, putative 0.0071 0.0212 0.0393
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0116 0.0385 0.0711
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0056 0.0153 0.0284
Treponema pallidum fructose-bisphosphate aldolase 0.0288 0.1049 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0068 0.0201 0.0252
Brugia malayi Niemann-Pick C1 protein precursor 0.022 0.0784 0.1518
Echinococcus multilocularis lysine specific demethylase 5A 0.0176 0.0614 0.0614
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.003 0.0055
Toxoplasma gondii hypothetical protein 0.0027 0.0041 0.0079
Mycobacterium tuberculosis Conserved protein 0.0142 0.0484 0.0937
Plasmodium vivax JmjC domain containing protein 0.0047 0.0117 0.0227
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0144 0.0493 0.0493
Brugia malayi AF-10 protein 0.0047 0.012 0.0232
Leishmania major 4-coumarate:coa ligase-like protein 0.0243 0.0874 0.1691
Echinococcus multilocularis jumonji domain containing 1A 0.0047 0.0117 0.0117
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1049 0.1948
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0036 0.0075 0.0094
Mycobacterium tuberculosis Probable oxidoreductase 0.012 0.0399 0.0773
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0071 0.0212 0.041
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0041 0.0041
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0002 0.0002
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0071 0.0212 0.041
Echinococcus granulosus tar DNA binding protein 0.0062 0.0176 0.022
Brugia malayi hypothetical protein 0.0021 0.0016 0.0031
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0119 0.0119
Treponema pallidum prolyl-tRNA synthetase 0.0036 0.0077 0.0738
Schistosoma mansoni nuclear receptor 0.0017 0.0002 0.0003
Onchocerca volvulus 0.0142 0.0484 0.0895
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0047 0.0116 0.0216
Onchocerca volvulus 0.0154 0.0532 0.0984
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0071 0.0212 0.038
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0036 0.0075 0.0094
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0142 0.0484 0.0937
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0024 0.0029 0.0036
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.0075 0.0075
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0212 0.041
Loa Loa (eye worm) hypothetical protein 0.0036 0.0075 0.0155
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0021 0.0016 0.003
Brugia malayi beta-lactamase 0.0142 0.0484 0.0937
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0017 0.0002 0.0003
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0071 0.0212 0.041
Echinococcus granulosus sterol regulatory element binding protein 0.0094 0.03 0.0377
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0119 0.015
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0031 0.006
Echinococcus multilocularis Niemann Pick C1 protein 0.022 0.0784 0.0784
Echinococcus granulosus nuclear factor of activated T cells 5 0.0341 0.125 0.1569
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0172 0.0599 0.1159
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0078 0.0239 0.0239
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0068 0.0201 0.0201
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0176 0.0367
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0124 0.0414 0.0519
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0243 0.0874 0.1665
Trichomonas vaginalis D-aminoacylase, putative 0.0142 0.0484 0.0899
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0534 0.1995 0.3705
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0223 0.0797 0.1
Loa Loa (eye worm) hypothetical protein 0.022 0.0784 0.1656
Toxoplasma gondii PHD-finger domain-containing protein 0.0047 0.012 0.0232
Schistosoma mansoni inositol monophosphatase 0.0041 0.0094 0.0118
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0017
Brugia malayi hypothetical protein 0.008 0.0246 0.0477
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0029 0.0055
Echinococcus multilocularis survival motor neuron protein 1 0.0757 0.2855 0.2855
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0036 0.0075 0.0155
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0124 0.0414 0.0414
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0153 0.0284
Schistosoma mansoni hypothetical protein 0.0098 0.0313 0.0393
Echinococcus granulosus Chromo domain 0.0034 0.0068 0.0085
Schistosoma mansoni cpg binding protein 0.0067 0.0194 0.0243
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.0075 0.0094
Loa Loa (eye worm) hypothetical protein 0.0374 0.1377 0.2912
Loa Loa (eye worm) hypothetical protein 0.0034 0.0068 0.0139
Wolbachia endosymbiont of Brugia malayi prolyl-tRNA synthetase 0.0036 0.0077 0.015
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0176 0.022
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0098 0.0313 0.0313
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0153 0.0284
Schistosoma mansoni DNA ligase IV 0.0021 0.0016 0.002
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0176 0.022
Schistosoma mansoni lamin 0.0056 0.0152 0.0191
Trichomonas vaginalis chromobox protein, putative 0.0034 0.0068 0.0125
Schistosoma mansoni dihydroorotate dehydrogenase 0.1356 0.5165 0.6481
Brugia malayi Death domain containing protein 0.0035 0.0071 0.0138
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0045 0.0109 0.0137
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.004 0.0093 0.0179
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0015 0.0019
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.1356 0.5165 1
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0071 0.0212 0.041
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0213 0.0758 0.0951
Leishmania major hypothetical protein, conserved 0.0047 0.0117 0.0227
Schistosoma mansoni coup transcription factor 0.0036 0.0075 0.0094
Brugia malayi nuclear receptor NHR-88 0.0036 0.0075 0.0146
Brugia malayi chromobox protein homolog 3 0.0116 0.0385 0.0745
Schistosoma mansoni ankyrin 23/unc44 0.0035 0.0071 0.0089
Brugia malayi Inositol-1 0.0041 0.0094 0.0181
Toxoplasma gondii hypothetical protein 0.004 0.0093 0.0179
Loa Loa (eye worm) hypothetical protein 0.0035 0.0071 0.0146
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.0109 0.021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0065 0.012
Echinococcus granulosus expressed conserved protein 0.0206 0.0732 0.0919
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0153 0.0284
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0179 0.0627 0.1215
Toxoplasma gondii thioredoxin reductase 0.0047 0.0119 0.0231
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0071 0.0212 0.041
Loa Loa (eye worm) hypothetical protein 0.0056 0.0152 0.0318
Brugia malayi Pre-SET motif family protein 0.1241 0.4724 0.9147
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0056 0.0154 0.0299
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0056 0.0153 0.0192
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0056 0.0153 0.0296
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0004 0.0008
Schistosoma mansoni hypothetical protein 0.0083 0.0256 0.0321
Echinococcus granulosus ecdysone induced protein 78C 0.0036 0.0075 0.0094
Loa Loa (eye worm) hypothetical protein 0.0142 0.0484 0.1021
Leishmania major dihydroorotate dehydrogenase 0.1356 0.5165 1
Entamoeba histolytica protein kinase, putative 0.0037 0.0081 0.0327
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0071 0.0212 0.041
Echinococcus granulosus dnaJ subfamily B 0.0398 0.1471 0.1846
Toxoplasma gondii hypothetical protein 0.004 0.0093 0.0179
Brugia malayi F/Y-rich N-terminus family protein 0.0079 0.024 0.0465
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0153 0.0284
Brugia malayi nuclear hormone receptor 0.0036 0.0075 0.0146
Schistosoma mansoni hypothetical protein 0.0047 0.012 0.015
Echinococcus multilocularis Chromobox protein 3 0.0034 0.0068 0.0068
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0052 0.0097
Schistosoma mansoni thyroid hormone receptor 0.0036 0.0075 0.0094
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0239 0.0462
Echinococcus granulosus geminin 0.0496 0.1851 0.2323
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0037 0.0081 0.0102
Trypanosoma brucei ISWI complex protein 0.0061 0.0174 0.0336
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0021 0.0016 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0116 0.0385 0.0714
Brugia malayi Nuclear hormone receptor-like 1 0.0036 0.0075 0.0146
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0212 0.041
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0534 0.1995 0.2504
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0111 0.0139
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0004 0.0008
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0047 0.0116 0.0216
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0153 0.0284
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.0109 0.021
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0534 0.1995 0.1995
Loa Loa (eye worm) bromodomain containing protein 0.0075 0.0225 0.0473
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0056 0.0153 0.0192
Loa Loa (eye worm) hypothetical protein 0.0036 0.0075 0.0155
Mycobacterium ulcerans beta-lactamase 0.0142 0.0484 0.0937
Schistosoma mansoni zinc finger protein 0.0086 0.0267 0.0335
Leishmania major 4-coumarate:coa ligase-like protein 0.0243 0.0874 0.1691
Schistosoma mansoni retinoic acid receptor RXR 0.0036 0.0075 0.0094
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0082
Entamoeba histolytica acetyltransferase, GNAT family 0.0043 0.0103 0.0437
Brugia malayi Steroid receptor seven-up type 2 0.0036 0.0075 0.0146
Loa Loa (eye worm) hypothetical protein 0.0058 0.0162 0.0338
Brugia malayi N-terminal motif family protein 0.0176 0.0614 0.1189
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0034 0.0068 0.0085
Mycobacterium tuberculosis Probable lipase LipD 0.0142 0.0484 0.0937
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0056 0.0153 0.0296
Loa Loa (eye worm) hypothetical protein 0.0182 0.0637 0.1344
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0125 0.0418 0.0525
Plasmodium vivax SET domain protein, putative 0.0179 0.0627 0.1215
Trypanosoma cruzi ISWI complex protein 0.0061 0.0174 0.0336
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0534 0.1995 1
Loa Loa (eye worm) glutathione reductase 0.0047 0.0119 0.0248
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0034 0.0068 0.0259
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0154 0.0532 0.103
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0024 0.0029 0.0029
Schistosoma mansoni hypothetical protein 0.0154 0.0532 0.0668
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0045 0.0109 0.0137
Brugia malayi AMP-binding enzyme family protein 0.0243 0.0874 0.1691
Brugia malayi nuclear receptor NHR-88 0.0017 0.0002 0.0004
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0047 0.0117 0.0227
Loa Loa (eye worm) hypothetical protein 0.0482 0.1796 0.3798
Brugia malayi Probable ClpP-like protease 0.0078 0.0239 0.0462
Plasmodium falciparum glutathione reductase 0.0047 0.0119 0.0231
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0047 0.0117 0.0147
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.012 0.0399 0.0744
Loa Loa (eye worm) hypothetical protein 0.0036 0.0075 0.0155
Brugia malayi PHD-finger family protein 0.0107 0.035 0.0677
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.0075 0.0146
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0036 0.0075 0.0146
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0153 0.0284
Loa Loa (eye worm) hypothetical protein 0.0182 0.0637 0.1344
Onchocerca volvulus 0.0149 0.051 0.0943
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0048 0.009
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.022 0.0784 0.3879
Echinococcus multilocularis prolyl tRNA synthetase, mitochondrial 0.0031 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0021 0.0016 0.003
Schistosoma mansoni hypothetical protein 0.0398 0.1471 0.1846
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0041 0.0094 0.0181
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0065 0.012
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0239 0.0462
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0142 0.0484 0.0608
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0071 0.0212 0.041
Echinococcus granulosus Protein patched homolog 1 0.0094 0.03 0.0377
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.0109 0.021
Brugia malayi Heterochromatin protein 1 0.0207 0.0736 0.1424
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0036 0.0075 0.0146
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0002 0.0003
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0243 0.0874 0.1691
Echinococcus multilocularis GPCR, family 2 0.0098 0.0313 0.0313
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.001 0.0019
Loa Loa (eye worm) helicase 0.0034 0.0068 0.0139
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0082 0.0255 0.032
Entamoeba histolytica acyl-coA synthetase, putative 0.0243 0.0874 0.4333
Brugia malayi hypothetical protein 0.0024 0.0031 0.006
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0498 0.1856 0.2329
Entamoeba histolytica hypothetical protein 0.0034 0.0068 0.0259
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0243 0.0874 0.1691
Brugia malayi Valyl-tRNA synthetase 0.0034 0.0068 0.0131
Schistosoma mansoni phd/f-box containing protein 0.0047 0.0117 0.0147
Schistosoma mansoni jumonji domain containing protein 0.0047 0.0117 0.0147
Loa Loa (eye worm) jmjC domain-containing protein 0.0047 0.0117 0.0244
Schistosoma mansoni nuclear receptor nhr-48 0.0017 0.0002 0.0003
Plasmodium vivax acyl-CoA synthetase, putative 0.0182 0.0637 0.1233
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0036 0.0075 0.0146
Brugia malayi photoreceptor-specific nuclear receptor 0.0036 0.0075 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.0094 0.03 0.0558
Entamoeba histolytica hypothetical protein 0.0034 0.0068 0.0259
Onchocerca volvulus 0.0056 0.0152 0.0279
Loa Loa (eye worm) hypothetical protein 0.0034 0.0068 0.0139
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0119 0.0231
Mycobacterium ulcerans putative regulatory protein 0.004 0.0093 0.0179
Trichomonas vaginalis chromobox protein, putative 0.0207 0.0736 0.1366
Brugia malayi hypothetical protein 0.0017 0.0002 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0036 0.0075 0.0155
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0017
Trichomonas vaginalis inositol monophosphatase, putative 0.0041 0.0094 0.0174
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.1356 0.5165 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0176 0.022
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.0353 0.0683
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0034 0.0068 0.0068
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0094 0.0174
Schistosoma mansoni hypothetical protein 0.0091 0.0287 0.036
Brugia malayi Zinc finger, C2H2 type family protein 0.0529 0.1978 0.383
Echinococcus multilocularis tumor protein p63 0.1015 0.3851 0.3851
Trichomonas vaginalis bromodomain-containing protein, putative 0.0056 0.0154 0.0287
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0071 0.0212 0.041
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0144 0.0493 0.0619
Echinococcus granulosus lysine specific demethylase 5A 0.0186 0.0656 0.0823
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.0414 0.0519
Mycobacterium tuberculosis Probable hydrolase 0.0142 0.0484 0.0937
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0074 0.0142
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0153 0.0284
Schistosoma mansoni jumonji/arid domain-containing protein 0.0186 0.0656 0.0823
Onchocerca volvulus 0.0091 0.0288 0.0531
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0248 0.0891 0.1119
Schistosoma mansoni hypothetical protein 0.008 0.0246 0.0309
Loa Loa (eye worm) heterochromatin protein 1 0.0207 0.0736 0.1554
Echinococcus granulosus Ankyrin 0.0035 0.0072 0.009
Loa Loa (eye worm) hypothetical protein 0.0036 0.0075 0.0155
Mycobacterium leprae Probable lipase LipE 0.0142 0.0484 0.0909
Loa Loa (eye worm) hypothetical protein 0.0142 0.0484 0.1021
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0239 0.2273
Onchocerca volvulus 0.0019 0.0009 0.0012
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0247 0.0888 0.1115
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0018 0.0004 0.0005
Echinococcus granulosus replication factor c subunit 1 0.0021 0.0016 0.002
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0041 0.0094 0.0181
Trichomonas vaginalis chromobox protein, putative 0.0125 0.0419 0.0777
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0065 0.012
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.004 0.009 0.0167
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0031 0.006
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0212 0.041
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0475 0.177 0.177
Mycobacterium ulcerans acetyl-CoA synthetase 0.0071 0.0212 0.041
Loa Loa (eye worm) hypothetical protein 0.0021 0.0016 0.003
Brugia malayi hypothetical protein 0.0034 0.0068 0.0132
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0056 0.0153 0.0296
Loa Loa (eye worm) CXXC zinc finger family protein 0.0056 0.0152 0.0317
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0094 0.0298 0.0298
Giardia lamblia GTOR 0.0045 0.0109 0.1035
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0035 0.0071 0.0071
Brugia malayi glutathione reductase 0.0047 0.0119 0.0231
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0071 0.0212 0.041
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0074 0.0142
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0078 0.0239 0.0462
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0047 0.0116 0.0216
Mycobacterium ulcerans lipase LipD 0.0142 0.0484 0.0937

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS Assay for Inhibitors of Human alpha-Galactosidase at pH 4.5. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Galactosidase From Spleen Homogenate. (Class of assay: confirmatory) [Related pubchem assays: 1472, 1467 ] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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